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Compile Data Set for Download or QSAR

Found 92 hits Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 2/Rho-kinase (ROCK I)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067513
PNG
(CHEMBL3401977)
Show SMILES OP(O)(=O)CC[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:13.15,wD:6.5,(3.73,4.94,;3.72,3.71,;4.79,4.32,;4.78,3.08,;2.38,2.95,;1.05,3.73,;-.29,2.98,;-1.7,3.76,;-3.03,2.98,;-3.03,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;.93,-.95,;-.42,-1.67,;-.48,-3.21,;.83,-4.02,;2.19,-3.3,;2.24,-1.76,;3.33,-1.18,;-1.83,-3.93,;-2.01,-5.43,;-3.53,-5.71,;-4.26,-4.36,;-5.76,-4.01,;-6.19,-2.51,;-5.12,-1.4,;-5.47,-.22,;-3.61,-1.77,;-3.19,-3.25,)|
Show InChI InChI=1/C21H24F2N5O3P/c22-13-7-15-16(9-25-19(15)24-8-13)20-26-10-17(23)21(28-20)27-18-12-3-1-11(2-4-12)14(18)5-6-32(29,30)31/h7-12,14,18H,1-6H2,(H,24,25)(H,26,27,28)(H2,29,30,31)/t11?,12?,14-,18-/s2
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250n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067537
PNG
(CHEMBL3401987)
Show SMILES [H][C@]1(C(C)O)C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wD:11.13,1.0,TLB:2:1:7.6:9.10,THB:12:11:7.6:9.10,(-.64,1.54,;.13,.87,;1.58,1.51,;1.76,2.72,;2.54,.74,;1.38,,;2.86,.48,;2.23,-.94,;,-.67,;-.29,-2.25,;1.15,-1.65,;-1.3,.28,;-2.82,.5,;-3.77,-.71,;-3.2,-2.14,;-4.15,-3.35,;-5.67,-3.13,;-6.25,-1.7,;-5.29,-.49,;-5.75,.65,;-3.58,-4.78,;-4.4,-6.03,;-3.42,-7.22,;-2,-6.66,;-.62,-7.36,;.67,-6.49,;.57,-4.96,;1.59,-4.27,;-.83,-4.26,;-2.1,-5.13,)|
Show InChI InChI=1/C21H23F2N5O/c1-10(29)17-11-2-4-12(5-3-11)18(17)27-21-16(23)9-26-20(28-21)15-8-25-19-14(15)6-13(22)7-24-19/h6-12,17-18,29H,2-5H2,1H3,(H,24,25)(H,26,27,28)/t10?,11?,12?,17-,18-/s2
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310n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067531
PNG
(CHEMBL3401983)
Show SMILES NS(=O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:11.13,wD:4.3,(1.06,4.97,;1.05,3.73,;1.93,3.21,;2.12,4.34,;-.29,2.98,;-1.7,3.76,;-3.03,2.98,;-3.03,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;2.34,1.32,;2.39,2.86,;3.74,3.59,;5.05,2.78,;5.01,1.24,;3.65,.51,;3.61,-.72,;3.79,5.12,;5.05,5.94,;4.63,7.43,;3.1,7.48,;2.12,8.67,;.58,8.39,;.06,6.95,;-1.15,6.73,;1.06,5.75,;2.58,6.04,)|
Show InChI InChI=1/C19H20F2N6O2S/c20-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(21)19(27-18)26-15-9-1-3-10(4-2-9)16(15)30(22,28)29/h5-10,15-16H,1-4H2,(H,23,24)(H2,22,28,29)(H,25,26,27)/t9?,10?,15-,16-/s2
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980n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067533
PNG
(CHEMBL3401984)
Show SMILES [H][C@]1(C(O)CO)C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wD:12.14,1.0,TLB:2:1:8.7:10.11,THB:13:12:8.7:10.11,(-.64,1.55,;.13,.87,;1.58,1.51,;2.6,.82,;1.69,3.04,;2.79,3.59,;1.39,,;2.86,.48,;2.23,-.94,;,-.67,;-.29,-2.25,;1.15,-1.65,;-1.3,.28,;-2.82,.5,;-3.77,-.71,;-3.2,-2.14,;-4.15,-3.35,;-5.68,-3.13,;-6.25,-1.7,;-5.3,-.49,;-5.76,.65,;-3.58,-4.78,;-4.4,-6.04,;-3.43,-7.23,;-2,-6.66,;-.62,-7.36,;.67,-6.49,;.57,-4.96,;1.59,-4.28,;-.83,-4.26,;-2.1,-5.13,)|
