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Patent code US8735386

Compile Data Set for Download or QSAR

Found 429 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122557
PNG
(US8735386, I-27)
Show SMILES COc1cc(OCCN2CCCC2)ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl |(-.13,-1.26,;-1.46,-.49,;-1.46,1.05,;-2.79,1.82,;-2.79,3.36,;-4.13,4.13,;-5.46,3.36,;-5.46,1.82,;-6.79,1.05,;-8.26,1.52,;-9.16,.28,;-8.26,-.97,;-6.79,-.49,;-1.46,4.13,;-.13,3.36,;-.13,1.82,;1.21,1.05,;2.54,1.82,;2.54,3.36,;3.88,4.13,;5.21,3.36,;6.54,4.13,;7.88,3.36,;7.88,1.82,;9.02,.79,;8.39,-.62,;9.16,-1.96,;6.86,-.46,;6.54,1.05,;5.21,1.82,;3.88,1.05,;5.77,-1.55,;4.29,-1.15,;3.2,-2.24,;3.6,-3.73,;5.08,-4.13,;6.17,-3.04,;7.66,-3.44,)|
Show InChI InChI=1S/C29H31ClN6O2/c1-35-28(21-7-3-4-8-22(21)30)26-24(34-35)11-9-19-18-31-29(33-27(19)26)32-23-12-10-20(17-25(23)37-2)38-16-15-36-13-5-6-14-36/h3-4,7-8,10,12,17-18H,5-6,9,11,13-16H2,1-2H3,(H,31,32,33)
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US Patent
n/an/a 0.180n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122640
PNG
(US8735386, I-110)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)N1CCN(C)CC1 |(-.64,-2.42,;-1.98,-1.65,;-1.98,-.11,;-3.31,.66,;-3.31,2.2,;-1.98,2.97,;-.64,2.2,;-.64,.66,;.69,-.11,;2.02,.66,;2.02,2.2,;3.36,2.97,;4.69,2.2,;6.02,2.97,;7.36,2.2,;7.36,.66,;8.5,-.37,;7.88,-1.78,;8.65,-3.11,;6.34,-1.62,;6.02,-.11,;4.69,.66,;3.36,-.11,;5.26,-2.7,;3.77,-2.31,;2.68,-3.39,;3.08,-4.88,;4.57,-5.28,;5.65,-4.19,;7.14,-4.59,;-4.65,2.97,;-4.65,4.51,;-5.98,5.28,;-7.31,4.51,;-8.65,5.28,;-7.31,2.97,;-5.98,2.2,)|
Show InChI InChI=1S/C28H30ClN7O/c1-34-12-14-36(15-13-34)19-9-11-22(24(16-19)37-3)31-28-30-17-18-8-10-23-25(26(18)32-28)27(35(2)33-23)20-6-4-5-7-21(20)29/h4-7,9,11,16-17H,8,10,12-15H2,1-3H3,(H,30,31,32)
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n/an/a 0.190n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122627
PNG
(US8735386, I-97)
Show SMILES COc1cc(ccc1Nc1ncc2C(C)Cc3nn(C)c(c3-c2n1)-c1ccccc1Cl)N1CCN(C)CC1 |(-.64,-2.42,;-1.98,-1.65,;-1.98,-.11,;-3.31,.66,;-3.31,2.2,;-1.98,2.97,;-.64,2.2,;-.64,.66,;.69,-.11,;2.02,.66,;2.02,2.2,;3.36,2.97,;4.69,2.2,;6.02,2.97,;6.02,4.51,;7.36,2.2,;7.36,.66,;8.5,-.37,;7.88,-1.78,;8.65,-3.11,;6.34,-1.62,;6.02,-.11,;4.69,.66,;3.36,-.11,;5.26,-2.7,;3.77,-2.31,;2.68,-3.39,;3.08,-4.88,;4.57,-5.28,;5.65,-4.19,;7.14,-4.59,;-4.65,2.97,;-4.65,4.51,;-5.98,5.28,;-7.31,4.51,;-8.65,5.28,;-7.31,2.97,;-5.98,2.2,)|
Show InChI InChI=1S/C29H32ClN7O/c1-18-15-24-26(28(36(3)34-24)20-7-5-6-8-22(20)30)27-21(18)17-31-29(33-27)32-23-10-9-19(16-25(23)38-4)37-13-11-35(2)12-14-37/h5-10,16-18H,11-15H2,1-4H3,(H,31,32,33)
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n/an/a 0.190n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122701
PNG
(US8735386, I-171)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C22H22ClN7O/c1-29-21(14-3-6-16(23)7-4-14)19-17(27-29)8-5-15-13-24-22(26-20(15)19)25-18-9-10-30(28-18)11-12-31-2/h3-4,6-7,9-10,13H,5,8,11-12H2,1-2H3,(H,24,25,26,28)
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n/an/a 0.200n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122699
PNG
(US8735386, I-169)
Show SMILES CC(=O)N1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(-c5sccc5Cl)c4-c3n2)cn1 |(-9.3,1.15,;-8.53,2.48,;-9.3,3.82,;-6.99,2.48,;-6.22,3.82,;-4.68,3.82,;-3.91,2.48,;-4.68,1.15,;-6.22,1.15,;-2.37,2.48,;-1.46,1.24,;0,1.71,;1.34,.94,;2.67,1.71,;2.67,3.25,;4.01,4.02,;5.34,3.25,;6.67,4.02,;8.01,3.25,;8.01,1.71,;9.15,.68,;8.53,-.72,;9.3,-2.06,;6.99,-.56,;5.9,-1.65,;6.38,-3.12,;5.13,-4.02,;3.89,-3.12,;4.36,-1.65,;3.59,-.32,;6.67,.94,;5.34,1.71,;4.01,.94,;0,3.25,;-1.46,3.73,)|
Show InChI InChI=1S/C24H25ClN8OS/c1-14(34)32-8-5-17(6-9-32)33-13-16(12-27-33)28-24-26-11-15-3-4-19-20(21(15)29-24)22(31(2)30-19)23-18(25)7-10-35-23/h7,10-13,17H,3-6,8-9H2,1-2H3,(H,26,28,29)
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n/an/a 0.200n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122952
PNG
(US8735386, IV-5)
Show SMILES CCOc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4)c3-c2n1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C32H39N7O/c1-5-40-29-20-25(39-17-15-38(16-18-39)22(2)3)12-14-26(29)34-32-33-21-24-11-13-27-30(31(24)35-32)28(37(4)36-27)19-23-9-7-6-8-10-23/h6-10,12,14,20-22H,5,11,13,15-19H2,1-4H3,(H,33,34,35)
