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Patent code US8501936

Compile Data Set for Download or QSAR

Found 1030 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99618
PNG
(US8501936, 119)
Show SMILES CN(c1ccc(cc1)-c1cccn2nc(Nc3ccc(CN4CCS(=O)(=O)CC4)cc3)nc12)S(C)(=O)=O
Show InChI InChI=1S/C25H28N6O4S2/c1-29(36(2,32)33)22-11-7-20(8-12-22)23-4-3-13-31-24(23)27-25(28-31)26-21-9-5-19(6-10-21)18-30-14-16-37(34,35)17-15-30/h3-13H,14-18H2,1-2H3,(H,26,28)
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US Patent
n/an/a 0.270n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99529
PNG
(CHEMBL2062802 | US8501936, 27)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)N3CCOCC3)nc12
Show InChI InChI=1S/C23H23N5O3S/c1-32(29,30)20-9-7-17(8-10-20)21-6-3-11-28-22(21)25-23(26-28)24-18-4-2-5-19(16-18)27-12-14-31-15-13-27/h2-11,16H,12-15H2,1H3,(H,24,26)
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n/an/a 0.400n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99683
PNG
(US8501936, 184)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)C3CCN(CC(N)=O)CC3)nc12
Show InChI InChI=1S/C26H28N6O3S/c1-36(34,35)22-9-7-19(8-10-22)23-6-3-13-32-25(23)29-26(30-32)28-21-5-2-4-20(16-21)18-11-14-31(15-12-18)17-24(27)33/h2-10,13,16,18H,11-12,14-15,17H2,1H3,(H2,27,33)(H,28,30)
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n/an/a 0.410n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99689
PNG
(US8501936, 190)
Show SMILES CS(=O)(=O)CCN1CCC(CC1)c1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1
Show InChI InChI=1S/C27H31N5O4S2/c1-37(33,34)18-17-31-15-12-20(13-16-31)22-5-3-6-23(19-22)28-27-29-26-25(7-4-14-32(26)30-27)21-8-10-24(11-9-21)38(2,35)36/h3-11,14,19-20H,12-13,15-18H2,1-2H3,(H,28,30)
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n/an/a 0.460n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99710
PNG
(US8501936, 212)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)n1cc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)cn1
Show InChI InChI=1S/C26H31N7O4S/c1-26(2,3)37-25(34)31-14-11-20(12-15-31)33-17-19(16-27-33)28-24-29-23-22(6-5-13-32(23)30-24)18-7-9-21(10-8-18)38(4,35)36/h5-10,13,16-17,20H,11-12,14-15H2,1-4H3,(H,28,30)
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n/an/a 0.5n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99620
PNG
(US8501936, 121)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccc2nc(Nc3cccc(CN4CCS(=O)(=O)CC4)c3)nn12
Show InChI InChI=1S/C24H25N5O4S2/c1-34(30,31)21-10-8-19(9-11-21)22-6-3-7-23-26-24(27-29(22)23)25-20-5-2-4-18(16-20)17-28-12-14-35(32,33)15-13-28/h2-11,16H,12-15,17H2,1H3,(H,25,27)
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n/an/a 0.550n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99690
PNG
(US8501936, 191)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)[C@@H]3CCN(CC(N)=O)C[C@@H]3O)nc12 |r|
Show InChI InChI=1S/C26H28N6O4S/c1-37(35,36)20-9-7-17(8-10-20)22-6-3-12-32-25(22)29-26(30-32)28-19-5-2-4-18(14-19)21-11-13-31(15-23(21)33)16-24(27)34/h2-10,12,14,21,23,33H,11,13,15-16H2,1H3,(H2,27,34)(H,28,30)/t21-,23-/m0/s1
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n/an/a 0.550n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99565
PNG
(US8501936, 63)
Show SMILES CN(c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)N3CCN(C)CC3)nc12)S(C)(=O)=O
Show InChI InChI=1S/C25H29N7O2S/c1-29-14-16-31(17-15-29)22-7-4-6-20(18-22)26-25-27-24-23(8-5-13-32(24)28-25)19-9-11-21(12-10-19)30(2)35(3,33)34/h4-13,18H,14-17H2,1-3H3,(H,26,28)
