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Patent code US8507676

Compile Data Set for Download or QSAR
Found 92 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100728
PNG
(US8507676, 78)
Show SMILES CC(N=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C17H12F2N6O/c1-9(24-26)13-4-5-15-21-22-16(25(15)23-13)7-11-12(18)8-14-10(17(11)19)3-2-6-20-14/h2-6,8-9H,7H2,1H3
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US Patent
n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100726
PNG
(US8507676, 77-S)
Show SMILES C[C@@H](c1nnc2ccc(nn12)C(C)=NOC(N)=O)c1c(F)cc2ncccc2c1F |r,w:13.15|
Show InChI InChI=1S/C19H15F2N7O2/c1-9(16-12(20)8-14-11(17(16)21)4-3-7-23-14)18-25-24-15-6-5-13(26-28(15)18)10(2)27-30-19(22)29/h3-9H,1-2H3,(H2,22,29)/t9-/m1/s1
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MMDB

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n/an/a 0.480n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100724
PNG
(US8507676, 75-S)
Show SMILES CC(N=O)c1ccc2nnc([C@@H](C)c3c(F)cc4ncccc4c3F)n2n1 |r|
Show InChI InChI=1S/C18H14F2N6O/c1-9(16-12(19)8-14-11(17(16)20)4-3-7-21-14)18-23-22-15-6-5-13(10(2)25-27)24-26(15)18/h3-10H,1-2H3/t9-,10?/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100659
PNG
(US8507676, 8)
Show SMILES CO\N=C(/C)c1ccc2ncc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C19H15F2N5O/c1-11(25-27-2)16-5-6-18-23-10-12(26(18)24-16)8-14-15(20)9-17-13(19(14)21)4-3-7-22-17/h3-7,9-10H,8H2,1-2H3/b25-11+
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n/an/a 1.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100674
PNG
(US8507676, 23)
Show SMILES C\C(=N/OCCO)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H17N7O2/c1-12(23-27-8-7-26)16-10-20-17-18(21-16)25(24-22-17)11-13-4-5-15-14(9-13)3-2-6-19-15/h2-6,9-10,26H,7-8,11H2,1H3/b23-12+
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n/an/a 2.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100673
PNG
(US8507676, 22)
Show SMILES CO\N=C(/C)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C17H15N7O/c1-11(22-25-2)15-9-19-16-17(20-15)24(23-21-16)10-12-5-6-14-13(8-12)4-3-7-18-14/h3-9H,10H2,1-2H3/b22-11+
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n/an/a 2.40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100707
PNG
(US8507676, 56)
Show SMILES C\C(=N/OCCCO)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C20H18F2N6O2/c1-12(27-30-9-3-8-29)16-5-6-18-24-25-19(28(18)26-16)10-14-15(21)11-17-13(20(14)22)4-2-7-23-17/h2,4-7,11,29H,3,8-10H2,1H3/b27-12+
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n/an/a 2.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100663
PNG
(US8507676, 12-S)
Show SMILES C[C@H](c1cnc2ccc(nn12)C(\C)=N\OCCO)c1c(F)cc2ncccc2c1F |r|
Show InChI InChI=1S/C21H19F2N5O2/c1-12(20-15(22)10-17-14(21(20)23)4-3-7-24-17)18-11-25-19-6-5-16(26-28(18)19)13(2)27-30-9-8-29/h3-7,10-12,29H,8-9H2,1-2H3/b27-13+/t12-/m1/s1
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n/an/a 2.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100666
PNG
(US8507676, 15)
Show SMILES C\C(=N/OCCO)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1
Show InChI InChI=1S/C18H16FN7O2/c1-11(24-28-6-5-27)16-9-21-17-18(22-16)26(25-23-17)10-13-7-12-3-2-4-20-15(12)8-14(13)19/h2-4,7-9,27H,5-6,10H2,1H3/b24-11+
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n/an/a 2.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100703
PNG
(US8507676, 51-R | US8507676, 51-S)
Show SMILES CC(c1cnc2ccc(nn12)C(\C)=N\OCCO)c1c(F)cc2n(C)ncc2c1F
Show InChI InChI=1S/C20H20F2N6O2/c1-11(19-14(21)8-16-13(20(19)22)9-24-27(16)3)17-10-23-18-5-4-15(25-28(17)18)12(2)26-30-7-6-29/h4-5,8-11,29H,6-7H2,1-3H3/b26-12+
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n/an/a 2.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100705
PNG
(US8507676, 54 | US8507676, 69)
Show SMILES C\C(=N/OCCO)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C19H16F2N6O2/c1-11(26-29-8-7-28)15-4-5-17-23-24-18(27(17)25-15)9-13-14(20)10-16-12(19(13)21)3-2-6-22-16/h2-6,10,28H,7-9H2,1H3/b26-11+
