Found 36 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99498
(US8501768, 26)Show SMILES OC(CN1C[C@H]2CCN(C(=O)[C@H]2C1)c1ccc(OCC(F)(F)F)cc1)c1ccc(Cl)cc1Cl |r| Show InChI InChI=1S/C23H23Cl2F3N2O3/c24-15-1-6-18(20(25)9-15)21(31)12-29-10-14-7-8-30(22(32)19(14)11-29)16-2-4-17(5-3-16)33-13-23(26,27)28/h1-6,9,14,19,21,31H,7-8,10-13H2/t14-,19+,21?/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99474
(US8501768, 2)Show SMILES FC(F)(F)Oc1ccc(cc1)N1CC[C@H]2CN(C[C@H]2C1=O)C(=O)Cc1ccccc1 |r| Show InChI InChI=1S/C22H21F3N2O3/c23-22(24,25)30-18-8-6-17(7-9-18)27-11-10-16-13-26(14-19(16)21(27)29)20(28)12-15-4-2-1-3-5-15/h1-9,16,19H,10-14H2/t16-,19+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 49.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99483
(US8501768, 11)Show SMILES FC(F)(F)Oc1ccc(cc1)N1CC[C@H]2CN(C[C@H]2C1=O)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C20H18ClF3N2O4S/c21-17-3-1-2-4-18(17)31(28,29)25-11-13-9-10-26(19(27)16(13)12-25)14-5-7-15(8-6-14)30-20(22,23)24/h1-8,13,16H,9-12H2/t13-,16+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 50.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99489
(US8501768, 17)Show SMILES FC(F)(F)COc1ccc(cc1)N1CC[C@@H]2CN(C[C@@H]2C1=O)S(=O)(=O)c1ccccc1OC(F)(F)F |r| Show InChI InChI=1S/C22H20F6N2O5S/c23-21(24,25)13-34-16-7-5-15(6-8-16)30-10-9-14-11-29(12-17(14)20(30)31)36(32,33)19-4-2-1-3-18(19)35-22(26,27)28/h1-8,14,17H,9-13H2/t14-,17+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 51.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99505
(US8501768, 33)Show SMILES FC(F)(F)Oc1ccc(cc1)N1C[C@@H]2CC(C[C@@H]2C1=O)NS(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C20H18ClF3N2O4S/c21-17-3-1-2-4-18(17)31(28,29)25-13-9-12-11-26(19(27)16(12)10-13)14-5-7-15(8-6-14)30-20(22,23)24/h1-8,12-13,16,25H,9-11H2/t12-,13?,16-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 96.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99477
(US8501768, 5)Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2C[C@@H]3CCN(C(=O)[C@@H]3C2)c2ccc(OC(F)(F)F)cc2)cc1 |r| Show InChI InChI=1S/C22H19F6N3O4/c23-21(24,25)34-16-5-1-14(2-6-16)29-20(33)30-11-13-9-10-31(19(32)18(13)12-30)15-3-7-17(8-4-15)35-22(26,27)28/h1-8,13,18H,9-12H2,(H,29,33)/t13-,18+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 136 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99508
(US8501768, 36)Show SMILES CCCCOC[C@]1(O)C[C@H]2CN(C(=O)[C@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C19H24F3NO4/c1-2-3-8-26-12-18(25)9-13-11-23(17(24)16(13)10-18)14-4-6-15(7-5-14)27-19(20,21)22/h4-7,13,16,25H,2-3,8-12H2,1H3/t13-,16-,18-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99496
(US8501768, 24)Show SMILES CC(C)C(N1C[C@H]2CCN(C(=O)[C@H]2C1)c1ccc(OCC(F)(F)F)cc1)C(=O)Nc1ccc(F)cc1 |r| Show InChI InChI=1S/C26H29F4N3O3/c1-16(2)23(24(34)31-19-5-3-18(27)4-6-19)32-13-17-11-12-33(25(35)22(17)14-32)20-7-9-21(10-8-20)36-15-26(28,29)30/h3-10,16-17,22-23H,11-15H2,1-2H3,(H,31,34)/t17-,22+,23?/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 153 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99495
(US8501768, 23)Show SMILES FC(F)(F)COc1ccc(cc1)N1CC[C@@H]2CN(C[C@@H]2C1=O)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C21H20ClF3N2O4S/c22-18-3-1-2-4-19(18)32(29,30)26-11-14-9-10-27(20(28)17(14)12-26)15-5-7-16(8-6-15)31-13-21(23,24)25/h1-8,14,17H,9-13H2/t14-,17+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 161 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99473
