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Patent code US8604028

Compile Data Set for Download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109200
PNG
(US8604028, 56)
Show SMILES CC1=NC(C)=C([N+]#[C-])C(C1C#N)c1cc2c(N)nccc2o1 |t:1,4|
Show InChI InChI=1S/C16H13N5O/c1-8-11(7-17)14(15(19-3)9(2)21-8)13-6-10-12(22-13)4-5-20-16(10)18/h4-6,11,14H,1-2H3,(H2,18,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 23n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109201
PNG
(US8604028, 57)
Show SMILES CC1=NC(C(F)F)=C(C#N)C(C1[N+]#[C-])c1cc2c(N)nccc2o1 |t:1,6|
Show InChI InChI=1S/C16H11F2N5O/c1-7-13(21-2)12(9(6-19)14(23-7)15(17)18)11-5-8-10(24-11)3-4-22-16(8)20/h3-5,12-13,15H,1H3,(H2,20,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 37n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109202
PNG
(US8604028, 61)
Show SMILES CC1=NC(=C([N+]#[C-])C(C1C#N)c1cc2c(N)nccc2o1)c1ccc(Cl)cc1 |t:1,3|
Show InChI InChI=1S/C21H14ClN5O/c1-11-15(10-23)18(17-9-14-16(28-17)7-8-26-21(14)24)20(25-2)19(27-11)12-3-5-13(22)6-4-12/h3-9,15,18H,1H3,(H2,24,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 43n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109203
PNG
(US8604028, 65)
Show SMILES CC1=NC2=C(C(C1[N+]#[C-])c1cc3c(NC(=O)c4ccccc4)nccc3o1)C(=O)OC2 |c:3,t:1|
Show InChI InChI=1S/C23H16N4O4/c1-12-20(24-2)19(18-15(26-12)11-30-23(18)29)17-10-14-16(31-17)8-9-25-21(14)27-22(28)13-6-4-3-5-7-13/h3-10,19-20H,11H2,1H3,(H,25,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 142n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109205
PNG
(US8604028, 72)
Show SMILES Nc1nccc2oc(cc12)[C@@H]1C2C(=O)OCC2=NC(=C1[N+]#[C-])c1ccc(Cl)cc1 |r,c:19,21|
Show InChI InChI=1S/C21H13ClN4O3/c1-24-19-17(15-8-12-14(29-15)6-7-25-20(12)23)16-13(9-28-21(16)27)26-18(19)10-2-4-11(22)5-3-10/h2-8,16-17H,9H2,(H2,23,25)/t16?,17-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 260n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109204
PNG
(US8604028, 70)
Show SMILES CC1=C(C#N)[C@@H](c2cc3c(N)nccc3o2)C([N+]#[C-])=C2COCCN12 |r,c:1,t:20|
Show InChI InChI=1S/C18H15N5O2/c1-10-12(8-19)16(17(21-2)13-9-24-6-5-23(10)13)15-7-11-14(25-15)3-4-22-18(11)20/h3-4,7,16H,5-6,9H2,1H3,(H2,20,22)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 610n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%