BindingDB logo
myBDB logout

Patent code US8765727

Compile Data Set for Download or QSAR
Found 95 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125902
PNG
(US8765727, 5)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-13-23-20-24-16-7-1-4-14(10-16)6-3-9-26-17-8-2-5-15(11-17)12-22-19(18)25-20/h1-2,4-5,7-8,10-11,13H,3,6,9,12H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.90n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125902
PNG
(US8765727, 5)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-13-23-20-24-16-7-1-4-14(10-16)6-3-9-26-17-8-2-5-15(11-17)12-22-19(18)25-20/h1-2,4-5,7-8,10-11,13H,3,6,9,12H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.40n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125902
PNG
(US8765727, 5)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-13-23-20-24-16-7-1-4-14(10-16)6-3-9-26-17-8-2-5-15(11-17)12-22-19(18)25-20/h1-2,4-5,7-8,10-11,13H,3,6,9,12H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4.20n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125913
PNG
(US8765727, 16)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cc(Br)cc(CNc1n2)c4)c3
Show InChI InChI=1S/C20H18BrClN4O/c21-15-7-14-9-17(10-15)27-6-2-4-13-3-1-5-16(8-13)25-20-24-12-18(22)19(26-20)23-11-14/h1,3,5,7-10,12H,2,4,6,11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125904
PNG
(US8765727, 7)
Show SMILES Clc1cnc2Nc3cccc(OCCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O2/c20-17-12-22-19-23-14-4-2-6-16(10-14)26-8-7-25-15-5-1-3-13(9-15)11-21-18(17)24-19/h1-6,9-10,12H,7-8,11H2,(H2,21,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6.40n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125904
PNG
(US8765727, 7)
Show SMILES Clc1cnc2Nc3cccc(OCCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O2/c20-17-12-22-19-23-14-4-2-6-16(10-14)26-8-7-25-15-5-1-3-13(9-15)11-21-18(17)24-19/h1-6,9-10,12H,7-8,11H2,(H2,21,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 8.30n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125899
PNG
(US8765727, 2)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O/c20-17-12-22-19-23-15-5-1-3-13(9-15)7-8-25-16-6-2-4-14(10-16)11-21-18(17)24-19/h1-6,9-10,12H,7-8,11H2,(H2,21,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 9.20n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125899
PNG
(US8765727, 2)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O/c20-17-12-22-19-23-15-5-1-3-13(9-15)7-8-25-16-6-2-4-14(10-16)11-21-18(17)24-19/h1-6,9-10,12H,7-8,11H2,(H2,21,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125899
PNG
(US8765727, 2)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O/c20-17-12-22-19-23-15-5-1-3-13(9-15)7-8-25-16-6-2-4-14(10-16)11-21-18(17)24-19/h1-6,9-10,12H,7-8,11H2,(H2,21,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 13n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125913
PNG
(US8765727, 16)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cc(Br)cc(CNc1n2)c4)c3
Show InChI InChI=1S/C20H18BrClN4O/c21-15-7-14-9-17(10-15)27-6-2-4-13-3-1-5-16(8-13)25-20-24-12-18(22)19(26-20)23-11-14/h1,3,5,7-10,12H,2,4,6,11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 15n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125913
PNG
(US8765727, 16)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cc(Br)cc(CNc1n2)c4)c3
Show InChI InChI=1S/C20H18BrClN4O/c21-15-7-14-9-17(10-15)27-6-2-4-13-3-1-5-16(8-13)25-20-24-12-18(22)19(26-20)23-11-14/h1,3,5,7-10,12H,2,4,6,11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 15n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125904
PNG
(US8765727, 7)
Show SMILES Clc1cnc2Nc3cccc(OCCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O2/c20-17-12-22-19-23-14-4-2-6-16(10-14)26-8-7-25-15-5-1-3-13(9-15)11-21-18(17)24-19/h1-6,9-10,12H,7-8,11H2,(H2,21,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 16n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125898
PNG