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n/an/a 0.260n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122860
PNG
(US8735386, III-22)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)N[C@H]1CC[C@@H](CC1)N1CCOCC1 |r,wU:36.44,wD:33.37,(2.02,-3.57,;.69,-2.8,;.69,-1.26,;-.64,-.49,;-.64,1.05,;.69,1.82,;2.02,1.05,;2.02,-.49,;3.36,-1.26,;4.69,-.49,;4.69,1.05,;6.02,1.82,;7.36,1.05,;8.69,1.82,;10.03,1.05,;10.03,-.49,;11.17,-1.52,;10.54,-2.93,;11.31,-4.27,;9.01,-2.77,;8.69,-1.26,;7.36,-.49,;6.02,-1.26,;7.92,-3.86,;6.44,-3.46,;5.35,-4.55,;5.75,-6.04,;7.23,-6.44,;8.32,-5.35,;9.81,-5.75,;-1.98,1.82,;-1.98,3.36,;-3.31,1.05,;-4.65,1.82,;-4.65,3.36,;-5.98,4.13,;-7.31,3.36,;-7.31,1.82,;-5.98,1.05,;-8.65,4.13,;-8.65,5.67,;-9.98,6.44,;-11.31,5.67,;-11.31,4.13,;-9.98,3.36,)|
Show InChI InChI=1S/C34H38ClN7O3/c1-41-32(25-5-3-4-6-26(25)35)30-28(40-41)14-8-22-20-36-34(39-31(22)30)38-27-13-7-21(19-29(27)44-2)33(43)37-23-9-11-24(12-10-23)42-15-17-45-18-16-42/h3-7,13,19-20,23-24H,8-12,14-18H2,1-2H3,(H,37,43)(H,36,38,39)/t23-,24-
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n/an/a 0.270n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122672
PNG
(US8735386, I-142)
Show SMILES COc1ccc(-c2c-3c(CCc4cnc(Nc5ccc(cc5OC)N5CCN(C)CC5)nc-34)nn2C)c(Cl)c1 |(2.39,-6.37,;1.99,-4.88,;3.08,-3.79,;2.68,-2.31,;3.77,-1.22,;5.26,-1.62,;6.34,-.53,;6.02,.98,;7.36,1.75,;7.36,3.29,;6.02,4.06,;4.69,3.29,;3.36,4.06,;2.02,3.29,;2.02,1.75,;.69,.98,;-.64,1.75,;-.64,3.29,;-1.98,4.06,;-3.31,3.29,;-3.31,1.75,;-1.98,.98,;-1.98,-.56,;-.64,-1.33,;-4.65,4.06,;-4.65,5.6,;-5.98,6.37,;-7.31,5.6,;-8.65,6.37,;-7.31,4.06,;-5.98,3.29,;3.36,.98,;4.69,1.75,;8.5,.72,;7.88,-.69,;8.65,-2.02,;5.65,-3.1,;7.14,-3.5,;4.57,-4.19,)|
Show InChI InChI=1S/C29H32ClN7O2/c1-35-11-13-37(14-12-35)19-6-10-23(25(15-19)39-4)32-29-31-17-18-5-9-24-26(27(18)33-29)28(36(2)34-24)21-8-7-20(38-3)16-22(21)30/h6-8,10,15-17H,5,9,11-14H2,1-4H3,(H,31,32,33)
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n/an/a 0.300n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122703
PNG
(US8735386, I-173)
Show SMILES Cn1cc(Nc2ncc3CCc4nn(C)c(-c5sccc5Cl)c4-c3n2)cn1 |(-5.69,4.54,;-4.92,3.21,;-3.46,2.73,;-3.46,1.19,;-2.13,.42,;-.79,1.19,;-.79,2.73,;.54,3.5,;1.87,2.73,;3.21,3.5,;4.54,2.73,;4.54,1.19,;5.69,.16,;5.06,-1.24,;5.83,-2.58,;3.53,-1.08,;2.44,-2.17,;2.92,-3.64,;1.67,-4.54,;.42,-3.64,;.9,-2.17,;.13,-.84,;3.21,.42,;1.87,1.19,;.54,.42,;-4.92,.72,;-5.83,1.96,)|
Show InChI InChI=1S/C18H16ClN7S/c1-25-9-11(8-21-25)22-18-20-7-10-3-4-13-14(15(10)23-18)16(26(2)24-13)17-12(19)5-6-27-17/h5-9H,3-4H2,1-2H3,(H,20,22,23)
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n/an/a 0.300n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122941
PNG
(US8735386, III-103)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(-c4sccc4Cl)c3-c2n1)C(=O)NC1CCN(C)CC1 |(.69,-2.52,;-.64,-1.75,;-.64,-.21,;-1.98,.56,;-1.98,2.1,;-.64,2.87,;.69,2.1,;.69,.56,;2.02,-.21,;3.36,.56,;3.36,2.1,;4.69,2.87,;6.02,2.1,;7.36,2.87,;8.69,2.1,;8.69,.56,;9.84,-.47,;9.21,-1.88,;9.98,-3.21,;7.68,-1.72,;6.59,-2.81,;7.07,-4.27,;5.82,-5.18,;4.57,-4.27,;5.05,-2.81,;4.28,-1.47,;7.36,-.21,;6.02,.56,;4.69,-.21,;-3.31,2.87,;-3.31,4.41,;-4.65,2.1,;-5.98,2.87,;-5.98,4.41,;-7.31,5.18,;-8.65,4.41,;-9.98,5.18,;-8.65,2.87,;-7.31,2.1,)|
Show InChI InChI=1S/C28H30ClN7O2S/c1-35-11-8-18(9-12-35)31-27(37)16-4-6-20(22(14-16)38-3)32-28-30-15-17-5-7-21-23(24(17)33-28)25(36(2)34-21)26-19(29)10-13-39-26/h4,6,10,13-15,18H,5,7-9,11-12H2,1-3H3,(H,31,37)(H,30,32,33)
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n/an/a 0.300n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122702
PNG
(US8735386, I-172)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(-c5sccc5C)c4-c3n2)n1 |(-6.53,4.54,;-4.99,4.54,;-4.22,3.21,;-5.13,1.96,;-4.22,.72,;-2.76,1.19,;-1.42,.42,;-.09,1.19,;-.09,2.73,;1.24,3.5,;2.58,2.73,;3.91,3.5,;5.24,2.73,;5.24,1.19,;6.39,.16,;5.76,-1.24,;6.53,-2.58,;4.23,-1.08,;3.14,-2.17,;3.62,-3.64,;2.37,-4.54,;1.13,-3.64,;1.6,-2.17,;.83,-.84,;3.91,.42,;2.58,1.19,;1.24,.42,;-2.76,2.73,)|
Show InChI InChI=1S/C20H21N7S/c1-4-27-9-7-15(25-27)22-20-21-11-13-5-6-14-16(17(13)23-20)18(26(3)24-14)19-12(2)8-10-28-19/h7-11H,4-6H2,1-3H3,(H,21,22,23,25)
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n/an/a 0.300n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122951
PNG
(US8735386, IV-4)
