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Compile Data Set for Download or QSAR

Found 720 hits Enz. Inhib. hit(s) with Target = 'Polycomb repressive complex 2 (PRC2)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291686
PNG
(8-(1,3-Dimethyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3-...)
Show SMILES Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cnnc23)n(C)n1
PDB

UniProtKB/SwissProt

antibodypedia
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n/an/a 0.900n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291695
PNG
(3-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl...)
Show SMILES [O-][N]1=CC(=CC=C1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12 |c:3,5,t:1|
PDB

UniProtKB/SwissProt

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n/an/a 1n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291815
PNG
((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...)
Show SMILES Cc1cc(ncc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12)C(=O)N1CCCC1
PDB

UniProtKB/SwissProt

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n/an/a 1.30n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291908
PNG
(8-(6-((dimethylamino)methyl)-2-methylpyridin-3-yl)...)
Show SMILES CN(C)Cc1ccc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 1.40n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291925
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(-n2ccnc2)c2nncn12
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 1.40n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291909
PNG
(8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...)
Show SMILES CCc1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 1.5n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291824
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Cc1nc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12)S(C)(=O)=O
PDB

UniProtKB/SwissProt

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n/an/a 1.60n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291824
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Cc1nc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12)S(C)(=O)=O
PDB

UniProtKB/SwissProt

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n/an/a 1.70n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291814
PNG
((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(nc2)C(=O)N2CCCC2)c2nncn12
PDB

UniProtKB/SwissProt

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n/an/a 1.90n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291909
PNG
(8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...)
Show SMILES CCc1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 1.90n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291823
PNG
(8-(4-chloro-6-methoxypyridin-3-yl)-N-((5-fluoro-2,...)
Show SMILES COc1cc(Cl)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 1.90n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291918
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Cc1cn(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291853
PNG
(8-(2-(difluoromethyl)pyridin-3-yl)-N-((5-fluoro-2,...)
Show SMILES FC(F)c1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291689
PNG
(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES CC(C)n1cc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2.10n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291909
PNG
(8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...)
Show SMILES CCc1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 2.20n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291882
PNG
(8-(6-(difluoromethoxy)-4-methylpyridin-3-yl)-N-((5...)
Show SMILES Cc1cc(OC(F)F)ncc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 2.20n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291873
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES CC(C)n1ncc(c1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 2.30n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291830
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES COc1cc(ccn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2.40n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291879
PNG
(8-(2,5-dimethylpyridin-4-yl)-N-((5-fluoro-2,3-dihy...)
Show SMILES Cc1cc(c(C)cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2.40n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291880
PNG
(8-(1,3-dimethyl-1H-pyrazol-4-yl)-N-((5-fluoro-2,3-...)
Show SMILES Cc1nn(C)cc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2.40n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291827
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES COc1ccc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2.40n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291867
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Cc1c(CF)nccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2.5n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291875
PNG
(2-(4-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)met...)
Show SMILES Cc1nn(CCO)cc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2.5n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291866
PNG
(8-(2-(difluoromethyl)-3-methylpyridin-4-yl)-N-((5-...)
Show SMILES Cc1c(ccnc1C(F)F)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291687
PNG
(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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PC sid
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US Patent
n/an/a 2.60n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291812
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Cc1cc(ncc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12)S(C)(=O)=O
PDB

UniProtKB/SwissProt

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n/an/a 2.60n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291914
PNG
(8-(6-ethyl-2-methylpyridin-3-yl)-N-((5-fluoro-2,3-...)
Show SMILES CCc1ccc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2.70n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291693
PNG
(8-(2-Cyclopropyl-4-methylpyrimidin-5-yl)-N-((5-flu...)
Show SMILES Cc1nc(ncc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12)C1CC1
PDB

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Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291690
PNG
(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES COc1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2.90n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291854
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Cn1nccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 2.90n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291885
PNG
(8-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)-N-...)
Show SMILES Cn1cc(c(n1)C(F)F)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 3n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291867
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Cc1c(CF)nccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

UniProtKB/SwissProt

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n/an/a 3.10n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291922
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(-n2cccn2)c2nncn12
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 3.10n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291689
PNG
(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES CC(C)n1cc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

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n/an/a 3.20n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291816
PNG
(5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl...)
Show SMILES CN(C)C(=O)c1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

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Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291852
PNG
(8-(2,6-dimethylpyridin-3-yl)-N-((5-fluoro-2,3-dihy...)
Show SMILES Cc1ccc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

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n/an/a 3.30n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291688
PNG
(8-(2,4-Dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-di...)
Show SMILES Cc1ncc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

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US Patent
n/an/a 3.40n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291860
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES COc1ncc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

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n/an/a 3.40n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291871
PNG
((2R)-1-(4-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-y...)
Show SMILES C[C@@H](O)Cn1nc(C)c(c1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12 |r,wD:1.1,(-5.91,-2.6,;-6.31,-4.09,;-7.79,-4.49,;-5.22,-5.18,;-3.73,-4.78,;-2.48,-5.68,;-1.24,-4.78,;.1,-5.55,;-1.71,-3.31,;-3.25,-3.31,;-4.02,-1.98,;-.63,-2.22,;.86,-2.62,;1.95,-1.53,;1.55,-.05,;2.64,1.04,;4.13,.64,;5.22,1.73,;4.82,3.22,;3.45,3.92,;3.69,5.44,;5.21,5.68,;5.91,4.31,;7.4,3.91,;7.79,2.42,;6.71,1.34,;7.1,-.15,;.06,.35,;-.63,1.73,;-2.16,1.48,;-2.4,-.04,;-1.02,-.74,)|
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Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291877
PNG
(8-(1-cyclopropyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3...)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(-c2ccnn2C2CC2)c2nncn12
PDB

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n/an/a 3.5n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291694
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES CC(C)Oc1ncc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

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Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291892
PNG
(N-((5-Fluorobenzofuran-4-yl)methyl)-8-(2-methylpyr...)
Show SMILES Cc1ncccc1-c1cnc(NCc2c(F)ccc3occc23)n2cnnc12
PDB

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n/an/a 3.60n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291886
PNG
(8-(2-(difluoromethyl)-6-methylpyridin-3-yl)-N-((5-...)
Show SMILES Cc1ccc(-c2cnc(NCc3c4CCOc4ccc3F)n3cnnc23)c(n1)C(F)F
PDB

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n/an/a 3.60n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291881
PNG
(8-(6-ethoxy-4-methylpyridin-3-yl)-N-((5-fluoro-2,3...)
Show SMILES CCOc1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

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n/an/a 3.60n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291846
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES COc1cc(F)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

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n/an/a 3.60n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291832
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Cn1cc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

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n/an/a 3.60n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291873
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES CC(C)n1ncc(c1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

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n/an/a 3.60n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291765
PNG
((5-(5-(((2,3-dihydrobenzofuran-4-yl)methyl)amino)-...)
Show SMILES O=C(N1CCCC1)c1ccc(cn1)-c1cnc(NCc2cccc3OCCc23)n2cnnc12
PDB

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n/an/a 3.70n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291813
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES Cc1cc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12)S(C)(=O)=O
PDB

UniProtKB/SwissProt

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n/an/a 3.70n/an/an/an/an/an/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM291873
PNG
(N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Show SMILES CC(C)n1ncc(c1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
PDB

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n/an/a 3.80n/an/an/an/a8.0n/a



Novartis AG

US Patent




US Patent US9580437 (2017)


BindingDB Entry DOI: 10.7270/Q24T6MD7
More data for this
Ligand-Target Pair
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