Found 52 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130075
(US8815901, 93)Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCCC3)[nH]2)c2nccnc12 |(10.31,-2.67,;8.77,-2.67,;8,-1.33,;8.77,,;8,1.33,;8.77,2.67,;8,4,;6.46,1.33,;5.69,2.67,;5.69,,;6.46,-1.33,;5.69,-2.67,;4.15,,;3.38,1.33,;1.84,1.33,;1.07,,;-.47,,;-1.24,1.33,;-1.24,-1.33,;-2.78,-1.33,;-3.69,-.09,;-5.15,-.56,;-5.15,-2.1,;-6.48,-2.87,;-7.82,-2.1,;-8.29,-.64,;-9.83,-.64,;-10.31,-2.1,;-9.06,-3.01,;-3.69,-2.58,;1.84,-1.33,;1.07,-2.67,;1.84,-4,;3.38,-4,;4.15,-2.67,;3.38,-1.33,)| Show InChI InChI=1S/C25H24F2N6O3/c1-35-17-11-18(36-2)21(27)19(20(17)26)15-5-6-16(23-22(15)28-7-8-29-23)24(34)32-25-30-12-14(31-25)13-33-9-3-4-10-33/h5-8,11-12H,3-4,9-10,13H2,1-2H3,(H2,30,31,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102540
(US8536175, 144)Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nccnc12 |(8.07,3.99,;8.84,2.66,;8.07,1.32,;8.84,-.01,;8.07,-1.34,;8.84,-2.68,;10.38,-2.68,;6.53,-1.34,;5.76,-2.68,;5.76,-.01,;6.53,1.32,;5.76,2.66,;4.22,-.01,;3.45,1.32,;1.91,1.32,;1.14,-.01,;-.4,-.01,;-1.17,1.32,;-1.17,-1.34,;-2.71,-1.34,;-3.48,-.01,;-5.02,-.01,;-5.79,-1.34,;-7.33,-1.34,;-8.1,-.01,;-9.64,-.01,;-10.41,1.32,;-9.64,2.66,;-10.41,3.99,;-8.1,2.66,;-7.33,1.32,;-5.02,-2.68,;-3.48,-2.68,;1.91,-1.34,;1.14,-2.68,;1.91,-4.01,;3.45,-4.01,;4.22,-2.68,;3.45,-1.34,)| Show InChI InChI=1S/C28H28ClFN6O3/c1-35-10-12-36(13-11-35)16-17-4-7-22(33-15-17)34-28(37)19-6-5-18(26-27(19)32-9-8-31-26)23-24(29)20(38-2)14-21(39-3)25(23)30/h4-9,14-15H,10-13,16H2,1-3H3,(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130080
(US8815901, 154)Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCN(C)CC3)[nH]2)c2nccnc12 |(8.7,3.96,;9.47,2.62,;8.7,1.29,;9.47,-.04,;8.7,-1.38,;9.47,-2.71,;11.01,-2.71,;7.16,-1.38,;6.39,-2.71,;6.39,-.04,;7.16,1.29,;6.39,2.62,;4.85,-.04,;4.08,1.29,;2.54,1.29,;1.77,-.04,;.23,-.04,;-.54,1.29,;-.54,-1.38,;-2.08,-1.38,;-2.98,-.13,;-4.45,-.61,;-4.45,-2.15,;-5.78,-2.92,;-7.11,-2.15,;-7.11,-.61,;-8.45,.16,;-9.78,-.61,;-11.12,.16,;-9.78,-2.15,;-8.45,-2.92,;-2.98,-2.62,;2.54,-1.38,;1.77,-2.71,;2.54,-4.05,;4.08,-4.05,;4.85,-2.71,;4.08,-1.38,)| Show InChI InChI=1S/C26H27ClFN7O3/c1-34-8-10-35(11-9-34)14-15-13-31-26(32-15)33-25(36)17-5-4-16(23-24(17)30-7-6-29-23)20-21(27)18(37-2)12-19(38-3)22(20)28/h4-7,12-13H,8-11,14H2,1-3H3,(H2,31,32,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130083
