Found 266 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124548
(US8759532, 226)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@@H]2CCC(=O)C2)cc1 |r| Show InChI InChI=1S/C24H19N3O3/c28-17-10-7-16(14-17)19-4-3-13-25-24(19)30-18-11-8-15(9-12-18)22(29)23-26-20-5-1-2-6-21(20)27-23/h1-6,8-9,11-13,16H,7,10,14H2,(H,26,27)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.0210 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124500
(US8759532, 176 | US8759532, 223)Show SMILES CC(=O)N1CCC[C@@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-15-5-6-19(16-30)21-7-4-14-27-26(21)33-20-12-10-18(11-13-20)24(32)25-28-22-8-2-3-9-23(22)29-25/h2-4,7-14,19H,5-6,15-16H2,1H3,(H,28,29)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124523
(US8759532, 201)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2C2CCC(=O)CC2)cc1 Show InChI InChI=1S/C25H21N3O3/c29-18-11-7-16(8-12-18)20-4-3-15-26-25(20)31-19-13-9-17(10-14-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-10,13-16H,7-8,11-12H2,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.0285 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124500
(US8759532, 176 | US8759532, 223)Show SMILES CC(=O)N1CCC[C@@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-15-5-6-19(16-30)21-7-4-14-27-26(21)33-20-12-10-18(11-13-20)24(32)25-28-22-8-2-3-9-23(22)29-25/h2-4,7-14,19H,5-6,15-16H2,1H3,(H,28,29)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.0503 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124551
(US8759532, 230)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@@H]2CCCOCC2)cc1 |r| Show InChI InChI=1S/C25H23N3O3/c29-23(24-27-21-7-1-2-8-22(21)28-24)18-9-11-19(12-10-18)31-25-20(6-3-14-26-25)17-5-4-15-30-16-13-17/h1-3,6-12,14,17H,4-5,13,15-16H2,(H,27,28)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.0505 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124550
(US8759532, 228)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@H]2CCNC(=O)CC2)cc1 |r| Show InChI InChI=1S/C25H22N4O3/c30-22-12-9-16(13-15-26-22)19-4-3-14-27-25(19)32-18-10-7-17(8-11-18)23(31)24-28-20-5-1-2-6-21(20)29-24/h1-8,10-11,14,16H,9,12-13,15H2,(H,26,30)(H,28,29)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.0595 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124522
(US8759532, 199)Show SMILES CC(=O)N1CCCC[C@@H]1c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-16-5-4-10-23(30)20-7-6-15-27-26(20)33-19-13-11-18(12-14-19)24(32)25-28-21-8-2-3-9-22(21)29-25/h2-3,6-9,11-15,23H,4-5,10,16H2,1H3,(H,28,29)/t23-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0645 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124596
(US8759532, 280)Show SMILES COc1ccncc1-c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C25H18N4O3/c1-31-22-12-14-26-15-19(22)18-5-4-13-27-25(18)32-17-10-8-16(9-11-17)23(30)24-28-20-6-2-3-7-21(20)29-24/h2-15H,1H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.0725 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124465
(US8759532, 132 | US8759532, 208)Show SMILES CN1C[C@@H](CC1=O)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C24H20N4O3/c1-28-14-16(13-21(28)29)18-5-4-12-25-24(18)31-17-10-8-15(9-11-17)22(30)23-26-19-6-2-3-7-20(19)27-23/h2-12,16H,13-14H2,1H3,(H,26,27)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.0748 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124559
(US8759532, 240)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2C2CCCC(=O)CC2)cc1 Show InChI InChI=1S/C26H23N3O3/c30-19-6-3-5-17(10-13-19)21-7-4-16-27-26(21)32-20-14-11-18(12-15-20)24(31)25-28-22-8-1-2-9-23(22)29-25/h1-2,4,7-9,11-12,14-17H,3,5-6,10,13H2,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.0770 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124578