(US8765727, 1)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C18H15ClN4O/c19-16-10-21-18-22-14-5-1-4-13(7-14)11-24-15-6-2-3-12(8-15)9-20-17(16)23-18/h1-8,10H,9,11H2,(H2,20,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 17n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125901
PNG
(US8765727, 4)
Show SMILES Clc1cnc2Nc3cccc(c3)C(=O)Nc3cccc(CNc1n2)c3
Show InChI InChI=1S/C18H14ClN5O/c19-15-10-21-18-23-14-6-2-4-12(8-14)17(25)22-13-5-1-3-11(7-13)9-20-16(15)24-18/h1-8,10H,9H2,(H,22,25)(H2,20,21,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125906
PNG
(US8765727, 9)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-13-23-20-24-16-5-1-3-15(11-16)8-10-26-17-6-2-4-14(12-17)7-9-22-19(18)25-20/h1-6,11-13H,7-10H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 23n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125902
PNG
(US8765727, 5)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-13-23-20-24-16-7-1-4-14(10-16)6-3-9-26-17-8-2-5-15(11-17)12-22-19(18)25-20/h1-2,4-5,7-8,10-11,13H,3,6,9,12H2,(H2,22,23,24,25)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 25n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125910
PNG
(US8765727, 13)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CCCNc1n2)c4)c3
Show InChI InChI=1S/C21H21ClN4O/c22-19-14-24-21-25-17-7-1-4-16(12-17)9-11-27-18-8-2-5-15(13-18)6-3-10-23-20(19)26-21/h1-2,4-5,7-8,12-14H,3,6,9-11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 25n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125906
PNG
(US8765727, 9)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-13-23-20-24-16-5-1-3-15(11-16)8-10-26-17-6-2-4-14(12-17)7-9-22-19(18)25-20/h1-6,11-13H,7-10H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 28n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125912
PNG
(US8765727, 15)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4ccc(c(CNc1n2)c4)-c1ccccc1)c3
Show InChI InChI=1S/C26H23ClN4O/c27-24-17-29-26-30-21-10-4-6-18(14-21)7-5-13-32-22-11-12-23(19-8-2-1-3-9-19)20(15-22)16-28-25(24)31-26/h1-4,6,8-12,14-15,17H,5,7,13,16H2,(H2,28,29,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 31n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125910
PNG
(US8765727, 13)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CCCNc1n2)c4)c3
Show InChI InChI=1S/C21H21ClN4O/c22-19-14-24-21-25-17-7-1-4-16(12-17)9-11-27-18-8-2-5-15(13-18)6-3-10-23-20(19)26-21/h1-2,4-5,7-8,12-14H,3,6,9-11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 32n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125899
PNG
(US8765727, 2)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O/c20-17-12-22-19-23-15-5-1-3-13(9-15)7-8-25-16-6-2-4-14(10-16)11-21-18(17)24-19/h1-6,9-10,12H,7-8,11H2,(H2,21,22,23,24)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 35n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125912
PNG
(US8765727, 15)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4ccc(c(CNc1n2)c4)-c1ccccc1)c3
Show InChI InChI=1S/C26H23ClN4O/c27-24-17-29-26-30-21-10-4-6-18(14-21)7-5-13-32-22-11-12-23(19-8-2-1-3-9-19)20(15-22)16-28-25(24)31-26/h1-4,6,8-12,14-15,17H,5,7,13,16H2,(H2,28,29,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 41n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125904
PNG
(US8765727, 7)
Show SMILES Clc1cnc2Nc3cccc(OCCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O2/c20-17-12-22-19-23-14-4-2-6-16(10-14)26-8-7-25-15-5-1-3-13(9-15)11-21-18(17)24-19/h1-6,9-10,12H,7-8,11H2,(H2,21,22,23,24)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 43n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125898
PNG
(US8765727, 1)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C18H15ClN4O/c19-16-10-21-18-22-14-5-1-4-13(7-14)11-24-15-6-2-3-12(8-15)9-20-17(16)23-18/h1-8,10H,9,11H2,(H2,20,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 49n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125898
PNG