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n/an/a 0.600n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99520
PNG
(US8501936, 18)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc(cc3)N3CCCCC3)nc12
Show InChI InChI=1S/C24H25N5O2S/c1-32(30,31)21-13-7-18(8-14-21)22-6-5-17-29-23(22)26-24(27-29)25-19-9-11-20(12-10-19)28-15-3-2-4-16-28/h5-14,17H,2-4,15-16H2,1H3,(H,25,27)
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n/an/a 0.600n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99564
PNG
(US8501936, 62)
Show SMILES CN(c1ccc(cc1)-c1cccn2nc(Nc3ccc(cc3)N3CCN(C)CC3)nc12)S(C)(=O)=O
Show InChI InChI=1S/C25H29N7O2S/c1-29-15-17-31(18-16-29)22-12-8-20(9-13-22)26-25-27-24-23(5-4-14-32(24)28-25)19-6-10-21(11-7-19)30(2)35(3,33)34/h4-14H,15-18H2,1-3H3,(H,26,28)
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n/an/a 0.600n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99548
PNG
(US8501936, 46)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(CN4CCOCC4)c3)nc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(30,31)21-9-7-19(8-10-21)22-6-3-11-29-23(22)26-24(27-29)25-20-5-2-4-18(16-20)17-28-12-14-32-15-13-28/h2-11,16H,12-15,17H2,1H3,(H,25,27)
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n/an/a 0.600n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99682
PNG
(US8501936, 183)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)N3CCN(CC(N)=O)CC3)nc12
Show InChI InChI=1S/C25H27N7O3S/c1-36(34,35)21-9-7-18(8-10-21)22-6-3-11-32-24(22)28-25(29-32)27-19-4-2-5-20(16-19)31-14-12-30(13-15-31)17-23(26)33/h2-11,16H,12-15,17H2,1H3,(H2,26,33)(H,27,29)
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n/an/a 0.650n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99614
PNG
(US8501936, 115)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccc2nc(Nc3ccc(CN4CCS(=O)(=O)CC4)cc3)nn12
Show InChI InChI=1S/C24H25N5O4S2/c1-34(30,31)21-11-7-19(8-12-21)22-3-2-4-23-26-24(27-29(22)23)25-20-9-5-18(6-10-20)17-28-13-15-35(32,33)16-14-28/h2-12H,13-17H2,1H3,(H,25,27)
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n/an/a 0.660n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99619
PNG
(CHEMBL2062807 | US8501936, 120)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(CN4CCS(=O)(=O)CC4)c3)nc12
Show InChI InChI=1S/C24H25N5O4S2/c1-34(30,31)21-9-7-19(8-10-21)22-6-3-11-29-23(22)26-24(27-29)25-20-5-2-4-18(16-20)17-28-12-14-35(32,33)15-13-28/h2-11,16H,12-15,17H2,1H3,(H,25,27)
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n/an/a 0.670n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99516
PNG
(US8501936, 12)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccc2nc(Nc3ccc(cc3)N3CCOCC3)nn12
Show InChI InChI=1S/C23H23N5O3S/c1-32(29,30)20-11-5-17(6-12-20)21-3-2-4-22-25-23(26-28(21)22)24-18-7-9-19(10-8-18)27-13-15-31-16-14-27/h2-12H,13-16H2,1H3,(H,24,26)
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n/an/a 0.700n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99563
PNG
(CHEMBL2062809 | US8501936, 61)
Show SMILES CN1CCC(CC1)c1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1
Show InChI InChI=1S/C25H27N5O2S/c1-29-15-12-18(13-16-29)20-5-3-6-21(17-20)26-25-27-24-23(7-4-14-30(24)28-25)19-8-10-22(11-9-19)33(2,31)32/h3-11,14,17-18H,12-13,15-16H2,1-2H3,(H,26,28)
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n/an/a 0.700n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99550
PNG
