Affinity Data by Patent

Patent code US8470835

Found 3 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50419247 (CHEMBL1835071 \| US8470835, 1) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	7.4	25
Glaxo Group Limited US Patent					Assay Description Recombinant human Syk was express as a His-tagged protein. The activity of Syk was asses using a time-resolved fluorescence resonance entery transfe...				US Patent US8470835 (2013) BindingDB Entry DOI: 10.7270/Q28S4NJK
Glaxo Group Limited US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50419247 (CHEMBL1835071 \| US8470835, 1) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	>7.90E+3	n/a	n/a	n/a	n/a	7.5	25
Glaxo Group Limited US Patent					Assay Description Recombinant human VEGFR2 (KDR) intracellular domain (including the entire kinase domain) was expressed as a GST-6His-tagged protein. The activity of...				US Patent US8470835 (2013) BindingDB Entry DOI: 10.7270/Q28S4NJK
Glaxo Group Limited US Patent					More data for this Ligand-Target Pair
Aurora kinase B [2-344]/Inner centromere protein [826-918] (Homo sapiens (Human))	BDBM50419247 (CHEMBL1835071 \| US8470835, 1) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	8.0	30
Glaxo Group Limited US Patent					Assay Description Recombinant human Aurora B (2-344) was expressed as a Flag-6His-Thr-tagged protein. The activity of Aurora B was assessed using a Fluorescence Polar...				US Patent US8470835 (2013) BindingDB Entry DOI: 10.7270/Q28S4NJK
Glaxo Group Limited US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%