(US8765727, 1)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C18H15ClN4O/c19-16-10-21-18-22-14-5-1-4-13(7-14)11-24-15-6-2-3-12(8-15)9-20-17(16)23-18/h1-8,10H,9,11H2,(H2,20,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 51n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125906
PNG
(US8765727, 9)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-13-23-20-24-16-5-1-3-15(11-16)8-10-26-17-6-2-4-14(12-17)7-9-22-19(18)25-20/h1-6,11-13H,7-10H2,(H2,22,23,24,25)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 53n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125906
PNG
(US8765727, 9)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-13-23-20-24-16-5-1-3-15(11-16)8-10-26-17-6-2-4-14(12-17)7-9-22-19(18)25-20/h1-6,11-13H,7-10H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 55n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125911
PNG
(US8765727, 14)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4ccc(Br)c(CNc1n2)c4)c3
Show InChI InChI=1S/C20H18BrClN4O/c21-17-7-6-16-10-14(17)11-23-19-18(22)12-24-20(26-19)25-15-5-1-3-13(9-15)4-2-8-27-16/h1,3,5-7,9-10,12H,2,4,8,11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 57n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125910
PNG
(US8765727, 13)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CCCNc1n2)c4)c3
Show InChI InChI=1S/C21H21ClN4O/c22-19-14-24-21-25-17-7-1-4-16(12-17)9-11-27-18-8-2-5-15(13-18)6-3-10-23-20(19)26-21/h1-2,4-5,7-8,12-14H,3,6,9-11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 62n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125912
PNG
(US8765727, 15)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4ccc(c(CNc1n2)c4)-c1ccccc1)c3
Show InChI InChI=1S/C26H23ClN4O/c27-24-17-29-26-30-21-10-4-6-18(14-21)7-5-13-32-22-11-12-23(19-8-2-1-3-9-19)20(15-22)16-28-25(24)31-26/h1-4,6,8-12,14-15,17H,5,7,13,16H2,(H2,28,29,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 81n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125911
PNG
(US8765727, 14)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4ccc(Br)c(CNc1n2)c4)c3
Show InChI InChI=1S/C20H18BrClN4O/c21-17-7-6-16-10-14(17)11-23-19-18(22)12-24-20(26-19)25-15-5-1-3-13(9-15)4-2-8-27-16/h1,3,5-7,9-10,12H,2,4,8,11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 91n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125901
PNG
(US8765727, 4)
Show SMILES Clc1cnc2Nc3cccc(c3)C(=O)Nc3cccc(CNc1n2)c3
Show InChI InChI=1S/C18H14ClN5O/c19-15-10-21-18-23-14-6-2-4-12(8-14)17(25)22-13-5-1-3-11(7-13)9-20-16(15)24-18/h1-8,10H,9H2,(H,22,25)(H2,20,21,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 96n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125911
PNG
(US8765727, 14)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4ccc(Br)c(CNc1n2)c4)c3
Show InChI InChI=1S/C20H18BrClN4O/c21-17-7-6-16-10-14(17)11-23-19-18(22)12-24-20(26-19)25-15-5-1-3-13(9-15)4-2-8-27-16/h1,3,5-7,9-10,12H,2,4,8,11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 100n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125914
PNG
(US8765727, 17)
Show SMILES Nc1ccc2CNc3nc(Nc4cncc(CCc1c2)c4)ncc3Cl
Show InChI InChI=1S/C18H17ClN6/c19-15-10-23-18-24-14-6-12(7-21-9-14)1-3-13-5-11(2-4-16(13)20)8-22-17(15)25-18/h2,4-7,9-10H,1,3,8,20H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 102n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125901
PNG
(US8765727, 4)
Show SMILES Clc1cnc2Nc3cccc(c3)C(=O)Nc3cccc(CNc1n2)c3
Show InChI InChI=1S/C18H14ClN5O/c19-15-10-21-18-23-14-6-2-4-12(8-14)17(25)22-13-5-1-3-11(7-13)9-20-16(15)24-18/h1-8,10H,9H2,(H,22,25)(H2,20,21,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 104n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125910
PNG
(US8765727, 13)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CCCNc1n2)c4)c3
Show InChI InChI=1S/C21H21ClN4O/c22-19-14-24-21-25-17-7-1-4-16(12-17)9-11-27-18-8-2-5-15(13-18)6-3-10-23-20(19)26-21/h1-2,4-5,7-8,12-14H,3,6,9-11H2,(H2,23,24,25,26)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 106n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125914