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n/an/a 3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100675
PNG
(US8507676, 24)
Show SMILES CC(N=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C16H13N7O/c1-10(21-24)14-8-18-15-16(19-14)23(22-20-15)9-11-4-5-13-12(7-11)3-2-6-17-13/h2-8,10H,9H2,1H3
PDB
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n/an/a 3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM2214
PNG
(US8507676, 53-S)
Show SMILES C[C@H](c1nnc2ccc(nn12)C(\C)=N\OCCO)c1c(F)cc2ncccc2c1F |r|
Show InChI InChI=1S/C20H18F2N6O2/c1-11(18-14(21)10-16-13(19(18)22)4-3-7-23-16)20-25-24-17-6-5-15(26-28(17)20)12(2)27-30-9-8-29/h3-7,10-11,29H,8-9H2,1-2H3/b27-12+/t11-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100691
PNG
(US8507676, 38)
Show SMILES OCCO\N=C\c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C17H15N7O2/c25-6-7-26-20-10-14-9-19-16-17(21-14)24(23-22-16)11-12-3-4-15-13(8-12)2-1-5-18-15/h1-5,8-10,25H,6-7,11H2/b20-10+
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n/an/a 3.60n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM2221
PNG
(US8507676, 80)
Show SMILES C\C(=N/O)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C17H14N6O/c1-11(22-24)14-6-7-16-19-20-17(23(16)21-14)10-12-4-5-15-13(9-12)3-2-8-18-15/h2-9,24H,10H2,1H3/b22-11+
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n/an/a 3.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100706
PNG
(US8507676, 55)
Show SMILES C\C(=N/OCCF)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C19H15F3N6O/c1-11(27-29-8-6-20)15-4-5-17-24-25-18(28(17)26-15)9-13-14(21)10-16-12(19(13)22)3-2-7-23-16/h2-5,7,10H,6,8-9H2,1H3/b27-11+
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n/an/a 3.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100690
PNG
(US8507676, 37B)
Show SMILES C\C(=N/OCCNC(N)=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H19N9O2/c1-12(26-30-8-7-22-19(20)29)16-10-23-17-18(24-16)28(27-25-17)11-13-4-5-15-14(9-13)3-2-6-21-15/h2-6,9-10H,7-8,11H2,1H3,(H3,20,22,29)/b26-12+
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n/an/a 3.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100705
PNG
(US8507676, 54 | US8507676, 69)
Show SMILES C\C(=N/OCCO)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C19H16F2N6O2/c1-11(26-29-8-7-28)15-4-5-17-23-24-18(27(17)25-15)9-13-14(20)10-16-12(19(13)21)3-2-6-22-16/h2-6,10,28H,7-9H2,1H3/b26-11+
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n/an/a 4.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100672
PNG
(US8507676, 21)
Show SMILES C\C(=N/O[C@H]1CCN(C1)C(N)=O)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 |r|
Show InChI InChI=1S/C21H20FN9O2/c1-12(28-33-15-4-6-30(11-15)21(23)32)18-9-25-19-20(26-18)31(29-27-19)10-14-7-13-3-2-5-24-17(13)8-16(14)22/h2-3,5,7-9,15H,4,6,10-11H2,1H3,(H2,23,32)/b28-12+/t15-/m0/s1
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n/an/a 5.10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100670
PNG
(US8507676, 19)
Show SMILES C\C(=N/O[C@H]1CCNC1)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 |r|
Show InChI InChI=1S/C20H19FN8O/c1-12(27-30-15-4-6-22-9-15)18-10-24-19-20(25-18)29(28-26-19)11-14-7-13-3-2-5-23-17(13)8-16(14)21/h2-3,5,7-8,10,15,22H,4,6,9,11H2,1H3/b27-12+/t15-/m0/s1
PDB
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n/an/a 5.40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100657
PNG
(US8507676, 6)
Show SMILES C\C(=N/OCCO)c1ccc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H19N5O2/c1-14(24-27-10-9-26)18-6-7-20-22-13-17(25(20)23-18)12-15-4-5-19-16(11-15)3-2-8-21-19/h2-8,11,13,26H,9-10,12H2,1H3/b24-14+
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n/an/a 5.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100662
PNG
(US8507676, 11-S)
Show SMILES C[C@H](c1cnc2ccc(nn12)C(\C)=N\OCCO)c1cc2cccnc2cc1F |r|
Show InChI InChI=1S/C21H20FN5O2/c1-13(16-10-15-4-3-7-23-19(15)11-17(16)22)20-12-24-21-6-5-18(25-27(20)21)14(2)26-29-9-8-28/h3-7,10-13,28H,8-9H2,1-2H3/b26-14+/t13-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100714