Show InChI InChI=1/C21H23F2N5O2/c22-12-5-13-14(7-25-19(13)24-6-12)20-26-8-15(23)21(28-20)27-18-11-3-1-10(2-4-11)17(18)16(30)9-29/h5-8,10-11,16-18,29-30H,1-4,9H2,(H,24,25)(H,26,27,28)/t10?,11?,16?,17-,18+/s2
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1.50E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067540
PNG
(CHEMBL3401990)
Show SMILES CS(=O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:11.13,wD:4.3,(1.06,4.97,;1.05,3.73,;1.93,3.21,;2.12,4.34,;-.29,2.98,;-1.7,3.76,;-3.03,2.98,;-3.03,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;2.34,1.32,;2.39,2.86,;3.74,3.59,;5.05,2.78,;5.01,1.24,;3.65,.51,;3.61,-.72,;3.79,5.12,;5.05,5.94,;4.63,7.43,;3.1,7.48,;2.12,8.67,;.58,8.39,;.06,6.95,;-1.15,6.73,;1.06,5.75,;2.58,6.04,)|
Show InChI InChI=1/C20H21F2N5O2S/c1-30(28,29)17-11-4-2-10(3-5-11)16(17)26-20-15(22)9-25-19(27-20)14-8-24-18-13(14)6-12(21)7-23-18/h6-11,16-17H,2-5H2,1H3,(H,23,24)(H,25,26,27)/t10?,11?,16-,17-/s2
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2.70E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067541
PNG
(CHEMBL3401975)
Show SMILES Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4C5CCC(CC5)[C@@H]4c4nnn[nH]4)n3)c2c1 |r,wU:15.14,wD:22.24,(-5.47,-.22,;-5.12,-1.4,;-6.19,-2.51,;-5.76,-4.01,;-4.26,-4.36,;-3.53,-5.71,;-2.01,-5.43,;-1.83,-3.93,;-.48,-3.21,;.83,-4.02,;2.19,-3.3,;2.24,-1.76,;3.33,-1.18,;.93,-.95,;.98,.59,;-.33,1.41,;-1.7,.63,;-3.03,1.41,;-3.03,2.98,;-1.7,3.76,;-2.37,2.68,;-.96,1.7,;-.29,2.98,;1.1,3.76,;2.47,3.09,;3.52,4.21,;2.78,5.56,;1.27,5.27,;-.42,-1.67,;-3.19,-3.25,;-3.61,-1.77,)|
Show InChI InChI=1/C20H19F2N9/c21-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(22)19(27-18)26-16-10-3-1-9(2-4-10)15(16)20-28-30-31-29-20/h5-10,15-16H,1-4H2,(H,23,24)(H,25,26,27)(H,28,29,30,31)/t9?,10?,15-,16-/s2
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067542
PNG
(CHEMBL3401976)
Show SMILES OP(O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:11.13,wD:4.3,(1.06,4.97,;1.05,3.73,;2.12,4.34,;1.93,3.21,;-.29,2.98,;-1.7,3.76,;-3.03,2.98,;-3.03,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;2.34,1.32,;2.39,2.86,;3.74,3.59,;5.05,2.78,;5.01,1.24,;3.65,.51,;3.61,-.72,;3.79,5.12,;5.05,5.94,;4.63,7.43,;3.1,7.48,;2.12,8.67,;.58,8.39,;.06,6.95,;-1.15,6.73,;1.06,5.75,;2.58,6.04,)|
Show InChI InChI=1/C19H20F2N5O3P/c20-11-5-12-13(7-23-17(12)22-6-11)18-24-8-14(21)19(26-18)25-15-9-1-3-10(4-2-9)16(15)30(27,28)29/h5-10,15-16H,1-4H2,(H,22,23)(H,24,25,26)(H2,27,28,29)/t9?,10?,15-,16-/s2
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067520
PNG
(CHEMBL3401982)
Show SMILES Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4C5CCC(CC5)[C@@H]4c4nc(=O)o[nH]4)n3)c2c1 |r,wU:22.24,wD:15.14,(3.52,6.58,;2.32,6.87,;1.9,8.35,;.39,8.73,;-.67,7.61,;-2.2,7.65,;-2.72,6.2,;-1.52,5.3,;-1.57,3.76,;-2.93,3.04,;-2.99,1.5,;-1.68,.68,;-1.73,-.55,;-.32,1.41,;.98,.59,;.93,-.96,;-.48,-1.66,;-.57,-3.2,;.73,-4.07,;2.12,-3.4,;.86,-3.35,;.83,-1.64,;2.26,-1.79,;3.68,-1.07,;5.04,-1.77,;6.11,-.67,;7.33,-.85,;5.4,.7,;3.88,.44,;-.27,2.95,;-.25,6.13,;1.24,5.75,)|
Show InChI InChI=1/C21H19F2N7O2/c22-11-5-12-13(7-25-17(12)24-6-11)18-26-8-14(23)19(28-18)27-16-10-3-1-9(2-4-10)15(16)20-29-21(31)32-30-20/h5-10,15-16H,1-4H2,(H,24,25)(H,26,27,28)(H,29,30,31)/t9?,10?,15-,16-/s2