Show SMILES CCOc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4)c3-c2n1)N1CCN(C)CC1
Show InChI InChI=1S/C30H35N7O/c1-4-38-27-19-23(37-16-14-35(2)15-17-37)11-13-24(27)32-30-31-20-22-10-12-25-28(29(22)33-30)26(36(3)34-25)18-21-8-6-5-7-9-21/h5-9,11,13,19-20H,4,10,12,14-18H2,1-3H3,(H,31,32,33)
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n/an/a 0.310n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122673
PNG
(US8735386, I-143)
Show SMILES COc1ccc(-c2c-3c(CCc4cnc(Nc5ccc(cc5OC)C(=O)NC5CCN(C)CC5)nc-34)nn2C)c(Cl)c1 |(3.72,-6.37,;3.32,-4.88,;4.41,-3.79,;4.01,-2.31,;5.1,-1.22,;6.59,-1.62,;7.68,-.53,;7.36,.98,;8.69,1.75,;8.69,3.29,;7.36,4.06,;6.02,3.29,;4.69,4.06,;3.36,3.29,;3.36,1.75,;2.02,.98,;.69,1.75,;.69,3.29,;-.64,4.06,;-1.98,3.29,;-1.98,1.75,;-.64,.98,;-.64,-.56,;.69,-1.33,;-3.31,4.06,;-3.31,5.6,;-4.65,3.29,;-5.98,4.06,;-5.98,5.6,;-7.31,6.37,;-8.65,5.6,;-9.98,6.37,;-8.65,4.06,;-7.31,3.29,;4.69,.98,;6.02,1.75,;9.84,.72,;9.21,-.69,;9.98,-2.02,;6.99,-3.1,;8.48,-3.5,;5.9,-4.19,)|
Show InChI InChI=1S/C31H34ClN7O3/c1-38-13-11-20(12-14-38)34-30(40)18-5-9-24(26(15-18)42-4)35-31-33-17-19-6-10-25-27(28(19)36-31)29(39(2)37-25)22-8-7-21(41-3)16-23(22)32/h5,7-9,15-17,20H,6,10-14H2,1-4H3,(H,34,40)(H,33,35,36)
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n/an/a 0.400n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122704
PNG
(US8735386, I-174)
Show SMILES Cn1nc2CCc3cnc(Nc4ccccc4)nc3-c2c1-c1sccc1Cl |(5.98,-2.06,;5.21,-.72,;5.84,.68,;4.69,1.71,;4.69,3.25,;3.36,4.02,;2.02,3.25,;.69,4.02,;-.64,3.25,;-.64,1.71,;-1.98,.94,;-3.31,1.71,;-3.31,3.25,;-4.65,4.02,;-5.98,3.25,;-5.98,1.71,;-4.65,.94,;.69,.94,;2.02,1.71,;3.36,.94,;3.68,-.56,;2.59,-1.65,;3.06,-3.12,;1.82,-4.02,;.57,-3.12,;1.05,-1.65,;.28,-.32,)|
Show InChI InChI=1S/C20H16ClN5S/c1-26-18(19-14(21)9-10-27-19)16-15(25-26)8-7-12-11-22-20(24-17(12)16)23-13-5-3-2-4-6-13/h2-6,9-11H,7-8H2,1H3,(H,22,23,24)
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n/an/a 0.400n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122706
PNG
(US8735386, I-176)
Show SMILES COc1ccc(cc1)-c1c-2c(CCc3cnc(Nc4cnn(c4)C4CCN(CC4)C(C)=O)nc-23)nn1C
Show InChI InChI=1S/C27H30N8O2/c1-17(36)34-12-10-21(11-13-34)35-16-20(15-29-35)30-27-28-14-19-6-9-23-24(25(19)31-27)26(33(2)32-23)18-4-7-22(37-3)8-5-18/h4-5,7-8,14-16,21H,6,9-13H2,1-3H3,(H,28,30,31)
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n/an/a 0.400n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122942
PNG
(US8735386, III-104)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4Cl)c3-c2n1)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C31H34ClN7O2/c1-38-14-12-22(13-15-38)34-30(40)20-8-10-24(27(17-20)41-3)35-31-33-18-21-9-11-25-28(29(21)36-31)26(39(2)37-25)16-19-6-4-5-7-23(19)32/h4-8,10,17-18,22H,9,11-16H2,1-3H3,(H,34,40)(H,33,35,36)
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n/an/a 0.400n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122705
PNG
(US8735386, I-175)
Show SMILES CN(C)C1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(c5-c4n3)-c3ccccc3)n2)CC1
Show InChI InChI=1S/C28H35N9/c1-34(2)22-11-14-36(15-12-22)17-18-37-16-13-24(33-37)30-28-29-19-21-9-10-23-25(26(21)31-28)27(35(3)32-23)20-7-5-4-6-8-20/h4-8,13,16,19,22H,9-12,14-15,17-18H2,1-3H3,(H,29,30,31,33)
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n/an/a 0.400n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122950
PNG
(US8735386, IV-3)
Show SMILES CCOc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4)c3-c2n1)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C34H41N7O2/c1-3-43-31-22-27(41-17-15-40(16-18-41)26-13-19-42-20-14-26)10-12-28(31)36-34-35-23-25-9-11-29-32(33(25)37-34)30(39(2)38-29)21-24-7-5-4-6-8-24/h4-8,10,12,22-23,26H,3,9,11,13-21H2,1-2H3,(H,35,36,37)
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n/an/a 0.430n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122670
PNG
(US8735386, I-140)
Show SMILES COc1ccc(-c2c-3c(CCc4cnc(Nc5ccc(OCCN6CCCC6)cc5OC)nc-34)nn2C)c(Cl)c1 |(2.91,-5.21,;2.51,-3.73,;3.6,-2.64,;3.2,-1.15,;4.29,-.06,;5.77,-.46,;6.86,.63,;6.54,2.13,;7.88,2.9,;7.88,4.44,;6.54,5.21,;5.21,4.44,;3.88,5.21,;2.54,4.44,;2.54,2.9,;1.21,2.13,;-.13,2.9,;-.13,4.44,;-1.46,5.21,;-2.79,4.44,;-4.13,5.21,;-5.46,4.44,;-5.46,2.9,;-6.79,2.13,;-8.26,2.61,;-9.16,1.36,;-8.26,.12,;-6.79,.59,;-2.79,2.9,;-1.46,2.13,;-1.46,.59,;-.13,-.18,;3.88,2.13,;5.21,2.9,;9.02,1.87,;8.39,.47,;9.16,-.87,;6.17,-1.95,;7.66,-2.35,;5.08,-3.04,)|