PNG
(US8507676, 63 | US9062045, Comparator No. 2)
Show SMILES CN1CCN(CC1)c1cnc2ccc(Cc3nnc4ccc(nn34)C(\C)=N\OCCO)cc2c1
Show InChI InChI=1S/C24H28N8O2/c1-17(29-34-12-11-33)21-5-6-23-26-27-24(32(23)28-21)14-18-3-4-22-19(13-18)15-20(16-25-22)31-9-7-30(2)8-10-31/h3-6,13,15-16,33H,7-12,14H2,1-2H3/b29-17+
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n/an/a 6n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100660
PNG
(US8507676, 9)
Show SMILES C\C(=N/OCCO)c1ccc2ncc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C20H17F2N5O2/c1-12(26-29-8-7-28)17-4-5-19-24-11-13(27(19)25-17)9-15-16(21)10-18-14(20(15)22)3-2-6-23-18/h2-6,10-11,28H,7-9H2,1H3/b26-12+
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n/an/a 6.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100721
PNG
(US8507676, 71)
Show SMILES C\C(=N/OC1COC1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H17N7O2/c1-12(24-28-15-10-27-11-15)17-8-21-18-19(22-17)26(25-23-18)9-13-4-5-16-14(7-13)3-2-6-20-16/h2-8,15H,9-11H2,1H3/b24-12+
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n/an/a 7n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100695
PNG
(US8507676, 42)
Show SMILES CCO\N=C(/C)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H18N6O/c1-3-26-24-13(2)16-8-9-18-21-22-19(25(18)23-16)12-14-6-7-17-15(11-14)5-4-10-20-17/h4-11H,3,12H2,1-2H3/b24-13+
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n/an/a 7n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100729
PNG
(US8507676, 79)
Show SMILES C\C(=N/OCCO)c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H18N6O2/c1-13(24-27-8-7-26)18-12-22-19-21-11-16(25(19)23-18)10-14-4-5-17-15(9-14)3-2-6-20-17/h2-6,9,11-12,26H,7-8,10H2,1H3/b24-13+
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n/an/a 7.10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100667
PNG
(US8507676, 16)
Show SMILES CO\N=C(/C)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1
Show InChI InChI=1S/C17H14FN7O/c1-10(23-26-2)15-8-20-16-17(21-15)25(24-22-16)9-12-6-11-4-3-5-19-14(11)7-13(12)18/h3-8H,9H2,1-2H3/b23-10+
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n/an/a 7.30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100718
PNG
(US8507676, 67)
Show SMILES C\C(=N/OCCO)c1cnc2ccc(Cn3nnc4ncc(nc34)C(\C)=N\OCCO)cc2c1
Show InChI InChI=1S/C22H24N8O4/c1-14(27-33-7-5-31)18-10-17-9-16(3-4-19(17)23-11-18)13-30-22-21(26-29-30)24-12-20(25-22)15(2)28-34-8-6-32/h3-4,9-12,31-32H,5-8,13H2,1-2H3/b27-14+,28-15+
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n/an/a 8n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100654
PNG
(US8507676, 3)
Show SMILES C\C(=N/OCCO)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1
Show InChI InChI=1S/C20H18FN5O2/c1-13(25-28-8-7-27)18-4-5-20-23-12-16(26(20)24-18)10-15-9-14-3-2-6-22-19(14)11-17(15)21/h2-6,9,11-12,27H,7-8,10H2,1H3/b25-13+
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n/an/a 8n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100678
PNG
(US8507676, 26B)
Show SMILES C\C(=N/OCC(O)CO)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H19N7O3/c1-12(24-29-11-15(28)10-27)17-8-21-18-19(22-17)26(25-23-18)9-13-4-5-16-14(7-13)3-2-6-20-16/h2-8,15,27-28H,9-11H2,1H3/b24-12+
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n/an/a 9n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100653
PNG
(US8507676, 2)
Show SMILES CO\N=C(/C)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1
Show InChI InChI=1S/C19H16FN5O/c1-12(24-26-2)17-5-6-19-22-11-15(25(19)23-17)9-14-8-13-4-3-7-21-18(13)10-16(14)20/h3-8,10-11H,9H2,1-2H3/b24-12+
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n/an/a 10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100694
PNG
(US8507676, 41)
Show SMILES CO\N=C(/C)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C18H16N6O/c1-12(23-25-2)15-7-8-17-20-21-18(24(17)22-15)11-13-5-6-16-14(10-13)4-3-9-19-16/h3-10H,11H2,1-2H3/b23-12+
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n/an/a 10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100704
PNG
(US8507676, 52)