(US8501936, 48)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nc3c(cccn3n2)-c2ccc(CS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C25H28N6O2S/c1-29-14-16-30(17-15-29)22-11-9-21(10-12-22)26-25-27-24-23(4-3-13-31(24)28-25)20-7-5-19(6-8-20)18-34(2,32)33/h3-13H,14-18H2,1-2H3,(H,26,28)
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n/an/a 0.700n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99711
PNG
(US8501936, 213)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cnn(c3)C3CCNCC3)nc12
Show InChI InChI=1S/C21H23N7O2S/c1-31(29,30)18-6-4-15(5-7-18)19-3-2-12-27-20(19)25-21(26-27)24-16-13-23-28(14-16)17-8-10-22-11-9-17/h2-7,12-14,17,22H,8-11H2,1H3,(H,24,26)
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n/an/a 0.710n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99667
PNG
(US8501936, 168)
Show SMILES CN1Cc2ccc(Nc3nc4c(cccn4n3)-c3ccc(cc3)S(C)(=O)=O)cc2C1
Show InChI InChI=1S/C22H21N5O2S/c1-26-13-16-5-8-18(12-17(16)14-26)23-22-24-21-20(4-3-11-27(21)25-22)15-6-9-19(10-7-15)30(2,28)29/h3-12H,13-14H2,1-2H3,(H,23,25)
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n/an/a 0.730n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99613
PNG
(US8501936, 114)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc(CN4CCS(=O)(=O)CC4)cc3)nc12
Show InChI InChI=1S/C24H25N5O4S2/c1-34(30,31)21-10-6-19(7-11-21)22-3-2-12-29-23(22)26-24(27-29)25-20-8-4-18(5-9-20)17-28-13-15-35(32,33)16-14-28/h2-12H,13-17H2,1H3,(H,25,27)
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n/an/a 0.75n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99641
PNG
(US8501936, 142)
Show SMILES C[C@H](O)CN1CCN(CC1)c1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1 |r|
Show InChI InChI=1S/C26H30N6O3S/c1-19(33)18-30-13-15-31(16-14-30)22-6-3-5-21(17-22)27-26-28-25-24(7-4-12-32(25)29-26)20-8-10-23(11-9-20)36(2,34)35/h3-12,17,19,33H,13-16,18H2,1-2H3,(H,27,29)/t19-/m0/s1
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n/an/a 0.75n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99573
PNG
(US8501936, 71)
Show SMILES CN1CCN(CC1)c1cccc(Nc2nc3cccc(-c4ccc(CN5CCS(=O)(=O)CC5)cc4)n3n2)c1
Show InChI InChI=1S/C28H33N7O2S/c1-32-12-14-34(15-13-32)25-5-2-4-24(20-25)29-28-30-27-7-3-6-26(35(27)31-28)23-10-8-22(9-11-23)21-33-16-18-38(36,37)19-17-33/h2-11,20H,12-19,21H2,1H3,(H,29,31)
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n/an/a 0.800n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50389186
PNG
(CHEMBL2062803 | US8501936, 4)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc(cc3)N3CCOCC3)nc12
Show InChI InChI=1S/C23H23N5O3S/c1-32(29,30)20-10-4-17(5-11-20)21-3-2-12-28-22(21)25-23(26-28)24-18-6-8-19(9-7-18)27-13-15-31-16-14-27/h2-12H,13-16H2,1H3,(H,24,26)
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n/an/a 0.900n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99616
PNG
(US8501936, 117)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccc2nc(Nc3cccc(CN4CCOCC4)c3)nn12
Show InChI InChI=1S/C24H25N5O3S/c1-33(30,31)21-10-8-19(9-11-21)22-6-3-7-23-26-24(27-29(22)23)25-20-5-2-4-18(16-20)17-28-12-14-32-15-13-28/h2-11,16H,12-15,17H2,1H3,(H,25,27)
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n/an/a 0.950n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99680
PNG
(US8501936, 181)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)N3CCNCC3)nc12
Show InChI InChI=1S/C23H24N6O2S/c1-32(30,31)20-9-7-17(8-10-20)21-6-3-13-29-22(21)26-23(27-29)25-18-4-2-5-19(16-18)28-14-11-24-12-15-28/h2-10,13,16,24H,11-12,14-15H2,1H3,(H,25,27)