Show InChI InChI=1S/C30H33ClN6O3/c1-36-29(22-9-7-20(38-2)16-23(22)31)27-25(35-36)10-6-19-18-32-30(34-28(19)27)33-24-11-8-21(17-26(24)39-3)40-15-14-37-12-4-5-13-37/h7-9,11,16-18H,4-6,10,12-15H2,1-3H3,(H,32,33,34)
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n/an/a 0.5n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122708
PNG
(US8735386, I-178)
Show SMILES CC(=O)N1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(Cc5ccccc5C)c4-c3n2)cn1
Show InChI InChI=1S/C28H32N8O/c1-18-6-4-5-7-20(18)14-25-26-24(33-34(25)3)9-8-21-15-29-28(32-27(21)26)31-22-16-30-36(17-22)23-10-12-35(13-11-23)19(2)37/h4-7,15-17,23H,8-14H2,1-3H3,(H,29,31,32)
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n/an/a 0.5n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122707
PNG
(US8735386, I-177)
Show SMILES CN(C)CCn1ccc(Nc2ncc3CCc4nn(C)c(-c5sccc5Cl)c4-c3n2)n1 |(-8.14,4.59,;-7.37,3.25,;-8.14,1.92,;-5.83,3.25,;-5.06,1.92,;-3.52,1.92,;-2.61,3.16,;-1.15,2.69,;-1.15,1.15,;.18,.38,;1.52,1.15,;1.52,2.69,;2.85,3.46,;4.18,2.69,;5.52,3.46,;6.85,2.69,;6.85,1.15,;8,.12,;7.37,-1.29,;8.14,-2.62,;5.84,-1.13,;4.75,-2.22,;5.23,-3.68,;3.98,-4.59,;2.73,-3.68,;3.21,-2.22,;2.44,-.88,;5.52,.38,;4.18,1.15,;2.85,.38,;-2.61,.67,)|
Show InChI InChI=1S/C21H23ClN8S/c1-28(2)9-10-30-8-6-16(27-30)24-21-23-12-13-4-5-15-17(18(13)25-21)19(29(3)26-15)20-14(22)7-11-31-20/h6-8,11-12H,4-5,9-10H2,1-3H3,(H,23,24,25,27)
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n/an/a 0.5n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122955
PNG
(US8735386, IV-8)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(Cl)c4)c3-c2n1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C31H36ClN7O/c1-20(2)38-12-14-39(15-13-38)24-9-11-25(28(18-24)40-4)34-31-33-19-22-8-10-26-29(30(22)35-31)27(37(3)36-26)17-21-6-5-7-23(32)16-21/h5-7,9,11,16,18-20H,8,10,12-15,17H2,1-4H3,(H,33,34,35)
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n/an/a 0.5n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122859
PNG
(US8735386, III-21)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NC1CCN(CCO)CC1 |(2.02,-2.42,;.69,-1.65,;.69,-.11,;-.64,.66,;-.64,2.2,;.69,2.97,;2.02,2.2,;2.02,.66,;3.36,-.11,;4.69,.66,;4.69,2.2,;6.02,2.97,;7.36,2.2,;8.69,2.97,;10.03,2.2,;10.03,.66,;11.17,-.37,;10.54,-1.78,;11.31,-3.11,;9.01,-1.62,;8.69,-.11,;7.36,.66,;6.02,-.11,;7.92,-2.7,;6.44,-2.31,;5.35,-3.39,;5.75,-4.88,;7.23,-5.28,;8.32,-4.19,;9.81,-4.59,;-1.98,2.97,;-1.98,4.51,;-3.31,2.2,;-4.65,2.97,;-4.65,4.51,;-5.98,5.28,;-7.31,4.51,;-8.65,5.28,;-9.98,4.51,;-11.31,5.28,;-7.31,2.97,;-5.98,2.2,)|
Show InChI InChI=1S/C31H34ClN7O3/c1-38-29(22-5-3-4-6-23(22)32)27-25(37-38)10-8-20-18-33-31(36-28(20)27)35-24-9-7-19(17-26(24)42-2)30(41)34-21-11-13-39(14-12-21)15-16-40/h3-7,9,17-18,21,40H,8,10-16H2,1-2H3,(H,34,41)(H,33,35,36)
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n/an/a 0.540n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122898
PNG
(US8735386, III-60)
Show SMILES CCOc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4)c3-c2n1)C(=O)NC1CN(C)C1
Show InChI InChI=1S/C30H33N7O2/c1-4-39-26-15-20(29(38)32-22-17-36(2)18-22)10-12-23(26)33-30-31-16-21-11-13-24-27(28(21)34-30)25(37(3)35-24)14-19-8-6-5-7-9-19/h5-10,12,15-16,22H,4,11,13-14,17-18H2,1-3H3,(H,32,38)(H,31,33,34)
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n/an/a 0.570n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122710
PNG
(US8735386, I-180)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(-c5sccc5Cl)c4-c3n2)n1 |(-8.14,4.59,;-7.37,3.25,;-5.83,3.25,;-5.06,1.92,;-3.52,1.92,;-2.61,3.16,;-1.15,2.69,;-1.15,1.15,;.18,.38,;1.52,1.15,;1.52,2.69,;2.85,3.46,;4.18,2.69,;5.52,3.46,;6.85,2.69,;6.85,1.15,;8,.12,;7.37,-1.29,;8.14,-2.62,;5.84,-1.13,;4.75,-2.22,;5.23,-3.68,;3.98,-4.59,;2.73,-3.68,;3.21,-2.22,;2.44,-.88,;5.52,.38,;4.18,1.15,;2.85,.38,;-2.61,.67,)|
Show InChI InChI=1S/C20H20ClN7OS/c1-27-18(19-13(21)6-10-30-19)16-14(25-27)4-3-12-11-22-20(24-17(12)16)23-15-5-7-28(26-15)8-9-29-2/h5-7,10-11H,3-4,8-9H2,1-2H3,(H,22,23,24,26)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122712
PNG
(US8735386, I-182)
Show SMILES Cn1nc2CCc3cnc(Nc4ccn(CCN5CCNCC5)n4)nc3-c2c1-c1ccccc1
Show InChI InChI=1S/C25H29N9/c1-32-24(18-5-3-2-4-6-18)22-20(30-32)8-7-19-17-27-25(29-23(19)22)28-21-9-12-34(31-21)16-15-33-13-10-26-11-14-33/h2-6,9,12,17,26H,7-8,10-11,13-16H2,1H3,(H,27,28,29,31)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122696