(US8815901, 175)Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2ncccc12 |(9.64,-2.74,;8.1,-2.74,;7.33,-1.41,;8.1,-.08,;7.33,1.26,;8.1,2.59,;7.33,3.93,;5.79,1.26,;5.02,2.59,;5.02,-.08,;5.79,-1.41,;5.02,-2.74,;3.48,-.08,;2.71,1.26,;1.17,1.26,;.4,-.08,;-1.14,-.08,;-1.91,1.26,;-1.91,-1.41,;-3.44,-1.41,;-4.34,-.16,;-5.81,-.64,;-5.81,-2.18,;-7.14,-2.95,;-8.48,-2.18,;-9.81,-2.95,;-8.48,-.64,;-4.34,-2.65,;1.17,-1.41,;.4,-2.74,;1.17,-4.08,;2.71,-4.08,;3.48,-2.74,;2.71,-1.41,)| Show InChI InChI=1S/C24H23F2N5O3/c1-31(2)12-13-11-28-24(29-13)30-23(32)16-8-7-14(15-6-5-9-27-22(15)16)19-20(25)17(33-3)10-18(34-4)21(19)26/h5-11H,12H2,1-4H3,(H2,28,29,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130076
(US8815901, 124)Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCNCC3)cn2)c2nccnc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.33,;8.85,,;8.08,1.33,;8.85,2.67,;8.08,4,;6.54,1.33,;5.78,2.67,;5.78,,;6.54,-1.33,;5.78,-2.67,;4.23,,;3.47,1.33,;1.93,1.33,;1.15,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.47,,;-5,,;-5.78,-1.33,;-7.31,-1.33,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.63,2.67,;-10.39,1.33,;-9.63,,;-5,-2.67,;-3.47,-2.67,;1.93,-1.33,;1.15,-2.67,;1.93,-4,;3.47,-4,;4.23,-2.67,;3.47,-1.33,)| Show InChI InChI=1S/C27H26F2N6O3/c1-37-19-13-20(38-2)24(29)22(23(19)28)17-4-5-18(26-25(17)31-7-8-32-26)27(36)34-21-6-3-16(14-33-21)15-35-11-9-30-10-12-35/h3-8,13-14,30H,9-12,15H2,1-2H3,(H,33,34,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130069
(US8815901, 22)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2nccnc12 |(7.31,3.91,;8.08,2.57,;7.31,1.24,;8.08,-.1,;7.31,-1.43,;8.08,-2.76,;9.62,-2.76,;5.77,-1.43,;5,-2.76,;5,-.1,;5.77,1.24,;5,2.57,;3.46,-.1,;2.69,1.24,;1.15,1.24,;.38,-.1,;-1.16,-.1,;-1.93,1.24,;-1.93,-1.43,;-3.47,-1.43,;-4.37,-.18,;-5.84,-.66,;-5.84,-2.2,;-7.17,-2.97,;-8.51,-2.2,;-9.84,-2.97,;-8.51,-.66,;-4.37,-2.67,;1.15,-1.43,;.38,-2.76,;1.15,-4.1,;2.69,-4.1,;3.46,-2.76,;2.69,-1.43,)| Show InChI InChI=1S/C23H22Cl2N6O3/c1-31(2)11-12-10-28-23(29-12)30-22(32)14-6-5-13(20-21(14)27-8-7-26-20)17-18(24)15(33-3)9-16(34-4)19(17)25/h5-10H,11H2,1-4H3,(H2,28,29,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130084