(US8501768, 1)Show SMILES CC(C)(C)OC(=O)N1C[C@H]2CCN(C(=O)[C@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C19H23F3N2O4/c1-18(2,3)28-17(26)23-10-12-8-9-24(16(25)15(12)11-23)13-4-6-14(7-5-13)27-19(20,21)22/h4-7,12,15H,8-11H2,1-3H3/t12-,15+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99485
(US8501768, 13)Show SMILES FC(F)(F)Oc1ccc(cc1)N1CC[C@H]2CN(C[C@H]2C1=O)S(=O)(=O)Cc1ccccc1 |r| Show InChI InChI=1S/C21H21F3N2O4S/c22-21(23,24)30-18-8-6-17(7-9-18)26-11-10-16-12-25(13-19(16)20(26)27)31(28,29)14-15-4-2-1-3-5-15/h1-9,16,19H,10-14H2/t16-,19+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 174 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99490
(US8501768, 18)Show SMILES Cc1ccc(CC(=O)N2C[C@H]3CCN(C(=O)[C@H]3C2)c2ccc(OCC(F)(F)F)cc2)cc1 |r| Show InChI InChI=1S/C24H25F3N2O3/c1-16-2-4-17(5-3-16)12-22(30)28-13-18-10-11-29(23(31)21(18)14-28)19-6-8-20(9-7-19)32-15-24(25,26)27/h2-9,18,21H,10-15H2,1H3/t18-,21+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 244 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99480
(US8501768, 8)Show SMILES CC(C)c1ccc(cc1)C(=O)N1C[C@@H]2CCN(C(=O)[C@@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C24H25F3N2O3/c1-15(2)16-3-5-17(6-4-16)22(30)28-13-18-11-12-29(23(31)21(18)14-28)19-7-9-20(10-8-19)32-24(25,26)27/h3-10,15,18,21H,11-14H2,1-2H3/t18-,21+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 259 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99492
(US8501768, 20)Show SMILES FC(F)(F)COc1ccc(cc1)N1CC[C@@H]2CN(C[C@@H]2C1=O)S(=O)(=O)c1ccccc1C(F)(F)F |r| Show InChI InChI=1S/C22H20F6N2O4S/c23-21(24,25)13-34-16-7-5-15(6-8-16)30-10-9-14-11-29(12-17(14)20(30)31)35(32,33)19-4-2-1-3-18(19)22(26,27)28/h1-8,14,17H,9-13H2/t14-,17+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 268 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99504
(US8501768, 32)Show SMILES O[C@@]1(CNc2ccccc2)C[C@H]2CN(C(=O)[C@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C21H21F3N2O3/c22-21(23,24)29-17-8-6-16(7-9-17)26-12-14-10-20(28,11-18(14)19(26)27)13-25-15-4-2-1-3-5-15/h1-9,14,18,25,28H,10-13H2/t14-,18-,20-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 279 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99479
(US8501768, 7)Show SMILES FC(F)(F)Oc1ccc(cc1)N1CC[C@H]2CN(C[C@H]2C1=O)C(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C21H18ClF3N2O3/c22-18-4-2-1-3-16(18)19(28)26-11-13-9-10-27(20(29)17(13)12-26)14-5-7-15(8-6-14)30-21(23,24)25/h1-8,13,17H,9-12H2/t13-,17+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 311 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99493
(US8501768, 21)Show SMILES FC(F)(F)COc1ccc(cc1)N1CC[C@@H]2CN(C[C@@H]2C1=O)C(=O)Cc1ccccc1 |r| Show InChI InChI=1S/C23H23F3N2O3/c24-23(25,26)15-31-19-8-6-18(7-9-19)28-11-10-17-13-27(14-20(17)22(28)30)21(29)12-16-4-2-1-3-5-16/h1-9,17,20H,10-15H2/t17-,20+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 327 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99497
(US8501768, 25)Show SMILES CC(C)(C)OC(=O)N1C[C@H]2CCN(C(=O)[C@H]2C1)c1ccc(OCC(F)(F)F)cc1 |r| Show InChI InChI=1S/C20H25F3N2O4/c1-19(2,3)29-18(27)24-10-13-8-9-25(17(26)16(13)11-24)14-4-6-15(7-5-14)28-12-20(21,22)23/h4-7,13,16H,8-12H2,1-3H3/t13-,16+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 334 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99475
