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Patent code US8637501

Compile Data Set for Download or QSAR
Found 113 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113660
PNG
(US8637501, 64)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)N1CCN(CCc2ccc(Cl)cc2)CC1=O
Show InChI InChI=1S/C25H29ClN4O/c1-28-23-3-2-11-27-16-22(23)21-9-8-20(15-24(21)28)30-14-13-29(17-25(30)31)12-10-18-4-6-19(26)7-5-18/h4-9,15,27H,2-3,10-14,16-17H2,1H3
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US Patent
 4.60 -47.6n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113619
PNG
(US8637501, 23)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O/c1-30-21-3-2-9-28-14-19(21)18-6-5-17(12-22(18)30)31-10-8-15(11-23(31)32)20-7-4-16(13-29-20)24(25,26)27/h4-8,10-13,28H,2-3,9,14H2,1H3
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US Patent
 4.70 -47.5n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113617
PNG
(US8637501, 21)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C25H25N3O2/c1-27-23-8-5-12-26-16-22(23)21-10-9-19(14-24(21)27)28-13-11-20(15-25(28)29)30-17-18-6-3-2-4-7-18/h2-4,6-7,9-11,13-15,26H,5,8,12,16-17H2,1H3
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 4.70 -47.5n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113628
PNG
(US8637501, 32)
Show SMILES CSc1ccc(cc1)-c1ccn(-c2ccc3c4CNCCCc4n(C)c3c2)c(=O)c1
Show InChI InChI=1S/C25H25N3OS/c1-27-23-4-3-12-26-16-22(23)21-10-7-19(15-24(21)27)28-13-11-18(14-25(28)29)17-5-8-20(30-2)9-6-17/h5-11,13-15,26H,3-4,12,16H2,1-2H3
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 4.90 -47.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113626
PNG
(US8637501, 30)
Show SMILES CCN1CCCc2c(C1)c1ccc(cc1n2C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C27H29N3O2/c1-3-29-14-7-10-25-24(18-29)23-12-11-21(16-26(23)28(25)2)30-15-13-22(17-27(30)31)32-19-20-8-5-4-6-9-20/h4-6,8-9,11-13,15-17H,3,7,10,14,18-19H2,1-2H3
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 5 -47.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113659
PNG
(US8637501, 63)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ccc(Cl)cn2)cc1=O
Show InChI InChI=1S/C24H23ClN4O2/c1-28-22-3-2-9-26-14-21(22)20-7-6-18(11-23(20)28)29-10-8-19(12-24(29)30)31-15-17-5-4-16(25)13-27-17/h4-8,10-13,26H,2-3,9,14-15H2,1H3
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 5 -47.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113625
PNG
(US8637501, 29)
Show SMILES CN1CCCc2c(C1)c1ccc(cc1n2C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C26H27N3O2/c1-27-13-6-9-24-23(17-27)22-11-10-20(15-25(22)28(24)2)29-14-12-21(16-26(29)30)31-18-19-7-4-3-5-8-19/h3-5,7-8,10-12,14-16H,6,9,13,17-18H2,1-2H3
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 5 -47.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113623
PNG
(US8637501, 27)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O/c1-30-20-3-2-9-28-14-19(20)18-6-5-17(12-21(18)30)31-10-8-15(11-23(31)32)16-4-7-22(29-13-16)24(25,26)27/h4-8,10-13,28H,2-3,9,14H2,1H3
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 5.30 -47.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113631
PNG
(US8637501, 35)
Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc2c3CNCCCc3[nH]c2c1
Show InChI InChI=1S/C24H23N3O2/c28-24-14-19(29-16-17-5-2-1-3-6-17)10-12-27(24)18-8-9-20-21-15-25-11-4-7-22(21)26-23(20)13-18/h1-3,5-6,8-10,12-14,25-26H,4,7,11,15-16H2
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 5.80 -47.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113709
PNG
(US8637501, 113)
Show SMILES Cn1c2CCCNCc2c2ccc(nc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O
Show InChI InChI=1S/C24H23ClN4O2/c1-28-21-3-2-11-26-14-20(21)19-8-9-22(27-24(19)28)29-12-10-18(13-23(29)30)31-15-16-4-6-17(25)7-5-16/h4-10,12-13,26H,2-3,11,14-15H2,1H3
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 5.90 -47.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113603
PNG
(US8637501, 7)
Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc2c3CCNCCc3[nH]c2c1
Show InChI InChI=1S/C24H23N3O2/c28-24-15-19(29-16-17-4-2-1-3-5-17)10-13-27(24)18-6-7-20-21-8-11-25-12-9-22(21)26-23(20)14-18/h1-7,10,13-15,25-26H,8-9,11-12,16H2
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 6 -46.9n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113699
PNG
(US8637501, 103)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C25H24FN3O2/c1-28-23-3-2-11-27-15-22(23)21-9-8-19(13-24(21)28)29-12-10-20(14-25(29)30)31-16-17-4-6-18(26)7-5-17/h4-10,12-14,27H,2-3,11,15-16H2,1H3
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 6 -46.9n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113622
PNG
(US8637501, 26)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O/c1-30-22-3-2-11-29-15-21(22)20-9-8-19(14-23(20)30)31-12-10-17(13-24(31)32)16-4-6-18(7-5-16)25(26,27)28/h4-10,12-14,29H,2-3,11,15H2,1H3
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 6.10 -46.9n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113686
PNG
(US8637501, 90)
Show SMILES Cn1c2CCCNCc2c2ccc(nc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C24H24N4O2/c1-27-21-8-5-12-25-15-20(21)19-9-10-22(26-24(19)27)28-13-11-18(14-23(28)29)30-16-17-6-3-2-4-7-17/h2-4,6-7,9-11,13-14,25H,5,8,12,15-16H2,1H3
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 6.40 -46.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113620
PNG
