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Compile Data Set for Download or QSAR

Found 79 hits Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein phosphatase beta (PTPβ)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50270587
PNG
(5-(3-Cyclohexyl-4'-fluoro-2'-trifluoromethyl-biphe...)
Show SMILES OC(=O)c1cc(on1)-c1ccc(cc1C1CCCCC1)-c1ccc(F)cc1C(F)(F)F
Show InChI InChI=1S/C23H19F4NO3/c24-15-7-9-16(19(11-15)23(25,26)27)14-6-8-17(21-12-20(22(29)30)28-31-21)18(10-14)13-4-2-1-3-5-13/h6-13H,1-5H2,(H,29,30)
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220n/an/an/an/an/an/an/an/a



Astex Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PtpB


J Med Chem 51: 3661-80 (2008)


Article DOI: 10.1021/jm8000373
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118751
PNG
(6-(Oxalyl-amino)-1H-indole-7-carboxylic acid | 6-(...)
Show SMILES OC(=O)C(=O)Nc1ccc2cc[nH]c2c1C(O)=O
Show InChI InChI=1S/C11H8N2O5/c14-9(11(17)18)13-6-2-1-5-3-4-12-8(5)7(6)10(15)16/h1-4,12H,(H,13,14)(H,15,16)(H,17,18)
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3.60E+3n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118796
PNG
(6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID | 6-(...)
Show SMILES OC(=O)C(=O)Nc1cc2[nH]ccc2cc1C(O)=O
Show InChI InChI=1S/C11H8N2O5/c14-9(11(17)18)13-8-4-7-5(1-2-12-7)3-6(8)10(15)16/h1-4,12H,(H,13,14)(H,15,16)(H,17,18)
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6.00E+3n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118744
PNG
(2-(Oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran...)
Show SMILES OC(=O)C(=O)Nc1sc2COCCc2c1C(O)=O
Show InChI InChI=1S/C10H9NO6S/c12-7(10(15)16)11-8-6(9(13)14)4-1-2-17-3-5(4)18-8/h1-3H2,(H,11,12)(H,13,14)(H,15,16)
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1.10E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50299462
PNG
(2-(3-(dihydroxymethyl)naphthalen-2-ylamino)-2-oxoa...)
Show SMILES OC(O)c1cc2ccccc2cc1NC(=O)C(O)=O
Show InChI InChI=1S/C13H11NO5/c15-11(13(18)19)14-10-6-8-4-2-1-3-7(8)5-9(10)12(16)17/h1-6,12,16-17H,(H,14,15)(H,18,19)
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1.40E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118778
PNG
(5-iodo-2-(oxaloamino)benzoic acid | CHEMBL336908)
Show SMILES OC(=O)C(=O)Nc1ccc(I)cc1C(O)=O
Show InChI InChI=1S/C9H6INO5/c10-4-1-2-6(5(3-4)8(13)14)11-7(12)9(15)16/h1-3H,(H,11,12)(H,13,14)(H,15,16)
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1.70E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118749
PNG
(2-(Oxalyl-amino)-thiophene-3-carboxylic acid | 2-(...)
Show SMILES OC(=O)C(=O)Nc1sccc1C(O)=O
Show InChI InChI=1S/C7H5NO5S/c9-4(7(12)13)8-5-3(6(10)11)1-2-14-5/h1-2H,(H,8,9)(H,10,11)(H,12,13)
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1.80E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118762
PNG
(2-(Oxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thioph...)
Show SMILES OC(=O)C(=O)Nc1sc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C11H11NO5S/c13-8(11(16)17)12-9-7(10(14)15)5-3-1-2-4-6(5)18-9/h1-4H2,(H,12,13)(H,14,15)(H,16,17)
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1.90E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50299461
PNG
((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)
Show SMILES OC(=O)C(=O)Nc1sc2[C@H](COC3=NS(=O)(=O)c4ccccc34)OCCc2c1C(O)=O |r,t:12|
Show InChI InChI=1S/C18H14N2O9S2/c21-14(18(24)25)19-16-12(17(22)23)9-5-6-28-10(13(9)30-16)7-29-15-8-3-1-2-4-11(8)31(26,27)20-15/h1-4,10H,5-7H2,(H,19,21)(H,22,23)(H,24,25)/t10-/m0/s1
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2.10E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50441456
PNG
(CHEMBL1369374)
Show SMILES OC(=O)c1nc2nc(Cl)c(Cl)nc2[nH]1
Show InChI InChI=1S/C6H2Cl2N4O2/c7-1-2(8)10-4-3(9-1)11-5(12-4)6(13)14/h(H,13,14)(H,9,10,11,12)
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2.60E+4n/an/an/an/an/an/an/an/a



Saint John's University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of human GST-tagged LMW-PTP-B expressed in Escherichia coli JM 109 cells using p-nitrophenyl phosphate as substrate after 1...