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n/an/a 0.970n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99521
PNG
(CHEMBL2062799 | US8501936, 19)
Show SMILES COc1ccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C20H18N4O3S/c1-27-16-9-7-15(8-10-16)21-20-22-19-18(4-3-13-24(19)23-20)14-5-11-17(12-6-14)28(2,25)26/h3-13H,1-2H3,(H,21,23)
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n/an/a 1n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99542
PNG
(CHEMBL2062798 | US8501936, 40)
Show SMILES COc1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1
Show InChI InChI=1S/C20H18N4O3S/c1-27-16-6-3-5-15(13-16)21-20-22-19-18(7-4-12-24(19)23-20)14-8-10-17(11-9-14)28(2,25)26/h3-13H,1-2H3,(H,21,23)
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n/an/a 1n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99514
PNG
(US8501936, 10)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc(OCCN4CCCC4)cc3)nc12
Show InChI InChI=1S/C25H27N5O3S/c1-34(31,32)22-12-6-19(7-13-22)23-5-4-16-30-24(23)27-25(28-30)26-20-8-10-21(11-9-20)33-18-17-29-14-2-3-15-29/h4-13,16H,2-3,14-15,17-18H2,1H3,(H,26,28)
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n/an/a 1n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99596
PNG
(US8501936, 95)
Show SMILES COc1ccc(Nc2nc3cccc(-c4ccc(CN5CCS(=O)(=O)CC5)cc4)n3n2)cc1
Show InChI InChI=1S/C24H25N5O3S/c1-32-21-11-9-20(10-12-21)25-24-26-23-4-2-3-22(29(23)27-24)19-7-5-18(6-8-19)17-28-13-15-33(30,31)16-14-28/h2-12H,13-17H2,1H3,(H,25,27)
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n/an/a 1n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99536
PNG
(US8501936, 34)
Show SMILES COc1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)S(C)(=O)=O)cc1 |t:18|
Show InChI InChI=1S/C19H21N5O3S/c1-27-16-7-5-15(6-8-16)20-19-21-18-17(4-3-11-24(18)22-19)14-9-12-23(13-10-14)28(2,25)26/h3-9,11H,10,12-13H2,1-2H3,(H,20,22)
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n/an/a 1n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99767
PNG
(US8501936, 283)
Show SMILES CN(C)C(=O)CN1CCC(CC1)c1ccc(Nc2nc3c(cccn3n2)-c2cnn(c2)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C30H31FN8O/c1-36(2)28(40)20-37-16-13-22(14-17-37)21-5-9-25(10-6-21)33-30-34-29-27(4-3-15-38(29)35-30)23-18-32-39(19-23)26-11-7-24(31)8-12-26/h3-12,15,18-19,22H,13-14,16-17,20H2,1-2H3,(H,33,35)
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n/an/a 1.06n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99572
PNG
(US8501936, 70)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nc3cccc(-c4ccc(CN5CCS(=O)(=O)CC5)cc4)n3n2)cc1
Show InChI InChI=1S/C28H33N7O2S/c1-32-13-15-34(16-14-32)25-11-9-24(10-12-25)29-28-30-27-4-2-3-26(35(27)31-28)23-7-5-22(6-8-23)21-33-17-19-38(36,37)20-18-33/h2-12H,13-21H2,1H3,(H,29,31)
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n/an/a 1.10n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99552
PNG
(US8501936, 50)
Show SMILES CN1CCC(CC1)c1ccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C25H27N5O2S/c1-29-16-13-19(14-17-29)18-5-9-21(10-6-18)26-25-27-24-23(4-3-15-30(24)28-25)20-7-11-22(12-8-20)33(2,31)32/h3-12,15,19H,13-14,16-17H2,1-2H3,(H,26,28)
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n/an/a 1.10n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99586
PNG
(US8501936, 85)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccc2nc(Nc3ccc(CN4CCOCC4)cc3)nn12
Show InChI InChI=1S/C24H25N5O3S/c1-33(30,31)21-11-7-19(8-12-21)22-3-2-4-23-26-24(27-29(22)23)25-20-9-5-18(6-10-20)17-28-13-15-32-16-14-28/h2-12H,13-17H2,1H3,(H,25,27)