(US8759532, 262)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@H]2CCC(=O)C2)cc1 |r| Show InChI InChI=1S/C24H19N3O3/c28-17-10-7-16(14-17)19-4-3-13-25-24(19)30-18-11-8-15(9-12-18)22(29)23-26-20-5-1-2-6-21(20)27-23/h1-6,8-9,11-13,16H,7,10,14H2,(H,26,27)/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.0957 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124518
(US8759532, 195)Show SMILES O[C@H]1CC[C@@H](CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r,wU:4.7,wD:1.0,(-6.37,5.39,;-6.37,3.85,;-7.71,3.08,;-7.71,1.54,;-6.37,.77,;-5.04,1.54,;-5.04,3.08,;-6.37,-.77,;-7.71,-1.54,;-7.71,-3.08,;-6.37,-3.85,;-5.04,-3.08,;-5.04,-1.54,;-3.71,-.77,;-2.37,-1.54,;-2.37,-3.08,;-1.04,-3.85,;.29,-3.08,;.29,-1.54,;-1.04,-.77,;1.63,-3.85,;1.63,-5.39,;2.96,-3.08,;3.12,-1.55,;4.63,-1.23,;5.4,.11,;6.94,.11,;7.71,-1.23,;6.94,-2.56,;5.4,-2.56,;4.37,-3.71,)| Show InChI InChI=1S/C25H23N3O3/c29-18-11-7-16(8-12-18)20-4-3-15-26-25(20)31-19-13-9-17(10-14-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-10,13-16,18,29H,7-8,11-12H2,(H,27,28)/t16-,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.101 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124593
(US8759532, 277)Show SMILES COc1cnccc1-c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2n1C Show InChI InChI=1S/C26H20N4O3/c1-30-22-8-4-3-7-21(22)29-25(30)24(31)17-9-11-18(12-10-17)33-26-20(6-5-14-28-26)19-13-15-27-16-23(19)32-2/h3-16H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.121 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124521
(US8759532, 198)Show SMILES O=C1CCC(CC1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C24H21N3O2S/c28-18-11-7-16(8-12-18)20-4-3-15-25-23(20)29-19-13-9-17(10-14-19)26-24-27-21-5-1-2-6-22(21)30-24/h1-6,9-10,13-16H,7-8,11-12H2,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.123 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124476
(US8759532, 146)Show SMILES C[C@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C29H23FN4O3/c1-18(17-19-8-12-21(30)13-9-19)32-28(36)23-5-4-16-31-29(23)37-22-14-10-20(11-15-22)26(35)27-33-24-6-2-3-7-25(24)34-27/h2-16,18H,17H2,1H3,(H,32,36)(H,33,34)/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.135 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124562
(US8759532, 243 | US8759532, 250)Show SMILES O[C@@H]1CCC[C@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C25H23N3O3/c29-18-6-3-5-17(15-18)20-7-4-14-26-25(20)31-19-12-10-16(11-13-19)23(30)24-27-21-8-1-2-9-22(21)28-24/h1-2,4,7-14,17-18,29H,3,5-6,15H2,(H,27,28)/t17-,18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.145 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124447
(US8759532, 103)Show SMILES CC(=O)N1CCC(CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-15-12-18(13-16-30)21-5-4-14-27-26(21)33-20-10-8-19(9-11-20)24(32)25-28-22-6-2-3-7-23(22)29-25/h2-11,14,18H,12-13,15-16H2,1H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.158 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124583
(US8759532, 267)Show SMILES Fc1ncccc1-c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C24H15FN4O2/c25-22-17(5-3-13-26-22)18-6-4-14-27-24(18)31-16-11-9-15(10-12-16)21(30)23-28-19-7-1-2-8-20(19)29-23/h1-14H,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.162 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124463
(US8759532, 130)Show SMILES O[C@@H]1CC[C@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C24H21N3O3/c28-17-10-7-16(14-17)19-4-3-13-25-24(19)30-18-11-8-15(9-12-18)22(29)23-26-20-5-1-2-6-21(20)27-23/h1-6,8-9,11-13,16-17,28H,7,10,14H2,(H,26,27)/t16-,17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.167 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124412
(US8759532, 65)Show SMILES O=C(NC1(Cc2ccccc2)CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C30H24N4O3/c35-26(27-32-24-10-4-5-11-25(24)33-27)21-12-14-22(15-13-21)37-29-23(9-6-18-31-29)28(36)34-30(16-17-30)19-20-7-2-1-3-8-20/h1-15,18H,16-17,19H2,(H,32,33)(H,34,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.168 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124600