PNG
(US8735386, I-166)
Show SMILES Cn1nc2CCc3cnc(Nc4ccn(CCN5CCN(CCO)CC5)n4)nc3-c2c1-c1ccccc1
Show InChI InChI=1S/C27H33N9O/c1-33-26(20-5-3-2-4-6-20)24-22(31-33)8-7-21-19-28-27(30-25(21)24)29-23-9-10-36(32-23)16-15-34-11-13-35(14-12-34)17-18-37/h2-6,9-10,19,37H,7-8,11-18H2,1H3,(H,28,29,30,32)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122711
PNG
(US8735386, I-181)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(-c5sccc5Cl)c4-c3n2)n1 |(-6.32,4.82,;-4.83,4.42,;-4.43,2.93,;-5.34,1.69,;-4.43,.44,;-2.97,.92,;-1.64,.15,;-.3,.92,;-.3,2.46,;1.03,3.23,;2.37,2.46,;3.7,3.23,;5.03,2.46,;5.03,.92,;6.18,-.11,;5.55,-1.52,;6.32,-2.85,;4.02,-1.36,;2.93,-2.45,;3.41,-3.91,;2.16,-4.82,;.91,-3.91,;1.39,-2.45,;.62,-1.12,;3.7,.15,;2.37,.92,;1.03,.15,;-2.97,2.46,)|
Show InChI InChI=1S/C19H18ClN7S/c1-3-27-8-6-14(25-27)22-19-21-10-11-4-5-13-15(16(11)23-19)17(26(2)24-13)18-12(20)7-9-28-18/h6-10H,3-5H2,1-2H3,(H,21,22,23,25)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122697
PNG
(US8735386, I-167)
Show SMILES COCCN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(c5-c4n3)-c3ccccc3)n2)CC1
Show InChI InChI=1S/C28H35N9O/c1-34-27(21-6-4-3-5-7-21)25-23(32-34)9-8-22-20-29-28(31-26(22)25)30-24-10-11-37(33-24)17-16-35-12-14-36(15-13-35)18-19-38-2/h3-7,10-11,20H,8-9,12-19H2,1-2H3,(H,29,30,31,33)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122709
PNG
(US8735386, I-179)
Show SMILES CC(=O)N1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(-c5sccc5C)c4-c3n2)cn1 |(-9.3,1.15,;-8.53,2.48,;-9.3,3.82,;-6.99,2.48,;-6.22,3.82,;-4.68,3.82,;-3.91,2.48,;-4.68,1.15,;-6.22,1.15,;-2.37,2.48,;-1.46,1.24,;0,1.71,;1.34,.94,;2.67,1.71,;2.67,3.25,;4.01,4.02,;5.34,3.25,;6.67,4.02,;8.01,3.25,;8.01,1.71,;9.15,.68,;8.53,-.72,;9.3,-2.06,;6.99,-.56,;5.9,-1.65,;6.38,-3.12,;5.13,-4.02,;3.89,-3.12,;4.36,-1.65,;3.59,-.32,;6.67,.94,;5.34,1.71,;4.01,.94,;0,3.25,;-1.46,3.73,)|
Show InChI InChI=1S/C25H28N8OS/c1-15-8-11-35-24(15)23-21-20(30-31(23)3)5-4-17-12-26-25(29-22(17)21)28-18-13-27-33(14-18)19-6-9-32(10-7-19)16(2)34/h8,11-14,19H,4-7,9-10H2,1-3H3,(H,26,28,29)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122948
PNG
(US8735386, IV-1)
Show SMILES CCOc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4)c3-c2n1)N1CCNCC1
Show InChI InChI=1S/C29H33N7O/c1-3-37-26-18-22(36-15-13-30-14-16-36)10-12-23(26)32-29-31-19-21-9-11-24-27(28(21)33-29)25(35(2)34-24)17-20-7-5-4-6-8-20/h4-8,10,12,18-19,30H,3,9,11,13-17H2,1-2H3,(H,31,32,33)
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n/an/a 0.630n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122578
PNG
(US8735386, I-48)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c([C@@H](C)c4ccccc4)c3-c2n1)N1CCN(C)CC1 |r|
Show InChI InChI=1S/C30H35N7O/c1-20(21-8-6-5-7-9-21)29-27-25(34-36(29)3)12-10-22-19-31-30(33-28(22)27)32-24-13-11-23(18-26(24)38-4)37-16-14-35(2)15-17-37/h5-9,11,13,18-20H,10,12,14-17H2,1-4H3,(H,31,32,33)/t20-/m0/s1
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n/an/a 0.690n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122713
PNG
(US8735386, I-183)
Show SMILES COCCn1cc(Nc2ncc3CCc4nn(C)c(-c5sccc5Cl)c4-c3n2)cn1 |(-8.14,4.59,;-7.37,3.25,;-5.83,3.25,;-5.06,1.92,;-3.52,1.92,;-2.61,.67,;-1.15,1.15,;.18,.38,;1.52,1.15,;1.52,2.69,;2.85,3.46,;4.18,2.69,;5.52,3.46,;6.85,2.69,;6.85,1.15,;8,.12,;7.37,-1.29,;8.14,-2.62,;5.84,-1.13,;4.75,-2.22,;5.23,-3.68,;3.98,-4.59,;2.73,-3.68,;3.21,-2.22,;2.44,-.88,;5.52,.38,;4.18,1.15,;2.85,.38,;-1.15,2.69,;-2.61,3.16,)|
Show InChI InChI=1S/C20H20ClN7OS/c1-27-18(19-14(21)5-8-30-19)16-15(26-27)4-3-12-9-22-20(25-17(12)16)24-13-10-23-28(11-13)6-7-29-2/h5,8-11H,3-4,6-7H2,1-2H3,(H,22,24,25)
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n/an/a 0.700n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122857
PNG
(US8735386, III-19)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NCCCN(C)C |(.69,-2.03,;-.64,-1.26,;-.64,.28,;-1.98,1.05,;-1.98,2.59,;-.64,3.36,;.69,2.59,;.69,1.05,;2.02,.28,;3.36,1.05,;3.36,2.59,;4.69,3.36,;6.02,2.59,;7.36,3.36,;8.69,2.59,;8.69,1.05,;9.84,.02,;9.21,-1.39,;9.98,-2.73,;7.68,-1.23,;7.36,.28,;6.02,1.05,;4.69,.28,;6.59,-2.32,;5.1,-1.92,;4.01,-3.01,;4.41,-4.5,;5.9,-4.9,;6.99,-3.81,;8.48,-4.21,;-3.31,3.36,;-3.31,4.9,;-4.65,2.59,;-5.98,3.36,;-7.31,2.59,;-7.31,1.05,;-8.65,.28,;-8.65,-1.26,;-9.98,1.05,)|
