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Patent code US8497376

Compile Data Set for Download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98644
PNG
(US8497376, 20)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1C[C@@](C)(CO)O[C@@](C)(CO)C1 |r,c:5|
Show InChI InChI=1S/C27H35N5O4/c1-25(2)9-7-17(8-10-25)22-21(32-24(35)23-29-14-19(13-28)30-23)6-5-20(31-22)18-11-26(3,15-33)36-27(4,12-18)16-34/h5-7,14,18,33-34H,8-12,15-16H2,1-4H3,(H,29,30)(H,32,35)/t18?,26-,27+
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n/an/a 0.410n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98627
PNG
(US8497376, 8)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)[N+]#[C-])[C@]1(O)C[C@@]2(CO)CC[C@@](CO)(C1)O2 |r,c:5|
Show InChI InChI=1S/C28H34N4O5/c1-25(2)8-6-18(7-9-25)20-12-19(4-5-21(20)31-24(35)23-30-13-22(29-3)32-23)28(36)14-26(16-33)10-11-27(15-28,17-34)37-26/h4-6,12-13,33-34,36H,7-11,14-17H2,1-2H3,(H,30,32)(H,31,35)/t26-,27+,28+
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98621
PNG
(US8497376, 2)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@]1(O)C[C@]2(CO)O[C@](CO)(C1)C=C2 |r,c:5,39|
Show InChI InChI=1S/C28H32N4O5/c1-25(2)7-5-18(6-8-25)21-11-19(3-4-22(21)32-24(35)23-30-13-20(12-29)31-23)28(36)14-26(16-33)9-10-27(15-28,17-34)37-26/h3-5,9-11,13,33-34,36H,6-8,14-17H2,1-2H3,(H,30,31)(H,32,35)/t26-,27+,28+
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98624
PNG
(US8497376, 5)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@H]1C[C@@]2(CO)CC[C@@](CO)(C1)O2 |r,c:5|
Show InChI InChI=1S/C28H34N4O4/c1-26(2)7-5-18(6-8-26)22-11-19(20-12-27(16-33)9-10-28(13-20,17-34)36-27)3-4-23(22)32-25(35)24-30-15-21(14-29)31-24/h3-5,11,15,20,33-34H,6-10,12-13,16-17H2,1-2H3,(H,30,31)(H,32,35)/t20-,27+,28-
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n/an/a 0.470n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98622
PNG
(US8497376, 3)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1=C[C@]2(CO)O[C@](CO)(C1)C=C2 |r,c:5,38,t:27|
Show InChI InChI=1S/C28H30N4O4/c1-26(2)7-5-18(6-8-26)22-11-19(20-12-27(16-33)9-10-28(13-20,17-34)36-27)3-4-23(22)32-25(35)24-30-15-21(14-29)31-24/h3-5,9-12,15,33-34H,6-8,13,16-17H2,1-2H3,(H,30,31)(H,32,35)/t27-,28+/m1/s1
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98631
PNG
(US8497376, 12)
Show SMILES C[C@@]12C[C@](O)(C[C@@](C)(O1)[C@@H](O)[C@H]2O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,t:33|
Show InChI InChI=1S/C28H34N4O5/c1-25(2)9-7-16(8-10-25)19-11-17(5-6-20(19)32-24(35)23-30-13-18(12-29)31-23)28(36)14-26(3)21(33)22(34)27(4,15-28)37-26/h5-7,11,13,21-22,33-34,36H,8-10,14-15H2,1-4H3,(H,30,31)(H,32,35)/t21-,22+,26+,27-,28+
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98648
PNG
(US8497376, 27)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@@]1(O)CC2O[C@@H](C1)C=C2 |r,c:5,35|