PNG
(US8765727, 17)
Show SMILES Nc1ccc2CNc3nc(Nc4cncc(CCc1c2)c4)ncc3Cl
Show InChI InChI=1S/C18H17ClN6/c19-15-10-23-18-24-14-6-12(7-21-9-14)1-3-13-5-11(2-4-16(13)20)8-22-17(15)25-18/h2,4-7,9-10H,1,3,8,20H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 114n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125907
PNG
(US8765727, 10)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CCCNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-12-23-20-24-16-7-1-5-15(10-16)13-26-17-8-2-4-14(11-17)6-3-9-22-19(18)25-20/h1-2,4-5,7-8,10-12H,3,6,9,13H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 117n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125909
PNG
(US8765727, 12)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C21H21ClN4O/c22-19-14-24-21-25-17-7-1-4-15(12-17)6-3-11-27-18-8-2-5-16(13-18)9-10-23-20(19)26-21/h1-2,4-5,7-8,12-14H,3,6,9-11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 120n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125907
PNG
(US8765727, 10)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CCCNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-12-23-20-24-16-7-1-5-15(10-16)13-26-17-8-2-4-14(11-17)6-3-9-22-19(18)25-20/h1-2,4-5,7-8,10-12H,3,6,9,13H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 122n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125903
PNG
(US8765727, 6)
Show SMILES C[C@H]1Nc2nc(Nc3cccc(COc4cccc1c4)c3)ncc2Cl |r|
Show InChI InChI=1S/C19H17ClN4O/c1-12-14-5-3-7-16(9-14)25-11-13-4-2-6-15(8-13)23-19-21-10-17(20)18(22-12)24-19/h2-10,12H,11H2,1H3,(H2,21,22,23,24)/t12-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 140n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125913
PNG
(US8765727, 16)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cc(Br)cc(CNc1n2)c4)c3
Show InChI InChI=1S/C20H18BrClN4O/c21-15-7-14-9-17(10-15)27-6-2-4-13-3-1-5-16(8-13)25-20-24-12-18(22)19(26-20)23-11-14/h1,3,5,7-10,12H,2,4,6,11H2,(H2,23,24,25,26)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 149n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125907
PNG
(US8765727, 10)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CCCNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-12-23-20-24-16-7-1-5-15(10-16)13-26-17-8-2-4-14(11-17)6-3-9-22-19(18)25-20/h1-2,4-5,7-8,10-12H,3,6,9,13H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 180n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125907
PNG
(US8765727, 10)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CCCNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-12-23-20-24-16-7-1-5-15(10-16)13-26-17-8-2-4-14(11-17)6-3-9-22-19(18)25-20/h1-2,4-5,7-8,10-12H,3,6,9,13H2,(H2,22,23,24,25)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 237n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125913
PNG
(US8765727, 16)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cc(Br)cc(CNc1n2)c4)c3
Show InChI InChI=1S/C20H18BrClN4O/c21-15-7-14-9-17(10-15)27-6-2-4-13-3-1-5-16(8-13)25-20-24-12-18(22)19(26-20)23-11-14/h1,3,5,7-10,12H,2,4,6,11H2,(H2,23,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 280n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125900
PNG
(US8765727, 3)
Show SMILES Clc1cnc2Nc3cccc(c3)S(=O)(=O)Nc3cccc(CNc1n2)c3
Show InChI InChI=1S/C17H14ClN5O2S/c18-15-10-20-17-21-12-4-2-6-14(8-12)26(24,25)23-13-5-1-3-11(7-13)9-19-16(15)22-17/h1-8,10,23H,9H2,(H2,19,20,21,22)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125911
PNG
(US8765727, 14)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4ccc(Br)c(CNc1n2)c4)c3
Show InChI InChI=1S/C20H18BrClN4O/c21-17-7-6-16-10-14(17)11-23-19-18(22)12-24-20(26-19)25-15-5-1-3-13(9-15)4-2-8-27-16/h1,3,5-7,9-10,12H,2,4,8,11H2,(H2,23,24,25,26)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125905
PNG