Bioorg Med Chem Lett 23: 5912-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.079
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118789
PNG
(2-(oxaloamino)benzoic acid | CHEMBL139050)
Show SMILES OC(=O)C(=O)Nc1ccccc1C(O)=O
Show InChI InChI=1S/C9H7NO5/c11-7(9(14)15)10-6-4-2-1-3-5(6)8(12)13/h1-4H,(H,10,11)(H,12,13)(H,14,15)
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3.30E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50441457
PNG
(CHEMBL1358072)
Show SMILES CC(=O)Nc1c(C)cc(OCC(O)=O)cc1C
Show InChI InChI=1S/C12H15NO4/c1-7-4-10(17-6-11(15)16)5-8(2)12(7)13-9(3)14/h4-5H,6H2,1-3H3,(H,13,14)(H,15,16)
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7.32E+4n/an/an/an/an/an/an/an/a



Saint John's University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of human GST-tagged LMW-PTP-B expressed in Escherichia coli JM 109 cells using p-nitrophenyl phosphate as substrate after 1...


Bioorg Med Chem Lett 23: 5912-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.079
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50312261
PNG
((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
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>1.00E+5n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of human PtpB


Bioorg Med Chem Lett 19: 6851-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.090
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118779
PNG
(3-(Oxalyl-amino)-thiophene-2-carboxylic acid | 3-(...)
Show SMILES OC(=O)C(=O)Nc1ccsc1C(O)=O
Show InChI InChI=1S/C7H5NO5S/c9-5(7(12)13)8-3-1-2-14-4(3)6(10)11/h1-2H,(H,8,9)(H,10,11)(H,12,13)
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1.60E+5n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118792
PNG
(2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]P...)
Show SMILES OC(=O)C(=O)Nc1sc2CNCCc2c1C(O)=O
Show InChI InChI=1S/C10H10N2O5S/c13-7(10(16)17)12-8-6(9(14)15)4-1-2-11-3-5(4)18-8/h11H,1-3H2,(H,12,13)(H,14,15)(H,16,17)
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5.60E+5n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50308835
PNG
(4-((S)-2-(4-ethylthiazol-2-yl)-2-((S)-2-(methoxyca...)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](CC(C)C)C(=O)OC |r|
Show InChI InChI=1S/C21H29N3O6S2/c1-5-15-12-31-20(22-15)18(23-19(25)17(10-13(2)3)21(26)30-4)11-14-6-8-16(9-7-14)24-32(27,28)29/h6-9,12-13,17-18,24H,5,10-11H2,1-4H3,(H,23,25)(H,27,28,29)/t17-,18-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Incyte Corporation

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase beta


J Med Chem 53: 2333-44 (2010)