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n/an/a 1.10n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99642
PNG
(US8501936, 143)
Show SMILES C[C@@H](O)CN1CCN(CC1)c1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1 |r|
Show InChI InChI=1S/C26H30N6O3S/c1-19(33)18-30-13-15-31(16-14-30)22-6-3-5-21(17-22)27-26-28-25-24(7-4-12-32(25)29-26)20-8-10-23(11-9-20)36(2,34)35/h3-12,17,19,33H,13-16,18H2,1-2H3,(H,27,29)/t19-/m1/s1
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n/an/a 1.13n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99611
PNG
(CHEMBL2062801 | US8501936, 112)
Show SMILES CS(=O)(=O)c1ccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C20H18N4O4S2/c1-29(25,26)16-9-5-14(6-10-16)18-4-3-13-24-19(18)22-20(23-24)21-15-7-11-17(12-8-15)30(2,27)28/h3-13H,1-2H3,(H,21,23)
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n/an/a 1.30n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99537
PNG
(CHEMBL2062804 | US8501936, 35)
Show SMILES CN1CCN(CC1)c1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1
Show InChI InChI=1S/C24H26N6O2S/c1-28-13-15-29(16-14-28)20-6-3-5-19(17-20)25-24-26-23-22(7-4-12-30(23)27-24)18-8-10-21(11-9-18)33(2,31)32/h3-12,17H,13-16H2,1-2H3,(H,25,27)
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n/an/a 1.30n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99555
PNG
(CHEMBL2062810 | US8501936, 53)
Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C26H30N6O2S/c1-19(2)35(33,34)23-11-9-20(10-12-23)24-8-5-13-32-25(24)28-26(29-32)27-21-6-4-7-22(18-21)31-16-14-30(3)15-17-31/h4-13,18-19H,14-17H2,1-3H3,(H,27,29)
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Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99528
PNG
(US8501936, 26)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc(OCCN4CCOCC4)cc3)nc12
Show InChI InChI=1S/C25H27N5O4S/c1-35(31,32)22-10-4-19(5-11-22)23-3-2-12-30-24(23)27-25(28-30)26-20-6-8-21(9-7-20)34-18-15-29-13-16-33-17-14-29/h2-12H,13-18H2,1H3,(H,26,28)
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n/an/a 1.30n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99576
PNG
(US8501936, 75)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(Nc2nc3cccc(-c4ccc(cc4)S(C)(=O)=O)n3n2)cc1
Show InChI InChI=1S/C28H32N6O4S/c1-28(2,3)38-27(35)33-18-16-32(17-19-33)22-12-10-21(11-13-22)29-26-30-25-7-5-6-24(34(25)31-26)20-8-14-23(15-9-20)39(4,36)37/h5-15H,16-19H2,1-4H3,(H,29,31)
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n/an/a 1.30n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99685
PNG
(US8501936, 186)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H]([C@@H](O)C1)c1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1 |r|
Show InChI InChI=1S/C29H33N5O5S/c1-29(2,3)39-28(36)33-16-14-23(25(35)18-33)20-7-5-8-21(17-20)30-27-31-26-24(9-6-15-34(26)32-27)19-10-12-22(13-11-19)40(4,37)38/h5-13,15,17,23,25,35H,14,16,18H2,1-4H3,(H,30,32)/t23-,25-/m0/s1
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n/an/a 1.35n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99594
PNG
(US8501936, 93)
Show SMILES CS(=O)(=O)c1ccc(Nc2nc3cccc(-c4ccc(cc4)S(C)(=O)=O)n3n2)cc1
Show InChI InChI=1S/C20H18N4O4S2/c1-29(25,26)16-10-6-14(7-11-16)18-4-3-5-19-22-20(23-24(18)19)21-15-8-12-17(13-9-15)30(2,27)28/h3-13H,1-2H3,(H,21,23)
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n/an/a 1.40n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99617
PNG