Show InChI InChI=1S/C29H32ClN7O2/c1-36(2)15-7-14-31-28(38)18-10-12-22(24(16-18)39-4)33-29-32-17-19-11-13-23-25(26(19)34-29)27(37(3)35-23)20-8-5-6-9-21(20)30/h5-6,8-10,12,16-17H,7,11,13-15H2,1-4H3,(H,31,38)(H,32,33,34)
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n/an/a 0.75n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122626
PNG
(US8735386, I-96)
Show SMILES COc1cc(OCCN2CCCC2)ccc1Nc1ncc2C(C)Cc3nn(C)c(c3-c2n1)-c1ccccc1Cl |(-.13,-2.03,;-1.46,-1.26,;-1.46,.28,;-2.79,1.05,;-2.79,2.59,;-4.13,3.36,;-5.46,2.59,;-5.46,1.05,;-6.79,.28,;-8.26,.75,;-9.16,-.49,;-8.26,-1.74,;-6.79,-1.26,;-1.46,3.36,;-.13,2.59,;-.13,1.05,;1.21,.28,;2.54,1.05,;2.54,2.59,;3.88,3.36,;5.21,2.59,;6.54,3.36,;6.54,4.9,;7.88,2.59,;7.88,1.05,;9.02,.02,;8.39,-1.39,;9.16,-2.73,;6.86,-1.23,;6.54,.28,;5.21,1.05,;3.88,.28,;5.77,-2.32,;4.29,-1.92,;3.2,-3.01,;3.6,-4.5,;5.08,-4.9,;6.17,-3.81,;7.66,-4.21,)|
Show InChI InChI=1S/C30H33ClN6O2/c1-19-16-25-27(29(36(2)35-25)21-8-4-5-9-23(21)31)28-22(19)18-32-30(34-28)33-24-11-10-20(17-26(24)38-3)39-15-14-37-12-6-7-13-37/h4-5,8-11,17-19H,6-7,12-16H2,1-3H3,(H,32,33,34)
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n/an/a 0.800n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122924
PNG
(US8735386, III-86)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NC1CN(C)C1 |(.3,-2.19,;-1.03,-1.42,;-1.03,.12,;-2.37,.89,;-2.37,2.43,;-1.03,3.2,;.3,2.43,;.3,.89,;1.63,.12,;2.97,.89,;2.97,2.43,;4.3,3.2,;5.63,2.43,;6.97,3.2,;8.3,2.43,;8.3,.89,;9.45,-.14,;8.82,-1.55,;9.59,-2.88,;7.29,-1.39,;6.97,.12,;5.63,.89,;4.3,.12,;6.2,-2.48,;4.71,-2.08,;3.62,-3.17,;4.02,-4.66,;5.51,-5.06,;6.6,-3.97,;8.08,-4.37,;-3.7,3.2,;-3.7,4.74,;-5.04,2.43,;-6.37,3.2,;-6.77,4.68,;-8.26,4.29,;-9.59,5.06,;-7.86,2.8,)|
Show InChI InChI=1S/C28H28ClN7O2/c1-35-14-18(15-35)31-27(37)16-8-10-21(23(12-16)38-3)32-28-30-13-17-9-11-22-24(25(17)33-28)26(36(2)34-22)19-6-4-5-7-20(19)29/h4-8,10,12-13,18H,9,11,14-15H2,1-3H3,(H,31,37)(H,30,32,33)
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n/an/a 0.870n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122642
PNG
(US8735386, I-112)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NC1CCN(C)CC1 |(.69,-2.42,;-.64,-1.65,;-.64,-.11,;-1.98,.66,;-1.98,2.2,;-.64,2.97,;.69,2.2,;.69,.66,;2.02,-.11,;3.36,.66,;3.36,2.2,;4.69,2.97,;6.02,2.2,;7.36,2.97,;8.69,2.2,;8.69,.66,;9.84,-.37,;9.21,-1.78,;9.98,-3.11,;7.68,-1.62,;7.36,-.11,;6.02,.66,;4.69,-.11,;6.59,-2.7,;5.1,-2.31,;4.01,-3.39,;4.41,-4.88,;5.9,-5.28,;6.99,-4.19,;8.48,-4.59,;-3.31,2.97,;-3.31,4.51,;-4.65,2.2,;-5.98,2.97,;-5.98,4.51,;-7.31,5.28,;-8.65,4.51,;-9.98,5.28,;-8.65,2.97,;-7.31,2.2,)|
Show InChI InChI=1S/C30H32ClN7O2/c1-37-14-12-20(13-15-37)33-29(39)18-8-10-23(25(16-18)40-3)34-30-32-17-19-9-11-24-26(27(19)35-30)28(38(2)36-24)21-6-4-5-7-22(21)31/h4-8,10,16-17,20H,9,11-15H2,1-3H3,(H,33,39)(H,32,34,35)
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n/an/a 0.870n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122608
PNG
(US8735386, I-78)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1C)N1CCN(C)CC1 |(-3.31,-2.42,;-1.98,-1.65,;-1.98,-.11,;-3.31,.66,;-3.31,2.2,;-1.98,2.97,;-.64,2.2,;-.64,.66,;.69,-.11,;2.02,.66,;2.02,2.2,;3.36,2.97,;4.69,2.2,;6.02,2.97,;7.36,2.2,;7.36,.66,;8.5,-.37,;7.88,-1.78,;8.65,-3.11,;6.34,-1.62,;6.02,-.11,;4.69,.66,;3.36,-.11,;5.26,-2.7,;3.77,-2.31,;2.68,-3.39,;3.08,-4.88,;4.57,-5.28,;5.65,-4.19,;7.14,-4.59,;-4.65,2.97,;-4.65,4.51,;-5.98,5.28,;-7.31,4.51,;-8.65,5.28,;-7.31,2.97,;-5.98,2.2,)|
Show InChI InChI=1S/C29H33N7O/c1-19-7-5-6-8-22(19)28-26-24(33-35(28)3)11-9-20-18-30-29(32-27(20)26)31-23-12-10-21(17-25(23)37-4)36-15-13-34(2)14-16-36/h5-8,10,12,17-18H,9,11,13-16H2,1-4H3,(H,30,31,32)
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n/an/a 0.920n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122885
PNG
(US8735386, III-47)
Show SMILES COc1cc(ccc1Nc1ncc2C(C)Cc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NC1CCN(CC1)C1CCOCC1 |(2.02,-3.57,;.69,-2.8,;.69,-1.26,;-.64,-.49,;-.64,1.05,;.69,1.82,;2.02,1.05,;2.02,-.49,;3.36,-1.26,;4.69,-.49,;4.69,1.05,;6.02,1.82,;7.36,1.05,;8.69,1.82,;8.69,3.36,;10.03,1.05,;10.03,-.49,;11.17,-1.52,;10.54,-2.93,;11.31,-4.27,;9.01,-2.77,;8.69,-1.26,;7.36,-.49,;6.02,-1.26,;7.92,-3.86,;6.44,-3.46,;5.35,-4.55,;5.75,-6.04,;7.23,-6.44,;8.32,-5.35,;9.81,-5.75,;-1.98,1.82,;-1.98,3.36,;-3.31,1.05,;-4.65,1.82,;-4.65,3.36,;-5.98,4.13,;-7.31,3.36,;-7.31,1.82,;-5.98,1.05,;-8.65,4.13,;-8.65,5.67,;-9.98,6.44,;-11.31,5.67,;-11.31,4.13,;-9.98,3.36,)|