(US8759532, 284)Show SMILES O=C1CC[C@H](C1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 |r| Show InChI InChI=1S/C23H19N3O2S/c27-17-10-7-15(14-17)19-4-3-13-24-22(19)28-18-11-8-16(9-12-18)25-23-26-20-5-1-2-6-21(20)29-23/h1-6,8-9,11-13,15H,7,10,14H2,(H,25,26)/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.169 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124444
(US8759532, 99)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2C2CCOCC2)cc1 Show InChI InChI=1S/C24H21N3O3/c28-22(23-26-20-5-1-2-6-21(20)27-23)17-7-9-18(10-8-17)30-24-19(4-3-13-25-24)16-11-14-29-15-12-16/h1-10,13,16H,11-12,14-15H2,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| PDB
US Patent
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124458
(US8759532, 124)Show SMILES CC(=O)N1CCC(CC1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C25H24N4O2S/c1-17(30)29-15-12-18(13-16-29)21-5-4-14-26-24(21)31-20-10-8-19(9-11-20)27-25-28-22-6-2-3-7-23(22)32-25/h2-11,14,18H,12-13,15-16H2,1H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.175 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124394
(US8759532, 46)Show SMILES Cc1ccc(cn1)-c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C25H18N4O2/c1-16-8-9-18(15-27-16)20-5-4-14-26-25(20)31-19-12-10-17(11-13-19)23(30)24-28-21-6-2-3-7-22(21)29-24/h2-15H,1H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.177 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124432
(US8759532, 85)Show SMILES N(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2-c2cccnc2)cc1 Show InChI InChI=1S/C23H17N5O/c1-2-8-21-20(7-1)27-23(28-21)26-17-9-11-18(12-10-17)29-22-19(6-4-14-25-22)16-5-3-13-24-15-16/h1-15H,(H2,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.179 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124435
(US8759532, 88)Show SMILES CC(=O)N1CCC(=CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |c:6| Show InChI InChI=1S/C26H22N4O3/c1-17(31)30-15-12-18(13-16-30)21-5-4-14-27-26(21)33-20-10-8-19(9-11-20)24(32)25-28-22-6-2-3-7-23(22)29-25/h2-12,14H,13,15-16H2,1H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.194 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124466
(US8759532, 134)Show SMILES CN1C[C@H](CC1=O)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 |r| Show InChI InChI=1S/C23H20N4O2S/c1-27-14-15(13-21(27)28)18-5-4-12-24-22(18)29-17-10-8-16(9-11-17)25-23-26-19-6-2-3-7-20(19)30-23/h2-12,15H,13-14H2,1H3,(H,25,26)/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.195 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124541
(US8759532, 219)Show SMILES OC[C@H]1CC[C@@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C25H23N3O3/c29-15-16-7-8-18(14-16)20-4-3-13-26-25(20)31-19-11-9-17(10-12-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-13,16,18,29H,7-8,14-15H2,(H,27,28)/t16-,18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.199 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124465
(US8759532, 132 | US8759532, 208)Show SMILES CN1C[C@@H](CC1=O)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C24H20N4O3/c1-28-14-16(13-21(28)29)18-5-4-12-25-24(18)31-17-10-8-15(9-11-17)22(30)23-26-19-6-2-3-7-20(19)27-23/h2-12,16H,13-14H2,1H3,(H,26,27)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.207 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124542
(US8759532, 220)Show SMILES OC[C@@H]1CC[C@@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C25H23N3O3/c29-15-16-7-8-18(14-16)20-4-3-13-26-25(20)31-19-11-9-17(10-12-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-13,16,18,29H,7-8,14-15H2,(H,27,28)/t16-,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.212 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124494