Show SMILES C\C(=N/OCCO)c1ccc2ncc(Cc3c(F)cc4n(C)ncc4c3F)n2n1
Show InChI InChI=1S/C19H18F2N6O2/c1-11(25-29-6-5-28)16-3-4-18-22-9-12(27(18)24-16)7-13-15(20)8-17-14(19(13)21)10-23-26(17)2/h3-4,8-10,28H,5-7H2,1-2H3/b25-11+
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n/an/a 11n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100722
PNG
(US8507676, 72)
Show SMILES CC(N=O)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1
Show InChI InChI=1S/C16H12FN7O/c1-9(22-25)14-7-19-15-16(20-14)24(23-21-15)8-11-5-10-3-2-4-18-13(10)6-12(11)17/h2-7,9H,8H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100686
PNG
(US8507676, 34)
Show SMILES C\C(=N/OCCN)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H18N8O/c1-12(24-27-8-6-19)16-10-21-17-18(22-16)26(25-23-17)11-13-4-5-15-14(9-13)3-2-7-20-15/h2-5,7,9-10H,6,8,11,19H2,1H3/b24-12+
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n/an/a 12n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100736
PNG
(US8507676, 73)
Show SMILES CC(c1nnc2ncc(nn12)C(\C)=N\OCCO)c1c(F)cc2ncccc2c1F
Show InChI InChI=1S/C19H17F2N7O2/c1-10(16-13(20)8-14-12(17(16)21)4-3-5-22-14)18-24-25-19-23-9-15(26-28(18)19)11(2)27-30-7-6-29/h3-5,8-10,29H,6-7H2,1-2H3/b27-11+
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n/an/a 12n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100697
PNG
(US8507676, 44)
Show SMILES C\C(=N/OCCO)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H18N6O2/c1-13(24-27-10-9-26)16-6-7-18-21-22-19(25(18)23-16)12-14-4-5-17-15(11-14)3-2-8-20-17/h2-8,11,26H,9-10,12H2,1H3/b24-13+
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n/an/a 13n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100719
PNG
(US8507676, 68-R | US8507676, 68-S)
Show SMILES CC(c1nnc2ccc(nn12)C(\C)=N\OCC(O)=O)c1c(F)cc2ncccc2c1F
Show InChI InChI=1S/C20H16F2N6O3/c1-10(18-13(21)8-15-12(19(18)22)4-3-7-23-15)20-25-24-16-6-5-14(26-28(16)20)11(2)27-31-9-17(29)30/h3-8,10H,9H2,1-2H3,(H,29,30)/b27-11+
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n/an/a 13n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100709
PNG
(US8507676, 58)
Show SMILES C\C(=N/OCCO)c1ccc2nnc(Cc3ccc4ncccc4c3F)n2n1
Show InChI InChI=1S/C19H17FN6O2/c1-12(25-28-10-9-27)15-6-7-17-22-23-18(26(17)24-15)11-13-4-5-16-14(19(13)20)3-2-8-21-16/h2-8,27H,9-11H2,1H3/b25-12+
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n/an/a 14n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100716
PNG
(US8507676, 65)
Show SMILES C\C(=N/OCCCCO)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C21H20F2N6O2/c1-13(28-31-10-3-2-9-30)17-6-7-19-25-26-20(29(19)27-17)11-15-16(22)12-18-14(21(15)23)5-4-8-24-18/h4-8,12,30H,2-3,9-11H2,1H3/b28-13+
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n/an/a 15n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100689
PNG
(US8507676, 37A)
Show SMILES COC(=O)NCCO\N=C(/C)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C20H20N8O3/c1-13(26-31-9-8-22-20(29)30-2)17-11-23-18-19(24-17)28(27-25-18)12-14-5-6-16-15(10-14)4-3-7-21-16/h3-7,10-11H,8-9,12H2,1-2H3,(H,22,29)/b26-13+
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n/an/a 16.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100723
PNG
(US8507676, 74)
Show SMILES CC(N=O)c1cnc2nnn(C(C)c3c(F)cc4ncccc4c3F)c2n1
Show InChI InChI=1S/C17H13F2N7O/c1-8(24-27)13-7-21-16-17(22-13)26(25-23-16)9(2)14-11(18)6-12-10(15(14)19)4-3-5-20-12/h3-9H,1-2H3
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n/an/a 17n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100715
PNG
(US8507676, 64)
Show SMILES COCCO\N=C(/C)c1ccc2nnc(C(C)c3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C21H20F2N6O2/c1-12(19-15(22)11-17-14(20(19)23)5-4-8-24-17)21-26-25-18-7-6-16(27-29(18)21)13(2)28-31-10-9-30-3/h4-8,11-12H,9-10H2,1-3H3/b28-13+
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n/an/a 18n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM2212
PNG
(US8507676, 39-S)
Show SMILES C[C@H](c1nnc2ccc(nn12)C(\C)=N\OCCO)c1cc2cnn(C)c2cc1C |r|