(US8765727, 8)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O/c20-17-11-22-19-23-15-5-1-4-14(9-15)12-25-16-6-2-3-13(10-16)7-8-21-18(17)24-19/h1-6,9-11H,7-8,12H2,(H2,21,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 300n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125909
PNG
(US8765727, 12)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C21H21ClN4O/c22-19-14-24-21-25-17-7-1-4-15(12-17)6-3-11-27-18-8-2-5-16(13-18)9-10-23-20(19)26-21/h1-2,4-5,7-8,12-14H,3,6,9-11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 300n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125909
PNG
(US8765727, 12)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C21H21ClN4O/c22-19-14-24-21-25-17-7-1-4-15(12-17)6-3-11-27-18-8-2-5-16(13-18)9-10-23-20(19)26-21/h1-2,4-5,7-8,12-14H,3,6,9-11H2,(H2,23,24,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 315n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125900
PNG
(US8765727, 3)
Show SMILES Clc1cnc2Nc3cccc(c3)S(=O)(=O)Nc3cccc(CNc1n2)c3
Show InChI InChI=1S/C17H14ClN5O2S/c18-15-10-20-17-21-12-4-2-6-14(8-12)26(24,25)23-13-5-1-3-11(7-13)9-19-16(15)22-17/h1-8,10,23H,9H2,(H2,19,20,21,22)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 325n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125905
PNG
(US8765727, 8)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O/c20-17-11-22-19-23-15-5-1-4-14(9-15)12-25-16-6-2-3-13(10-16)7-8-21-18(17)24-19/h1-6,9-11H,7-8,12H2,(H2,21,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 333n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125903
PNG
(US8765727, 6)
Show SMILES C[C@H]1Nc2nc(Nc3cccc(COc4cccc1c4)c3)ncc2Cl |r|
Show InChI InChI=1S/C19H17ClN4O/c1-12-14-5-3-7-16(9-14)25-11-13-4-2-6-15(8-13)23-19-21-10-17(20)18(22-12)24-19/h2-10,12H,11H2,1H3,(H2,21,22,23,24)/t12-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 346n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125903
PNG
(US8765727, 6)
Show SMILES C[C@H]1Nc2nc(Nc3cccc(COc4cccc1c4)c3)ncc2Cl |r|
Show InChI InChI=1S/C19H17ClN4O/c1-12-14-5-3-7-16(9-14)25-11-13-4-2-6-15(8-13)23-19-21-10-17(20)18(22-12)24-19/h2-10,12H,11H2,1H3,(H2,21,22,23,24)/t12-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 350n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125914
PNG
(US8765727, 17)
Show SMILES Nc1ccc2CNc3nc(Nc4cncc(CCc1c2)c4)ncc3Cl
Show InChI InChI=1S/C18H17ClN6/c19-15-10-23-18-24-14-6-12(7-21-9-14)1-3-13-5-11(2-4-16(13)20)8-22-17(15)25-18/h2,4-7,9-10H,1,3,8,20H2,(H2,22,23,24,25)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 386n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125898
PNG
(US8765727, 1)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C18H15ClN4O/c19-16-10-21-18-22-14-5-1-4-13(7-14)11-24-15-6-2-3-12(8-15)9-20-17(16)23-18/h1-8,10H,9,11H2,(H2,20,21,22,23)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 400n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125909
PNG
(US8765727, 12)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C21H21ClN4O/c22-19-14-24-21-25-17-7-1-4-15(12-17)6-3-11-27-18-8-2-5-16(13-18)9-10-23-20(19)26-21/h1-2,4-5,7-8,12-14H,3,6,9-11H2,(H2,23,24,25,26)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 400n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125912
PNG
(US8765727, 15)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4ccc(c(CNc1n2)c4)-c1ccccc1)c3
Show InChI InChI=1S/C26H23ClN4O/c27-24-17-29-26-30-21-10-4-6-18(14-21)7-5-13-32-22-11-12-23(19-8-2-1-3-9-19)20(15-22)16-28-25(24)31-26/h1-4,6,8-12,14-15,17H,5,7,13,16H2,(H2,28,29,30,31)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 400n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125905
PNG
(US8765727, 8)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O/c20-17-11-22-19-23-15-5-1-4-14(9-15)12-25-16-6-2-3-13(10-16)7-8-21-18(17)24-19/h1-6,9-11H,7-8,12H2,(H2,21,22,23,24)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 438n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125914