(US8759532, 168)Show SMILES CC(=O)N1CCCC(=C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |c:7| Show InChI InChI=1S/C26H22N4O3/c1-17(31)30-15-5-6-19(16-30)21-7-4-14-27-26(21)33-20-12-10-18(11-13-20)24(32)25-28-22-8-2-3-9-23(22)29-25/h2-4,7-14,16H,5-6,15H2,1H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.214 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124561
(US8759532, 242)Show SMILES CN1CCC(CCC1=O)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C26H24N4O3/c1-30-16-14-17(10-13-23(30)31)20-5-4-15-27-26(20)33-19-11-8-18(9-12-19)24(32)25-28-21-6-2-3-7-22(21)29-25/h2-9,11-12,15,17H,10,13-14,16H2,1H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.218 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124423
(US8759532, 76 | US8759532, 79)Show SMILES Cc1ccc(cn1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C24H18N4OS/c1-16-8-9-17(15-26-16)20-5-4-14-25-23(20)29-19-12-10-18(11-13-19)27-24-28-21-6-2-3-7-22(21)30-24/h2-15H,1H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.219 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124450
(US8759532, 107 | US8759532, 187)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@@H]2CCOC2)cc1 |r| Show InChI InChI=1S/C23H19N3O3/c27-21(22-25-19-5-1-2-6-20(19)26-22)15-7-9-17(10-8-15)29-23-18(4-3-12-24-23)16-11-13-28-14-16/h1-10,12,16H,11,13-14H2,(H,25,26)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.232 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124430
(US8759532, 83)Show SMILES Cn1c(Nc2ccc(Oc3ncccc3-c3cccnc3)cc2)nc2ccccc12 Show InChI InChI=1S/C24H19N5O/c1-29-22-9-3-2-8-21(22)28-24(29)27-18-10-12-19(13-11-18)30-23-20(7-5-15-26-23)17-6-4-14-25-16-17/h2-16H,1H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.249 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124355
(US8759532, 6)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2-c2ccncc2)cc1 Show InChI InChI=1S/C24H16N4O2/c29-22(23-27-20-5-1-2-6-21(20)28-23)17-7-9-18(10-8-17)30-24-19(4-3-13-26-24)16-11-14-25-15-12-16/h1-15H,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.256 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124393
(US8759532, 45)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2-c2cccnc2)cc1 Show InChI InChI=1S/C24H16N4O2/c29-22(23-27-20-7-1-2-8-21(20)28-23)16-9-11-18(12-10-16)30-24-19(6-4-14-26-24)17-5-3-13-25-15-17/h1-15H,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124565
(US8759532, 247)Show SMILES COc1cnccc1-c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C25H18N4O3/c1-31-22-15-26-14-12-18(22)19-5-4-13-27-25(19)32-17-10-8-16(9-11-17)23(30)24-28-20-6-2-3-7-21(20)29-24/h2-15H,1H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.261 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124437
(US8759532, 90)Show SMILES C1CC(CCO1)c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)cc1 Show InChI InChI=1S/C23H22N4O2/c1-2-6-21-20(5-1)26-23(27-21)25-17-7-9-18(10-8-17)29-22-19(4-3-13-24-22)16-11-14-28-15-12-16/h1-10,13,16H,11-12,14-15H2,(H2,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.267 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124496
(US8759532, 170)Show SMILES CC(=O)N1CCC[C@H](C1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 |r| Show InChI InChI=1S/C25H24N4O2S/c1-17(30)29-15-5-6-18(16-29)21-7-4-14-26-24(21)31-20-12-10-19(11-13-20)27-25-28-22-8-2-3-9-23(22)32-25/h2-4,7-14,18H,5-6,15-16H2,1H3,(H,27,28)/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.268 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124392
(US8759532, 44)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2-c2cncnc2)cc1 Show InChI InChI=1S/C23H15N5O2/c29-21(22-27-19-5-1-2-6-20(19)28-22)15-7-9-17(10-8-15)30-23-18(4-3-11-26-23)16-12-24-14-25-13-16/h1-14H,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.271 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124498