Article DOI: 10.1021/jm901090b
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188792
PNG
(CHEMBL213750 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS(O)(=O)=O)cc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C19H22N2O10S2/c1-30-17(22)19(18(23)31-2,11-13-3-7-15(8-4-13)20-32(24,25)26)12-14-5-9-16(10-6-14)21-33(27,28)29/h3-10,20-21H,11-12H2,1-2H3,(H,24,25,26)(H,27,28,29)/p-1
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n/an/a 60n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188795
PNG
(CHEMBL386550 | ammonium N-{4-[2,2-bis(3-methyl-1,2...)
Show SMILES Cc1noc(n1)C(CCCc1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)c1nc(C)no1
Show InChI InChI=1S/C23H25N5O5S/c1-16-24-21(32-26-16)23(22-25-17(2)27-33-22,14-6-9-18-7-4-3-5-8-18)15-19-10-12-20(13-11-19)28-34(29,30)31/h3-5,7-8,10-13,28H,6,9,14-15H2,1-2H3,(H,29,30,31)/p-1
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n/an/a 70n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188791
PNG
(CHEMBL213732 | ammonium N-{4-[2,2-bis(3-methyl-1,2...)
Show SMILES Cc1noc(n1)C(Cc1ccc(NS(O)(=O)=O)cc1)(Cc1ccc(NS([O-])(=O)=O)cc1)c1nc(C)no1
Show InChI InChI=1S/C21H22N6O8S2/c1-13-22-19(34-24-13)21(20-23-14(2)25-35-20,11-15-3-7-17(8-4-15)26-36(28,29)30)12-16-5-9-18(10-6-16)27-37(31,32)33/h3-10,26-27H,11-12H2,1-2H3,(H,28,29,30)(H,31,32,33)/p-1
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n/an/a 80n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188775
PNG
(CHEMBL214192 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(CCCS(=O)(=O)c1nnnn1-c1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C22H25N5O9S2/c1-35-19(28)22(20(29)36-2,15-16-9-11-17(12-10-16)24-38(32,33)34)13-6-14-37(30,31)21-23-25-26-27(21)18-7-4-3-5-8-18/h3-5,7-12,24H,6,13-15H2,1-2H3,(H,32,33,34)/p-1
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n/an/a 80n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188801
PNG
(CHEMBL213620 | ammonium N-{4-[2-(2-{[(tert-butoxy)...)
Show SMILES CCOC(=O)C(CCNC(=O)OC(C)(C)C)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C20H30N2O9S/c1-6-30-17(24)20(16(23)29-5,11-12-21-18(25)31-19(2,3)4)13-14-7-9-15(10-8-14)22-32(26,27)28/h7-10,22H,6,11-13H2,1-5H3,(H,21,25)(H,26,27,28)/p-1
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n/an/a 90n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50388723
PNG
(CHEMBL2057662)
Show SMILES OC(=O)CCc1cccc(c1)[Sb](O)(O)=O
Show InChI InChI=1S/C9H9O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-5H,6-7H2,(H,10,11);2*1H2;;/q;;;;+2/p-2
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n/an/a 100n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of PTP-beta receptor using para-nitrophenol as substrate by colorimetric analysis


Bioorg Med Chem 20: 4371-6 (2012)


Article DOI: 10.1016/j.bmc.2012.05.040
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM26613
PNG
((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Show SMILES OC(=O)\C=C\c1cccc(c1)[Sb](O)(O)=O
Show InChI InChI=1S/C9H7O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-7H,(H,10,11);2*1H2;;/q;;;;+2/p-2/b7-6+;;;;
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Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of PTP-beta receptor using para-nitrophenol as substrate by colorimetric analysis


Bioorg Med Chem 20: 4371-6 (2012)


Article DOI: 10.1016/j.bmc.2012.05.040
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188797
PNG
(CHEMBL213802 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1cccc(NS(O)(=O)=O)c1)C(=O)OC
Show InChI InChI=1S/C19H22N2O10S2/c1-30-17(22)19(18(23)31-2,11-13-6-8-15(9-7-13)20-32(24,25)26)12-14-4-3-5-16(10-14)21-33(27,28)29/h3-10,20-21H,11-12H2,1-2H3,(H,24,25,26)(H,27,28,29)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50306213
PNG
(CHEMBL611318 | {[25,26,27,28-tetrahydroxy-11,17,23...)
Show SMILES Oc1c2cc(CP(O)(O)=O)cc1sc1cc(CP(O)(O)=O)cc(sc3cc(CP(O)(O)=O)cc(sc4cc(CP(O)(O)=O)cc(s2)c4O)c3O)c1O
Show InChI InChI=1S/C28H28O16P4S4/c29-25-17-1-13(9-45(33,34)35)2-18(25)50-21-5-15(11-47(39,40)41)6-22(27(21)31)52-24-8-16(12-48(42,43)44)7-23(28(24)32)51-20-4-14(10-46(36,37)38)3-19(49-17)26(20)30/h1-8,29-32H,9-12H2,(H2,33,34,35)(H2,36,37,38)(H2,39,40,41)(H2,42,43,44)
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n/an/a 130n/an/an/an/an/an/a