(US8815901, 177)Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2ncccc12 |(7.33,3.93,;8.1,2.59,;7.33,1.26,;8.1,-.08,;7.33,-1.41,;8.1,-2.74,;9.64,-2.74,;5.79,-1.41,;5.02,-2.74,;5.02,-.08,;5.79,1.26,;5.02,2.59,;3.48,-.08,;2.71,1.26,;1.17,1.26,;.4,-.08,;-1.14,-.08,;-1.91,1.26,;-1.91,-1.41,;-3.44,-1.41,;-4.34,-.16,;-5.81,-.64,;-5.81,-2.18,;-7.14,-2.95,;-8.48,-2.18,;-9.81,-2.95,;-8.48,-.64,;-4.34,-2.65,;1.17,-1.41,;.4,-2.74,;1.17,-4.08,;2.71,-4.08,;3.48,-2.74,;2.71,-1.41,)| Show InChI InChI=1S/C24H23ClFN5O3/c1-31(2)12-13-11-28-24(29-13)30-23(32)16-8-7-14(15-6-5-9-27-22(15)16)19-20(25)17(33-3)10-18(34-4)21(19)26/h5-11H,12H2,1-4H3,(H2,28,29,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130079
(US8815901, 153)Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2nccnc12 |(7.37,3.96,;8.14,2.62,;7.37,1.29,;8.14,-.04,;7.37,-1.38,;8.14,-2.71,;9.68,-2.71,;5.83,-1.38,;5.06,-2.71,;5.06,-.04,;5.83,1.29,;5.06,2.62,;3.52,-.04,;2.75,1.29,;1.21,1.29,;.44,-.04,;-1.1,-.04,;-1.87,1.29,;-1.87,-1.38,;-3.41,-1.38,;-4.32,-.13,;-5.78,-.61,;-5.78,-2.15,;-7.11,-2.92,;-8.45,-2.15,;-9.78,-2.92,;-8.45,-.61,;-4.32,-2.62,;1.21,-1.38,;.44,-2.71,;1.21,-4.05,;2.75,-4.05,;3.52,-2.71,;2.75,-1.38,)| Show InChI InChI=1S/C23H22ClFN6O3/c1-31(2)11-12-10-28-23(29-12)30-22(32)14-6-5-13(20-21(14)27-8-7-26-20)17-18(24)15(33-3)9-16(34-4)19(17)25/h5-10H,11H2,1-4H3,(H2,28,29,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130078
(US8815901, 135)Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCOCC3)[nH]2)c2nccnc12 |(10.4,-2.67,;8.86,-2.67,;8.09,-1.33,;8.86,,;8.09,1.33,;8.86,2.67,;8.09,4,;6.55,1.33,;5.78,2.67,;5.78,,;6.55,-1.33,;5.78,-2.67,;4.24,,;3.47,1.33,;1.93,1.33,;1.16,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.6,-.09,;-5.06,-.56,;-5.06,-2.1,;-6.4,-2.87,;-7.73,-2.1,;-7.73,-.56,;-9.06,.21,;-10.4,-.56,;-10.4,-2.1,;-9.06,-2.87,;-3.6,-2.58,;1.93,-1.33,;1.16,-2.67,;1.93,-4,;3.47,-4,;4.24,-2.67,;3.47,-1.33,)| Show InChI InChI=1S/C25H24F2N6O4/c1-35-17-11-18(36-2)21(27)19(20(17)26)15-3-4-16(23-22(15)28-5-6-29-23)24(34)32-25-30-12-14(31-25)13-33-7-9-37-10-8-33/h3-6,11-12H,7-10,13H2,1-2H3,(H2,30,31,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102537