(US8637501, 24)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ccc(nc2)C(F)(F)F)cc1=O
Show InChI InChI=1S/C25H23F3N4O2/c1-31-21-3-2-9-29-14-20(21)19-6-5-17(11-22(19)31)32-10-8-18(12-24(32)33)34-15-16-4-7-23(30-13-16)25(26,27)28/h4-8,10-13,29H,2-3,9,14-15H2,1H3
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 6.40 -46.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113683
PNG
(US8637501, 87)
Show SMILES CCN1CCc2c(CC1)c1ccc(nc1n2C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C26H28N4O2/c1-3-29-14-12-21-22-9-10-24(27-26(22)28(2)23(21)13-15-29)30-16-11-20(17-25(30)31)32-18-19-7-5-4-6-8-19/h4-11,16-17H,3,12-15,18H2,1-2H3
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 6.90 -46.6n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113600
PNG
(US8637501, 4)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O/c1-30-20-7-10-28-9-6-19(20)18-4-3-17(13-21(18)30)31-11-8-15(12-23(31)32)16-2-5-22(29-14-16)24(25,26)27/h2-5,8,11-14,28H,6-7,9-10H2,1H3
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 7.10 -46.5n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113636
PNG
(US8637501, 40)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C24H23FN4O2/c1-28-22-7-10-26-9-6-21(22)20-5-4-18(12-23(20)28)29-11-8-19(13-24(29)30)31-15-17-3-2-16(25)14-27-17/h2-5,8,11-14,26H,6-7,9-10,15H2,1H3
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 7.20 -46.5n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113613
PNG
(US8637501, 17)
Show SMILES CC(C)N1CCc2[nH]c3cc(ccc3c2CC1)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C27H29N3O2/c1-19(2)29-13-11-24-23-9-8-21(16-26(23)28-25(24)12-14-29)30-15-10-22(17-27(30)31)32-18-20-6-4-3-5-7-20/h3-10,15-17,19,28H,11-14,18H2,1-2H3
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 7.20 -46.5n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113662
PNG
(US8637501, 66)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cc2F)cc1=O
Show InChI InChI=1S/C25H23F2N3O2/c1-29-23-3-2-9-28-14-21(23)20-7-6-18(12-24(20)29)30-10-8-19(13-25(30)31)32-15-16-4-5-17(26)11-22(16)27/h4-8,10-13,28H,2-3,9,14-15H2,1H3
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 7.30 -46.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113653
PNG
(US8637501, 57)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C25H24FN3O2/c1-28-23-9-12-27-11-8-22(23)21-7-6-19(14-24(21)28)29-13-10-20(15-25(29)30)31-16-17-2-4-18(26)5-3-17/h2-7,10,13-15,27H,8-9,11-12,16H2,1H3
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 7.30 -46.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113646
PNG
(US8637501, 50)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(OCc2ccc(Cl)cn2)cc1=O
Show InChI InChI=1S/C24H23ClN4O2/c1-28-22-7-10-26-9-6-21(22)20-5-4-18(12-23(20)28)29-11-8-19(13-24(29)30)31-15-17-3-2-16(25)14-27-17/h2-5,8,11-14,26H,6-7,9-10,15H2,1H3
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 7.40 -46.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113668
PNG
(US8637501, 72)
Show SMILES Cn1c2CCCN(Cc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cn2)cc1=O)C1CCC1
Show InChI InChI=1S/C28H29FN4O2/c1-31-26-6-3-12-32(21-4-2-5-21)17-25(26)24-10-9-22(14-27(24)31)33-13-11-23(15-28(33)34)35-18-20-8-7-19(29)16-30-20/h7-11,13-16,21H,2-6,12,17-18H2,1H3
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 7.5 -46.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113701
PNG
(US8637501, 105)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O
Show InChI InChI=1S/C25H24ClN3O2/c1-28-23-3-2-11-27-15-22(23)21-9-8-19(13-24(21)28)29-12-10-20(14-25(29)30)31-16-17-4-6-18(26)7-5-17/h4-10,12-14,27H,2-3,11,15-16H2,1H3
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 7.60 -46.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113691
PNG
(US8637501, 95)
Show SMILES Cn1c2CCCNCc2c2ccc(nc12)-n1ccc(cc1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O/c1-30-20-3-2-11-28-14-19(20)18-8-9-21(29-23(18)30)31-12-10-16(13-22(31)32)15-4-6-17(7-5-15)24(25,26)27/h4-10,12-13,28H,2-3,11,14H2,1H3
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 7.80 -46.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113648
PNG
(US8637501, 52)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cc2F)cc1=O
Show InChI InChI=1S/C25H23F2N3O2/c1-29-23-7-10-28-9-6-21(23)20-5-4-18(13-24(20)29)30-11-8-19(14-25(30)31)32-15-16-2-3-17(26)12-22(16)27/h2-5,8,11-14,28H,6-7,9-10,15H2,1H3
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 7.80 -46.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113664
PNG
(US8637501, 68)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2F)cc1=O
Show InChI InChI=1S/C25H23ClFN3O2/c1-29-23-3-2-9-28-14-21(23)20-7-6-18(12-24(20)29)30-10-8-19(13-25(30)31)32-15-16-4-5-17(26)11-22(16)27/h4-8,10-13,28H,2-3,9,14-15H2,1H3
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 8.20 -46.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113667
PNG
(US8637501, 71)
Show SMILES CN1CCCc2c(C1)c1ccc(cc1n2C)-n1ccc(OCc2ccc(nc2)C(F)(F)F)cc1=O
Show InChI InChI=1S/C26H25F3N4O2/c1-31-10-3-4-22-21(15-31)20-7-6-18(12-23(20)32(22)2)33-11-9-19(13-25(33)34)35-16-17-5-8-24(30-14-17)26(27,28)29/h5-9,11-14H,3-4,10,15-16H2,1-2H3
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 8.5 -46.1n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113684
PNG
(US8637501, 88)
Show SMILES CN1CCc2c(CC1)c1ccc(nc1n2C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C25H26N4O2/c1-27-13-11-20-21-8-9-23(26-25(21)28(2)22(20)12-14-27)29-15-10-19(16-24(29)30)31-17-18-6-4-3-5-7-18/h3-10,15-16H,11-14,17H2,1-2H3