(US8501768, 3)Show SMILES Fc1ccc(cc1)C(=O)N1C[C@@H]2CCN(C(=O)[C@@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C21H18F4N2O3/c22-15-3-1-13(2-4-15)19(28)26-11-14-9-10-27(20(29)18(14)12-26)16-5-7-17(8-6-16)30-21(23,24)25/h1-8,14,18H,9-12H2/t14-,18+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 354 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99478
(US8501768, 6)Show SMILES Fc1ccc(CN2C[C@@H]3CCN(C(=O)[C@@H]3C2)c2ccc(OC(F)(F)F)cc2)cc1 |r| Show InChI InChI=1S/C21H20F4N2O2/c22-16-3-1-14(2-4-16)11-26-12-15-9-10-27(20(28)19(15)13-26)17-5-7-18(8-6-17)29-21(23,24)25/h1-8,15,19H,9-13H2/t15-,19+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 359 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99484
(US8501768, 12)Show SMILES Fc1ccc(cc1)S(=O)(=O)N1C[C@@H]2CCN(C(=O)[C@@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C20H18F4N2O4S/c21-14-1-7-17(8-2-14)31(28,29)25-11-13-9-10-26(19(27)18(13)12-25)15-3-5-16(6-4-15)30-20(22,23)24/h1-8,13,18H,9-12H2/t13-,18+/m0/s1 | Reactome pathway
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| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99481
(US8501768, 9)Show SMILES CC(C)CCS(=O)(=O)N1C[C@@H]2CCN(C(=O)[C@@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C19H25F3N2O4S/c1-13(2)8-10-29(26,27)23-11-14-7-9-24(18(25)17(14)12-23)15-3-5-16(6-4-15)28-19(20,21)22/h3-6,13-14,17H,7-12H2,1-2H3/t14-,17+/m0/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99503
(US8501768, 31)Show SMILES O[C@@]1(COCC(F)(F)F)C[C@H]2CN(C(=O)[C@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C17H17F6NO4/c18-16(19,20)9-27-8-15(26)5-10-7-24(14(25)13(10)6-15)11-1-3-12(4-2-11)28-17(21,22)23/h1-4,10,13,26H,5-9H2/t10-,13-,15-/m0/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99506
(US8501768, 34)Show SMILES O[C@@]1(COc2ccccc2)C[C@H]2CN(C(=O)[C@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C21H20F3NO4/c22-21(23,24)29-17-8-6-15(7-9-17)25-12-14-10-20(27,11-18(14)19(25)26)13-28-16-4-2-1-3-5-16/h1-9,14,18,27H,10-13H2/t14-,18-,20-/m0/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99502
(US8501768, 30)Show SMILES CCCC1(O)C[C@H]2CN(C(=O)[C@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C17H20F3NO3/c1-2-7-16(23)8-11-10-21(15(22)14(11)9-16)12-3-5-13(6-4-12)24-17(18,19)20/h3-6,11,14,23H,2,7-10H2,1H3/t11-,14-,16?/m0/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99507
(US8501768, 35)Show SMILES CCCOC[C@]1(O)C[C@H]2CN(C(=O)[C@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C18H22F3NO4/c1-2-7-25-11-17(24)8-12-10-22(16(23)15(12)9-17)13-3-5-14(6-4-13)26-18(19,20)21/h3-6,12,15,24H,2,7-11H2,1H3/t12-,15-,17-/m0/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99501
(US8501768, 29)Show SMILES CCc1ccc(cc1)N1C[C@H]2CN(C[C@H]2C1=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C22H22F3N3O3/c1-2-14-3-7-17(8-4-14)28-12-15-11-27(13-19(15)20(28)29)21(30)26-16-5-9-18(10-6-16)31-22(23,24)25/h3-10,15,19H,2,11-13H2,1H3,(H,26,30)/t15-,19-/m1/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99499