PNG
(US8765727, 17)
Show SMILES Nc1ccc2CNc3nc(Nc4cncc(CCc1c2)c4)ncc3Cl
Show InChI InChI=1S/C18H17ClN6/c19-15-10-23-18-24-14-6-12(7-21-9-14)1-3-13-5-11(2-4-16(13)20)8-22-17(15)25-18/h2,4-7,9-10H,1,3,8,20H2,(H2,22,23,24,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 447n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125900
PNG
(US8765727, 3)
Show SMILES Clc1cnc2Nc3cccc(c3)S(=O)(=O)Nc3cccc(CNc1n2)c3
Show InChI InChI=1S/C17H14ClN5O2S/c18-15-10-20-17-21-12-4-2-6-14(8-12)26(24,25)23-13-5-1-3-11(7-13)9-19-16(15)22-17/h1-8,10,23H,9H2,(H2,19,20,21,22)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 589n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125905
PNG
(US8765727, 8)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O/c20-17-11-22-19-23-15-5-1-4-14(9-15)12-25-16-6-2-3-13(10-16)7-8-21-18(17)24-19/h1-6,9-11H,7-8,12H2,(H2,21,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 600n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125902
PNG
(US8765727, 5)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-13-23-20-24-16-7-1-4-14(10-16)6-3-9-26-17-8-2-5-15(11-17)12-22-19(18)25-20/h1-2,4-5,7-8,10-11,13H,3,6,9,12H2,(H2,22,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 706n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125900
PNG
(US8765727, 3)
Show SMILES Clc1cnc2Nc3cccc(c3)S(=O)(=O)Nc3cccc(CNc1n2)c3
Show InChI InChI=1S/C17H14ClN5O2S/c18-15-10-20-17-21-12-4-2-6-14(8-12)26(24,25)23-13-5-1-3-11(7-13)9-19-16(15)22-17/h1-8,10,23H,9H2,(H2,19,20,21,22)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 830n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125916
PNG
(US8765727, 19)
Show SMILES Clc1cnc2Nc3cncc(CCc4cc(CNc1n2)ccc4NS(=O)(=O)c1ccccc1C#N)c3
Show InChI InChI=1S/C25H20ClN7O2S/c26-21-15-30-25-31-20-10-17(12-28-14-20)5-7-18-9-16(13-29-24(21)32-25)6-8-22(18)33-36(34,35)23-4-2-1-3-19(23)11-27/h1-4,6,8-10,12,14-15,33H,5,7,13H2,(H2,29,30,31,32)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125908
PNG
(US8765727, 11)
Show SMILES C[C@@H]1Nc2nc(Nc3cccc(COc4cccc1c4)c3)ncc2Cl |r|
Show InChI InChI=1S/C19H17ClN4O/c1-12-14-5-3-7-16(9-14)25-11-13-4-2-6-15(8-13)23-19-21-10-17(20)18(22-12)24-19/h2-10,12H,11H2,1H3,(H2,21,22,23,24)/t12-/m0/s1
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125915
PNG
(US8765727, 18)
Show SMILES Clc1cnc2Nc3cncc(CCc4cc(CNc1n2)ccc4NC(=O)c1ccccc1)c3
Show InChI InChI=1S/C25H21ClN6O/c26-21-15-29-25-30-20-11-17(12-27-14-20)6-8-19-10-16(13-28-23(21)32-25)7-9-22(19)31-24(33)18-4-2-1-3-5-18/h1-5,7,9-12,14-15H,6,8,13H2,(H,31,33)(H2,28,29,30,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125916
PNG
(US8765727, 19)
Show SMILES Clc1cnc2Nc3cncc(CCc4cc(CNc1n2)ccc4NS(=O)(=O)c1ccccc1C#N)c3
Show InChI InChI=1S/C25H20ClN7O2S/c26-21-15-30-25-31-20-10-17(12-28-14-20)5-7-18-9-16(13-29-24(21)32-25)6-8-22(18)33-36(34,35)23-4-2-1-3-19(23)11-27/h1-4,6,8-10,12,14-15,33H,5,7,13H2,(H2,29,30,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125903
PNG
(US8765727, 6)
Show SMILES C[C@H]1Nc2nc(Nc3cccc(COc4cccc1c4)c3)ncc2Cl |r|
Show InChI InChI=1S/C19H17ClN4O/c1-12-14-5-3-7-16(9-14)25-11-13-4-2-6-15(8-13)23-19-21-10-17(20)18(22-12)24-19/h2-10,12H,11H2,1H3,(H2,21,22,23,24)/t12-/m1/s1
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM125908
PNG
(US8765727, 11)
Show SMILES C[C@@H]1Nc2nc(Nc3cccc(COc4cccc1c4)c3)ncc2Cl |r|
Show InChI InChI=1S/C19H17ClN4O/c1-12-14-5-3-7-16(9-14)25-11-13-4-2-6-15(8-13)23-19-21-10-17(20)18(22-12)24-19/h2-10,12H,11H2,1H3,(H2,21,22,23,24)/t12-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125915
PNG
(US8765727, 18)
Show SMILES Clc1cnc2Nc3cncc(CCc4cc(CNc1n2)ccc4NC(=O)c1ccccc1)c3
Show InChI InChI=1S/C25H21ClN6O/c26-21-15-29-25-30-20-11-17(12-27-14-20)6-8-19-10-16(13-28-23(21)32-25)7-9-22(19)31-24(33)18-4-2-1-3-5-18/h1-5,7,9-12,14-15H,6,8,13H2,(H,31,33)(H2,28,29,30,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125912
PNG