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067518
PNG
(CHEMBL3401981)
Show SMILES Oc1cc(on1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:13.16,wD:6.6,(4.75,4.05,;3.53,4.21,;2.47,3.09,;1.1,3.76,;1.27,5.28,;2.79,5.56,;-.29,2.98,;-1.7,3.76,;-3.04,2.98,;-3.04,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;.93,-.95,;-.42,-1.67,;-.48,-3.21,;.83,-4.03,;2.19,-3.3,;2.24,-1.76,;3.33,-1.18,;-1.84,-3.94,;-2.01,-5.43,;-3.53,-5.71,;-4.26,-4.36,;-5.76,-4.01,;-6.19,-2.51,;-5.13,-1.4,;-5.47,-.22,;-3.61,-1.77,;-3.19,-3.25,)|
Show InChI InChI=1/C22H20F2N6O2/c23-12-5-13-14(8-26-20(13)25-7-12)21-27-9-15(24)22(29-21)28-19-11-3-1-10(2-4-11)18(19)16-6-17(31)30-32-16/h5-11,18-19H,1-4H2,(H,25,26)(H,30,31)(H,27,28,29)/t10?,11?,18-,19+/s2
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067539
PNG
(CHEMBL3401989)
Show SMILES Cc1nnc(o1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:6.6,wD:13.16,(7.33,-.85,;6.11,-.67,;5.4,.7,;3.88,.44,;3.68,-1.07,;5.04,-1.77,;2.26,-1.79,;2.12,-3.4,;.73,-4.07,;-.57,-3.2,;-.48,-1.66,;.83,-1.64,;.86,-3.35,;.93,-.96,;.98,.59,;-.32,1.41,;-.27,2.95,;-1.57,3.76,;-2.93,3.04,;-2.99,1.5,;-1.68,.68,;-1.73,-.55,;-1.52,5.3,;-2.72,6.2,;-2.2,7.65,;-.67,7.61,;.39,8.73,;1.9,8.35,;2.32,6.87,;3.52,6.58,;1.24,5.75,;-.25,6.13,)|
Show InChI InChI=1/C22H21F2N7O/c1-10-30-31-22(32-10)17-11-2-4-12(5-3-11)18(17)28-21-16(24)9-27-20(29-21)15-8-26-19-14(15)6-13(23)7-25-19/h6-9,11-12,17-18H,2-5H2,1H3,(H,25,26)(H,27,28,29)/t11?,12?,17-,18-/s2
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067538
PNG
(CHEMBL3401988)
Show SMILES Cc1noc(n1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:13.16,wD:6.6,(4.75,4.05,;3.52,4.21,;2.78,5.56,;1.27,5.27,;1.1,3.76,;2.47,3.09,;-.29,2.98,;-1.7,3.76,;-3.03,2.98,;-3.03,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;.93,-.95,;-.42,-1.67,;-.48,-3.21,;.83,-4.02,;2.19,-3.3,;2.24,-1.76,;3.33,-1.18,;-1.83,-3.93,;-2.01,-5.43,;-3.53,-5.71,;-4.26,-4.36,;-5.76,-4.01,;-6.19,-2.51,;-5.12,-1.4,;-5.47,-.22,;-3.61,-1.77,;-3.19,-3.25,)|
Show InChI InChI=1/C22H21F2N7O/c1-10-28-22(32-31-10)17-11-2-4-12(5-3-11)18(17)29-21-16(24)9-27-20(30-21)15-8-26-19-14(15)6-13(23)7-25-19/h6-9,11-12,17-18H,2-5H2,1H3,(H,25,26)(H,27,29,30)/t11?,12?,17-,18-/s2
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067535
PNG
(CHEMBL3401986)
Show SMILES CNC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:11.13,wD:4.3,(3.45,3.56,;2.38,2.95,;1.05,3.73,;1.06,4.97,;-.29,2.98,;-1.7,3.76,;-3.03,2.98,;-3.03,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;.93,-.95,;-.42,-1.67,;-.48,-3.21,;.83,-4.02,;2.19,-3.3,;2.24,-1.76,;3.33,-1.18,;-1.83,-3.93,;-2.01,-5.43,;-3.53,-5.71,;-4.26,-4.36,;-5.76,-4.01,;-6.19,-2.51,;-5.12,-1.4,;-5.47,-.22,;-3.61,-1.77,;-3.19,-3.25,)|
Show InChI InChI=1/C21H22F2N6O/c1-24-21(30)16-10-2-4-11(5-3-10)17(16)28-20-15(23)9-27-19(29-20)14-8-26-18-13(14)6-12(22)7-25-18/h6-11,16-17H,2-5H2,1H3,(H,24,30)(H,25,26)(H,27,28,29)/t10?,11?,16-,17-/s2
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067534
PNG
(CHEMBL3401985)