Show InChI InChI=1S/C35H40ClN7O3/c1-21-18-29-31(33(42(2)41-29)25-6-4-5-7-27(25)36)32-26(21)20-37-35(40-32)39-28-9-8-22(19-30(28)45-3)34(44)38-23-10-14-43(15-11-23)24-12-16-46-17-13-24/h4-9,19-21,23-24H,10-18H2,1-3H3,(H,38,44)(H,37,39,40)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122593
PNG
(US8735386, I-63)
Show SMILES COc1ccccc1Cc1c-2c(CCc3cnc(Nc4ccc(OCCN5CCCC5)cc4OC)nc-23)nn1C
Show InChI InChI=1S/C31H36N6O3/c1-36-26(18-21-8-4-5-9-27(21)38-2)29-25(35-36)12-10-22-20-32-31(34-30(22)29)33-24-13-11-23(19-28(24)39-3)40-17-16-37-14-6-7-15-37/h4-5,8-9,11,13,19-20H,6-7,10,12,14-18H2,1-3H3,(H,32,33,34)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122878
PNG
(US8735386, III-40)
Show SMILES COc1cc(ccc1Nc1ncc2C(C)Cc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NC1CCN(CC1)C(C)(C)C |(1.36,-3.09,;.02,-2.32,;.02,-.78,;-1.31,-.01,;-1.31,1.53,;.02,2.3,;1.36,1.53,;1.36,-.01,;2.69,-.78,;4.02,-.01,;4.02,1.53,;5.36,2.3,;6.69,1.53,;8.02,2.3,;8.02,3.84,;9.36,1.53,;9.36,-.01,;10.5,-1.04,;9.88,-2.44,;10.65,-3.78,;8.35,-2.28,;8.02,-.78,;6.69,-.01,;5.36,-.78,;7.26,-3.37,;5.77,-2.97,;4.68,-4.06,;5.08,-5.55,;6.57,-5.95,;7.65,-4.86,;9.14,-5.26,;-2.64,2.3,;-2.64,3.84,;-3.98,1.53,;-5.31,2.3,;-5.31,3.84,;-6.65,4.61,;-7.98,3.84,;-7.98,2.3,;-6.65,1.53,;-9.31,4.61,;-10.65,5.38,;-8.54,5.95,;-10.08,3.28,)|
Show InChI InChI=1S/C34H40ClN7O2/c1-20-17-27-29(31(41(5)40-27)23-9-7-8-10-25(23)35)30-24(20)19-36-33(39-30)38-26-12-11-21(18-28(26)44-6)32(43)37-22-13-15-42(16-14-22)34(2,3)4/h7-12,18-20,22H,13-17H2,1-6H3,(H,37,43)(H,36,38,39)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122881
PNG
(US8735386, III-43)
Show SMILES COCCN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3C(C)Cc4nn(C)c(c4-c3n2)-c2ccccc2Cl)c(OC)c1 |(-11.31,2.2,;-9.98,2.97,;-9.98,4.51,;-8.65,5.28,;-7.31,4.51,;-5.98,5.28,;-4.65,4.51,;-4.65,2.97,;-5.98,2.2,;-7.31,2.97,;-3.31,2.2,;-1.98,2.97,;-1.98,4.51,;-.64,2.2,;.69,2.97,;2.02,2.2,;2.02,.66,;3.36,-.11,;4.69,.66,;4.69,2.2,;6.02,2.97,;7.36,2.2,;8.69,2.97,;8.69,4.51,;10.03,2.2,;10.03,.66,;11.17,-.37,;10.54,-1.78,;11.31,-3.11,;9.01,-1.62,;8.69,-.11,;7.36,.66,;6.02,-.11,;7.92,-2.7,;6.44,-2.31,;5.35,-3.39,;5.75,-4.88,;7.23,-5.28,;8.32,-4.19,;9.81,-4.59,;.69,-.11,;.69,-1.65,;2.02,-2.42,;-.64,.66,)|
Show InChI InChI=1S/C33H38ClN7O3/c1-20-17-27-29(31(40(2)39-27)23-7-5-6-8-25(23)34)30-24(20)19-35-33(38-30)37-26-10-9-21(18-28(26)44-4)32(42)36-22-11-13-41(14-12-22)15-16-43-3/h5-10,18-20,22H,11-17H2,1-4H3,(H,36,42)(H,35,37,38)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122606
PNG
(US8735386, I-76)
Show SMILES COc1cc(OCCN2CCCC2)ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1C |(-2.79,-1.26,;-1.46,-.49,;-1.46,1.05,;-2.79,1.82,;-2.79,3.36,;-4.13,4.13,;-5.46,3.36,;-5.46,1.82,;-6.79,1.05,;-8.26,1.52,;-9.16,.28,;-8.26,-.97,;-6.79,-.49,;-1.46,4.13,;-.13,3.36,;-.13,1.82,;1.21,1.05,;2.54,1.82,;2.54,3.36,;3.88,4.13,;5.21,3.36,;6.54,4.13,;7.88,3.36,;7.88,1.82,;9.02,.79,;8.39,-.62,;9.16,-1.96,;6.86,-.46,;6.54,1.05,;5.21,1.82,;3.88,1.05,;5.77,-1.55,;4.29,-1.15,;3.2,-2.24,;3.6,-3.73,;5.08,-4.13,;6.17,-3.04,;7.66,-3.44,)|
Show InChI InChI=1S/C30H34N6O2/c1-20-8-4-5-9-23(20)29-27-25(34-35(29)2)12-10-21-19-31-30(33-28(21)27)32-24-13-11-22(18-26(24)37-3)38-17-16-36-14-6-7-15-36/h4-5,8-9,11,13,18-19H,6-7,10,12,14-17H2,1-3H3,(H,31,32,33)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122953
PNG
(US8735386, IV-6)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(Cl)c4)c3-c2n1)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C33H38ClN7O2/c1-39-29(19-22-4-3-5-24(34)18-22)31-28(38-39)8-6-23-21-35-33(37-32(23)31)36-27-9-7-26(20-30(27)42-2)41-14-12-40(13-15-41)25-10-16-43-17-11-25/h3-5,7,9,18,20-21,25H,6,8,10-17,19H2,1-2H3,(H,35,36,37)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122687
PNG
(US8735386, I-157)
Show SMILES COc1cc(ccc1Nc1ncc2C(C)Cc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NC1CCN(C)CC1 |(-2.64,-3.57,;-1.31,-2.8,;-1.31,-1.26,;-2.64,-.49,;-2.64,1.05,;-1.31,1.82,;.02,1.05,;.02,-.49,;1.36,-1.26,;2.69,-.49,;2.69,1.05,;4.02,1.82,;5.36,1.05,;6.69,1.82,;6.69,3.36,;8.02,1.05,;8.02,-.49,;9.17,-1.52,;8.54,-2.93,;9.31,-4.27,;7.01,-2.77,;6.69,-1.26,;5.36,-.49,;4.02,-1.26,;5.92,-3.86,;4.43,-3.46,;3.35,-4.55,;3.74,-6.04,;5.23,-6.44,;6.32,-5.35,;7.81,-5.75,;-3.98,1.82,;-5.31,1.05,;-3.98,3.36,;-5.31,4.13,;-5.31,5.67,;-6.65,6.44,;-7.98,5.67,;-9.31,6.44,;-7.98,4.13,;-6.65,3.36,)|
