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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'c-Met/EGFR'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
c-Met/EGFR


(Homo sapiens (Human))
BDBM24470
PNG
(7-methoxy-4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyrid...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
PC cid
PC sid
PDB
UniChem

Patents

PDB
Article
PubMed
n/an/a 90n/an/an/an/an/an/a



China Pharmaceutical University



Assay Description
The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...


Bioorg Chem 70: 126-132 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
c-Met/EGFR


(Homo sapiens (Human))
BDBM222078
PNG
(6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]p...)
Show SMILES Clc1ccc(-c2cn3cccc(COc4nnc5ccc(Cl)nn45)c3n2)c(Cl)c1
Show InChI InChI=1S/C19H11Cl3N6O/c20-12-3-4-13(14(21)8-12)15-9-27-7-1-2-11(18(27)23-15)10-29-19-25-24-17-6-5-16(22)26-28(17)19/h1-9H,10H2
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.42E+4n/an/an/an/an/an/a



China Pharmaceutical University



Assay Description
The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...


Bioorg Chem 70: 126-132 (2017)

More data for this
Ligand-Target Pair
c-Met/EGFR


(Homo sapiens (Human))
BDBM222077
PNG
(6-chloro-3-((2-(2,5-dichlorophenyl)imidazo[1,2-a]p...)
Show SMILES Clc1ccc(Cl)c(c1)-c1cn2cccc(COc3nnc4ccc(Cl)nn34)c2n1
Show InChI InChI=1S/C19H11Cl3N6O/c20-12-3-4-14(21)13(8-12)15-9-27-7-1-2-11(18(27)23-15)10-29-19-25-24-17-6-5-16(22)26-28(17)19/h1-9H,10H2
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.56E+4n/an/an/an/an/an/a



China Pharmaceutical University



Assay Description
The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...


Bioorg Chem 70: 126-132 (2017)

More data for this
Ligand-Target Pair