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 8.70 -46.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113666
PNG
(US8637501, 70)
Show SMILES CN1CCCc2c(C1)c1ccc(cc1n2C)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C25H25FN4O2/c1-28-10-3-4-23-22(15-28)21-8-7-19(12-24(21)29(23)2)30-11-9-20(13-25(30)31)32-16-18-6-5-17(26)14-27-18/h5-9,11-14H,3-4,10,15-16H2,1-2H3
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 8.80 -46.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113639
PNG
(US8637501, 43)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C25H25N3O2/c1-27-23-10-13-26-12-9-22(23)21-8-7-19(15-24(21)27)28-14-11-20(16-25(28)29)30-17-18-5-3-2-4-6-18/h2-8,11,14-16,26H,9-10,12-13,17H2,1H3
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 8.90 -46.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113708
PNG
(US8637501, 112)
Show SMILES Cn1c2CCCNCc2c2ccc(nc12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C24H23FN4O2/c1-28-21-3-2-11-26-14-20(21)19-8-9-22(27-24(19)28)29-12-10-18(13-23(29)30)31-15-16-4-6-17(25)7-5-16/h4-10,12-13,26H,2-3,11,14-15H2,1H3
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 8.90 -46.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113692
PNG
(US8637501, 96)
Show SMILES Cn1c2CCCNCc2c2ccc(nc12)-n1ccc(OCc2ccc(Cl)cc2F)cc1=O
Show InChI InChI=1S/C24H22ClFN4O2/c1-29-21-3-2-9-27-13-19(21)18-6-7-22(28-24(18)29)30-10-8-17(12-23(30)31)32-14-15-4-5-16(25)11-20(15)26/h4-8,10-12,27H,2-3,9,13-14H2,1H3
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 9.20 -45.9n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113627
PNG
(US8637501, 31)
Show SMILES CC(C)N1CCCc2c(C1)c1ccc(cc1n2C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C28H31N3O2/c1-20(2)30-14-7-10-26-25(18-30)24-12-11-22(16-27(24)29(26)3)31-15-13-23(17-28(31)32)33-19-21-8-5-4-6-9-21/h4-6,8-9,11-13,15-17,20H,7,10,14,18-19H2,1-3H3
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 9.40 -45.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113669
PNG
(US8637501, 73)
Show SMILES CCN1CCCc2c(C1)c1ccc(cc1n2C)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C26H27FN4O2/c1-3-30-11-4-5-24-23(16-30)22-9-8-20(13-25(22)29(24)2)31-12-10-21(14-26(31)32)33-17-19-7-6-18(27)15-28-19/h6-10,12-15H,3-5,11,16-17H2,1-2H3
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 9.40 -45.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113705
PNG
(US8637501, 109)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O
Show InChI InChI=1S/C24H23ClN4O2/c1-28-21-9-12-26-11-8-19(21)20-6-7-22(27-24(20)28)29-13-10-18(14-23(29)30)31-15-16-2-4-17(25)5-3-16/h2-7,10,13-14,26H,8-9,11-12,15H2,1H3
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 9.60 -45.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113610
PNG
(US8637501, 14)
Show SMILES CCN1CCc2c(CC1)c1ccc(cc1n2C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C27H29N3O2/c1-3-29-14-12-24-23-10-9-21(17-26(23)28(2)25(24)13-15-29)30-16-11-22(18-27(30)31)32-19-20-7-5-4-6-8-20/h4-11,16-18H,3,12-15,19H2,1-2H3
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 9.60 -45.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113703
PNG
(US8637501, 107)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(CCc2ccccc2)nc1=O
Show InChI InChI=1S/C25H26N4O/c1-28-23-8-5-14-26-17-22(23)21-12-11-20(16-24(21)28)29-15-13-19(27-25(29)30)10-9-18-6-3-2-4-7-18/h2-4,6-7,11-13,15-16,26H,5,8-10,14,17H2,1H3
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 9.70 -45.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113672
PNG
(US8637501, 76)
Show SMILES CCN1CCCc2c(C1)c1ccc(cc1n2C)N1CCN(CCc2ccc(F)cc2)CC1=O
Show InChI InChI=1S/C27H33FN4O/c1-3-30-13-4-5-25-24(18-30)23-11-10-22(17-26(23)29(25)2)32-16-15-31(19-27(32)33)14-12-20-6-8-21(28)9-7-20/h6-11,17H,3-5,12-16,18-19H2,1-2H3
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 9.80 -45.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113697
PNG
(US8637501, 101)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(CCc2ccccc2)nc1=O
Show InChI InChI=1S/C25H26N4O/c1-28-23-12-15-26-14-11-22(23)21-10-9-20(17-24(21)28)29-16-13-19(27-25(29)30)8-7-18-5-3-2-4-6-18/h2-6,9-10,13,16-17,26H,7-8,11-12,14-15H2,1H3
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 9.90 -45.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113637
PNG
(US8637501, 41)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O/c1-30-22-9-12-29-11-8-21(22)20-7-6-19(15-23(20)30)31-13-10-17(14-24(31)32)16-2-4-18(5-3-16)25(26,27)28/h2-7,10,13-15,29H,8-9,11-12H2,1H3
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 10 -45.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113670
PNG
(US8637501, 74)
Show SMILES CN1CCCc2c(C1)c1ccc(cc1n2C)N1CCN(CCc2ccc(F)cc2)CC1=O
Show InChI InChI=1S/C26H31FN4O/c1-28-12-3-4-24-23(17-28)22-10-9-21(16-25(22)29(24)2)31-15-14-30(18-26(31)32)13-11-19-5-7-20(27)8-6-19/h5-10,16H,3-4,11-15,17-18H2,1-2H3
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 10 -45.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113696
PNG
(US8637501, 100)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O
Show InChI InChI=1S/C25H24ClN3O2/c1-28-23-9-12-27-11-8-22(23)21-7-6-19(14-24(21)28)29-13-10-20(15-25(29)30)31-16-17-2-4-18(26)5-3-17/h2-7,10,13-15,27H,8-9,11-12,16H2,1H3
