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Found 3 hits Enz. Inhib. hit(s) with Target = 'RNA-directed RNA polymerase (NS5B) (S282T)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RNA-directed RNA polymerase (NS5B) (S282T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM240845
PNG
(US9394331, 140 | US9394331, 52)
Show SMILES Nc1ccn(C2OC(CO)[C@@H](O)[C@]22CCO2)c(=O)n1
Show InChI InChI=1/C11H15N3O5/c12-7-1-3-14(10(17)13-7)9-11(2-4-18-11)8(16)6(5-15)19-9/h1,3,6,8-9,15-16H,2,4-5H2,(H2,12,13,17)/t6?,8-,9?,11-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.67E+4n/an/an/an/a7.527



Gilead Pharmasset LLC

US Patent


Assay Description
The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...


Citation and Details
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B) (S282T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM240844
PNG
(US9394331, 136 | US9394331, 48)
Show SMILES OCC1OC(n2ccc(=O)[nH]c2=O)[C@@]2(CCO2)[C@@H]1O
Show InChI InChI=1/C11H14N2O6/c14-5-6-8(16)11(2-4-18-11)9(19-6)13-3-1-7(15)12-10(13)17/h1,3,6,8-9,14,16H,2,4-5H2,(H,12,15,17)/t6?,8-,9?,11-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/a7.527



Gilead Pharmasset LLC

US Patent


Assay Description
The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...


Citation and Details
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase (NS5B) (S282T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM240843
PNG
(US9394331, 137 | US9394331, 49)
Show SMILES Nc1ccn(C2OC(CO)[C@@H](O)[C@]22CCCO2)c(=O)n1
Show InChI InChI=1/C12H17N3O5/c13-8-2-4-15(11(18)14-8)10-12(3-1-5-19-12)9(17)7(6-16)20-10/h2,4,7,9-10,16-17H,1,3,5-6H2,(H2,13,14,18)/t7?,9-,10?,12-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/a7.527



Gilead Pharmasset LLC

US Patent


Assay Description
The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...


Citation and Details
More data for this
Ligand-Target Pair