National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PTPbeta


Bioorg Med Chem Lett 20: 483-7 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.126
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188781
PNG
(CHEMBL209527 | ammonium N-(4-{2-[(4-carboxyphenyl)...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1ccc(cc1)C(O)=O)C(=O)OC
Show InChI InChI=1S/C20H21NO9S/c1-29-18(24)20(19(25)30-2,11-13-3-7-15(8-4-13)17(22)23)12-14-5-9-16(10-6-14)21-31(26,27)28/h3-10,21H,11-12H2,1-2H3,(H,22,23)(H,26,27,28)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188780
PNG
(CHEMBL211786 | ammonium N-(4-{2-[3-(benzenesulfony...)
Show SMILES COC(=O)C(CCCS(=O)(=O)c1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C21H25NO9S2/c1-30-19(23)21(20(24)31-2,13-6-14-32(25,26)18-7-4-3-5-8-18)15-16-9-11-17(12-10-16)22-33(27,28)29/h3-5,7-12,22H,6,13-15H2,1-2H3,(H,27,28,29)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188784
PNG
(CHEMBL385251 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(CCCc1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C21H25NO7S/c1-28-19(23)21(20(24)29-2,14-6-9-16-7-4-3-5-8-16)15-17-10-12-18(13-11-17)22-30(25,26)27/h3-5,7-8,10-13,22H,6,9,14-15H2,1-2H3,(H,25,26,27)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188778
PNG
(CHEMBL213626 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(CCCSc1nnnn1-c1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C22H25N5O7S2/c1-33-19(28)22(20(29)34-2,15-16-9-11-17(12-10-16)24-36(30,31)32)13-6-14-35-21-23-25-26-27(21)18-7-4-3-5-8-18/h3-5,7-12,24H,6,13-15H2,1-2H3,(H,30,31,32)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188782
PNG
(CHEMBL384201 | ammonium N-{4-[3-(3-cyanophenyl)-2,...)
Show SMILES Cc1noc(n1)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1cccc(c1)C#N)c1nc(C)no1
Show InChI InChI=1S/C22H20N6O5S/c1-14-24-20(32-26-14)22(21-25-15(2)27-33-21,12-17-4-3-5-18(10-17)13-23)11-16-6-8-19(9-7-16)28-34(29,30)31/h3-10,28H,11-12H2,1-2H3,(H,29,30,31)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188779
PNG
(CHEMBL378423 | ammonium N-{4-[4-ethoxy-2,2-bis(met...)
Show SMILES CCOC(=O)CC(Cc1ccc(NS([O-])(=O)=O)cc1)(C(=O)OC)C(=O)OC
Show InChI InChI=1S/C16H21NO9S/c1-4-26-13(18)10-16(14(19)24-2,15(20)25-3)9-11-5-7-12(8-6-11)17-27(21,22)23/h5-8,17H,4,9-10H2,1-3H3,(H,21,22,23)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188783
PNG
(CHEMBL213226 | ammonium N-{4-[3-(3-methoxyphenyl)-...)
Show SMILES COc1cccc(CC(Cc2ccc(NS([O-])(=O)=O)cc2)(c2nc(C)no2)c2nc(C)no2)c1
Show InChI InChI=1S/C22H23N5O6S/c1-14-23-20(32-25-14)22(21-24-15(2)26-33-21,13-17-5-4-6-19(11-17)31-3)12-16-7-9-18(10-8-16)27-34(28,29)30/h4-11,27H,12-13H2,1-3H3,(H,28,29,30)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188798
PNG
(CHEMBL385818 | ammonium N-(4-{2-[(benzyloxy)methyl...)
Show SMILES COC(=O)C(COCc1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C20H23NO8S/c1-27-18(22)20(19(23)28-2,14-29-13-16-6-4-3-5-7-16)12-15-8-10-17(11-9-15)21-30(24,25)26/h3-11,21H,12-14H2,1-2H3,(H,24,25,26)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188794
PNG
(CHEMBL380374 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)c1cccc(CC(Cc2ccc(NS([O-])(=O)=O)cc2)(C(=O)OC)C(=O)OC)c1
Show InChI InChI=1S/C21H23NO9S/c1-29-18(23)16-6-4-5-15(11-16)13-21(19(24)30-2,20(25)31-3)12-14-7-9-17(10-8-14)22-32(26,27)28/h4-11,22H,12-13H2,1-3H3,(H,26,27,28)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188793
PNG
(CHEMBL209957 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1cccc(c1)S(N)(=O)=O)C(=O)OC
Show InChI InChI=1S/C19H22N2O9S2/c1-29-17(22)19(18(23)30-2,12-14-4-3-5-16(10-14)31(20,24)25)11-13-6-8-15(9-7-13)21-32(26,27)28/h3-10,21H,11-12H2,1-2H3,(H2,20,24,25)(H,26,27,28)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188776
PNG
(4-(2-benzyl-3-methoxy-2-(methoxycarbonyl)-3-oxopro...)
Show SMILES COC(=O)C(Cc1ccccc1)(Cc1ccc(NS(O)(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C19H21NO7S/c1-26-17(21)19(18(22)27-2,12-14-6-4-3-5-7-14)13-15-8-10-16(11-9-15)20-28(23,24)25/h3-11,20H,12-13H2,1-2H3,(H,23,24,25)
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n/an/a 320n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188796
PNG
(CHEMBL213728 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1cccc(OC)c1)C(=O)OC
Show InChI InChI=1S/C20H23NO8S/c1-27-17-6-4-5-15(11-17)13-20(18(22)28-2,19(23)29-3)12-14-7-9-16(10-8-14)21-30(24,25)26/h4-11,21H,12-13H2,1-3H3,(H,24,25,26)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188785
PNG
(CHEMBL209955 | ammonium N-{4-[3-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(CC(Cc2ccc(NS([O-])(=O)=O)cc2)(c2nc(C)no2)c2nc(C)no2)cc1
Show InChI InChI=1S/C22H23N5O6S/c1-14-23-20(32-25-14)22(21-24-15(2)26-33-21,13-17-6-10-19(31-3)11-7-17)12-16-4-8-18(9-5-16)27-34(28,29)30/h4-11,27H,12-13H2,1-3H3,(H,28,29,30)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188786
PNG
(CHEMBL213826 | ammonium N-{4-[6-methoxy-2,2-bis(me...)
Show SMILES COC(=O)CCCC(Cc1ccc(NS([O-])(=O)=O)cc1)(C(=O)OC)C(=O)OC
Show InChI InChI=1S/C17H23NO9S/c1-25-14(19)5-4-10-17(15(20)26-2,16(21)27-3)11-12-6-8-13(9-7-12)18-28(22,23)24/h6-9,18H,4-5,10-11H2,1-3H3,(H,22,23,24)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188799
PNG
(CHEMBL213727 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1ccc(OC)cc1)C(=O)OC
Show InChI InChI=1S/C20H23NO8S/c1-27-17-10-6-15(7-11-17)13-20(18(22)28-2,19(23)29-3)12-14-4-8-16(9-5-14)21-30(24,25)26/h4-11,21H,12-13H2,1-3H3,(H,24,25,26)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50214527
PNG
(4-((5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazoli...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(OCc4ccccc4)cc3)C2=O)cc1
Show InChI InChI=1S/C25H19NO5S/c27-23-22(32-25(30)26(23)15-18-6-10-20(11-7-18)24(28)29)14-17-8-12-21(13-9-17)31-16-19-4-2-1-3-5-19/h1-14H,15-16H2,(H,28,29)/b22-14-
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Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase beta


