BindingDB logo
myBDB logout

Patent code US8618075

Compile Data Set for Download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytidine deaminase


(Homo sapiens (Human))
BDBM111578
PNG
(US8618075, 2a)
Show SMILES OC[C@H]1OC([C@@H](F)[C@@H]1O)N1CC[C@@H](O)NC1=O |r|
Show InChI InChI=1S/C9H15FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h4-8,13-15H,1-3H2,(H,11,16)/t4-,5-,6+,7-,8?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 200n/an/an/an/a7.4n/a



Eisai Inc.

US Patent


Assay Description
The procedure to determine CDA enzymatic activity is based on published methodologies (for example, Cacciamani, T. et al., Arch. Biochem. Biophys. 19...


US Patent US8618075 (2013)


BindingDB Entry DOI: 10.7270/Q20000RG
More data for this
Ligand-Target Pair
Cytidine deaminase


(Homo sapiens (Human))
BDBM111577
PNG
(US8618075, 1a)
Show SMILES OC[C@H]1OC(N2CC[C@@H](O)NC2=O)C(F)(F)[C@@H]1O |r|
Show InChI InChI=1S/C9H14F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h4-7,14-16H,1-3H2,(H,12,17)/t4-,5-,6-,7?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 400n/an/an/an/a7.4n/a



Eisai Inc.

US Patent


Assay Description
The procedure to determine CDA enzymatic activity is based on published methodologies (for example, Cacciamani, T. et al., Arch. Biochem. Biophys. 19...


US Patent US8618075 (2013)


BindingDB Entry DOI: 10.7270/Q20000RG
More data for this
Ligand-Target Pair
Cytidine deaminase


(Homo sapiens (Human))
BDBM111585
PNG
(US8618075, 3a)
Show SMILES OC[C@H]1OC([C@H](F)[C@@H]1O)N1CC[C@@H](O)NC1=O |r|
Show InChI InChI=1S/C9H15FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h4-8,13-15H,1-3H2,(H,11,16)/t4-,5-,6-,7-,8?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 400n/an/an/an/a7.4n/a



Eisai Inc.

US Patent


Assay Description
The procedure to determine CDA enzymatic activity is based on published methodologies (for example, Cacciamani, T. et al., Arch. Biochem. Biophys. 19...


US Patent US8618075 (2013)


BindingDB Entry DOI: 10.7270/Q20000RG
More data for this
Ligand-Target Pair
Cytidine deaminase


(Homo sapiens (Human))
BDBM111579
PNG
(US8618075, 1)
Show SMILES OC[C@H]1OC(N2CCC(O)NC2=O)C(F)(F)[C@@H]1O |r|
Show InChI InChI=1S/C9H14F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h4-7,14-16H,1-3H2,(H,12,17)/t4-,5?,6-,7?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 400n/an/an/an/a7.4n/a



Eisai Inc.

US Patent


Assay Description
The procedure to determine CDA enzymatic activity is based on published methodologies (for example, Cacciamani, T. et al., Arch. Biochem. Biophys. 19...


US Patent US8618075 (2013)


BindingDB Entry DOI: 10.7270/Q20000RG
More data for this
Ligand-Target Pair
Cytidine deaminase


(Homo sapiens (Human))
BDBM111582
PNG
(US8618075, 3)
Show SMILES OC[C@H]1OC([C@H](F)[C@@H]1O)N1CCC(O)NC1=O |r|
Show InChI InChI=1S/C9H15FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h4-8,13-15H,1-3H2,(H,11,16)/t4-,5?,6-,7-,8?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.00E+3n/an/an/an/a7.4n/a



Eisai Inc.

US Patent


Assay Description
The procedure to determine CDA enzymatic activity is based on published methodologies (for example, Cacciamani, T. et al., Arch. Biochem. Biophys. 19...


US Patent US8618075 (2013)


BindingDB Entry DOI: 10.7270/Q20000RG
More data for this
Ligand-Target Pair
Cytidine deaminase


(Homo sapiens (Human))
BDBM111581
PNG
(US8618075, 2)
Show SMILES OC[C@H]1OC([C@@H](F)[C@@H]1O)N1CCC(O)NC1=O |r|
Show InChI InChI=1S/C9H15FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h4-8,13-15H,1-3H2,(H,11,16)/t4-,5?,6+,7-,8?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.00E+3n/an/an/an/a7.4n/a



Eisai Inc.

US Patent


Assay Description
The procedure to determine CDA enzymatic activity is based on published methodologies (for example, Cacciamani, T. et al., Arch. Biochem. Biophys. 19...


US Patent US8618075 (2013)


BindingDB Entry DOI: 10.7270/Q20000RG
More data for this
Ligand-Target Pair
Cytidine deaminase


(Homo sapiens (Human))
BDBM111580
PNG
(US8618075, 3b)
Show SMILES OC[C@H]1OC([C@H](F)[C@@H]1O)N1CC[C@H](O)NC1=O |r|
Show InChI InChI=1S/C9H15FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h4-8,13-15H,1-3H2,(H,11,16)/t4-,5+,6-,7-,8?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.00E+3n/an/an/an/a7.4n/a



Eisai Inc.

US Patent


Assay Description
The procedure to determine CDA enzymatic activity is based on published methodologies (for example, Cacciamani, T. et al., Arch. Biochem. Biophys. 19...


US Patent US8618075 (2013)


BindingDB Entry DOI: 10.7270/Q20000RG
More data for this
Ligand-Target Pair
Cytidine deaminase


(Homo sapiens (Human))
BDBM111583
PNG
(US8618075, 1b)
Show SMILES OC[C@H]1OC(N2CC[C@H](O)NC2=O)C(F)(F)[C@@H]1O |r|
Show InChI InChI=1S/C9H14F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h4-7,14-16H,1-3H2,(H,12,17)/t4-,5+,6-,7?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.00E+3n/an/an/an/a7.4n/a



Eisai Inc.

US Patent


Assay Description
The procedure to determine CDA enzymatic activity is based on published methodologies (for example, Cacciamani, T. et al., Arch. Biochem. Biophys. 19...


US Patent US8618075 (2013)


BindingDB Entry DOI: 10.7270/Q20000RG
More data for this
Ligand-Target Pair
Cytidine deaminase


(Homo sapiens (Human))
BDBM111584
PNG
(US8618075, 2b)
Show SMILES OC[C@H]1OC([C@@H](F)[C@@H]1O)N1CC[C@H](O)NC1=O |r|
Show InChI InChI=1S/C9H15FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h4-8,13-15H,1-3H2,(H,11,16)/t4-,5+,6+,7-,8?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.00E+3n/an/an/an/a7.4n/a



Eisai Inc.

US Patent


Assay Description
The procedure to determine CDA enzymatic activity is based on published methodologies (for example, Cacciamani, T. et al., Arch. Biochem. Biophys. 19...


US Patent US8618075 (2013)


BindingDB Entry DOI: 10.7270/Q20000RG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%