Show InChI InChI=1S/C20H23N7O2/c1-12-9-18-15(11-21-26(18)4)10-16(12)13(2)20-23-22-19-6-5-17(24-27(19)20)14(3)25-29-8-7-28/h5-6,9-11,13,28H,7-8H2,1-4H3/b25-14+/t13-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100737
PNG
(US8507676, 75-R)
Show SMILES CC(N=O)c1ccc2nnc([C@H](C)c3c(F)cc4ncccc4c3F)n2n1 |r|
Show InChI InChI=1S/C18H14F2N6O/c1-9(16-12(19)8-14-11(17(16)20)4-3-7-21-14)18-23-22-15-6-5-13(10(2)25-27)24-26(15)18/h3-10H,1-2H3/t9-,10?/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100727
PNG
(US8507676, 77-R)
Show SMILES C[C@H](c1nnc2ccc(nn12)C(\C)=N\OC(N)=O)c1c(F)cc2ncccc2c1F |r|
Show InChI InChI=1S/C19H15F2N7O2/c1-9(16-12(20)8-14-11(17(16)21)4-3-7-23-14)18-25-24-15-6-5-13(26-28(15)18)10(2)27-30-19(22)29/h3-9H,1-2H3,(H2,22,29)/b27-10+/t9-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100677
PNG
(US8507676, 26A)
Show SMILES C\C(=N/OC(CO)CO)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H19N7O3/c1-12(24-29-15(10-27)11-28)17-8-21-18-19(22-17)26(25-23-18)9-13-4-5-16-14(7-13)3-2-6-20-16/h2-8,15,27-28H,9-11H2,1H3/b24-12+
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n/an/a 20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100713
PNG
(US8507676, 62-S)
Show SMILES C[C@H](c1nnc2ccc(nn12)C(\C)=N\OCCO)c1cc2cccnc2cc1F |r|
Show InChI InChI=1S/C20H19FN6O2/c1-12(15-10-14-4-3-7-22-18(14)11-16(15)21)20-24-23-19-6-5-17(25-27(19)20)13(2)26-29-9-8-28/h3-7,10-12,28H,8-9H2,1-2H3/b26-13+/t12-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100661
PNG
(US8507676, 10)
Show SMILES CO\N=C(/C)c1ccc2ncc(C(O)c3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C19H15F2N5O2/c1-10(25-28-2)13-5-6-16-23-9-15(26(16)24-13)19(27)17-12(20)8-14-11(18(17)21)4-3-7-22-14/h3-9,19,27H,1-2H3/b25-10+
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n/an/a 24n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100725
PNG
(US8507676, 76-S)
Show SMILES C[C@H](c1nnc2ccc(nn12)C(\C)=N\OCC1CC1)c1c(F)cc2ncccc2c1F |r|
Show InChI InChI=1S/C22H20F2N6O/c1-12(20-16(23)10-18-15(21(20)24)4-3-9-25-18)22-27-26-19-8-7-17(28-30(19)22)13(2)29-31-11-14-5-6-14/h3-4,7-10,12,14H,5-6,11H2,1-2H3/b29-13+/t12-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100656
PNG
(US8507676, 5)
Show SMILES CO\N=C(/C)c1ccc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H17N5O/c1-13(23-25-2)17-7-8-19-21-12-16(24(19)22-17)11-14-5-6-18-15(10-14)4-3-9-20-18/h3-10,12H,11H2,1-2H3/b23-13+
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n/an/a 27n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100683
PNG
(US8507676, 31)
Show SMILES COC(=O)CO\N=C(/C)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H17N7O3/c1-12(24-29-11-17(27)28-2)16-9-21-18-19(22-16)26(25-23-18)10-13-5-6-15-14(8-13)4-3-7-20-15/h3-9H,10-11H2,1-2H3/b24-12+
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n/an/a 28n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100708
PNG
(US8507676, 57)
Show SMILES C\C(=N/OCCO)c1ccc2nnc(Cc3cc4cccnc4cc3F)n2n1
Show InChI InChI=1S/C19H17FN6O2/c1-12(25-28-8-7-27)16-4-5-18-22-23-19(26(18)24-16)10-14-9-13-3-2-6-21-17(13)11-15(14)20/h2-6,9,11,27H,7-8,10H2,1H3/b25-12+
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n/an/a 28n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100671
PNG
(US8507676, 20)
Show SMILES C\C(=N/O[C@@H]1CCNC1)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 |r|
Show InChI InChI=1S/C20H19FN8O/c1-12(27-30-15-4-6-22-9-15)18-10-24-19-20(25-18)29(28-26-19)11-14-7-13-3-2-5-23-17(13)8-16(14)21/h2-3,5,7-8,10,15,22H,4,6,9,11H2,1H3/b27-12+/t15-/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100696
PNG
(US8507676, 43)
Show SMILES CC(CO)O\N=C(/C)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H20N6O2/c1-13(12-27)28-25-14(2)17-7-8-19-22-23-20(26(19)24-17)11-15-5-6-18-16(10-15)4-3-9-21-18/h3-10,13,27H,11-12H2,1-2H3/b25-14+
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n/an/a 29n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100669
PNG
(US8507676, 18)
Show SMILES C\C(=N/OCC(C)(C)O)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1
