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Compile Data Set for Download or QSAR

Found 583 hits Enz. Inhib. hit(s) with Target = 'SYK Kinase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 0.403n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225517
PNG
(GTC000226A | GTC000226B)
Show SMILES OCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H21N7O3S/c29-10-2-9-28(18-4-1-3-17-16(18)13-23-27-17)20-7-8-22-21(26-20)25-15-6-5-14-12-24-32(30,31)19(14)11-15/h1,3-8,11,13,24,29H,2,9-10,12H2,(H,23,27)(H,22,25,26)
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n/an/a 0.412n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225517
PNG
(GTC000226A | GTC000226B)
Show SMILES OCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H21N7O3S/c29-10-2-9-28(18-4-1-3-17-16(18)13-23-27-17)20-7-8-22-21(26-20)25-15-6-5-14-12-24-32(30,31)19(14)11-15/h1,3-8,11,13,24,29H,2,9-10,12H2,(H,23,27)(H,22,25,26)
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n/an/a 0.746n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225519
PNG
(GTC000227A)
Show SMILES NCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H22N8O2S/c22-8-2-10-29(18-4-1-3-17-16(18)13-24-28-17)20-7-9-23-21(27-20)26-15-6-5-14-12-25-32(30,31)19(14)11-15/h1,3-7,9,11,13,25H,2,8,10,12,22H2,(H,24,28)(H,23,26,27)
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n/an/a 0.75n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225519
PNG
(GTC000227A)
Show SMILES NCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H22N8O2S/c22-8-2-10-29(18-4-1-3-17-16(18)13-24-28-17)20-7-9-23-21(27-20)26-15-6-5-14-12-25-32(30,31)19(14)11-15/h1,3-7,9,11,13,25H,2,8,10,12,22H2,(H,24,28)(H,23,26,27)
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n/an/a 0.857n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 0.869n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225517
PNG
(GTC000226A | GTC000226B)
Show SMILES OCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H21N7O3S/c29-10-2-9-28(18-4-1-3-17-16(18)13-23-27-17)20-7-8-22-21(26-20)25-15-6-5-14-12-24-32(30,31)19(14)11-15/h1,3-8,11,13,24,29H,2,9-10,12H2,(H,23,27)(H,22,25,26)
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n/an/a 0.925n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 0.977n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225520
PNG
(GTC000228A | GTC000228B | GTC000228C)
Show SMILES COCCCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C22H22FN7O3S/c1-33-9-3-8-30(19-5-2-4-18-16(19)12-25-29-18)21-17(23)13-24-22(28-21)27-15-7-6-14-11-26-34(31,32)20(14)10-15/h2,4-7,10,12-13,26H,3,8-9,11H2,1H3,(H,25,29)(H,24,27,28)
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n/an/a 1.10n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225523
PNG
(GTC000229A)
Show SMILES OC(=O)CCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C23H23N7O4S/c31-22(32)6-1-2-11-30(19-5-3-4-18-17(19)14-25-29-18)21-9-10-24-23(28-21)27-16-8-7-15-13-26-35(33,34)20(15)12-16/h3-5,7-10,12,14,26H,1-2,6,11,13H2,(H,25,29)(H,31,32)(H,24,27,28)
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n/an/a 1.19n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.26n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.27n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225562
PNG
(GTC000266A | GTC000266B | GTC000266C)
Show SMILES Cn1ncc2ccc(Nc3ncc(F)c(n3)N(CCCO)c3cccc4[nH]ncc34)cc12
Show InChI InChI=1S/C22H21FN8O/c1-30-20-10-15(7-6-14(20)11-26-30)27-22-24-13-17(23)21(28-22)31(8-3-9-32)19-5-2-4-18-16(19)12-25-29-18/h2,4-7,10-13,32H,3,8-9H2,1H3,(H,25,29)(H,24,27,28)
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n/an/a 1.30n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225520
PNG
(GTC000228A | GTC000228B | GTC000228C)
Show SMILES COCCCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C22H22FN7O3S/c1-33-9-3-8-30(19-5-2-4-18-16(19)12-25-29-18)21-17(23)13-24-22(28-21)27-15-7-6-14-11-26-34(31,32)20(14)10-15/h2,4-7,10,12-13,26H,3,8-9,11H2,1H3,(H,25,29)(H,24,27,28)
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n/an/a 1.38n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225523
PNG
(GTC000229A)
Show SMILES OC(=O)CCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C23H23N7O4S/c31-22(32)6-1-2-11-30(19-5-3-4-18-17(19)14-25-29-18)21-9-10-24-23(28-21)27-16-8-7-15-13-26-35(33,34)20(15)12-16/h3-5,7-10,12,14,26H,1-2,6,11,13H2,(H,25,29)(H,31,32)(H,24,27,28)
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n/an/a 1.41n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225525
PNG
(GTC000231A)
Show SMILES CC(=O)NCCCCN(c1ccnc(Nc2ccc3[nH]c(=O)[nH]c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C24H25N9O2/c1-15(34)25-10-2-3-12-33(21-6-4-5-18-17(21)14-27-32-18)22-9-11-26-23(31-22)28-16-7-8-19-20(13-16)30-24(35)29-19/h4-9,11,13-14H,2-3,10,12H2,1H3,(H,25,34)(H,27,32)(H,26,28,31)(H2,29,30,35)
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n/an/a 1.42n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.43n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225524
PNG
(GTC000230A)
Show SMILES OCCCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C21H20FN7O3S/c22-16-12-23-21(26-14-6-5-13-10-25-33(31,32)19(13)9-14)27-20(16)29(7-2-8-30)18-4-1-3-17-15(18)11-24-28-17/h1,3-6,9,11-12,25,30H,2,7-8,10H2,(H,24,28)(H,23,26,27)
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n/an/a 1.46n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225520
PNG
(GTC000228A | GTC000228B | GTC000228C)
Show SMILES COCCCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C22H22FN7O3S/c1-33-9-3-8-30(19-5-2-4-18-16(19)12-25-29-18)21-17(23)13-24-22(28-21)27-15-7-6-14-11-26-34(31,32)20(14)10-15/h2,4-7,10,12-13,26H,3,8-9,11H2,1H3,(H,25,29)(H,24,27,28)
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n/an/a 1.47n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.48n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225530
PNG
(GTC000236A)
Show SMILES COCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C22H23N7O3S/c1-32-11-3-10-29(19-5-2-4-18-17(19)14-24-28-18)21-8-9-23-22(27-21)26-16-7-6-15-13-25-33(30,31)20(15)12-16/h2,4-9,12,14,25H,3,10-11,13H2,1H3,(H,24,28)(H,23,26,27)
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n/an/a 1.48n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.51n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.54n/an/an/an/an/an/a