Show InChI InChI=1S/C31H34ClN7O2/c1-18-15-25-27(29(39(3)37-25)21-7-5-6-8-23(21)32)28-22(18)17-33-31(36-28)35-24-10-9-19(16-26(24)41-4)30(40)34-20-11-13-38(2)14-12-20/h5-10,16-18,20H,11-15H2,1-4H3,(H,34,40)(H,33,35,36)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122858
PNG
(US8735386, III-20)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NC1CCN(CC1)C1CCOCC1 |(2.02,-3.57,;.69,-2.8,;.69,-1.26,;-.64,-.49,;-.64,1.05,;.69,1.82,;2.02,1.05,;2.02,-.49,;3.36,-1.26,;4.69,-.49,;4.69,1.05,;6.02,1.82,;7.36,1.05,;8.69,1.82,;10.03,1.05,;10.03,-.49,;11.17,-1.52,;10.54,-2.93,;11.31,-4.27,;9.01,-2.77,;8.69,-1.26,;7.36,-.49,;6.02,-1.26,;7.92,-3.86,;6.44,-3.46,;5.35,-4.55,;5.75,-6.04,;7.23,-6.44,;8.32,-5.35,;9.81,-5.75,;-1.98,1.82,;-1.98,3.36,;-3.31,1.05,;-4.65,1.82,;-4.65,3.36,;-5.98,4.13,;-7.31,3.36,;-7.31,1.82,;-5.98,1.05,;-8.65,4.13,;-8.65,5.67,;-9.98,6.44,;-11.31,5.67,;-11.31,4.13,;-9.98,3.36,)|
Show InChI InChI=1S/C34H38ClN7O3/c1-41-32(25-5-3-4-6-26(25)35)30-28(40-41)10-8-22-20-36-34(39-31(22)30)38-27-9-7-21(19-29(27)44-2)33(43)37-23-11-15-42(16-12-23)24-13-17-45-18-14-24/h3-7,9,19-20,23-24H,8,10-18H2,1-2H3,(H,37,43)(H,36,38,39)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122921
PNG
(US8735386, III-83)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NCCN(C)C |(.69,-2.03,;-.64,-1.26,;-.64,.28,;-1.98,1.05,;-1.98,2.59,;-.64,3.36,;.69,2.59,;.69,1.05,;2.02,.28,;3.36,1.05,;3.36,2.59,;4.69,3.36,;6.02,2.59,;7.36,3.36,;8.69,2.59,;8.69,1.05,;9.84,.02,;9.21,-1.39,;9.98,-2.73,;7.68,-1.23,;7.36,.28,;6.02,1.05,;4.69,.28,;6.59,-2.32,;5.1,-1.92,;4.01,-3.01,;4.41,-4.5,;5.9,-4.9,;6.99,-3.81,;8.48,-4.21,;-3.31,3.36,;-3.31,4.9,;-4.65,2.59,;-5.98,3.36,;-7.31,2.59,;-8.65,3.36,;-9.98,2.59,;-8.65,4.9,)|
Show InChI InChI=1S/C28H30ClN7O2/c1-35(2)14-13-30-27(37)17-9-11-21(23(15-17)38-4)32-28-31-16-18-10-12-22-24(25(18)33-28)26(36(3)34-22)19-7-5-6-8-20(19)29/h5-9,11,15-16H,10,12-14H2,1-4H3,(H,30,37)(H,31,32,33)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122957
PNG
(US8735386, IV-9a)
Show SMILES CC1Cc2nn(C)c(Cc3ccccc3Cl)c2-c2nc(Nc3cnn(c3)C3CCN(CC3)C3CCOCC3)ncc12
Show InChI InChI=1S/C31H37ClN8O/c1-20-15-27-29(28(38(2)37-27)16-21-5-3-4-6-26(21)32)30-25(20)18-33-31(36-30)35-22-17-34-40(19-22)24-7-11-39(12-8-24)23-9-13-41-14-10-23/h3-6,17-20,23-24H,7-16H2,1-2H3,(H,33,35,36)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122623
PNG
(US8735386, I-93)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(C)cc1C)N1CCN(C)CC1 |(-.64,-2.07,;-1.98,-1.3,;-1.98,.24,;-3.31,1.01,;-3.31,2.55,;-1.98,3.32,;-.64,2.55,;-.64,1.01,;.69,.24,;2.02,1.01,;2.02,2.55,;3.36,3.32,;4.69,2.55,;6.02,3.32,;7.36,2.55,;7.36,1.01,;8.5,-.02,;7.88,-1.43,;8.65,-2.76,;6.34,-1.27,;6.02,.24,;4.69,1.01,;3.36,.24,;5.26,-2.36,;3.77,-1.96,;2.68,-3.05,;3.08,-4.54,;1.99,-5.63,;4.57,-4.94,;5.65,-3.85,;7.14,-4.25,;-4.65,3.32,;-4.65,4.86,;-5.98,5.63,;-7.31,4.86,;-8.65,5.63,;-7.31,3.32,;-5.98,2.55,)|
Show InChI InChI=1S/C30H35N7O/c1-19-6-9-23(20(2)16-19)29-27-25(34-36(29)4)10-7-21-18-31-30(33-28(21)27)32-24-11-8-22(17-26(24)38-5)37-14-12-35(3)13-15-37/h6,8-9,11,16-18H,7,10,12-15H2,1-5H3,(H,31,32,33)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM122676
PNG
(US8735386, I-146)
Show SMILES COc1cc(OCCN2CCCC2)ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1cccc(C)c1Cl |(-.13,-.52,;-1.46,.25,;-1.46,1.79,;-2.79,2.56,;-2.79,4.1,;-4.13,4.87,;-5.46,4.1,;-5.46,2.56,;-6.79,1.79,;-8.26,2.27,;-9.16,1.02,;-8.26,-.23,;-6.79,.25,;-1.46,4.87,;-.13,4.1,;-.13,2.56,;1.21,1.79,;2.54,2.56,;2.54,4.1,;3.88,4.87,;5.21,4.1,;6.54,4.87,;7.88,4.1,;7.88,2.56,;9.02,1.53,;8.39,.12,;9.16,-1.21,;6.86,.28,;6.54,1.79,;5.21,2.56,;3.88,1.79,;5.77,-.81,;4.29,-.41,;3.2,-1.5,;3.6,-2.98,;5.08,-3.38,;5.48,-4.87,;6.17,-2.29,;7.66,-2.69,)|
Show InChI InChI=1S/C30H33ClN6O2/c1-19-7-6-8-22(27(19)31)29-26-24(35-36(29)2)11-9-20-18-32-30(34-28(20)26)33-23-12-10-21(17-25(23)38-3)39-16-15-37-13-4-5-14-37/h6-8,10,12,17-18H,4-5,9,11,13-16H2,1-3H3,(H,32,33,34)
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US Patent
n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...

US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%