Show SMILES Oc1cc([nH]n1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:6.6,wD:13.16,(7.34,-.85,;6.12,-.67,;5.04,-1.77,;3.68,-1.07,;3.89,.44,;5.4,.7,;2.26,-1.79,;2.13,-3.4,;.73,-4.07,;-.57,-3.2,;-.48,-1.66,;.83,-1.64,;.86,-3.36,;.93,-.96,;.98,.59,;-.32,1.41,;-.27,2.95,;-1.58,3.76,;-2.94,3.04,;-2.99,1.5,;-1.68,.69,;-1.73,-.55,;-1.52,5.3,;-2.72,6.2,;-2.21,7.66,;-.67,7.61,;.39,8.73,;1.9,8.35,;2.32,6.88,;3.52,6.58,;1.25,5.75,;-.25,6.14,)|
Show InChI InChI=1/C22H21F2N7O/c23-12-5-13-14(8-26-20(13)25-7-12)21-27-9-15(24)22(29-21)28-19-11-3-1-10(2-4-11)18(19)16-6-17(32)31-30-16/h5-11,18-19H,1-4H2,(H,25,26)(H,27,28,29)(H2,30,31,32)/t10?,11?,18-,19+/s2
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067517
PNG
(CHEMBL3401980)
Show SMILES CC(=O)NS(=O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:14.16,wD:7.6,(3.73,4.94,;3.72,3.71,;4.78,3.08,;2.38,2.95,;1.05,3.73,;1.06,4.97,;2.12,4.34,;-.29,2.98,;-1.7,3.76,;-3.03,2.98,;-3.03,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;.93,-.95,;-.42,-1.67,;-.48,-3.21,;.83,-4.02,;2.19,-3.3,;2.24,-1.76,;3.33,-1.18,;-1.83,-3.93,;-2.01,-5.43,;-3.53,-5.71,;-4.26,-4.36,;-5.76,-4.01,;-6.19,-2.51,;-5.12,-1.4,;-5.47,-.22,;-3.61,-1.77,;-3.19,-3.25,)|
Show InChI InChI=1/C21H22F2N6O3S/c1-10(30)29-33(31,32)18-12-4-2-11(3-5-12)17(18)27-21-16(23)9-26-20(28-21)15-8-25-19-14(15)6-13(22)7-24-19/h6-9,11-12,17-18H,2-5H2,1H3,(H,24,25)(H,29,30)(H,26,27,28)/t11?,12?,17-,18-/s2
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067515
PNG
(CHEMBL3401979)
Show SMILES Oc1cc(no1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:13.16,wD:6.6,(4.75,4.05,;3.53,4.21,;2.47,3.09,;1.1,3.76,;1.27,5.28,;2.79,5.56,;-.29,2.98,;-1.7,3.76,;-3.04,2.98,;-3.04,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;.93,-.95,;-.42,-1.67,;-.48,-3.21,;.83,-4.03,;2.19,-3.3,;2.24,-1.76,;3.33,-1.18,;-1.84,-3.94,;-2.01,-5.43,;-3.53,-5.71,;-4.26,-4.36,;-5.76,-4.01,;-6.19,-2.51,;-5.13,-1.4,;-5.47,-.22,;-3.61,-1.77,;-3.19,-3.25,)|
Show InChI InChI=1/C22H20F2N6O2/c23-12-5-13-14(8-26-20(13)25-7-12)21-27-9-15(24)22(29-21)28-19-11-3-1-10(2-4-11)18(19)16-6-17(31)32-30-16/h5-11,18-19,31H,1-4H2,(H,25,26)(H,27,28,29)/t10?,11?,18-,19+/s2
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50067514
PNG
(CHEMBL3401978)
Show SMILES Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4C5CCC(CC5)[C@@H]4Cn4oc(=O)[nH]c4=O)n3)c2c1 |r,wU:15.14,wD:22.24,(-5.47,-.22,;-5.12,-1.4,;-6.19,-2.51,;-5.76,-4.01,;-4.26,-4.36,;-3.53,-5.71,;-2.01,-5.43,;-1.83,-3.93,;-.48,-3.21,;.83,-4.02,;2.19,-3.3,;2.24,-1.76,;3.33,-1.18,;.93,-.95,;.98,.59,;-.33,1.41,;-1.7,.63,;-3.03,1.41,;-3.03,2.98,;-1.7,3.76,;-2.37,2.68,;-.96,1.7,;-.29,2.98,;1.05,3.73,;2.38,2.95,;2.5,1.43,;4,1.09,;4.49,-.04,;4.79,2.42,;3.77,3.57,;4.03,4.78,;-.42,-1.67,;-3.19,-3.25,;-3.61,-1.77,)|
Show InChI InChI=1/C22H21F2N7O3/c23-12-5-13-14(7-26-18(13)25-6-12)19-27-8-16(24)20(29-19)28-17-11-3-1-10(2-4-11)15(17)9-31-21(32)30-22(33)34-31/h5-8,10-11,15,17H,1-4,9H2,(H,25,26)(H,27,28,29)(H,30,32,33)/t10?,11?,15-,17-/s2
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROCK (unknown origin)


Bioorg Med Chem Lett 25: 1990-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.013
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196700
PNG
(5-((3-(3-(prop-1-en-2-yl)benzyl)cyclohexyl)methyl)...)
