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Patent code US8722718

Compile Data Set for Download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM121396
PNG
(US8722718, 1)
Show SMILES CC1(OCCO1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:25|
Show InChI InChI=1S/C21H22N4O3/c1-21(27-9-10-28-21)15-7-8-18(17(11-15)14-5-3-2-4-6-14)25-20(26)19-23-13-16(12-22)24-19/h5,7-8,11,13H,2-4,6,9-10H2,1H3,(H,23,24)(H,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.40n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...

US Patent US8722718 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TV4
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM121397
PNG
(US8722718, 2)
Show SMILES CC1(OCCCO1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:26|
Show InChI InChI=1S/C22H24N4O3/c1-22(28-10-5-11-29-22)16-8-9-19(18(12-16)15-6-3-2-4-7-15)26-21(27)20-24-14-17(13-23)25-20/h6,8-9,12,14H,2-5,7,10-11H2,1H3,(H,24,25)(H,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...

US Patent US8722718 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TV4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%