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188777
PNG
(CHEMBL213452 | ammonium N-[4-(2-{[(benzyloxy)carbo...)
Show SMILES CCOC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(NC(=O)OCc1ccccc1)C(=O)OC
Show InChI InChI=1S/C21H24N2O9S/c1-3-31-19(25)21(18(24)30-2,22-20(26)32-14-16-7-5-4-6-8-16)13-15-9-11-17(12-10-15)23-33(27,28)29/h4-12,23H,3,13-14H2,1-2H3,(H,22,26)(H,27,28,29)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188800
PNG
(CHEMBL386657 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)c1ccc(CC(Cc2ccc(NS([O-])(=O)=O)cc2)(C(=O)OC)C(=O)OC)cc1
Show InChI InChI=1S/C21H23NO9S/c1-29-18(23)16-8-4-14(5-9-16)12-21(19(24)30-2,20(25)31-3)13-15-6-10-17(11-7-15)22-32(26,27)28/h4-11,22H,12-13H2,1-3H3,(H,26,27,28)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188788
PNG
(CHEMBL214241 | ammonium N-{4-[2-(3-methanesulfonyl...)
Show SMILES COC(=O)C(CCCS(C)(=O)=O)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C16H23NO9S2/c1-25-14(18)16(15(19)26-2,9-4-10-27(3,20)21)11-12-5-7-13(8-6-12)17-28(22,23)24/h5-8,17H,4,9-11H2,1-3H3,(H,22,23,24)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188789
PNG
(CHEMBL378337 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1ccc(cc1)S(N)(=O)=O)C(=O)OC
Show InChI InChI=1S/C19H22N2O9S2/c1-29-17(22)19(18(23)30-2,12-14-5-9-16(10-6-14)31(20,24)25)11-13-3-7-15(8-4-13)21-32(26,27)28/h3-10,21H,11-12H2,1-2H3,(H2,20,24,25)(H,26,27,28)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188802
PNG
(CHEMBL210180 | ammonium N-[4-(2-{[(tert-butoxy)car...)
Show SMILES CCOC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(NC(=O)OC(C)(C)C)C(=O)OC
Show InChI InChI=1S/C18H26N2O9S/c1-6-28-15(22)18(14(21)27-5,19-16(23)29-17(2,3)4)11-12-7-9-13(10-8-12)20-30(24,25)26/h7-10,20H,6,11H2,1-5H3,(H,19,23)(H,24,25,26)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50436358
PNG
(CHEMBL2396718)
Show SMILES CCCNC(=O)COc1ccc(cc1)-c1oc2cc(O)c(cc2c1C#Cc1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C28H22ClNO6/c1-2-12-30-26(32)16-35-20-9-7-18(8-10-20)27-21(11-6-17-4-3-5-19(29)13-17)22-14-23(28(33)34)24(31)15-25(22)36-27/h3-5,7-10,13-15,31H,2,12,16H2,1H3,(H,30,32)(H,33,34)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant PTPbeta (unknown origin) using pNPP as substrate by spectrophotometric analysis