Show InChI InChI=1S/C26H28N4O3/c1-25(2)9-7-16(8-10-25)21-11-17(26(32)12-19-4-5-20(13-26)33-19)3-6-22(21)30-24(31)23-28-15-18(14-27)29-23/h3-7,11,15,19-20,32H,8-10,12-13H2,1-2H3,(H,28,29)(H,30,31)/t19-,20?,26+/m1/s1
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98642
PNG
(US8497376, 18)
Show SMILES C[C@@]12CC(C[C@@](C)(O1)[C@@H](O)[C@H]2O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(n1)C1=CCC(C)(C)CC1 |r,t:32|
Show InChI InChI=1S/C27H33N5O4/c1-25(2)9-7-15(8-10-25)20-19(32-24(35)23-29-14-17(13-28)30-23)6-5-18(31-20)16-11-26(3)21(33)22(34)27(4,12-16)36-26/h5-7,14,16,21-22,33-34H,8-12H2,1-4H3,(H,29,30)(H,32,35)/t16?,21-,22+,26+,27-
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98623
PNG
(US8497376, 4)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@@H]1C[C@@]2(CO)CC[C@@](CO)(C1)O2 |r,c:5|
Show InChI InChI=1S/C28H34N4O4/c1-26(2)7-5-18(6-8-26)22-11-19(20-12-27(16-33)9-10-28(13-20,17-34)36-27)3-4-23(22)32-25(35)24-30-15-21(14-29)31-24/h3-5,11,15,20,33-34H,6-10,12-13,16-17H2,1-2H3,(H,30,31)(H,32,35)/t20-,27-,28+
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98632
PNG
(US8497376, 13)
Show SMILES C[C@@]12C[C@@H](C[C@@](C)(O1)[C@@H](O)[C@H]2O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,t:32|
Show InChI InChI=1S/C28H34N4O4/c1-26(2)9-7-16(8-10-26)20-11-17(18-12-27(3)22(33)23(34)28(4,13-18)36-27)5-6-21(20)32-25(35)24-30-15-19(14-29)31-24/h5-7,11,15,18,22-23,33-34H,8-10,12-13H2,1-4H3,(H,30,31)(H,32,35)/t18-,22+,23-,27-,28+
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98620
PNG
(US8497376, 1)
Show SMILES COC[C@@]12C[C@](O)(C[C@@](COC)(O1)C=C2)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,c:14,t:35|
Show InChI InChI=1S/C30H36N4O5/c1-27(2)9-7-20(8-10-27)23-13-21(5-6-24(23)34-26(35)25-32-15-22(14-31)33-25)30(36)16-28(18-37-3)11-12-29(17-30,39-28)19-38-4/h5-7,11-13,15,36H,8-10,16-19H2,1-4H3,(H,32,33)(H,34,35)/t28-,29+,30+
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98628
PNG
(US8497376, 9)
Show SMILES C[C@@]12C[C@](O)(C[C@@](C)(O1)C=C2)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,c:10,t:31|
Show InChI InChI=1S/C28H32N4O3/c1-25(2)9-7-18(8-10-25)21-13-19(28(34)16-26(3)11-12-27(4,17-28)35-26)5-6-22(21)32-24(33)23-30-15-20(14-29)31-23/h5-7,11-13,15,34H,8-10,16-17H2,1-4H3,(H,30,31)(H,32,33)/t26-,27+,28+
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98633
PNG
(US8497376, 14)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1C[C@@](C)(CO)O[C@@](C)(CO)C1 |r,c:5|
Show InChI InChI=1S/C28H36N4O4/c1-26(2)9-7-18(8-10-26)22-11-19(20-12-27(3,16-33)36-28(4,13-20)17-34)5-6-23(22)32-25(35)24-30-15-21(14-29)31-24/h5-7,11,15,20,33-34H,8-10,12-13,16-17H2,1-4H3,(H,30,31)(H,32,35)/t20?,27-,28+
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98635
PNG
(US8497376, 16)
Show SMILES CC1(C)CC(CC(C)(C)O1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(n1)C1=CCCCC1 |t:29|