(US8759532, 173)Show SMILES O[C@@H]1CC[C@H](C1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 |r| Show InChI InChI=1S/C23H21N3O2S/c27-17-10-7-15(14-17)19-4-3-13-24-22(19)28-18-11-8-16(9-12-18)25-23-26-20-5-1-2-6-21(20)29-23/h1-6,8-9,11-13,15,17,27H,7,10,14H2,(H,25,26)/t15-,17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.286 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124370
(US8759532, 21)Show SMILES N(c1nc2ccccc2s1)c1ccc(Oc2ncccc2-c2cncnc2)cc1 Show InChI InChI=1S/C22H15N5OS/c1-2-6-20-19(5-1)27-22(29-20)26-16-7-9-17(10-8-16)28-21-18(4-3-11-25-21)15-12-23-14-24-13-15/h1-14H,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.303 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124517
(US8759532, 194)Show SMILES O[C@H]1CC[C@H](CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r,wU:4.7,1.0,(-6.37,5.39,;-6.37,3.85,;-5.04,3.08,;-5.04,1.54,;-6.37,.77,;-7.71,1.54,;-7.71,3.08,;-6.37,-.77,;-7.71,-1.54,;-7.71,-3.08,;-6.37,-3.85,;-5.04,-3.08,;-5.04,-1.54,;-3.71,-.77,;-2.37,-1.54,;-2.37,-3.08,;-1.04,-3.85,;.29,-3.08,;.29,-1.54,;-1.04,-.77,;1.63,-3.85,;1.63,-5.39,;2.96,-3.08,;3.12,-1.55,;4.63,-1.23,;5.4,.11,;6.94,.11,;7.71,-1.23,;6.94,-2.56,;5.4,-2.56,;4.37,-3.71,)| Show InChI InChI=1S/C25H23N3O3/c29-18-11-7-16(8-12-18)20-4-3-15-26-25(20)31-19-13-9-17(10-14-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-10,13-16,18,29H,7-8,11-12H2,(H,27,28)/t16-,18+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.308 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124460
(US8759532, 126)Show SMILES FC1(CCOCC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C24H20FN3O3/c25-24(11-14-30-15-12-24)18-4-3-13-26-23(18)31-17-9-7-16(8-10-17)21(29)22-27-19-5-1-2-6-20(19)28-22/h1-10,13H,11-12,14-15H2,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.311 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124540
(US8759532, 218)Show SMILES OC[C@H]1CC[C@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C25H23N3O3/c29-15-16-7-8-18(14-16)20-4-3-13-26-25(20)31-19-11-9-17(10-12-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-13,16,18,29H,7-8,14-15H2,(H,27,28)/t16-,18+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.312 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124539
(US8759532, 217)Show SMILES OC[C@@H]1CC[C@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C25H23N3O3/c29-15-16-7-8-18(14-16)20-4-3-13-26-25(20)31-19-11-9-17(10-12-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-13,16,18,29H,7-8,14-15H2,(H,27,28)/t16-,18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.315 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124431
(US8759532, 84)Show SMILES Cc1ccc(cn1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3n2C)cc1 Show InChI InChI=1S/C25H21N5O/c1-17-9-10-18(16-27-17)21-6-5-15-26-24(21)31-20-13-11-19(12-14-20)28-25-29-22-7-3-4-8-23(22)30(25)2/h3-16H,1-2H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.338 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124408
(US8759532, 61)Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2-c2cccc3ncccc23)cc1 Show InChI InChI=1S/C28H18N4O2/c33-26(27-31-24-9-1-2-10-25(24)32-27)18-12-14-19(15-13-18)34-28-22(8-5-17-30-28)20-6-3-11-23-21(20)7-4-16-29-23/h1-17H,(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.342 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124434
(US8759532, 87)Show SMILES CC(=O)N1CCC(=CC1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 |c:6| Show InChI InChI=1S/C25H22N4O2S/c1-17(30)29-15-12-18(13-16-29)21-5-4-14-26-24(21)31-20-10-8-19(9-11-20)27-25-28-22-6-2-3-7-23(22)32-25/h2-12,14H,13,15-16H2,1H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.363 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this
Ligand-Target Pair | |
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