(US8765727, 15)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4ccc(c(CNc1n2)c4)-c1ccccc1)c3
Show InChI InChI=1S/C26H23ClN4O/c27-24-17-29-26-30-21-10-4-6-18(14-21)7-5-13-32-22-11-12-23(19-8-2-1-3-9-19)20(15-22)16-28-25(24)31-26/h1-4,6,8-12,14-15,17H,5,7,13,16H2,(H2,28,29,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125907
PNG
(US8765727, 10)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CCCNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-12-23-20-24-16-7-1-5-15(10-16)13-26-17-8-2-4-14(11-17)6-3-9-22-19(18)25-20/h1-2,4-5,7-8,10-12H,3,6,9,13H2,(H2,22,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125908
PNG
(US8765727, 11)
Show SMILES C[C@@H]1Nc2nc(Nc3cccc(COc4cccc1c4)c3)ncc2Cl |r|
Show InChI InChI=1S/C19H17ClN4O/c1-12-14-5-3-7-16(9-14)25-11-13-4-2-6-15(8-13)23-19-21-10-17(20)18(22-12)24-19/h2-10,12H,11H2,1H3,(H2,21,22,23,24)/t12-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125898
PNG
(US8765727, 1)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C18H15ClN4O/c19-16-10-21-18-22-14-5-1-4-13(7-14)11-24-15-6-2-3-12(8-15)9-20-17(16)23-18/h1-8,10H,9,11H2,(H2,20,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM125916
PNG
(US8765727, 19)
Show SMILES Clc1cnc2Nc3cncc(CCc4cc(CNc1n2)ccc4NS(=O)(=O)c1ccccc1C#N)c3
Show InChI InChI=1S/C25H20ClN7O2S/c26-21-15-30-25-31-20-10-17(12-28-14-20)5-7-18-9-16(13-29-24(21)32-25)6-8-22(18)33-36(34,35)23-4-2-1-3-19(23)11-27/h1-4,6,8-10,12,14-15,33H,5,7,13H2,(H2,29,30,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125915
PNG
(US8765727, 18)
Show SMILES Clc1cnc2Nc3cncc(CCc4cc(CNc1n2)ccc4NC(=O)c1ccccc1)c3
Show InChI InChI=1S/C25H21ClN6O/c26-21-15-29-25-30-20-11-17(12-27-14-20)6-8-19-10-16(13-28-23(21)32-25)7-9-22(19)31-24(33)18-4-2-1-3-5-18/h1-5,7,9-12,14-15H,6,8,13H2,(H,31,33)(H2,28,29,30,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125915
PNG
(US8765727, 18)
Show SMILES Clc1cnc2Nc3cncc(CCc4cc(CNc1n2)ccc4NC(=O)c1ccccc1)c3
Show InChI InChI=1S/C25H21ClN6O/c26-21-15-29-25-30-20-11-17(12-27-14-20)6-8-19-10-16(13-28-23(21)32-25)7-9-22(19)31-24(33)18-4-2-1-3-5-18/h1-5,7,9-12,14-15H,6,8,13H2,(H,31,33)(H2,28,29,30,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125908
PNG
(US8765727, 11)
Show SMILES C[C@@H]1Nc2nc(Nc3cccc(COc4cccc1c4)c3)ncc2Cl |r|
Show InChI InChI=1S/C19H17ClN4O/c1-12-14-5-3-7-16(9-14)25-11-13-4-2-6-15(8-13)23-19-21-10-17(20)18(22-12)24-19/h2-10,12H,11H2,1H3,(H2,21,22,23,24)/t12-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM125916
PNG
(US8765727, 19)
Show SMILES Clc1cnc2Nc3cncc(CCc4cc(CNc1n2)ccc4NS(=O)(=O)c1ccccc1C#N)c3
Show InChI InChI=1S/C25H20ClN7O2S/c26-21-15-30-25-31-20-10-17(12-28-14-20)5-7-18-9-16(13-29-24(21)32-25)6-8-22(18)33-36(34,35)23-4-2-1-3-19(23)11-27/h1-4,6,8-10,12,14-15,33H,5,7,13H2,(H2,29,30,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125915
PNG
(US8765727, 18)
Show SMILES Clc1cnc2Nc3cncc(CCc4cc(CNc1n2)ccc4NC(=O)c1ccccc1)c3
Show InChI InChI=1S/C25H21ClN6O/c26-21-15-29-25-30-20-11-17(12-27-14-20)6-8-19-10-16(13-28-23(21)32-25)7-9-22(19)31-24(33)18-4-2-1-3-5-18/h1-5,7,9-12,14-15H,6,8,13H2,(H,31,33)(H2,28,29,30,32)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125914
PNG
(US8765727, 17)
Show SMILES Nc1ccc2CNc3nc(Nc4cncc(CCc1c2)c4)ncc3Cl
Show InChI InChI=1S/C18H17ClN6/c19-15-10-23-18-24-14-6-12(7-21-9-14)1-3-13-5-11(2-4-16(13)20)8-22-17(15)25-18/h2,4-7,9-10H,1,3,8,20H2,(H2,22,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125916
PNG
(US8765727, 19)
Show SMILES Clc1cnc2Nc3cncc(CCc4cc(CNc1n2)ccc4NS(=O)(=O)c1ccccc1C#N)c3
Show InChI InChI=1S/C25H20ClN7O2S/c26-21-15-30-25-31-20-10-17(12-28-14-20)5-7-18-9-16(13-29-24(21)32-25)6-8-22(18)33-36(34,35)23-4-2-1-3-19(23)11-27/h1-4,6,8-10,12,14-15,33H,5,7,13H2,(H2,29,30,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM125901
PNG
(US8765727, 4)
Show SMILES Clc1cnc2Nc3cccc(c3)C(=O)Nc3cccc(CNc1n2)c3
