Found 10 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Translocator protein
(Homo sapiens (Human)) | BDBM98172
(US8492379, 28)Show SMILES CCN(CC)C(=O)Cc1c(nc2c(C)cc(C)nn12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C20H23ClN4O/c1-5-24(6-2)18(26)12-17-19(15-7-9-16(21)10-8-15)22-20-13(3)11-14(4)23-25(17)20/h7-11H,5-6,12H2,1-4H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
US Patent
| Assay Description
In vitro binding activity of TSPO. |
US Patent US8492379 (2013)
BindingDB Entry DOI: 10.7270/Q25T3J40 |
More data for this
Ligand-Target Pair | |
Translocator protein
(Homo sapiens (Human)) | BDBM98171
(US8492379, 27)Show SMILES CCN(CC)C(=O)Cc1c(nc2c(C)cc(C)nn12)-c1ccc(C)cc1 Show InChI InChI=1S/C21H26N4O/c1-6-24(7-2)19(26)13-18-20(17-10-8-14(3)9-11-17)22-21-15(4)12-16(5)23-25(18)21/h8-12H,6-7,13H2,1-5H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
US Patent
| Assay Description
In vitro binding activity of TSPO. |
US Patent US8492379 (2013)
BindingDB Entry DOI: 10.7270/Q25T3J40 |
More data for this
Ligand-Target Pair | |
Translocator protein
(Homo sapiens (Human)) | BDBM98173
(US8492379, 29)Show SMILES CCN(CC)C(=O)Cc1c(nc2c(C)cc(C)nn12)-c1ccc(Br)cc1 Show InChI InChI=1S/C20H23BrN4O/c1-5-24(6-2)18(26)12-17-19(15-7-9-16(21)10-8-15)22-20-13(3)11-14(4)23-25(17)20/h7-11H,5-6,12H2,1-4H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
US Patent
| Assay Description
In vitro binding activity of TSPO. |
US Patent US8492379 (2013)
BindingDB Entry DOI: 10.7270/Q25T3J40 |
More data for this
Ligand-Target Pair | |
Translocator protein
(Homo sapiens (Human)) | BDBM98176
(US8492379, 53)Show SMILES CCN(CC)C(=O)Cc1c(nc2c(C)cc(C)nn12)-c1ccc(OCCF)cc1 Show InChI InChI=1S/C22H27FN4O2/c1-5-26(6-2)20(28)14-19-21(17-7-9-18(10-8-17)29-12-11-23)24-22-15(3)13-16(4)25-27(19)22/h7-10,13H,5-6,11-12,14H2,1-4H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 1.55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
US Patent
| Assay Description
In vitro binding activity of TSPO. |
US Patent US8492379 (2013)
BindingDB Entry DOI: 10.7270/Q25T3J40 |
More data for this
Ligand-Target Pair | |
Translocator protein
(Homo sapiens (Human)) | BDBM98174
(US8492379, 30)Show SMILES CCN(CC)C(=O)Cc1c(nc2c(C)cc(C)nn12)-c1ccc(F)cc1 Show InChI InChI=1S/C20H23FN4O/c1-5-24(6-2)18(26)12-17-19(15-7-9-16(21)10-8-15)22-20-13(3)11-14(4)23-25(17)20/h7-11H,5-6,12H2,1-4H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
US Patent
| Assay Description
In vitro binding activity of TSPO. |
US Patent US8492379 (2013)
BindingDB Entry DOI: 10.7270/Q25T3J40 |
More data for this
Ligand-Target Pair | |
Translocator protein
(Homo sapiens (Human)) | BDBM98170
(US8492379, 26)Show SMILES CCN(CC)C(=O)Cc1c(nc2c(C)cc(C)nn12)-c1ccc(OC)cc1 Show InChI InChI=1S/C21H26N4O2/c1-6-24(7-2)19(26)13-18-20(16-8-10-17(27-5)11-9-16)22-21-14(3)12-15(4)23-25(18)21/h8-12H,6-7,13H2,1-5H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 2.61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
US Patent
| Assay Description
In vitro binding activity of TSPO. |
US Patent US8492379 (2013)
BindingDB Entry DOI: 10.7270/Q25T3J40 |
More data for this
Ligand-Target Pair | |
Translocator protein
(Homo sapiens (Human)) | BDBM98177
(US8492379, 54)Show SMILES CCN(CC)C(=O)C(Oc1cccnc1-n1cccc1)c1ccc(OC)cc1 Show InChI InChI=1S/C22H25N3O3/c1-4-24(5-2)22(26)20(17-10-12-18(27-3)13-11-17)28-19-9-8-14-23-21(19)25-15-6-7-16-25/h6-16,20H,4-5H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
US Patent
| Assay Description
In vitro binding activity of TSPO. |
US Patent US8492379 (2013)
BindingDB Entry DOI: 10.7270/Q25T3J40 |
More data for this
Ligand-Target Pair | |
Translocator protein
(Homo sapiens (Human)) | BDBM98178
(US8492379, 55)Show SMILES CCN(CC)C(=O)C(Oc1ccccc1-n1cccc1)c1ccc(OC)cc1 Show InChI InChI=1S/C23H26N2O3/c1-4-24(5-2)23(26)22(18-12-14-19(27-3)15-13-18)28-21-11-7-6-10-20(21)25-16-8-9-17-25/h6-17,22H,4-5H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
US Patent
| Assay Description
In vitro binding activity of TSPO. |
US Patent US8492379 (2013)
BindingDB Entry DOI: 10.7270/Q25T3J40 |
More data for this
Ligand-Target Pair | |
Translocator protein
(Homo sapiens (Human)) | BDBM98179
(US8492379, 56)Show SMILES CCN(CC)C(=O)C(Oc1ccc(Cl)cc1-n1cccc1)c1ccc(OC)cc1 Show InChI InChI=1S/C23H25ClN2O3/c1-4-25(5-2)23(27)22(17-8-11-19(28-3)12-9-17)29-21-13-10-18(24)16-20(21)26-14-6-7-15-26/h6-16,22H,4-5H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 5.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
US Patent
| Assay Description
In vitro binding activity of TSPO. |
US Patent US8492379 (2013)
BindingDB Entry DOI: 10.7270/Q25T3J40 |
More data for this
Ligand-Target Pair | |
Translocator protein
(Homo sapiens (Human)) | BDBM98175
(US8492379, 52)Show SMILES CCN(CC)C(=O)Cc1c(nc2c(C)cc(C)nn12)-c1ccc(O)cc1 Show InChI InChI=1S/C20H24N4O2/c1-5-23(6-2)18(26)12-17-19(15-7-9-16(25)10-8-15)21-20-13(3)11-14(4)22-24(17)20/h7-11,25H,5-6,12H2,1-4H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 11.0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
US Patent
| Assay Description
In vitro binding activity of TSPO. |
US Patent US8492379 (2013)
BindingDB Entry DOI: 10.7270/Q25T3J40 |
More data for this
Ligand-Target Pair | |
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