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Compile Data Set for Download or QSAR

Found 16 hits Enz. Inhib. hit(s) with Target = 'cFMS'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cFMS


(Homo sapiens (Human))
BDBM181020
PNG
(US9133183, Example 29)
Show SMILES Cc1nc(NC(=O)N2CCN(C3CCCC3)C2=O)ccc1Oc1ccnc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C24H27N7O3/c1-16-21(34-19-9-10-25-20(13-19)17-14-26-29(2)15-17)7-8-22(27-16)28-23(32)31-12-11-30(24(31)33)18-5-3-4-6-18/h7-10,13-15,18H,3-6,11-12H2,1-2H3,(H,27,28,32)
PDB
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UniChem
US Patent
n/an/a 2n/an/an/an/a7.530



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


Citation and Details
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (Human))
BDBM181019
PNG
(US9133183, Example 15)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCCCC4)C3=O)nc2)ccn1
Show InChI InChI=1S/C24H27N7O3/c1-29-16-17(14-27-29)21-13-19(9-10-25-21)34-20-7-8-22(26-15-20)28-23(32)31-12-11-30(24(31)33)18-5-3-2-4-6-18/h7-10,13-16,18H,2-6,11-12H2,1H3,(H,26,28,32)
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n/an/a 3n/an/an/an/a7.530



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


Citation and Details
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (Human))
BDBM181027
PNG
(US9133183, Example 90)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)C(C)(C)C)nc2)ccn1
Show InChI InChI=1S/C20H24N6O4/c1-20(2,3)26-10-9-25(19(26)29)18(28)24-16-6-5-14(12-23-16)30-13-7-8-22-15(11-13)17(27)21-4/h5-8,11-12H,9-10H2,1-4H3,(H,21,27)(H,23,24,28)
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n/an/a 5n/an/an/an/a7.530



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


Citation and Details
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (Human))
BDBM181018
PNG
(US9133183, Example 1)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCOCC4)C3=O)nc2)ccn1
Show InChI InChI=1S/C23H25N7O4/c1-28-15-16(13-26-28)20-12-18(4-7-24-20)34-19-2-3-21(25-14-19)27-22(31)30-9-8-29(23(30)32)17-5-10-33-11-6-17/h2-4,7,12-15,17H,5-6,8-11H2,1H3,(H,25,27,31)
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n/an/a 6n/an/an/an/a7.530



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


Citation and Details
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (Human))
BDBM181034
PNG
(US9133183, Example 91)
Show SMILES Cn1cc(cn1)-c1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2F)ccn1
Show InChI InChI=1S/C24H24F2N6O4/c1-30-14-15(13-28-30)20-10-17(2-5-27-20)36-22-12-18(25)21(11-19(22)26)29-23(33)32-7-6-31(24(32)34)16-3-8-35-9-4-16/h2,5,10-14,16H,3-4,6-9H2,1H3,(H,29,33)
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n/an/a 7n/an/an/an/a7.530



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


Citation and Details
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (Human))
BDBM181035
PNG
(US9133183, Example 101)
Show SMILES CN(C)C(=O)Nc1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2Cl)ccn1
Show InChI InChI=1S/C23H26ClFN6O5/c1-29(2)21(32)28-20-11-15(3-6-26-20)36-19-13-17(25)18(12-16(19)24)27-22(33)31-8-7-30(23(31)34)14-4-9-35-10-5-14/h3,6,11-14H,4-5,7-10H2,1-2H3,(H,27,33)(H,26,28,32)
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n/an/a 8n/an/an/an/a7.530



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


Citation and Details
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (Human))
BDBM181037
PNG
(US9133183, Example 42)
Show SMILES CCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O
Show InChI InChI=1S/C21H23N7O3/c1-4-27-9-10-28(21(27)30)20(29)25-19-6-5-18(14(2)24-19)31-16-7-8-22-17(11-16)15-12-23-26(3)13-15/h5-8,11-13H,4,9-10H2,1-3H3,(H,24,25,29)
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n/an/a 8n/an/an/an/a7.530



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


Citation and Details
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (Human))
BDBM181023
PNG
(US9133183, Compound A)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccc(F)cc3)nc2)ccn1
Show InChI InChI=1S/C24H20FN7O3/c1-30-15-16(13-28-30)21-12-19(8-9-26-21)35-20-6-7-22(27-14-20)29-23(33)32-11-10-31(24(32)34)18-4-2-17(25)3-5-18/h2-9,12-15H,10-11H2,1H3,(H,27,29,33)
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n/an/a 13n/an/an/an/a7.530



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


Citation and Details
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (Human))
BDBM181026
PNG
(US9133183, Example 18)
Show SMILES COCCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O
Show InChI InChI=1S/C22H25N7O4/c1-15-19(33-17-6-7-23-18(12-17)16-13-24-27(2)14-16)4-5-20(25-15)26-21(30)29-9-8-28(22(29)31)10-11-32-3/h4-7,12-14H,8-11H2,1-3H3,(H,25,26,30)
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n/an/a 20n/an/an/an/a7.530



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


Citation and Details
More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 49n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


J Biol Chem 282: 4085-93 (2007)

More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (Human))
BDBM17015
PNG
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc[nH]1
Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8-
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n/an/a 1.30E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


J Biol Chem 282: 4085-93 (2007)

More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (Human))
BDBM17749
PNG
(JNJ31117164)
PDB
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n/an/a 1.30E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


J Biol Chem 282: 4085-93 (2007)

More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (Human))
BDBM4363
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)
Show SMILES NC(=S)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
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n/an/a 3.30E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


J Biol Chem 282: 4085-93 (2007)

More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (Human))
BDBM7393
PNG
(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)
Show SMILES O=Nc1c([nH]c2ccccc12)C1C(=O)Nc2ccccc12
Show InChI InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,13,17H,(H,18,20)
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n/an/a 4.50E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


J Biol Chem 282: 4085-93 (2007)

More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (Human))
BDBM17747
PNG
((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11-
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n/an/a 4.60E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


J Biol Chem 282: 4085-93 (2007)

More data for this
Ligand-Target Pair
cFMS -Tie-2 Chimera


(Homo sapiens (Human))
BDBM17748
PNG
(2-(3,4-Dihydroxyphenyl)-6,7-dimethylquinoxaline | ...)
Show SMILES Cc1cc2ncc(nc2cc1C)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C16H14N2O2/c1-9-5-12-13(6-10(9)2)18-14(8-17-12)11-3-4-15(19)16(20)7-11/h3-8,19-20H,1-2H3
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n/an/a 8.30E+3n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...


J Biol Chem 282: 4085-93 (2007)

More data for this
Ligand-Target Pair