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 10 -45.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113599
PNG
(US8637501, 3)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O/c1-30-21-7-10-28-9-6-19(21)18-4-3-17(13-22(18)30)31-11-8-15(12-23(31)32)20-5-2-16(14-29-20)24(25,26)27/h2-5,8,11-14,28H,6-7,9-10H2,1H3
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 10.1 -45.6n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113609
PNG
(US8637501, 13)
Show SMILES Fc1ccc(COc2ccn(-c3ccc4c5CCNCCc5[nH]c4c3)c(=O)c2)nc1
Show InChI InChI=1S/C23H21FN4O2/c24-15-1-2-16(26-13-15)14-30-18-7-10-28(23(29)12-18)17-3-4-19-20-5-8-25-9-6-21(20)27-22(19)11-17/h1-4,7,10-13,25,27H,5-6,8-9,14H2
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 10.3 -45.6n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113611
PNG
(US8637501, 15)
Show SMILES CC(C)N1CCc2c(CC1)c1ccc(cc1n2C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C28H31N3O2/c1-20(2)30-14-12-25-24-10-9-22(17-27(24)29(3)26(25)13-15-30)31-16-11-23(18-28(31)32)33-19-21-7-5-4-6-8-21/h4-11,16-18,20H,12-15,19H2,1-3H3
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 10.4 -45.6n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113630
PNG
(US8637501, 34)
Show SMILES Cc1ccc(COc2ccn(-c3ccc4c5CNCCCc5n(C)c4c3)c(=O)c2)cn1
Show InChI InChI=1S/C25H26N4O2/c1-17-5-6-18(14-27-17)16-31-20-9-11-29(25(30)13-20)19-7-8-21-22-15-26-10-3-4-23(22)28(2)24(21)12-19/h5-9,11-14,26H,3-4,10,15-16H2,1-2H3
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 10.6 -45.5n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113624
PNG
(US8637501, 28)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(nn1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N5O/c1-30-19-3-2-9-27-13-17(19)16-5-4-15(12-20(16)30)31-10-8-14(11-22(31)32)18-6-7-21(29-28-18)23(24,25)26/h4-8,10-12,27H,2-3,9,13H2,1H3
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 10.9 -45.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113673
PNG
(US8637501, 77)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C24H24N4O2/c1-27-21-10-13-25-12-9-19(21)20-7-8-22(26-24(20)27)28-14-11-18(15-23(28)29)30-16-17-5-3-2-4-6-17/h2-8,11,14-15,25H,9-10,12-13,16H2,1H3
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 11 -45.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113661
PNG
(US8637501, 65)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2Cl)cc1=O
Show InChI InChI=1S/C25H23Cl2N3O2/c1-29-23-3-2-9-28-14-21(23)20-7-6-18(12-24(20)29)30-10-8-19(13-25(30)31)32-15-16-4-5-17(26)11-22(16)27/h4-8,10-13,28H,2-3,9,14-15H2,1H3
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 11 -45.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113681
PNG
(US8637501, 85)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ccc(OCc2ccc(Cl)cn2)cc1=O
Show InChI InChI=1S/C23H22ClN5O2/c1-28-20-7-10-25-9-6-18(20)19-4-5-21(27-23(19)28)29-11-8-17(12-22(29)30)31-14-16-3-2-15(24)13-26-16/h2-5,8,11-13,25H,6-7,9-10,14H2,1H3
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 11 -45.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113690
PNG
(US8637501, 94)
Show SMILES Cn1c2CCCNCc2c2ccc(nc12)-n1ccc(OCc2ccc(F)cc2F)cc1=O
Show InChI InChI=1S/C24H22F2N4O2/c1-29-21-3-2-9-27-13-19(21)18-6-7-22(28-24(18)29)30-10-8-17(12-23(30)31)32-14-15-4-5-16(25)11-20(15)26/h4-8,10-12,27H,2-3,9,13-14H2,1H3
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 11 -45.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113680
PNG
(US8637501, 84)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ccc(OCc2ccc(Cl)cc2F)cc1=O
Show InChI InChI=1S/C24H22ClFN4O2/c1-29-21-7-10-27-9-6-18(21)19-4-5-22(28-24(19)29)30-11-8-17(13-23(30)31)32-14-15-2-3-16(25)12-20(15)26/h2-5,8,11-13,27H,6-7,9-10,14H2,1H3
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 11 -45.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113618
PNG
(US8637501, 22 | US8637501, 39)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C24H23FN4O2/c1-28-22-3-2-9-26-14-21(22)20-7-6-18(11-23(20)28)29-10-8-19(12-24(29)30)31-15-17-5-4-16(25)13-27-17/h4-8,10-13,26H,2-3,9,14-15H2,1H3
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 11.2 -45.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113608
PNG
(US8637501, 12)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccn(-c2ccc3c4CCNCCc4[nH]c3c2)c(=O)c1
Show InChI InChI=1S/C24H20F3N3O/c25-24(26,27)17-3-1-15(2-4-17)16-9-12-30(23(31)13-16)18-5-6-19-20-7-10-28-11-8-21(20)29-22(19)14-18/h1-6,9,12-14,28-29H,7-8,10-11H2
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 11.4 -45.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113640
PNG
(US8637501, 44)
Show SMILES CN1CCc2c(CC1)c1ccc(cc1n2C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C26H27N3O2/c1-27-13-11-23-22-9-8-20(16-25(22)28(2)24(23)12-14-27)29-15-10-21(17-26(29)30)31-18-19-6-4-3-5-7-19/h3-10,15-17H,11-14,18H2,1-2H3
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 11.6 -45.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113601
PNG
(US8637501, 5)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(OCc2ccc(nc2)C(F)(F)F)cc1=O
Show InChI InChI=1S/C25H23F3N4O2/c1-31-21-7-10-29-9-6-20(21)19-4-3-17(12-22(19)31)32-11-8-18(13-24(32)33)34-15-16-2-5-23(30-14-16)25(26,27)28/h2-5,8,11-14,29H,6-7,9-10,15H2,1H3
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 11.8 -45.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113614
PNG
(US8637501, 18)