Show InChI InChI=1S/C25H31N5O2/c1-24(2)12-17(13-25(3,4)32-24)19-10-11-20(21(29-19)16-8-6-5-7-9-16)30-23(31)22-27-15-18(14-26)28-22/h8,10-11,15,17H,5-7,9,12-13H2,1-4H3,(H,27,28)(H,30,31)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98630
PNG
(US8497376, 11)
Show SMILES CC1(C)O[C@H]2[C@@H](O1)[C@]1(C)C[C@](O)(C[C@@]2(C)O1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,t:37|
Show InChI InChI=1S/C31H38N4O5/c1-27(2)11-9-18(10-12-27)21-13-19(7-8-22(21)35-26(36)25-33-15-20(14-32)34-25)31(37)16-29(5)23-24(30(6,17-31)40-29)39-28(3,4)38-23/h7-9,13,15,23-24,37H,10-12,16-17H2,1-6H3,(H,33,34)(H,35,36)/t23-,24+,29+,30-,31+
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98646
PNG
(US8497376, 22)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)S(=O)(=O)C(C)(C)C1 |c:5|
Show InChI InChI=1S/C28H36N4O3S/c1-26(2)11-9-18(10-12-26)22-13-19(20-14-27(3,4)36(34,35)28(5,6)15-20)7-8-23(22)32-25(33)24-30-17-21(16-29)31-24/h7-9,13,17,20H,10-12,14-15H2,1-6H3,(H,30,31)(H,32,33)
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98626
PNG
(US8497376, 7)
Show SMILES COC[C@@]12CC[C@@](COC)(C[C@@H](C1)c1ccc(NC(=O)c3ncc([nH]3)C#N)c(c1)C1=CCC(C)(C)CC1)O2 |r,t:32|
Show InChI InChI=1S/C30H38N4O4/c1-28(2)9-7-20(8-10-28)24-13-21(5-6-25(24)34-27(35)26-32-17-23(16-31)33-26)22-14-29(18-36-3)11-12-30(15-22,38-29)19-37-4/h5-7,13,17,22H,8-12,14-15,18-19H2,1-4H3,(H,32,33)(H,34,35)/t22-,29-,30+
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98625
PNG
(US8497376, 6)
Show SMILES COC[C@@]12CC[C@@](COC)(C[C@H](C1)c1ccc(NC(=O)c3ncc([nH]3)C#N)c(c1)C1=CCC(C)(C)CC1)O2 |r,t:32|
Show InChI InChI=1S/C30H38N4O4/c1-28(2)9-7-20(8-10-28)24-13-21(5-6-25(24)34-27(35)26-32-17-23(16-31)33-26)22-14-29(18-36-3)11-12-30(15-22,38-29)19-37-4/h5-7,13,17,22H,8-12,14-15,18-19H2,1-4H3,(H,32,33)(H,34,35)/t22-,29+,30-
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n/an/a 2.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98634
PNG
(US8497376, 15)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)OC(C)(C)C1 |c:5|
Show InChI InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)
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n/an/a 2.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98643
PNG
(US8497376, 19)
Show SMILES C[C@@]12CC(C[C@@](C)(O1)[C@@H](O)[C@H]2O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(n1)C1=CCCCC1 |r,t:32|
Show InChI InChI=1S/C25H29N5O4/c1-24-10-15(11-25(2,34-24)21(32)20(24)31)17-8-9-18(19(29-17)14-6-4-3-5-7-14)30-23(33)22-27-13-16(12-26)28-22/h6,8-9,13,15,20-21,31-32H,3-5,7,10-11H2,1-2H3,(H,27,28)(H,30,33)/t15?,20-,21+,24+,25-
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n/an/a 2.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98629
PNG
(US8497376, 10)
Show SMILES COC(=O)N1[C@]2(C)C[C@@](O)(C[C@@]1(C)C=C2)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,c:14,t:35,TLB:2:4:8.7.10:13.14|
Show InChI InChI=1S/C30H35N5O4/c1-27(2)10-8-19(9-11-27)22-14-20(6-7-23(22)34-25(36)24-32-16-21(15-31)33-24)30(38)17-28(3)12-13-29(4,18-30)35(28)26(37)39-5/h6-8,12-14,16,38H,9-11,17-18H2,1-5H3,(H,32,33)(H,34,36)/t28-,29+,30+