Show SMILES [O-][N+](=O)c1cccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C19H21N5O2/c25-24(26)18-5-1-3-14(9-18)12-23-8-2-4-17(13-23)21-16-6-7-19-15(10-16)11-20-22-19/h1,3,5-7,9-11,17,21H,2,4,8,12-13H2,(H,20,22)
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n/an/a 3n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196694
PNG
(CHEMBL225166 | N-(1-(thiophen-3-ylmethyl)piperidin...)
Show SMILES C(N1CCCC(C1)Nc1ccc2[nH]ncc2c1)c1ccsc1
Show InChI InChI=1S/C17H20N4S/c1-2-16(11-21(6-1)10-13-5-7-22-12-13)19-15-3-4-17-14(8-15)9-18-20-17/h3-5,7-9,12,16,19H,1-2,6,10-11H2,(H,18,20)
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n/an/a 3n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196718
PNG
(CHEMBL373512 | N-(1-(thiophen-2-ylmethyl)piperidin...)
Show SMILES C(N1CCCC(C1)Nc1ccc2[nH]ncc2c1)c1cccs1
Show InChI InChI=1S/C17H20N4S/c1-3-15(11-21(7-1)12-16-4-2-8-22-16)19-14-5-6-17-13(9-14)10-18-20-17/h2,4-6,8-10,15,19H,1,3,7,11-12H2,(H,18,20)
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n/an/a 5n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196692
PNG
(CHEMBL388516 | N-(1-(4-methylbenzyl)piperidin-3-yl...)
Show SMILES Cc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C20H24N4/c1-15-4-6-16(7-5-15)13-24-10-2-3-19(14-24)22-18-8-9-20-17(11-18)12-21-23-20/h4-9,11-12,19,22H,2-3,10,13-14H2,1H3,(H,21,23)
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n/an/a 9n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196690
PNG
(CHEMBL224535 | N-(1-(4-aminobenzyl)piperidin-3-yl)...)
Show SMILES Nc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C19H23N5/c20-16-5-3-14(4-6-16)12-24-9-1-2-18(13-24)22-17-7-8-19-15(10-17)11-21-23-19/h3-8,10-11,18,22H,1-2,9,12-13,20H2,(H,21,23)
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n/an/a 10n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196695
PNG
(CHEMBL224510 | N-(1-(3,4-difluorobenzyl)piperidin-...)
Show SMILES Fc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1F
Show InChI InChI=1S/C19H20F2N4/c20-17-5-3-13(8-18(17)21)11-25-7-1-2-16(12-25)23-15-4-6-19-14(9-15)10-22-24-19/h3-6,8-10,16,23H,1-2,7,11-12H2,(H,22,24)
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n/an/a 10n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196711
PNG
(1-benzyl-3-piperidyl-(1H-5-indazolyl)ether | 5-(1-...)
Show SMILES C(N1CCCC(C1)Oc1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C19H21N3O/c1-2-5-15(6-3-1)13-22-10-4-7-18(14-22)23-17-8-9-19-16(11-17)12-20-21-19/h1-3,5-6,8-9,11-12,18H,4,7,10,13-14H2,(H,20,21)
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Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196682
PNG
(CHEMBL426925 | N-(1-(4-chlorobenzyl)piperidin-3-yl...)