Show SMILES Cn1c2CNCCCc2c2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C25H25N3O2/c1-27-23-14-19(9-10-22(23)21-8-5-12-26-16-24(21)27)28-13-11-20(15-25(28)29)30-17-18-6-3-2-4-7-18/h2-4,6-7,9-11,13-15,26H,5,8,12,16-17H2,1H3
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 11.8 -45.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113665
PNG
(US8637501, 69)
Show SMILES CN1CCCc2c(C1)c1ccc(cc1n2C)-n1ccc(cc1=O)-c1ccc(nn1)C(F)(F)F
Show InChI InChI=1S/C24H22F3N5O/c1-30-10-3-4-20-18(14-30)17-6-5-16(13-21(17)31(20)2)32-11-9-15(12-23(32)33)19-7-8-22(29-28-19)24(25,26)27/h5-9,11-13H,3-4,10,14H2,1-2H3
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 12 -45.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113706
PNG
(US8637501, 110)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C24H23FN4O2/c1-28-21-9-12-26-11-8-19(21)20-6-7-22(27-24(20)28)29-13-10-18(14-23(29)30)31-15-16-2-4-17(25)5-3-16/h2-7,10,13-14,26H,8-9,11-12,15H2,1H3
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 12 -45.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113651
PNG
(US8637501, 55)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2F)cc1=O
Show InChI InChI=1S/C25H23ClFN3O2/c1-29-23-7-10-28-9-6-21(23)20-5-4-18(13-24(20)29)30-11-8-19(14-25(30)31)32-15-16-2-3-17(26)12-22(16)27/h2-5,8,11-14,28H,6-7,9-10,15H2,1H3
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 12 -45.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113632
PNG
(US8637501, 36)
Show SMILES FC(F)(F)c1ccc(nc1)-c1ccn(-c2ccc3c4CNCCCc4[nH]c3c2)c(=O)c1
Show InChI InChI=1S/C23H19F3N4O/c24-23(25,26)15-3-6-19(28-12-15)14-7-9-30(22(31)10-14)16-4-5-17-18-13-27-8-1-2-20(18)29-21(17)11-16/h3-7,9-12,27,29H,1-2,8,13H2
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 12.2 -45.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113694
PNG
(US8637501, 98)
Show SMILES CN1CCc2c(CC1)c1ccc(cc1n2C)N1CCN(CCc2ccc(F)cc2)CC1=O
Show InChI InChI=1S/C26H31FN4O/c1-28-12-10-23-22-8-7-21(17-25(22)29(2)24(23)11-13-28)31-16-15-30(18-26(31)32)14-9-19-3-5-20(27)6-4-19/h3-8,17H,9-16,18H2,1-2H3
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 13 -45.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113679
PNG
(US8637501, 83)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ccc(OCc2ccc(F)cc2F)cc1=O
Show InChI InChI=1S/C24H22F2N4O2/c1-29-21-7-10-27-9-6-18(21)19-4-5-22(28-24(19)29)30-11-8-17(13-23(30)31)32-14-15-2-3-16(25)12-20(15)26/h2-5,8,11-13,27H,6-7,9-10,14H2,1H3
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 13 -45.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113649
PNG
(US8637501, 53)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)N1CCN(CCc2ccc(Cl)cc2)CC1=O
Show InChI InChI=1S/C25H29ClN4O/c1-28-23-9-12-27-11-8-22(23)21-7-6-20(16-24(21)28)30-15-14-29(17-25(30)31)13-10-18-2-4-19(26)5-3-18/h2-7,16,27H,8-15,17H2,1H3
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 13 -45.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113693
PNG
(US8637501, 97)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)N1CCN(CCc2ccc(F)cc2)CC1=O
Show InChI InChI=1S/C25H29FN4O/c1-28-23-9-12-27-11-8-22(23)21-7-6-20(16-24(21)28)30-15-14-29(17-25(30)31)13-10-18-2-4-19(26)5-3-18/h2-7,16,27H,8-15,17H2,1H3
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 13 -45.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113606
PNG
(US8637501, 10)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ncc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C23H22FN5O2/c1-28-21-7-9-25-8-6-20(21)19-5-4-17(10-22(19)28)29-23(30)11-18(13-27-29)31-14-16-3-2-15(24)12-26-16/h2-5,10-13,25H,6-9,14H2,1H3
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 13.4 -44.9n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113612
PNG
(US8637501, 16)
Show SMILES CC(C)N1CCc2c(CC1)c1ccc(cc1n2C)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C27H29FN4O2/c1-18(2)31-11-9-24-23-7-6-21(14-26(23)30(3)25(24)10-12-31)32-13-8-22(15-27(32)33)34-17-20-5-4-19(28)16-29-20/h4-8,13-16,18H,9-12,17H2,1-3H3
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 13.7 -44.9n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113671
PNG
(US8637501, 75)
Show SMILES Cn1c2CCCN(Cc2c2ccc(cc12)N1CCN(CCc2ccc(F)cc2)CC1=O)C1CCC1
Show InChI InChI=1S/C29H35FN4O/c1-31-27-6-3-14-33(23-4-2-5-23)19-26(27)25-12-11-24(18-28(25)31)34-17-16-32(20-29(34)35)15-13-21-7-9-22(30)10-8-21/h7-12,18,23H,2-6,13-17,19-20H2,1H3
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 14 -44.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113598
PNG
(US8637501, 2)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(nn1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N5O/c1-30-19-7-10-27-9-6-17(19)16-3-2-15(13-20(16)30)31-11-8-14(12-22(31)32)18-4-5-21(29-28-18)23(24,25)26/h2-5,8,11-13,27H,6-7,9-10H2,1H3
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 14.4 -44.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113615
PNG
(US8637501, 19)
Show SMILES Cn1c2CNCCCc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C24H23FN4O2/c1-28-22-11-18(6-7-21(22)20-3-2-9-26-14-23(20)28)29-10-8-19(12-24(29)30)31-15-17-5-4-16(25)13-27-17/h4-8,10-13,26H,2-3,9,14-15H2,1H3
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 14.8 -44.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113687
PNG
(US8637501, 91 | US8637501, 92)