(US8501768, 27)Show SMILES Oc1ccccc1N1C[C@H]2CCN(C(=O)[C@H]2C1)c1ccc(OCC(F)(F)F)cc1 |r| Show InChI InChI=1S/C21H21F3N2O3/c22-21(23,24)13-29-16-7-5-15(6-8-16)26-10-9-14-11-25(12-17(14)20(26)28)18-3-1-2-4-19(18)27/h1-8,14,17,27H,9-13H2/t14-,17+/m1/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99494
(US8501768, 22)Show SMILES CC(C)(C)CC(=O)N1C[C@H]2CCN(C(=O)[C@H]2C1)c1ccc(OCC(F)(F)F)cc1 |r| Show InChI InChI=1S/C21H27F3N2O3/c1-20(2,3)10-18(27)25-11-14-8-9-26(19(28)17(14)12-25)15-4-6-16(7-5-15)29-13-21(22,23)24/h4-7,14,17H,8-13H2,1-3H3/t14-,17+/m1/s1 | Reactome pathway
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| n/a | n/a | 701 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99476
(US8501768, 4)Show SMILES CC(C)CC(=O)N1C[C@@H]2CCN(C(=O)[C@@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C19H23F3N2O3/c1-12(2)9-17(25)23-10-13-7-8-24(18(26)16(13)11-23)14-3-5-15(6-4-14)27-19(20,21)22/h3-6,12-13,16H,7-11H2,1-2H3/t13-,16+/m0/s1 | Reactome pathway
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| n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99487
(US8501768, 15)Show SMILES FC(F)(F)COc1ccc(cc1)N1CC[C@@H]2CN(C[C@@H]2C1=O)S(=O)(=O)c1cccnc1Cl |r| Show InChI InChI=1S/C20H19ClF3N3O4S/c21-18-17(2-1-8-25-18)32(29,30)26-10-13-7-9-27(19(28)16(13)11-26)14-3-5-15(6-4-14)31-12-20(22,23)24/h1-6,8,13,16H,7,9-12H2/t13-,16+/m1/s1 | Reactome pathway
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| n/a | n/a | 727 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99486
(US8501768, 14)Show SMILES Fc1ccc(NC(=O)N2C[C@@H]3CCN(C(=O)[C@@H]3C2)c2ccc(OC(F)(F)F)cc2)cc1 |r| Show InChI InChI=1S/C21H19F4N3O3/c22-14-1-3-15(4-2-14)26-20(30)27-11-13-9-10-28(19(29)18(13)12-27)16-5-7-17(8-6-16)31-21(23,24)25/h1-8,13,18H,9-12H2,(H,26,30)/t13-,18+/m0/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99491
(US8501768, 19)Show SMILES Fc1ccc(CC(=O)N2C[C@H]3CCN(C(=O)[C@H]3C2)c2ccc(OCC(F)(F)F)cc2)cc1 |r| Show InChI InChI=1S/C23H22F4N2O3/c24-17-3-1-15(2-4-17)11-21(30)28-12-16-9-10-29(22(31)20(16)13-28)18-5-7-19(8-6-18)32-14-23(25,26)27/h1-8,16,20H,9-14H2/t16-,20+/m1/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99500
(US8501768, 28)Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2C[C@@H]3CN(C(=O)[C@@H]3C2)c2ccc(OC(F)(F)F)cc2)cc1 |r| Show InChI InChI=1S/C21H17F6N3O4/c22-20(23,24)33-15-5-1-13(2-6-15)28-19(32)29-9-12-10-30(18(31)17(12)11-29)14-3-7-16(8-4-14)34-21(25,26)27/h1-8,12,17H,9-11H2,(H,28,32)/t12-,17-/m1/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99488
(US8501768, 16)Show SMILES FC(F)(F)COc1ccc(cc1)N1CC[C@@H]2CN(C[C@@H]2C1=O)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C21H21F3N2O4S/c22-21(23,24)14-30-17-8-6-16(7-9-17)26-11-10-15-12-25(13-19(15)20(26)27)31(28,29)18-4-2-1-3-5-18/h1-9,15,19H,10-14H2/t15-,19+/m1/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Homo sapiens (Human)) | BDBM99482
(US8501768, 10)Show SMILES CC(C)CS(=O)(=O)N1C[C@@H]2CCN(C(=O)[C@@H]2C1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C18H23F3N2O4S/c1-12(2)11-28(25,26)22-9-13-7-8-23(17(24)16(13)10-22)14-3-5-15(6-4-14)27-18(19,20)21/h3-6,12-13,16H,7-11H2,1-2H3/t13-,16+/m0/s1 | Reactome pathway
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
HSL enzyme activity was measured by a colorimetric assay. |
US Patent US8501768 (2013)
BindingDB Entry DOI: 10.7270/Q26Q1VW3 |
More data for this
Ligand-Target Pair | |
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