Show SMILES Clc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C19H21ClN4/c20-16-5-3-14(4-6-16)12-24-9-1-2-18(13-24)22-17-7-8-19-15(10-17)11-21-23-19/h3-8,10-11,18,22H,1-2,9,12-13H2,(H,21,23)
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n/an/a 11n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196689
PNG
(CHEMBL224166 | N-(1-((1H-pyrrol-2-yl)methyl)piperi...)
Show SMILES C(N1CCCC(C1)Nc1ccc2[nH]ncc2c1)c1ccc[nH]1
Show InChI InChI=1S/C17H21N5/c1-3-15(18-7-1)11-22-8-2-4-16(12-22)20-14-5-6-17-13(9-14)10-19-21-17/h1,3,5-7,9-10,16,18,20H,2,4,8,11-12H2,(H,19,21)
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Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196707
PNG
(CHEMBL390837 | N-(1-(2-chlorobenzyl)piperidin-3-yl...)
Show SMILES Clc1ccccc1CN1CCCC(C1)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C19H21ClN4/c20-18-6-2-1-4-14(18)12-24-9-3-5-17(13-24)22-16-7-8-19-15(10-16)11-21-23-19/h1-2,4,6-8,10-11,17,22H,3,5,9,12-13H2,(H,21,23)
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n/an/a 13n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196712
PNG
(CHEMBL225637 | N-(1-(4-methoxybenzyl)piperidin-3-y...)
Show SMILES COc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C20H24N4O/c1-25-19-7-4-15(5-8-19)13-24-10-2-3-18(14-24)22-17-6-9-20-16(11-17)12-21-23-20/h4-9,11-12,18,22H,2-3,10,13-14H2,1H3,(H,21,23)
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n/an/a 16n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196704
PNG
(1-benzyl-N-(1H-5-indazolyl)piperidine-3-carboxamid...)
Show SMILES O=C(Nc1ccc2[nH]ncc2c1)C1CCCN(Cc2ccccc2)C1
Show InChI InChI=1S/C20H22N4O/c25-20(22-18-8-9-19-17(11-18)12-21-23-19)16-7-4-10-24(14-16)13-15-5-2-1-3-6-15/h1-3,5-6,8-9,11-12,16H,4,7,10,13-14H2,(H,21,23)(H,22,25)
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n/an/a 18n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196728
PNG
(CHEMBL389168 | N-(1-(3-chlorobenzyl)piperidin-3-yl...)
Show SMILES Clc1cccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C19H21ClN4/c20-16-4-1-3-14(9-16)12-24-8-2-5-18(13-24)22-17-6-7-19-15(10-17)11-21-23-19/h1,3-4,6-7,9-11,18,22H,2,5,8,12-13H2,(H,21,23)
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n/an/a 19n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196687
PNG
(1-(2,6-dichlorobenzyl)-3-(1H-indazol-5-yl)urea | 1...)
Show SMILES Clc1cccc(Cl)c1CNC(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C15H12Cl2N4O/c16-12-2-1-3-13(17)11(12)8-18-15(22)20-10-4-5-14-9(6-10)7-19-21-14/h1-7H,8H2,(H,19,21)(H2,18,20,22)
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n/an/a 20n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196725
PNG
(CHEMBL224885 | N-(1-benzyl-3-piperidyl)-N-(1H-5-in...)
Show SMILES C(N1CCCC(C1)Nc1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-2-5-15(6-3-1)13-23-10-4-7-18(14-23)21-17-8-9-19-16(11-17)12-20-22-19/h1-3,5-6,8-9,11-12,18,21H,4,7,10,13-14H2,(H,20,22)
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n/an/a 20n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196725
PNG
(CHEMBL224885 | N-(1-benzyl-3-piperidyl)-N-(1H-5-in...)
Show SMILES C(N1CCCC(C1)Nc1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-2-5-15(6-3-1)13-23-10-4-7-18(14-23)21-17-8-9-19-16(11-17)12-20-22-19/h1-3,5-6,8-9,11-12,18,21H,4,7,10,13-14H2,(H,20,22)
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n/an/a 20n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196698
PNG
(CHEMBL390389 | N-(1-(3-chlorobenzyl)pyrrolidin-3-y...)
Show SMILES Clc1cccc(CN2CCC(C2)Nc2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C18H19ClN4/c19-15-3-1-2-13(8-15)11-23-7-6-17(12-23)21-16-4-5-18-14(9-16)10-20-22-18/h1-5,8-10,17,21H,6-7,11-12H2,(H,20,22)
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n/an/a 20n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196686
PNG
(CHEMBL427245 | N-(1-(4-chlorobenzyl)pyrrolidin-3-y...)