Show SMILES Cn1c2CCCNCc2c2ccc(nc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C23H22FN5O2/c1-28-20-3-2-9-25-13-19(20)18-6-7-21(27-23(18)28)29-10-8-17(11-22(29)30)31-14-16-5-4-15(24)12-26-16/h4-8,10-12,25H,2-3,9,13-14H2,1H3
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 15 -44.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113685
PNG
(US8637501, 89)
Show SMILES Cn1c2CCCNCc2c2ccc(nc12)-n1ccc(cc1=O)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N5O/c1-30-18-3-2-9-27-13-17(18)16-5-7-20(29-22(16)30)31-10-8-14(11-21(31)32)15-4-6-19(28-12-15)23(24,25)26/h4-8,10-12,27H,2-3,9,13H2,1H3
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 15 -44.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113682
PNG
(US8637501, 86)
Show SMILES Cn1c2CCN(CCc2c2ccc(nc12)-n1ccc(OCc2ccccc2)cc1=O)C1CCC1
Show InChI InChI=1S/C28H30N4O2/c1-30-25-14-16-31(21-8-5-9-21)15-13-23(25)24-10-11-26(29-28(24)30)32-17-12-22(18-27(32)33)34-19-20-6-3-2-4-7-20/h2-4,6-7,10-12,17-18,21H,5,8-9,13-16,19H2,1H3
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 16 -44.5n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113618
PNG
(US8637501, 22 | US8637501, 39)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C24H23FN4O2/c1-28-22-3-2-9-26-14-21(22)20-7-6-18(11-23(20)28)29-10-8-19(12-24(29)30)31-15-17-5-4-16(25)13-27-17/h4-8,10-13,26H,2-3,9,14-15H2,1H3
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 16.8 -44.4n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113645
PNG
(US8637501, 49)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(nc1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O/c1-30-21-9-12-28-11-8-19(21)18-7-6-17(14-22(18)30)31-13-10-20(29-23(31)32)15-2-4-16(5-3-15)24(25,26)27/h2-7,10,13-14,28H,8-9,11-12H2,1H3
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 17 -44.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113695
PNG
(US8637501, 99)
Show SMILES CCN1CCc2c(CC1)c1ccc(cc1n2C)N1CCN(CCc2ccc(F)cc2)CC1=O
Show InChI InChI=1S/C27H33FN4O/c1-3-30-14-11-24-23-9-8-22(18-26(23)29(2)25(24)12-15-30)32-17-16-31(19-27(32)33)13-10-20-4-6-21(28)7-5-20/h4-9,18H,3,10-17,19H2,1-2H3
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 17 -44.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113629
PNG
(US8637501, 33)
Show SMILES Cc1ccc(cn1)-c1ccn(-c2ccc3c4CNCCCc4n(C)c3c2)c(=O)c1
Show InChI InChI=1S/C24H24N4O/c1-16-5-6-18(14-26-16)17-9-11-28(24(29)12-17)19-7-8-20-21-15-25-10-3-4-22(21)27(2)23(20)13-19/h5-9,11-14,25H,3-4,10,15H2,1-2H3
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 17.5 -44.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113638
PNG
(US8637501, 42)
Show SMILES CC(C)N1CCc2[nH]c3cc(ccc3c2CC1)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C26H27FN4O2/c1-17(2)30-10-8-23-22-6-5-20(13-25(22)29-24(23)9-11-30)31-12-7-21(14-26(31)32)33-16-19-4-3-18(27)15-28-19/h3-7,12-15,17,29H,8-11,16H2,1-2H3
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 17.8 -44.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113702
PNG
(US8637501, 106)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ncc(F)cc2F)cc1=O
Show InChI InChI=1S/C24H22F2N4O2/c1-29-22-3-2-7-27-13-19(22)18-5-4-16(10-23(18)29)30-8-6-17(11-24(30)31)32-14-21-20(26)9-15(25)12-28-21/h4-6,8-12,27H,2-3,7,13-14H2,1H3
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 18 -44.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113687
PNG
(US8637501, 91 | US8637501, 92)
Show SMILES Cn1c2CCCNCc2c2ccc(nc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C23H22FN5O2/c1-28-20-3-2-9-25-13-19(20)18-6-7-21(27-23(18)28)29-10-8-17(11-22(29)30)31-14-16-5-4-15(24)12-26-16/h4-8,10-12,25H,2-3,9,13-14H2,1H3
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 20 -43.9n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113656
PNG
(US8637501, 60)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ncc(OCc2ccc(nc2)C(F)(F)F)cc1=O
Show InChI InChI=1S/C24H22F3N5O2/c1-31-20-3-2-8-28-13-19(20)18-6-5-16(9-21(18)31)32-23(33)10-17(12-30-32)34-14-15-4-7-22(29-11-15)24(25,26)27/h4-7,9-12,28H,2-3,8,13-14H2,1H3
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 21 -43.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113698
PNG
(US8637501, 102)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(OCc2ncc(F)cc2F)cc1=O
Show InChI InChI=1S/C24H22F2N4O2/c1-29-22-5-8-27-7-4-19(22)18-3-2-16(11-23(18)29)30-9-6-17(12-24(30)31)32-14-21-20(26)10-15(25)13-28-21/h2-3,6,9-13,27H,4-5,7-8,14H2,1H3
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 22 -43.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113663
PNG
(US8637501, 67)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(OCc2ncc(Cl)cc2Cl)cc1=O
Show InChI InChI=1S/C24H22Cl2N4O2/c1-29-22-3-2-7-27-13-19(22)18-5-4-16(10-23(18)29)30-8-6-17(11-24(30)31)32-14-21-20(26)9-15(25)12-28-21/h4-6,8-12,27H,2-3,7,13-14H2,1H3
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 22 -43.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113647
PNG
(US8637501, 51)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2Cl)cc1=O
Show InChI InChI=1S/C25H23Cl2N3O2/c1-29-23-7-10-28-9-6-21(23)20-5-4-18(13-24(20)29)30-11-8-19(14-25(30)31)32-15-16-2-3-17(26)12-22(16)27/h2-5,8,11-14,28H,6-7,9-10,15H2,1H3
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 24 -43.5n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113641
PNG
(US8637501, 45)
Show SMILES Cc1ccc(COc2ccn(-c3ccc4c5CCNCCc5n(C)c4c3)c(=O)c2)cn1