Show InChI InChI=1S/C20H20FN7O2/c1-12(26-30-11-20(2,3)29)17-9-23-18-19(24-17)28(27-25-18)10-14-7-13-5-4-6-22-16(13)8-15(14)21/h4-9,29H,10-11H2,1-3H3/b26-12+
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n/an/a 29n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100684
PNG
(US8507676, 32)
Show SMILES C\C(=N/OCC(N)=O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H16N8O2/c1-11(24-28-10-16(19)27)15-8-21-17-18(22-15)26(25-23-17)9-12-4-5-14-13(7-12)3-2-6-20-14/h2-8H,9-10H2,1H3,(H2,19,27)/b24-11+
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n/an/a 32.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100698
PNG
(US8507676, 45)
Show SMILES C\C(=N/OC(CO)CO)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H20N6O3/c1-13(25-29-16(11-27)12-28)17-6-7-19-22-23-20(26(19)24-17)10-14-4-5-18-15(9-14)3-2-8-21-18/h2-9,16,27-28H,10-12H2,1H3/b25-13+
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n/an/a 34n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100676
PNG
(US8507676, 25)
Show SMILES CCO\N=C(/C)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H17N7O/c1-3-26-23-12(2)16-10-20-17-18(21-16)25(24-22-17)11-13-6-7-15-14(9-13)5-4-8-19-15/h4-10H,3,11H2,1-2H3/b23-12+
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n/an/a 34n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100688
PNG
(US8507676, 36)
Show SMILES CC(CO)O\N=C(/C)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H19N7O2/c1-12(11-27)28-24-13(2)17-9-21-18-19(22-17)26(25-23-18)10-14-5-6-16-15(8-14)4-3-7-20-16/h3-9,12,27H,10-11H2,1-2H3/b24-13+
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n/an/a 35n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100652
PNG
(US8507676, 1)
Show SMILES CCO\N=C(/C)c1ccc2ncc(Cc3cc4cccnc4cc3F)n2n1
Show InChI InChI=1S/C20H18FN5O/c1-3-27-25-13(2)18-6-7-20-23-12-16(26(20)24-18)10-15-9-14-5-4-8-22-19(14)11-17(15)21/h4-9,11-12H,3,10H2,1-2H3/b25-13+
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n/an/a 36n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100717
PNG
(US8507676, 66)
Show SMILES C\C(=N/OCCCCF)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C21H19F3N6O/c1-13(29-31-10-3-2-8-22)17-6-7-19-26-27-20(30(19)28-17)11-15-16(23)12-18-14(21(15)24)5-4-9-25-18/h4-7,9,12H,2-3,8,10-11H2,1H3/b29-13+
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n/an/a 42n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100668
PNG
(US8507676, 17)
Show SMILES C\C(=N/OC(C)(C)CO)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1
Show InChI InChI=1S/C20H20FN7O2/c1-12(26-30-20(2,3)11-29)17-9-23-18-19(24-17)28(27-25-18)10-14-7-13-5-4-6-22-16(13)8-15(14)21/h4-9,29H,10-11H2,1-3H3/b26-12+
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n/an/a 46n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100664
PNG
(US8507676, 13)
Show SMILES C\C(=N/OCCO)c1ccc2ncc(Cc3ccc4n(C)ncc4c3)n2n1
Show InChI InChI=1S/C19H20N6O2/c1-13(23-27-8-7-26)17-4-6-19-20-12-16(25(19)22-17)10-14-3-5-18-15(9-14)11-21-24(18)2/h3-6,9,11-12,26H,7-8,10H2,1-2H3/b23-13+
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n/an/a 51n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100665
PNG
(US8507676, 69)
Show SMILES CC(c1cnc2ccc(nn12)C(\C)=N\OCCO)c1ccc2n(C)ncc2c1
Show InChI InChI=1S/C20H22N6O2/c1-13(15-4-6-18-16(10-15)11-22-25(18)3)19-12-21-20-7-5-17(23-26(19)20)14(2)24-28-9-8-27/h4-7,10-13,27H,8-9H2,1-3H3/b24-14+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100658
PNG
(US8507676, 7A)
Show SMILES C\C(=N/OC(CO)CO)c1ccc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C21H21N5O3/c1-14(25-29-18(12-27)13-28)19-6-7-21-23-11-17(26(21)24-19)10-15-4-5-20-16(9-15)3-2-8-22-20/h2-9,11,18,27-28H,10,12-13H2,1H3/b25-14+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM2220
PNG
(US8507676, 46 | US8507676, 7B)
Show SMILES C\C(=N/OCC(O)CO)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H20N6O3/c1-13(25-29-12-16(28)11-27)17-6-7-19-22-23-20(26(19)24-17)10-14-4-5-18-15(9-14)3-2-8-21-18/h2-9,16,27-28H,10-12H2,1H3/b25-13+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100687
PNG
(US8507676, 35)