Show SMILES Clc1ccc(CN2CCC(C2)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C18H19ClN4/c19-15-3-1-13(2-4-15)11-23-8-7-17(12-23)21-16-5-6-18-14(9-16)10-20-22-18/h1-6,9-10,17,21H,7-8,11-12H2,(H,20,22)
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n/an/a 24n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196688
PNG
(CHEMBL224509 | N-(1-(4-fluorobenzyl)piperidin-3-yl...)
Show SMILES Fc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C19H21FN4/c20-16-5-3-14(4-6-16)12-24-9-1-2-18(13-24)22-17-7-8-19-15(10-17)11-21-23-19/h3-8,10-11,18,22H,1-2,9,12-13H2,(H,21,23)
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n/an/a 25n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50197913
PNG
((3R)-N-[1-(3-aminobenzyl)-3-pyrrolidyl]-N-(5-isoqu...)
Show SMILES Nc1cccc(CN2CC[C@H](C2)Nc2cccc3cnccc23)c1
Show InChI InChI=1S/C20H22N4/c21-17-5-1-3-15(11-17)13-24-10-8-18(14-24)23-20-6-2-4-16-12-22-9-7-19(16)20/h1-7,9,11-12,18,23H,8,10,13-14,21H2/t18-/m1/s1
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n/an/a 25n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 1022-33 (2006)


Article DOI: 10.1016/j.bmc.2006.10.028
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196708
PNG
(CHEMBL386937 | N-(1-benzyl-3-pyrrolidyl)-N-(1H-5-i...)
Show SMILES C(N1CCC(C1)Nc1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C18H20N4/c1-2-4-14(5-3-1)12-22-9-8-17(13-22)20-16-6-7-18-15(10-16)11-19-21-18/h1-7,10-11,17,20H,8-9,12-13H2,(H,19,21)
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n/an/a 32n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196699
PNG
(CHEMBL390736 | N-(1-(3-aminobenzyl)piperidin-3-yl)...)
Show SMILES Nc1cccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C19H23N5/c20-16-4-1-3-14(9-16)12-24-8-2-5-18(13-24)22-17-6-7-19-15(10-17)11-21-23-19/h1,3-4,6-7,9-11,18,22H,2,5,8,12-13,20H2,(H,21,23)
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n/an/a 35n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196679
PNG
(CHEMBL388742 | N-(1-(2-chlorobenzyl)pyrrolidin-3-y...)
Show SMILES Clc1ccccc1CN1CCC(C1)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C18H19ClN4/c19-17-4-2-1-3-13(17)11-23-8-7-16(12-23)21-15-5-6-18-14(9-15)10-20-22-18/h1-6,9-10,16,21H,7-8,11-12H2,(H,20,22)
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n/an/a 45n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50197914
PNG
(CHEMBL375556 | N-(1-(4-chlorobenzyl)pyrrolidin-3-y...)
Show SMILES Clc1ccc(CN2CCC(C2)Nc2cccc3cnccc23)cc1
Show InChI InChI=1S/C20H20ClN3/c21-17-6-4-15(5-7-17)13-24-11-9-18(14-24)23-20-3-1-2-16-12-22-10-8-19(16)20/h1-8,10,12,18,23H,9,11,13-14H2
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n/an/a 65n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 1022-33 (2006)


Article DOI: 10.1016/j.bmc.2006.10.028
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50197915
PNG
(CHEMBL223815 | N-(1-(3-chlorobenzyl)pyrrolidin-3-y...)
Show SMILES Clc1cccc(CN2CCC(C2)Nc2cccc3cnccc23)c1
Show InChI InChI=1S/C20H20ClN3/c21-17-5-1-3-15(11-17)13-24-10-8-18(14-24)23-20-6-2-4-16-12-22-9-7-19(16)20/h1-7,9,11-12,18,23H,8,10,13-14H2
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n/an/a 65n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 1022-33 (2006)


Article DOI: 10.1016/j.bmc.2006.10.028
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196706
PNG
(CHEMBL225167 | N-(1-(furan-2-ylmethyl)piperidin-3-...)
Show SMILES C(N1CCCC(C1)Nc1ccc2[nH]ncc2c1)c1ccco1
Show InChI InChI=1S/C17H20N4O/c1-3-15(11-21(7-1)12-16-4-2-8-22-16)19-14-5-6-17-13(9-14)10-18-20-17/h2,4-6,8-10,15,19H,1,3,7,11-12H2,(H,18,20)
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n/an/a 65n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50197922
PNG
(CHEMBL224361 | N1-cyclopropyl-N4-(5-isoquinolyl)-1...)