(US8501936, 118)
Show SMILES CN1CCN(Cc2cccc(Nc3nc4cccc(-c5ccc(cc5)S(C)(=O)=O)n4n3)c2)CC1
Show InChI InChI=1S/C25H28N6O2S/c1-29-13-15-30(16-14-29)18-19-5-3-6-21(17-19)26-25-27-24-8-4-7-23(31(24)28-25)20-9-11-22(12-10-20)34(2,32)33/h3-12,17H,13-16,18H2,1-2H3,(H,26,28)
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n/an/a 1.43n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99687
PNG
(US8501936, 188)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)[C@@H]3CCNC[C@@H]3O)nc12 |r|
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)19-9-7-16(8-10-19)21-6-3-13-29-23(21)27-24(28-29)26-18-5-2-4-17(14-18)20-11-12-25-15-22(20)30/h2-10,13-14,20,22,25,30H,11-12,15H2,1H3,(H,26,28)/t20-,22-/m0/s1
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n/an/a 1.43n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM99550
PNG
(US8501936, 48)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nc3c(cccn3n2)-c2ccc(CS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C25H28N6O2S/c1-29-14-16-30(17-15-29)22-11-9-21(10-12-22)26-25-27-24-23(4-3-13-31(24)28-25)20-7-5-19(6-8-20)18-34(2,32)33/h3-13H,14-18H2,1-2H3,(H,26,28)
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n/an/a 1.5n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99560
PNG
(CHEMBL2062529 | US8501936, 58)
Show SMILES CN1CCN(CC1)C1CCN(CC1)c1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1
Show InChI InChI=1S/C29H35N7O2S/c1-33-17-19-35(20-18-33)24-12-15-34(16-13-24)25-6-3-5-23(21-25)30-29-31-28-27(7-4-14-36(28)32-29)22-8-10-26(11-9-22)39(2,37)38/h3-11,14,21,24H,12-13,15-20H2,1-2H3,(H,30,32)
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n/an/a 1.5n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99644
PNG
(US8501936, 145)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc4CCC(CCc4c3)N3CCOCC3)nc12
Show InChI InChI=1S/C28H31N5O3S/c1-37(34,35)25-12-7-21(8-13-25)26-3-2-14-33-27(26)30-28(31-33)29-23-9-4-20-5-10-24(11-6-22(20)19-23)32-15-17-36-18-16-32/h2-4,7-9,12-14,19,24H,5-6,10-11,15-18H2,1H3,(H,29,31)
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n/an/a 1.55n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99892
PNG
(US8501936, 411)
Show SMILES CCN1CCP(=O)(CC1)c1ccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C25H28N5O3PS/c1-3-29-15-17-34(31,18-16-29)21-10-8-20(9-11-21)26-25-27-24-23(5-4-14-30(24)28-25)19-6-12-22(13-7-19)35(2,32)33/h4-14H,3,15-18H2,1-2H3,(H,26,28)
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n/an/a 1.62n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99702
PNG
(US8501936, 204)
Show SMILES CN1CCN(C(=O)C1)c1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1
Show InChI InChI=1S/C24H24N6O3S/c1-28-13-14-29(22(31)16-28)19-6-3-5-18(15-19)25-24-26-23-21(7-4-12-30(23)27-24)17-8-10-20(11-9-17)34(2,32)33/h3-12,15H,13-14,16H2,1-2H3,(H,25,27)
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n/an/a 1.63n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM99587
PNG
(US8501936, 86)
Show SMILES CN1CCN(Cc2ccc(Nc3nc4cccc(-c5ccc(cc5)S(C)(=O)=O)n4n3)cc2)CC1
Show InChI InChI=1S/C25H28N6O2S/c1-29-14-16-30(17-15-29)18-19-6-10-21(11-7-19)26-25-27-24-5-3-4-23(31(24)28-25)20-8-12-22(13-9-20)34(2,32)33/h3-13H,14-18H2,1-2H3,(H,26,28)
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n/an/a 1.70n/an/an/an/an/an/a



Cephalon, Inc.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...

US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1030 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%