Show InChI InChI=1S/C25H26N4O2/c1-17-3-4-18(15-27-17)16-31-20-9-12-29(25(30)14-20)19-5-6-21-22-7-10-26-11-8-23(22)28(2)24(21)13-19/h3-6,9,12-15,26H,7-8,10-11,16H2,1-2H3
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 26 -43.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113689
PNG
(US8637501, 93)
Show SMILES Cn1c2CCCNCc2c2ccc(nc12)-n1ccc(OCc2ccc(Cl)cc2Cl)cc1=O
Show InChI InChI=1S/C24H22Cl2N4O2/c1-29-21-3-2-9-27-13-19(21)18-6-7-22(28-24(18)29)30-10-8-17(12-23(30)31)32-14-15-4-5-16(25)11-20(15)26/h4-8,10-12,27H,2-3,9,13-14H2,1H3
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 26 -43.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113652
PNG
(US8637501, 56)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(OCc2ncc(Cl)cc2Cl)cc1=O
Show InChI InChI=1S/C24H22Cl2N4O2/c1-29-22-5-8-27-7-4-19(22)18-3-2-16(11-23(18)29)30-9-6-17(12-24(30)31)32-14-21-20(26)10-15(25)13-28-21/h2-3,6,9-13,27H,4-5,7-8,14H2,1H3
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 27 -43.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113674
PNG
(US8637501, 78)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ccc(cc1=O)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N5O/c1-30-18-7-10-27-9-6-16(18)17-3-5-20(29-22(17)30)31-11-8-14(12-21(31)32)15-2-4-19(28-13-15)23(24,25)26/h2-5,8,11-13,27H,6-7,9-10H2,1H3
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 29 -43.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113633
PNG
(US8637501, 37)
Show SMILES FC(F)(F)c1ccc(nn1)-c1ccn(-c2ccc3c4CNCCCc4[nH]c3c2)c(=O)c1
Show InChI InChI=1S/C22H18F3N5O/c23-22(24,25)20-6-5-17(28-29-20)13-7-9-30(21(31)10-13)14-3-4-15-16-12-26-8-1-2-18(16)27-19(15)11-14/h3-7,9-11,26-27H,1-2,8,12H2
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 29.2 -43.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113677
PNG
(US8637501, 81)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C23H22FN5O2/c1-28-20-7-10-25-9-6-18(20)19-4-5-21(27-23(19)28)29-11-8-17(12-22(29)30)31-14-16-3-2-15(24)13-26-16/h2-5,8,11-13,25H,6-7,9-10,14H2,1H3
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 33 -42.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113621
PNG
(US8637501, 25)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(cc1=O)-c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N5O/c1-30-19-3-2-7-27-13-18(19)17-5-4-16(10-20(17)30)31-8-6-14(9-21(31)32)15-11-28-22(29-12-15)23(24,25)26/h4-6,8-12,27H,2-3,7,13H2,1H3
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 42.3 -42.1n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113710
PNG
(US8637501, 114)
Show SMILES Cn1c2CCCNCc2c2ccc(nc12)-n1ccc(OCc2ncc(F)cc2F)cc1=O
Show InChI InChI=1S/C23H21F2N5O2/c1-29-20-3-2-7-26-12-17(20)16-4-5-21(28-23(16)29)30-8-6-15(10-22(30)31)32-13-19-18(25)9-14(24)11-27-19/h4-6,8-11,26H,2-3,7,12-13H2,1H3
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 44 -42.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113655
PNG
(US8637501, 59)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)N1CCN(CCc2ccccn2)CC1=O
Show InChI InChI=1S/C24H29N5O/c1-27-22-6-4-10-25-16-21(22)20-8-7-19(15-23(20)27)29-14-13-28(17-24(29)30)12-9-18-5-2-3-11-26-18/h2-3,5,7-8,11,15,25H,4,6,9-10,12-14,16-17H2,1H3
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 44 -42.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113642
PNG
(US8637501, 46)
Show SMILES CC(=O)N1CCc2c(CC1)c1ccc(cc1n2C)-n1ccc(cc1=O)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C26H23F3N4O2/c1-16(34)32-10-8-21-20-5-4-19(14-23(20)31(2)22(21)9-11-32)33-12-7-17(13-25(33)35)18-3-6-24(30-15-18)26(27,28)29/h3-7,12-15H,8-11H2,1-2H3
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 47 -41.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113607
PNG
(US8637501, 11)
Show SMILES Cc1ccc(cn1)-c1ccn(-c2ccc3c4CCNCCc4n(C)c3c2)c(=O)c1
Show InChI InChI=1S/C24H24N4O/c1-16-3-4-18(15-26-16)17-9-12-28(24(29)13-17)19-5-6-20-21-7-10-25-11-8-22(21)27(2)23(20)14-19/h3-6,9,12-15,25H,7-8,10-11H2,1-2H3
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 49 -41.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113678
PNG
(US8637501, 82)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ncc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C22H21FN6O2/c1-28-19-7-9-24-8-6-17(19)18-4-5-20(27-22(18)28)29-21(30)10-16(12-26-29)31-13-15-3-2-14(23)11-25-15/h2-5,10-12,24H,6-9,13H2,1H3
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 53 -41.5n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113657
PNG
(US8637501, 61)
Show SMILES CC(=O)N1CCCc2c(C1)c1ccc(cc1n2C)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C26H25FN4O3/c1-17(32)30-10-3-4-24-23(15-30)22-8-7-20(12-25(22)29(24)2)31-11-9-21(13-26(31)33)34-16-19-6-5-18(27)14-28-19/h5-9,11-14H,3-4,10,15-16H2,1-2H3
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 57 -41.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113658
PNG
(US8637501, 62)
Show SMILES CC(=O)N1CCCc2c(C1)c1ccc(cc1n2C)-n1ccc(cc1=O)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C26H23F3N4O2/c1-16(34)32-10-3-4-22-21(15-32)20-7-6-19(13-23(20)31(22)2)33-11-9-17(12-25(33)35)18-5-8-24(30-14-18)26(27,28)29/h5-9,11-14H,3-4,10,15H2,1-2H3
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 60 -41.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113644
PNG
(US8637501, 48)