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n/an/a 3.5n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98636
PNG
(US8497376, 17)
Show SMILES CC1(C)O[C@H]2[C@@H](O1)[C@]1(C)C[C@H](C[C@@]2(C)O1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(n1)C1=CCC(C)(C)CC1 |r,t:36|
Show InChI InChI=1S/C30H37N5O4/c1-27(2)11-9-17(10-12-27)22-21(35-26(36)25-32-16-19(15-31)33-25)8-7-20(34-22)18-13-29(5)23-24(30(6,14-18)39-29)38-28(3,4)37-23/h7-9,16,18,23-24H,10-14H2,1-6H3,(H,32,33)(H,35,36)/t18-,23-,24+,29+,30-
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n/an/a 4.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98647
PNG
(US8497376, 26)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1=C[C@H]2O[C@@H](C1)C=C2 |r,c:5,34,t:27|
Show InChI InChI=1S/C26H26N4O2/c1-26(2)9-7-16(8-10-26)22-13-17(18-11-20-4-5-21(12-18)32-20)3-6-23(22)30-25(31)24-28-15-19(14-27)29-24/h3-7,11,13,15,20-21H,8-10,12H2,1-2H3,(H,28,29)(H,30,31)/t20-,21+/m0/s1
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n/an/a 7.10n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98645
PNG
(US8497376, 21)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)S(=O)(=O)C(C)(C)C1 |c:5|
Show InChI InChI=1S/C27H35N5O3S/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)36(34,35)27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)
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n/an/a 8.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98650
PNG
(US8497376, 29)
Show SMILES C[C@H]1[C@H]2CCC(O2)[C@@H](C)[C@]1(O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,t:31|
Show InChI InChI=1S/C28H34N4O3/c1-16-23-7-8-24(35-23)17(2)28(16,34)19-5-6-22(32-26(33)25-30-15-20(14-29)31-25)21(13-19)18-9-11-27(3,4)12-10-18/h5-6,9,13,15-17,23-24,34H,7-8,10-12H2,1-4H3,(H,30,31)(H,32,33)/t16-,17+,23+,24?,28-/m0/s1
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98649
PNG
(US8497376, 28)
Show SMILES C[C@H]1[C@@H]2OC(C=C2)[C@@H](C)[C@]1(O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,c:5,t:31|
Show InChI InChI=1S/C28H32N4O3/c1-16-23-7-8-24(35-23)17(2)28(16,34)19-5-6-22(32-26(33)25-30-15-20(14-29)31-25)21(13-19)18-9-11-27(3,4)12-10-18/h5-9,13,15-17,23-24,34H,10-12H2,1-4H3,(H,30,31)(H,32,33)/t16-,17+,23+,24?,28-/m0/s1
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Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98651
PNG
(US8497376, 30)
Show SMILES C[C@H]1[C@]2(C)OC(C)(C=C2)[C@@H](C)[C@]1(O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,c:7,t:33|
Show InChI InChI=1S/C30H36N4O3/c1-18-28(5)13-14-29(6,37-28)19(2)30(18,36)21-7-8-24(34-26(35)25-32-17-22(16-31)33-25)23(15-21)20-9-11-27(3,4)12-10-20/h7-9,13-15,17-19,36H,10-12H2,1-6H3,(H,32,33)(H,34,35)/t18-,19+,28+,29?,30-/m0/s1
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n/an/a 99n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%