J Med Chem 56: 4990-5008 (2013)


Article DOI: 10.1021/jm400248c
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50079855
PNG
((R)-2-[2,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)Oc1c(Br)cc(cc1Br)-c1c2c3ccccc3oc2c(Br)c2ccccc12
Show InChI InChI=1S/C31H19Br3O4/c32-22-15-18(16-23(33)29(22)38-25(31(35)36)14-17-8-2-1-3-9-17)26-19-10-4-5-11-20(19)28(34)30-27(26)21-12-6-7-13-24(21)37-30/h1-13,15-16,25H,14H2,(H,35,36)/t25-/m1/s1
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
The compound was tested in vitro for the inhibitory activity against Protein-tyrosine phosphatase beta (SH-PTP1) (human PTPases.)


J Med Chem 42: 3199-202 (1999)


Article DOI: 10.1021/jm990260v
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188787
PNG
(CHEMBL213594 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccncc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C18H20N2O7S/c1-26-16(21)18(17(22)27-2,12-14-7-9-19-10-8-14)11-13-3-5-15(6-4-13)20-28(23,24)25/h3-10,20H,11-12H2,1-2H3,(H,23,24,25)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Bioorg Med Chem Lett 16: 4252-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.074
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50079856
PNG
(CHEMBL108721 | [2,6-Dibromo-4-(6-bromo-benzo[b]nap...)
Show SMILES OC(=O)COc1c(Br)cc(cc1Br)-c1c2c(sc3ccccc23)c(Br)c2ccccc12
Show InChI InChI=1S/C24H13Br3O3S/c25-16-9-12(10-17(26)23(16)30-11-19(28)29)20-13-5-1-2-6-14(13)22(27)24-21(20)15-7-3-4-8-18(15)31-24/h1-10H,11H2,(H,28,29)
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
The compound was tested in vitro for the inhibitory activity against Protein-tyrosine phosphatase beta (SH-PTP1) (human PTPases.)


J Med Chem 42: 3199-202 (1999)


Article DOI: 10.1021/jm990260v
More data for this
Ligand-Target Pair
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