Show SMILES C1CC1N[C@H]1CC[C@@H](CC1)Nc1cccc2cnccc12 |wU:7.11,wD:4.4,(33.09,-14.61,;34.63,-14.61,;33.86,-13.28,;33.85,-11.74,;32.52,-10.97,;32.52,-9.43,;31.18,-8.65,;29.85,-9.44,;29.85,-10.98,;31.18,-11.74,;28.51,-8.67,;27.18,-9.45,;27.19,-11,;25.85,-11.77,;24.51,-11,;24.52,-9.46,;23.19,-8.7,;23.18,-7.17,;24.51,-6.39,;25.84,-7.16,;25.84,-8.69,)|
Show InChI InChI=1S/C18H23N3/c1-2-13-12-19-11-10-17(13)18(3-1)21-16-8-6-15(7-9-16)20-14-4-5-14/h1-3,10-12,14-16,20-21H,4-9H2/t15-,16-
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n/an/a 70n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 1022-33 (2006)


Article DOI: 10.1016/j.bmc.2006.10.028
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196683
PNG
(CHEMBL224746 | N-(1-(pyridin-3-ylmethyl)piperidin-...)
Show SMILES C(N1CCCC(C1)Nc1ccc2[nH]ncc2c1)c1cccnc1
Show InChI InChI=1S/C18H21N5/c1-3-14(10-19-7-1)12-23-8-2-4-17(13-23)21-16-5-6-18-15(9-16)11-20-22-18/h1,3,5-7,9-11,17,21H,2,4,8,12-13H2,(H,20,22)
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n/an/a 72n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50197907
PNG
(CHEMBL387954 | N-(1-(2,6-difluorobenzyl)pyrrolidin...)
Show SMILES Fc1cccc(F)c1CN1CCC(C1)Nc1cccc2cnccc12
Show InChI InChI=1S/C20H19F2N3/c21-18-4-2-5-19(22)17(18)13-25-10-8-15(12-25)24-20-6-1-3-14-11-23-9-7-16(14)20/h1-7,9,11,15,24H,8,10,12-13H2
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n/an/a 75n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 1022-33 (2006)


Article DOI: 10.1016/j.bmc.2006.10.028
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196685
PNG
(CHEMBL389622 | N-(1-(3,5-dimethoxybenzyl)piperidin...)
Show SMILES COc1cc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc(OC)c1
Show InChI InChI=1S/C21H26N4O2/c1-26-19-8-15(9-20(11-19)27-2)13-25-7-3-4-18(14-25)23-17-5-6-21-16(10-17)12-22-24-21/h5-6,8-12,18,23H,3-4,7,13-14H2,1-2H3,(H,22,24)
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n/an/a 80n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196681
PNG
(1-(2,6-difluorobenzyl)-3-(1H-indazol-5-yl)urea | C...)
Show SMILES Fc1cccc(F)c1CNC(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C15H12F2N4O/c16-12-2-1-3-13(17)11(12)8-18-15(22)20-10-4-5-14-9(6-10)7-19-21-14/h1-7H,8H2,(H,19,21)(H2,18,20,22)
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Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196702
PNG
(CHEMBL427254 | N-(1-(2-aminobenzyl)piperidin-3-yl)...)
Show SMILES Nc1ccccc1CN1CCCC(C1)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C19H23N5/c20-18-6-2-1-4-14(18)12-24-9-3-5-17(13-24)22-16-7-8-19-15(10-16)11-21-23-19/h1-2,4,6-8,10-11,17,22H,3,5,9,12-13,20H2,(H,21,23)
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n/an/a 85n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196691
PNG
(CHEMBL389915 | N-(1-(4-nitrobenzyl)piperidin-3-yl)...)
Show SMILES [O-][N+](=O)c1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C19H21N5O2/c25-24(26)18-6-3-14(4-7-18)12-23-9-1-2-17(13-23)21-16-5-8-19-15(10-16)11-20-22-19/h3-8,10-11,17,21H,1-2,9,12-13H2,(H,20,22)
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n/an/a 87n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50197900
PNG
(CHEMBL223336 | N-(1-(4-fluorobenzyl)pyrrolidin-3-y...)
Show SMILES Fc1ccc(CN2CCC(C2)Nc2cccc3cnccc23)cc1
Show InChI InChI=1S/C20H20FN3/c21-17-6-4-15(5-7-17)13-24-11-9-18(14-24)23-20-3-1-2-16-12-22-10-8-19(16)20/h1-8,10,12,18,23H,9,11,13-14H2
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n/an/a 95n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 1022-33 (2006)


Article DOI: 10.1016/j.bmc.2006.10.028
More data for this
Ligand-Target Pair
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