(US8536175, 136)Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN(C)CC(N)=O)cn2)c2nccnc12 |(11.15,2.66,;9.61,2.66,;8.84,1.32,;9.61,-.01,;8.84,-1.34,;9.61,-2.68,;11.15,-2.68,;7.3,-1.34,;6.53,-2.68,;6.53,-.01,;7.3,1.32,;6.53,2.66,;4.99,-.01,;4.22,1.32,;2.68,1.32,;1.91,-.01,;.37,-.01,;-.4,1.32,;-.4,-1.34,;-1.94,-1.34,;-2.71,-.01,;-4.25,-.01,;-5.02,-1.34,;-6.56,-1.34,;-7.33,-.01,;-6.56,1.32,;-8.87,-.01,;-9.64,1.32,;-8.87,2.66,;-11.18,1.32,;-4.25,-2.68,;-2.71,-2.68,;2.68,-1.34,;1.91,-2.68,;2.68,-4.01,;4.22,-4.01,;4.99,-2.68,;4.22,-1.34,)| Show InChI InChI=1S/C26H24F2N6O4/c1-34(13-19(29)35)12-14-4-7-20(32-11-14)33-26(36)16-6-5-15(24-25(16)31-9-8-30-24)21-22(27)17(37-2)10-18(38-3)23(21)28/h4-11H,12-13H2,1-3H3,(H2,29,35)(H,32,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130081
(US8815901, 155)Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCNC(=O)C3)[nH]2)c2nccnc12 |(8.7,3.96,;9.47,2.62,;8.7,1.29,;9.47,-.04,;8.7,-1.38,;9.47,-2.71,;11.01,-2.71,;7.16,-1.38,;6.39,-2.71,;6.39,-.04,;7.16,1.29,;6.39,2.62,;4.85,-.04,;4.08,1.29,;2.54,1.29,;1.77,-.04,;.23,-.04,;-.54,1.29,;-.54,-1.38,;-2.08,-1.38,;-2.98,-.13,;-4.45,-.61,;-4.45,-2.15,;-5.78,-2.92,;-7.11,-2.15,;-7.11,-.61,;-8.45,.16,;-9.78,-.61,;-9.78,-2.15,;-11.12,-2.92,;-8.45,-2.92,;-2.98,-2.62,;2.54,-1.38,;1.77,-2.71,;2.54,-4.05,;4.08,-4.05,;4.85,-2.71,;4.08,-1.38,)| Show InChI InChI=1S/C25H23ClFN7O4/c1-37-16-9-17(38-2)21(27)19(20(16)26)14-3-4-15(23-22(14)29-5-6-30-23)24(36)33-25-31-10-13(32-25)11-34-8-7-28-18(35)12-34/h3-6,9-10H,7-8,11-12H2,1-2H3,(H,28,35)(H2,31,32,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| PC cid
PC sid
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Similars
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102533
(US8536175, 122)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nc(C)c(C)nc12 |(10.39,-2,;8.85,-2,;8.08,-.67,;8.85,.67,;8.08,2,;8.85,3.33,;8.08,4.67,;6.54,2,;5.78,3.33,;5.78,.67,;6.54,-.67,;5.78,-2,;4.23,.67,;3.47,2,;1.93,2,;1.15,.67,;-.38,.67,;-1.15,2,;-1.15,-.67,;-2.69,-.67,;-3.47,.67,;-5,.67,;-5.78,-.67,;-7.31,-.67,;-8.08,.67,;-7.31,2,;-8.08,3.33,;-9.63,3.33,;-10.39,4.67,;-10.39,2,;-9.63,.67,;-5,-2,;-3.47,-2,;1.93,-.67,;1.15,-2,;1.93,-3.33,;1.15,-4.67,;3.47,-3.33,;4.23,-4.67,;4.23,-2,;3.47,-.67,)| Show InChI InChI=1S/C30H32Cl2N6O3/c1-17-18(2)35-29-21(30(39)36-24-9-6-19(15-33-24)16-38-12-10-37(3)11-13-38)8-7-20(28(29)34-17)25-26(31)22(40-4)14-23(41-5)27(25)32/h6-9,14-15H,10-13,16H2,1-5H3,(H,33,36,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
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Similars
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102548