Show SMILES CC(=O)N1CCc2c(CC1)c1ccc(cc1n2C)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C26H25FN4O3/c1-17(32)30-10-8-23-22-6-5-20(13-25(22)29(2)24(23)9-11-30)31-12-7-21(14-26(31)33)34-16-19-4-3-18(27)15-28-19/h3-7,12-15H,8-11,16H2,1-2H3
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 60 -41.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113704
PNG
(US8637501, 108)
Show SMILES Cn1c2CCCNCc2c2ccc(cc12)-n1ccc(nc1=O)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N5O/c1-30-19-3-2-9-27-13-17(19)16-6-5-15(11-20(16)30)31-10-8-18(29-22(31)32)14-4-7-21(28-12-14)23(24,25)26/h4-8,10-12,27H,2-3,9,13H2,1H3
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 60 -41.2n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113676
PNG
(US8637501, 80)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ccc(cc1=O)-c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N5O/c1-30-19-7-10-27-9-6-16(19)17-3-5-20(29-22(17)30)31-11-8-14(12-21(31)32)18-4-2-15(13-28-18)23(24,25)26/h2-5,8,11-13,27H,6-7,9-10H2,1H3
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 69 -40.9n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113707
PNG
(US8637501, 111)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ccc(OCc2ncc(F)cc2F)cc1=O
Show InChI InChI=1S/C23H21F2N5O2/c1-29-20-5-8-26-7-4-16(20)17-2-3-21(28-23(17)29)30-9-6-15(11-22(30)31)32-13-19-18(25)10-14(24)12-27-19/h2-3,6,9-12,26H,4-5,7-8,13H2,1H3
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 71 -40.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113643
PNG
(US8637501, 47)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ncc(OCc2ccc(nc2)C(F)(F)F)cc1=O
Show InChI InChI=1S/C24H22F3N5O2/c1-31-20-7-9-28-8-6-19(20)18-4-3-16(10-21(18)31)32-23(33)11-17(13-30-32)34-14-15-2-5-22(29-12-15)24(25,26)27/h2-5,10-13,28H,6-9,14H2,1H3
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 74 -40.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113634
PNG
(US8637501, 38)
Show SMILES Cn1c2CCCNC(=O)c2c2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C25H23N3O3/c1-27-21-8-5-12-26-25(30)24(21)20-10-9-18(14-22(20)27)28-13-11-19(15-23(28)29)31-16-17-6-3-2-4-7-17/h2-4,6-7,9-11,13-15H,5,8,12,16H2,1H3,(H,26,30)
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 100 -40.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113650
PNG
(US8637501, 54)
Show SMILES CC(=O)N1CCc2[nH]c3cc(ccc3c2CC1)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C26H25N3O3/c1-18(30)28-12-10-23-22-8-7-20(15-25(22)27-24(23)11-13-28)29-14-9-21(16-26(29)31)32-17-19-5-3-2-4-6-19/h2-9,14-16,27H,10-13,17H2,1H3
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 112 -39.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113602
PNG
(US8637501, 6)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(cc1=O)-c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N5O/c1-30-19-5-8-27-7-4-18(19)17-3-2-16(11-20(17)30)31-9-6-14(10-21(31)32)15-12-28-22(29-13-15)23(24,25)26/h2-3,6,9-13,27H,4-5,7-8H2,1H3
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 131 -39.3n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113604
PNG
(US8637501, 8)
Show SMILES FC(F)(F)c1ccc(nn1)-c1ccn(-c2ccc3c4CCNCCc4[nH]c3c2)c(=O)c1
Show InChI InChI=1S/C22H18F3N5O/c23-22(24,25)20-4-3-17(28-29-20)13-7-10-30(21(31)11-13)14-1-2-15-16-5-8-26-9-6-18(16)27-19(15)12-14/h1-4,7,10-12,26-27H,5-6,8-9H2
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 148 -39.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113700
PNG
(US8637501, 104)
Show SMILES Cn1c2CCCNC(=O)c2c2ccc(cc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C24H21FN4O3/c1-28-20-3-2-9-26-24(31)23(20)19-7-6-17(11-21(19)28)29-10-8-18(12-22(29)30)32-14-16-5-4-15(25)13-27-16/h4-8,10-13H,2-3,9,14H2,1H3,(H,26,31)
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 149 -39.0n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113654
PNG
(US8637501, 58)
Show SMILES Cn1c2CCNCCc2c2ccc(cc12)-n1ccc(nc1=O)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N5O/c1-30-19-7-10-27-9-6-17(19)16-4-3-15(12-20(16)30)31-11-8-18(29-22(31)32)14-2-5-21(28-13-14)23(24,25)26/h2-5,8,11-13,27H,6-7,9-10H2,1H3
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 163 -38.7n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113675
PNG
(US8637501, 79)
Show SMILES Cn1c2CCNCCc2c2ccc(nc12)-n1ccc(cc1=O)-c1ccc(nn1)C(F)(F)F
Show InChI InChI=1S/C22H19F3N6O/c1-30-17-7-10-26-9-6-14(17)15-2-5-19(27-21(15)30)31-11-8-13(12-20(31)32)16-3-4-18(29-28-16)22(23,24)25/h2-5,8,11-12,26H,6-7,9-10H2,1H3
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 235 -37.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113616
PNG
(US8637501, 20)
Show SMILES Cn1c2CNCCCc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O/c1-30-21-12-17(5-6-19(21)18-3-2-9-28-14-22(18)30)31-10-8-15(11-23(31)32)20-7-4-16(13-29-20)24(25,26)27/h4-8,10-13,28H,2-3,9,14H2,1H3
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 242 -37.8n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM113605
PNG
(US8637501, 9)
Show SMILES FC(F)(F)c1ccc(nc1)-c1ccn(-c2ccc3c4CCNCCc4[nH]c3c2)c(=O)c1
Show InChI InChI=1S/C23H19F3N4O/c24-23(25,26)15-1-4-19(28-13-15)14-7-10-30(22(31)11-14)16-2-3-17-18-5-8-27-9-6-20(18)29-21(17)12-16/h1-4,7,10-13,27,29H,5-6,8-9H2
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 1.37E+3 -33.5n/an/an/an/an/a7.425



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...

US Patent US8637501 (2014)


BindingDB Entry DOI: 10.7270/Q2B27SZ4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%