Show SMILES C\C(=N/OC1CCNC1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C20H20N8O/c1-13(26-29-16-6-8-21-10-16)18-11-23-19-20(24-18)28(27-25-19)12-14-4-5-17-15(9-14)3-2-7-22-17/h2-5,7,9,11,16,21H,6,8,10,12H2,1H3/b26-13+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100693
PNG
(US8507676, 40)
Show SMILES C\C(=N/OCCO)c1ccc2ncc(Cc3cc4cnn(C)c4cc3F)n2n1
Show InChI InChI=1S/C19H19FN6O2/c1-12(24-28-6-5-27)17-3-4-19-21-11-15(26(19)23-17)8-13-7-14-10-22-25(2)18(14)9-16(13)20/h3-4,7,9-11,27H,5-6,8H2,1-2H3/b24-12+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100685
PNG
(US8507676, 33)
Show SMILES C\C(=N/OCC(C)(C)O)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C20H21N7O2/c1-13(25-29-12-20(2,3)28)17-10-22-18-19(23-17)27(26-24-18)11-14-6-7-16-15(9-14)5-4-8-21-16/h4-10,28H,11-12H2,1-3H3/b25-13+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100655
PNG
(US8507676, 4)
Show SMILES CCO\N=C(/C)c1ccc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H19N5O/c1-3-26-24-14(2)18-8-9-20-22-13-17(25(20)23-18)12-15-6-7-19-16(11-15)5-4-10-21-19/h4-11,13H,3,12H2,1-2H3/b24-14+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100712
PNG
(US8507676, 61)
Show SMILES C\C(=N/OCC(N)=O)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H17N7O2/c1-12(25-28-11-17(20)27)15-6-7-18-22-23-19(26(18)24-15)10-13-4-5-16-14(9-13)3-2-8-21-16/h2-9H,10-11H2,1H3,(H2,20,27)/b25-12+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100731
PNG
(US8507676, 12-R)
Show SMILES C[C@@H](c1cnc2ccc(nn12)C(\C)=N\OCCO)c1c(F)cc2ncccc2c1F |r|
Show InChI InChI=1S/C21H19F2N5O2/c1-12(20-15(22)10-17-14(21(20)23)4-3-7-24-17)18-11-25-19-6-5-16(26-28(18)19)13(2)27-30-9-8-29/h3-7,10-12,29H,8-9H2,1-2H3/b27-13+/t12-/m0/s1
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100730
PNG
(US8507676, 11-R)
Show SMILES C[C@@H](c1cnc2ccc(nn12)C(\C)=N\OCCO)c1cc2cccnc2cc1F |r|
Show InChI InChI=1S/C21H20FN5O2/c1-13(16-10-15-4-3-7-23-19(15)11-17(16)22)20-12-24-21-6-5-18(25-27(20)21)14(2)26-29-9-8-28/h3-7,10-13,28H,8-9H2,1-2H3/b26-14+/t13-/m1/s1
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM2220
PNG
(US8507676, 46 | US8507676, 7B)
Show SMILES C\C(=N/OCC(O)CO)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H20N6O3/c1-13(25-29-12-16(28)11-27)17-6-7-19-22-23-20(26(19)24-17)10-14-4-5-18-15(9-14)3-2-8-21-18/h2-9,16,27-28H,10-12H2,1H3/b25-13+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100720
PNG
(US8507676, 70)
Show SMILES C\C(=N/OC(C)(C)CO)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C20H21N7O2/c1-13(25-29-20(2,3)12-28)17-10-22-18-19(23-17)27(26-24-18)11-14-6-7-16-15(9-14)5-4-8-21-16/h4-10,28H,11-12H2,1-3H3/b25-13+
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n/an/a 127n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM2218
PNG
(US8507676, 62-R)
Show SMILES C[C@@H](c1nnc2ccc(nn12)C(\C)=N\OCCO)c1cc2cccnc2cc1F |r|
Show InChI InChI=1S/C20H19FN6O2/c1-12(15-10-14-4-3-7-22-18(14)11-16(15)21)20-24-23-19-6-5-17(25-27(19)20)13(2)26-29-9-8-28/h3-7,10-12,28H,8-9H2,1-2H3/b26-13+/t12-/m1/s1
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100710
PNG
(US8507676, 59)
Show SMILES CCO\N=C(/C)c1ccc2nnc(n2n1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C21H20N6O/c1-3-28-26-14(2)17-8-9-19-23-24-20(27(19)25-17)21(10-11-21)16-6-7-18-15(13-16)5-4-12-22-18/h4-9,12-13H,3,10-11H2,1-2H3/b26-14+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100711
PNG
(US8507676, 60)
Show SMILES C\C(=N/OCCO)c1ccc2nnc(n2n1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C21H20N6O2/c1-14(26-29-12-11-28)17-6-7-19-23-24-20(27(19)25-17)21(8-9-21)16-4-5-18-15(13-16)3-2-10-22-18/h2-7,10,13,28H,8-9,11-12H2,1H3/b26-14+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100682
PNG
(US8507676, 30)
Show SMILES C\C(=N/OCC1CCNCC1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C22H24N8O/c1-15(28-31-14-16-6-9-23-10-7-16)20-12-25-21-22(26-20)30(29-27-21)13-17-4-5-19-18(11-17)3-2-8-24-19/h2-5,8,11-12,16,23H,6-7,9-10,13-14H2,1H3/b28-15+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100719
PNG
(US8507676, 68-R | US8507676, 68-S)