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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.56n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225538
PNG
(GTC000242A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3c(C)nn(CCCO)c3c2)ncc1F
Show InChI InChI=1S/C24H25FN8O/c1-3-32(21-7-4-6-20-18(21)13-27-30-20)23-19(25)14-26-24(29-23)28-16-8-9-17-15(2)31-33(10-5-11-34)22(17)12-16/h4,6-9,12-14,34H,3,5,10-11H2,1-2H3,(H,27,30)(H,26,28,29)
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n/an/a 1.58n/an/an/an/an/an/a



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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.60n/an/an/an/an/an/a



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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.61n/an/an/an/an/an/a



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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.62n/an/an/an/an/an/a



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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225529
PNG
(GTC000235A)
Show SMILES OCCCCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CCS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C23H23FN6O3S/c24-18-14-25-23(27-16-7-6-15-8-11-34(32,33)21(15)12-16)28-22(18)30(9-1-2-10-31)20-5-3-4-19-17(20)13-26-29-19/h3-7,12-14,31H,1-2,8-11H2,(H,26,29)(H,25,27,28)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.66n/an/an/an/an/an/a



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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.83n/an/an/an/an/an/a



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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225531
PNG
(GTC000237A | GTC000237B)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3[nH]c(=O)[nH]c3c2)ncc1F
Show InChI InChI=1S/C20H17FN8O/c1-2-29(17-5-3-4-14-12(17)9-23-28-14)18-13(21)10-22-19(27-18)24-11-6-7-15-16(8-11)26-20(30)25-15/h3-10H,2H2,1H3,(H,23,28)(H,22,24,27)(H2,25,26,30)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225528
PNG
(GTC000234A)
Show SMILES Cc1nn(CCCO)c2cc(Nc3ncc(F)c(n3)N(CCCO)c3cccc4[nH]ncc34)ccc12
Show InChI InChI=1S/C25H27FN8O2/c1-16-18-8-7-17(13-23(18)34(32-16)10-4-12-36)29-25-27-15-20(26)24(30-25)33(9-3-11-35)22-6-2-5-21-19(22)14-28-31-21/h2,5-8,13-15,35-36H,3-4,9-12H2,1H3,(H,28,31)(H,27,29,30)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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n/an/a 1.93n/an/an/an/an/an/a



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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225529
PNG
(GTC000235A)
Show SMILES OCCCCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CCS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C23H23FN6O3S/c24-18-14-25-23(27-16-7-6-15-8-11-34(32,33)21(15)12-16)28-22(18)30(9-1-2-10-31)20-5-3-4-19-17(20)13-26-29-19/h3-7,12-14,31H,1-2,8-11H2,(H,26,29)(H,25,27,28)
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D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225545
PNG
(GTC000249A)
Show SMILES CN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C19H16FN7O2S/c1-27(16-4-2-3-15-13(16)9-22-26-15)18-14(20)10-21-19(25-18)24-12-6-5-11-8-23-30(28,29)17(11)7-12/h2-7,9-10,23H,8H2,1H3,(H,22,26)(H,21,24,25)
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Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225520
PNG
(GTC000228A | GTC000228B | GTC000228C)
Show SMILES COCCCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C22H22FN7O3S/c1-33-9-3-8-30(19-5-2-4-18-16(19)12-25-29-18)21-17(23)13-24-22(28-21)27-15-7-6-14-11-26-34(31,32)20(14)10-15/h2,4-7,10,12-13,26H,3,8-9,11H2,1H3,(H,25,29)(H,24,27,28)
PDB

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UniChem
D3R
n/an/a 2n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
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PDB
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n/an/a 2.01n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
PDB

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PDB
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PDB
D3R
n/an/a 2.01n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225527
PNG
(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
PDB

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PDB
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PDB
D3R
n/an/a 2.02n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SYK Kinase


(Homo sapiens (Human))
BDBM225520
PNG
(GTC000228A | GTC000228B | GTC000228C)
Show SMILES COCCCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C22H22FN7O3S/c1-33-9-3-8-30(19-5-2-4-18-16(19)12-25-29-18)21-17(23)13-24-22(28-21)27-15-7-6-14-11-26-34(31,32)20(14)10-15/h2,4-7,10,12-13,26H,3,8-9,11H2,1H3,(H,25,29)(H,24,27,28)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
D3R
n/an/a 2.02n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
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