Affinity Data by Patent

Patent code US8546451

Found 20 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM102984 (US8546451, II) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM102985 (US8546451, III) Show SMILES Cc1cccc(CN(c2ccc(O)cc2)c2ccc(O)cc2)c1C Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.81	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM102989 (US8546451, VII) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	6.06	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM102985 (US8546451, III) Show SMILES Cc1cccc(CN(c2ccc(O)cc2)c2ccc(O)cc2)c1C Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.44	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM102987 (US8546451, V) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM102988 (US8546451, VI) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM102990 (US8546451, VIII) Show SMILES Oc1ccc(CN(c2ccc(O)cc2)c2ccc(F)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM102991 (US8546451, IX (or X)) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM102992 (US8546451, XI) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM102993 (US8546451, XII) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM102986 (US8546451, IV) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM102990 (US8546451, VIII) Show SMILES Oc1ccc(CN(c2ccc(O)cc2)c2ccc(F)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM102986 (US8546451, IV) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	21.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM102993 (US8546451, XII) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	25.0	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM102987 (US8546451, V) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	35.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM102992 (US8546451, XI) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM102988 (US8546451, VI) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	72	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM102989 (US8546451, VII) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	76.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM102984 (US8546451, II) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	81.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM102991 (US8546451, IX (or X)) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	646	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GTx, Inc. US Patent					Assay Description The ER binding affinity of the compounds was determined using an in vitro competitive radioligand binding assay was [2,4,6,7-3H(N)]-Estradiol ([3H]E2...				US Patent US8546451 (2013) BindingDB Entry DOI: 10.7270/Q2XW4HFH
GTx, Inc. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%