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Patent code US8470847

Compile Data Set for Download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98618
PNG
(2-amino-1-ethyl-7-[3-hydroxy-3-(3-thienyl)but-1-yn...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)c1ccsc1
Show InChI InChI=1S/C20H20N4O3S/c1-4-24-17(21)15(19(26)22-3)16(25)14-6-5-13(23-18(14)24)7-9-20(2,27)12-8-10-28-11-12/h5-6,8,10-11,27H,4,21H2,1-3H3,(H,22,26)
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n/an/a 2n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98616
PNG
(2-amino-1-cyclohexyl-7-(3-hydroxy-4-methoxy-3-meth...)
Show SMILES CNC(=O)c1c(N)n(C2CCCCC2)c2nc(ccc2c1=O)C#CC(C)(O)COC
Show InChI InChI=1S/C22H28N4O4/c1-22(29,13-30-3)12-11-14-9-10-16-18(27)17(21(28)24-2)19(23)26(20(16)25-14)15-7-5-4-6-8-15/h9-10,15,29H,4-8,13,23H2,1-3H3,(H,24,28)
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n/an/a 5n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98610
PNG
(2-amino-1-ethyl-7-[3-hydroxy-3-(3-methoxyphenyl)bu...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)c1cccc(OC)c1
Show InChI InChI=1S/C23H24N4O4/c1-5-27-20(24)18(22(29)25-3)19(28)17-10-9-15(26-21(17)27)11-12-23(2,30)14-7-6-8-16(13-14)31-4/h6-10,13,30H,5,24H2,1-4H3,(H,25,29)
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n/an/a 6n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98615
PNG
(2-amino-1-ethyl-7-(3-hydroxy-3-phenyl-but-1-ynyl)-...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)c1ccccc1
Show InChI InChI=1S/C22H22N4O3/c1-4-26-19(23)17(21(28)24-3)18(27)16-11-10-15(25-20(16)26)12-13-22(2,29)14-8-6-5-7-9-14/h5-11,29H,4,23H2,1-3H3,(H,24,28)
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n/an/a 14n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98608
PNG
(2-amino-1-ethyl-7-[2-(1-hydroxycyclobutyl)ethynyl]...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC1(O)CCC1
Show InChI InChI=1S/C18H20N4O3/c1-3-22-15(19)13(17(24)20-2)14(23)12-6-5-11(21-16(12)22)7-10-18(25)8-4-9-18/h5-6,25H,3-4,8-9,19H2,1-2H3,(H,20,24)
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n/an/a 21n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98617
PNG
(2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-bu...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)COC
Show InChI InChI=1S/C18H22N4O4/c1-5-22-15(19)13(17(24)20-3)14(23)12-7-6-11(21-16(12)22)8-9-18(2,25)10-26-4/h6-7,25H,5,10,19H2,1-4H3,(H,20,24)
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n/an/a 23n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98605
PNG
(2-amino-1-ethyl-7-[2-(3-hydroxytetrahydrofuran-3-y...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(C)O
Show InChI InChI=1S/C17H20N4O3/c1-5-21-14(18)12(16(23)19-4)13(22)11-7-6-10(20-15(11)21)8-9-17(2,3)24/h6-7,24H,5,18H2,1-4H3,(H,19,23)
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n/an/a 23n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98611
PNG
(2-amino-7-(3,4-dihydroxy-3-methyl-but-1-ynyl)-N-me...)
Show SMILES CNC(=O)c1c(N)n(C2CCOCC2)c2nc(ccc2c1=O)C#CC(C)(O)COC
Show InChI InChI=1S/C21H26N4O5/c1-21(28,12-29-3)9-6-13-4-5-15-17(26)16(20(27)23-2)18(22)25(19(15)24-13)14-7-10-30-11-8-14/h4-5,14,28H,7-8,10-12,22H2,1-3H3,(H,23,27)
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Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98607
PNG
(2-amino-7-(3-cyclopropyl-3-hydroxy-prop-1-ynyl)-1-...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(O)C1CC1
Show InChI InChI=1S/C18H20N4O3/c1-3-22-16(19)14(18(25)20-2)15(24)12-8-6-11(21-17(12)22)7-9-13(23)10-4-5-10/h6,8,10,13,23H,3-5,19H2,1-2H3,(H,20,25)
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n/an/a 37n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98618
PNG
(2-amino-1-ethyl-7-[3-hydroxy-3-(3-thienyl)but-1-yn...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)c1ccsc1
Show InChI InChI=1S/C20H20N4O3S/c1-4-24-17(21)15(19(26)22-3)16(25)14-6-5-13(23-18(14)24)7-9-20(2,27)12-8-10-28-11-12/h5-6,8,10-11,27H,4,21H2,1-3H3,(H,22,26)
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n/an/a 38n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98612
PNG
(2-amino-7-(3-hydroxy-3-methyl-but-1-ynyl)-N-methyl...)
Show SMILES CNC(=O)c1c(N)n(CC2CCCO2)c2nc(ccc2c1=O)C#CC(C)(C)O
Show InChI InChI=1S/C20H24N4O4/c1-20(2,27)9-8-12-6-7-14-16(25)15(19(26)22-3)17(21)24(18(14)23-12)11-13-5-4-10-28-13/h6-7,13,27H,4-5,10-11,21H2,1-3H3,(H,22,26)
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Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98614
PNG
(2-amino-7-(3,4-dihydroxy-3-methyl-but-1-ynyl)-1-et...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)CO
Show InChI InChI=1S/C17H20N4O4/c1-4-21-14(18)12(16(24)19-3)13(23)11-6-5-10(20-15(11)21)7-8-17(2,25)9-22/h5-6,22,25H,4,9,18H2,1-3H3,(H,19,24)
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Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98606
PNG
(2-amino-7-(3,4-dihydroxy-3-methyl-but-1-ynyl)-1-et...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC1(O)CCCC1
Show InChI InChI=1S/C19H22N4O3/c1-3-23-16(20)14(18(25)21-2)15(24)13-7-6-12(22-17(13)23)8-11-19(26)9-4-5-10-19/h6-7,26H,3-5,9-10,20H2,1-2H3,(H,21,25)
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n/an/a 46n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98613
PNG
(2-amino-7-(3-hydroxy-4-methoxy-3-methyl-but-1-ynyl...)
Show SMILES CNC(=O)c1c(N)n(Cc2ccccn2)c2nc(ccc2c1=O)C#CC(C)(O)COC
Show InChI InChI=1S/C22H23N5O4/c1-22(30,13-31-3)10-9-14-7-8-16-18(28)17(21(29)24-2)19(23)27(20(16)26-14)12-15-6-4-5-11-25-15/h4-8,11,30H,12-13,23H2,1-3H3,(H,24,29)
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Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))		BDBM98609
PNG
(2-amino-7-(3-hydroxy-4-methoxy-3-methyl-but-1-ynyl...)
Show SMILES CNC(=O)c1c(N)n(CCOC)c2nc(ccc2c1=O)C#CC(C)(O)COC
Show InChI InChI=1S/C19H24N4O5/c1-19(26,11-28-4)8-7-12-5-6-13-15(24)14(18(25)21-2)16(20)23(9-10-27-3)17(13)22-12/h5-6,26H,9-11,20H2,1-4H3,(H,21,25)
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n/an/a 257n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.

US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%