(US8536175, 174)Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2ncccc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.34,;8.85,-.01,;8.08,1.33,;8.85,2.66,;8.08,3.99,;6.54,1.33,;5.77,2.66,;5.77,-.01,;6.54,-1.34,;5.77,-2.67,;4.23,-.01,;3.46,1.33,;1.92,1.33,;1.15,-.01,;-.39,-.01,;-1.16,1.33,;-1.16,-1.34,;-2.7,-1.34,;-3.47,-.01,;-5.01,-.01,;-5.78,-1.34,;-7.32,-1.34,;-8.09,-.01,;-7.32,1.33,;-8.09,2.66,;-9.63,2.66,;-10.4,3.99,;-10.4,1.33,;-9.63,-.01,;-5.01,-2.67,;-3.47,-2.67,;1.92,-1.34,;1.15,-2.67,;1.92,-4.01,;3.46,-4.01,;4.23,-2.67,;3.46,-1.34,)| Show InChI InChI=1S/C29H29F2N5O3/c1-35-11-13-36(14-12-35)17-18-6-9-24(33-16-18)34-29(37)21-8-7-19(20-5-4-10-32-28(20)21)25-26(30)22(38-2)15-23(39-3)27(25)31/h4-10,15-16H,11-14,17H2,1-3H3,(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130068
(US8815901, 20)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc(CN3CCN(C)CC3)[nH]2)c2nccnc12 |(10.91,-2.76,;9.37,-2.76,;8.6,-1.43,;9.37,-.1,;8.6,1.24,;9.37,2.57,;8.6,3.91,;7.06,1.24,;6.29,2.57,;6.29,-.1,;7.06,-1.43,;6.29,-2.76,;4.75,-.1,;3.98,1.24,;2.44,1.24,;1.67,-.1,;.13,-.1,;-.64,1.24,;-.64,-1.43,;-2.18,-1.43,;-3.09,-.18,;-4.55,-.66,;-4.55,-2.2,;-5.8,-3.1,;-7.13,-2.33,;-7.13,-.79,;-8.46,-.02,;-9.8,-.79,;-11.13,-.02,;-9.8,-2.33,;-8.46,-3.1,;-3.09,-2.67,;2.44,-1.43,;1.67,-2.76,;2.44,-4.1,;3.98,-4.1,;4.75,-2.76,;3.98,-1.43,)| Show InChI InChI=1S/C26H27Cl2N7O3/c1-34-8-10-35(11-9-34)14-15-13-31-26(32-15)33-25(36)17-5-4-16(23-24(17)30-7-6-29-23)20-21(27)18(37-2)12-19(38-3)22(20)28/h4-7,12-13H,8-11,14H2,1-3H3,(H2,31,32,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130077
(US8815901, 127)Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2nccnc12 |(7.42,4,;8.19,2.67,;7.42,1.33,;8.19,,;7.42,-1.33,;8.19,-2.67,;9.73,-2.67,;5.88,-1.33,;5.11,-2.67,;5.11,,;5.88,1.33,;5.11,2.67,;3.57,,;2.8,1.33,;1.26,1.33,;.49,,;-1.05,,;-1.82,1.33,;-1.82,-1.33,;-3.36,-1.33,;-4.26,-.09,;-5.73,-.56,;-5.73,-2.1,;-7.06,-2.87,;-8.4,-2.1,;-8.4,-.56,;-9.73,-2.87,;-4.26,-2.58,;1.26,-1.33,;.49,-2.67,;1.26,-4,;2.8,-4,;3.57,-2.67,;2.8,-1.33,)| Show InChI InChI=1S/C23H22F2N6O3/c1-31(2)11-12-10-28-23(29-12)30-22(32)14-6-5-13(20-21(14)27-8-7-26-20)17-18(24)15(33-3)9-16(34-4)19(17)25/h5-10H,11H2,1-4H3,(H2,28,29,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102531