Show SMILES CC(c1nnc2ccc(nn12)C(\C)=N\OCC(O)=O)c1c(F)cc2ncccc2c1F
Show InChI InChI=1S/C20H16F2N6O3/c1-10(18-13(21)8-15-12(19(18)22)4-3-7-23-15)20-25-24-16-6-5-14(26-28(16)20)11(2)27-31-9-17(29)30/h3-8,10H,9H2,1-2H3,(H,29,30)/b27-11+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100681
PNG
(US8507676, 29)
Show SMILES C\C(=N/OC1CCNCC1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C21H22N8O/c1-14(27-30-17-6-9-22-10-7-17)19-12-24-20-21(25-19)29(28-26-20)13-15-4-5-18-16(11-15)3-2-8-23-18/h2-5,8,11-12,17,22H,6-7,9-10,13H2,1H3/b27-14+
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM2216
PNG
(US8507676, 53-R)
Show SMILES C[C@@H](c1nnc2ccc(nn12)C(\C)=N\OCCO)c1c(F)cc2ncccc2c1F |r|
Show InChI InChI=1S/C20H18F2N6O2/c1-11(18-14(21)10-16-13(19(18)22)4-3-7-23-16)20-25-24-17-6-5-15(26-28(17)20)12(2)27-30-9-8-29/h3-7,10-11,29H,8-9H2,1-2H3/b27-12+/t11-/m1/s1
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US Patent
n/an/a 368n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100701
PNG
(US8507676, 48)
Show SMILES C\C(=N/Oc1ccccc1)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C23H18N6O/c1-16(28-30-19-7-3-2-4-8-19)20-11-12-22-25-26-23(29(22)27-20)15-17-9-10-21-18(14-17)6-5-13-24-21/h2-14H,15H2,1H3/b28-16+
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n/an/a 380n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100702
PNG
(US8507676, 27)
Show SMILES C\C(=N/OCc1ccccc1)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C24H20N6O/c1-17(29-31-16-18-6-3-2-4-7-18)21-11-12-23-26-27-24(30(23)28-21)15-19-9-10-22-20(14-19)8-5-13-25-22/h2-14H,15-16H2,1H3/b29-17+
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n/an/a 440n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100679
PNG
(US8507676, 49)
Show SMILES C\C(=N/OCc1ccccc1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C23H19N7O/c1-16(28-31-15-17-6-3-2-4-7-17)21-13-25-22-23(26-21)30(29-27-22)14-18-9-10-20-19(12-18)8-5-11-24-20/h2-13H,14-15H2,1H3/b28-16+
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n/an/a 440n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100692
PNG
(US8507676, 39-R)
Show SMILES CC(c1cnc2ccc(nn12)C(\C)=N\OCCO)c1cc2cnn(C)c2cc1F
Show InChI InChI=1S/C20H21FN6O2/c1-12(15-8-14-10-23-26(3)18(14)9-16(15)21)19-11-22-20-5-4-17(24-27(19)20)13(2)25-29-7-6-28/h4-5,8-12,28H,6-7H2,1-3H3/b25-13+
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n/an/a 444n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100703
PNG
(US8507676, 51-R | US8507676, 51-S)
Show SMILES CC(c1cnc2ccc(nn12)C(\C)=N\OCCO)c1c(F)cc2n(C)ncc2c1F
Show InChI InChI=1S/C20H20F2N6O2/c1-11(19-14(21)8-16-13(20(19)22)9-24-27(16)3)17-10-23-18-5-4-15(25-28(17)18)12(2)26-30-7-6-29/h4-5,8-11,29H,6-7H2,1-3H3/b26-12+
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n/an/a 460n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100680
PNG
(US8507676, 28)
Show SMILES COc1ccc(CO\N=C(/C)c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1
Show InChI InChI=1S/C24H21N7O2/c1-16(29-33-15-17-5-8-20(32-2)9-6-17)22-13-26-23-24(27-22)31(30-28-23)14-18-7-10-21-19(12-18)4-3-11-25-21/h3-13H,14-15H2,1-2H3/b29-16+
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n/an/a 590n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100738
PNG
(US8507676, 76-R)
Show SMILES C[C@@H](c1nnc2ccc(nn12)C(\C)=N\OCC1CC1)c1c(F)cc2ncccc2c1F |r|
Show InChI InChI=1S/C22H20F2N6O/c1-12(20-16(23)10-18-15(21(20)24)4-3-9-25-18)22-27-26-19-8-7-17(28-30(19)22)13(2)29-31-11-14-5-6-14/h3-4,7-10,12,14H,5-6,11H2,1-2H3/b29-13+/t12-/m1/s1
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n/an/a 1.06E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100700
PNG
(US8507676, 47)
Show SMILES C\C(=N/Oc1cccc(c1)C(F)(F)F)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C24H17F3N6O/c1-15(32-34-19-6-2-5-18(14-19)24(25,26)27)20-9-10-22-29-30-23(33(22)31-20)13-16-7-8-21-17(12-16)4-3-11-28-21/h2-12,14H,13H2,1H3/b32-15+
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n/an/a 3.60E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%