Show InChI InChI=1S/C18H14ClN5O/c19-15-10-21-18-23-14-6-2-4-12(8-14)17(25)22-13-5-1-3-11(7-13)9-20-16(15)24-18/h1-8,10H,9H2,(H,22,25)(H2,20,21,23,24)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125906
PNG
(US8765727, 9)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C20H19ClN4O/c21-18-13-23-20-24-16-5-1-3-15(11-16)8-10-26-17-6-2-4-14(12-17)7-9-22-19(18)25-20/h1-6,11-13H,7-10H2,(H2,22,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.23E+3n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125899
PNG
(US8765727, 2)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O/c20-17-12-22-19-23-15-5-1-3-13(9-15)7-8-25-16-6-2-4-14(10-16)11-21-18(17)24-19/h1-6,9-10,12H,7-8,11H2,(H2,21,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.53E+3n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125904
PNG
(US8765727, 7)
Show SMILES Clc1cnc2Nc3cccc(OCCOc4cccc(CNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O2/c20-17-12-22-19-23-14-4-2-6-16(10-14)26-8-7-25-15-5-1-3-13(9-15)11-21-18(17)24-19/h1-6,9-10,12H,7-8,11H2,(H2,21,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.05E+3n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125911
PNG
(US8765727, 14)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4ccc(Br)c(CNc1n2)c4)c3
Show InChI InChI=1S/C20H18BrClN4O/c21-17-7-6-16-10-14(17)11-23-19-18(22)12-24-20(26-19)25-15-5-1-3-13(9-15)4-2-8-27-16/h1,3,5-7,9-10,12H,2,4,8,11H2,(H2,23,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 8.20E+3n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125909
PNG
(US8765727, 12)
Show SMILES Clc1cnc2Nc3cccc(CCCOc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C21H21ClN4O/c22-19-14-24-21-25-17-7-1-4-15(12-17)6-3-11-27-18-8-2-5-16(13-18)9-10-23-20(19)26-21/h1-2,4-5,7-8,12-14H,3,6,9-11H2,(H2,23,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+4n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125910
PNG
(US8765727, 13)
Show SMILES Clc1cnc2Nc3cccc(CCOc4cccc(CCCNc1n2)c4)c3
Show InChI InChI=1S/C21H21ClN4O/c22-19-14-24-21-25-17-7-1-4-16(12-17)9-11-27-18-8-2-5-15(13-18)6-3-10-23-20(19)26-21/h1-2,4-5,7-8,12-14H,3,6,9-11H2,(H2,23,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+4n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125901
PNG
(US8765727, 4)
Show SMILES Clc1cnc2Nc3cccc(c3)C(=O)Nc3cccc(CNc1n2)c3
Show InChI InChI=1S/C18H14ClN5O/c19-15-10-21-18-23-14-6-2-4-12(8-14)17(25)22-13-5-1-3-11(7-13)9-20-16(15)24-18/h1-8,10H,9H2,(H,22,25)(H2,20,21,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125900
PNG
(US8765727, 3)
Show SMILES Clc1cnc2Nc3cccc(c3)S(=O)(=O)Nc3cccc(CNc1n2)c3
Show InChI InChI=1S/C17H14ClN5O2S/c18-15-10-20-17-21-12-4-2-6-14(8-12)26(24,25)23-13-5-1-3-11(7-13)9-19-16(15)22-17/h1-8,10,23H,9H2,(H2,19,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125905
PNG
(US8765727, 8)
Show SMILES Clc1cnc2Nc3cccc(COc4cccc(CCNc1n2)c4)c3
Show InChI InChI=1S/C19H17ClN4O/c20-17-11-22-19-23-15-5-1-4-14(9-15)12-25-16-6-2-3-13(10-16)7-8-21-18(17)24-19/h1-6,9-11H,7-8,12H2,(H2,21,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+4n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125903
PNG
(US8765727, 6)
Show SMILES C[C@H]1Nc2nc(Nc3cccc(COc4cccc1c4)c3)ncc2Cl |r|
Show InChI InChI=1S/C19H17ClN4O/c1-12-14-5-3-7-16(9-14)25-11-13-4-2-6-15(8-13)23-19-21-10-17(20)18(22-12)24-19/h2-10,12H,11H2,1H3,(H2,21,22,23,24)/t12-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+4n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM125908
PNG
(US8765727, 11)
Show SMILES C[C@@H]1Nc2nc(Nc3cccc(COc4cccc1c4)c3)ncc2Cl |r|
Show InChI InChI=1S/C19H17ClN4O/c1-12-14-5-3-7-16(9-14)25-11-13-4-2-6-15(8-13)23-19-21-10-17(20)18(22-12)24-19/h2-10,12H,11H2,1H3,(H2,21,22,23,24)/t12-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+4n/an/an/an/a7.8n/a



Incyte Corporation

US Patent


Assay Description
HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...

US Patent US8765727 (2014)


BindingDB Entry DOI: 10.7270/Q2FQ9V87
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%