(US8536175, 106)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(CCO)CC3)cn2)c2nccnc12 |(11.55,2.62,;10.01,2.62,;9.24,1.28,;10.01,-.05,;9.24,-1.38,;10.01,-2.72,;11.55,-2.72,;7.7,-1.38,;6.93,-2.72,;6.93,-.05,;7.7,1.28,;6.93,2.61,;5.39,-.05,;4.62,1.28,;3.08,1.28,;2.31,-.05,;.77,-.05,;0,1.28,;0,-1.38,;-1.54,-1.38,;-2.31,-.05,;-3.85,-.05,;-4.62,-1.38,;-6.16,-1.38,;-6.93,-.05,;-6.16,1.28,;-6.93,2.62,;-8.47,2.62,;-9.24,3.95,;-10.78,3.95,;-11.55,2.62,;-9.24,1.28,;-8.47,-.05,;-3.85,-2.72,;-2.31,-2.72,;3.08,-1.38,;2.31,-2.72,;3.08,-4.05,;4.62,-4.05,;5.39,-2.72,;4.62,-1.38,)| Show InChI InChI=1S/C29H30Cl2N6O4/c1-40-21-15-22(41-2)26(31)24(25(21)30)19-4-5-20(28-27(19)32-7-8-33-28)29(39)35-23-6-3-18(16-34-23)17-37-11-9-36(10-12-37)13-14-38/h3-8,15-16,38H,9-14,17H2,1-2H3,(H,34,35,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102512
(US8536175, 31)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nccnc12 |(10.38,-2.67,;8.84,-2.67,;8.07,-1.33,;8.84,,;8.07,1.33,;8.84,2.67,;8.07,4,;6.53,1.33,;5.76,2.67,;5.76,,;6.53,-1.33,;5.76,-2.67,;4.22,,;3.45,1.33,;1.91,1.33,;1.14,,;-.4,,;-1.17,1.33,;-1.17,-1.33,;-2.71,-1.33,;-3.48,,;-5.02,,;-5.79,-1.33,;-7.33,-1.33,;-8.1,,;-7.33,1.33,;-8.08,2.65,;-9.61,2.65,;-10.38,3.98,;-10.36,1.33,;-9.64,,;-5.02,-2.67,;-3.48,-2.67,;1.91,-1.33,;1.14,-2.67,;1.91,-4,;3.45,-4,;4.22,-2.67,;3.45,-1.33,)| Show InChI InChI=1S/C28H28Cl2N6O3/c1-35-10-12-36(13-11-35)16-17-4-7-22(33-15-17)34-28(37)19-6-5-18(26-27(19)32-9-8-31-26)23-24(29)20(38-2)14-21(39-3)25(23)30/h4-9,14-15H,10-13,16H2,1-3H3,(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102506
(US8536175, 11)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(CC3)C(C)C)cc2)c2nccnc12 |(11.17,2,;9.63,2,;8.86,.67,;9.63,-.67,;8.86,-2,;9.63,-3.33,;11.17,-3.33,;7.32,-2,;6.54,-3.33,;6.54,-.67,;7.32,.67,;6.54,2,;5.01,-.67,;4.24,.67,;2.7,.67,;1.93,-.67,;.38,-.67,;-.38,.67,;-.38,-2,;-1.93,-2,;-2.7,-.67,;-4.24,-.67,;-5.01,-2,;-6.54,-2,;-7.32,-.67,;-6.54,.67,;-7.32,2,;-8.86,2,;-9.63,.67,;-8.86,-.67,;-9.63,3.33,;-11.17,3.33,;-8.86,4.67,;-4.24,-3.33,;-2.7,-3.33,;2.7,-2,;1.93,-3.33,;2.7,-4.67,;4.24,-4.67,;5.01,-3.33,;4.24,-2,)| Show InChI InChI=1S/C31H33Cl2N5O3/c1-19(2)38-15-13-37(14-16-38)18-20-5-7-21(8-6-20)36-31(39)23-10-9-22(29-30(23)35-12-11-34-29)26-27(32)24(40-3)17-25(41-4)28(26)33/h5-12,17,19H,13-16,18H2,1-4H3,(H,36,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102541
(US8536175, 152)Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCS(=O)(=O)CC3)cn2)c2nccnc12 |(8.08,4,;8.85,2.67,;8.08,1.33,;8.85,,;8.08,-1.33,;8.85,-2.67,;10.39,-2.67,;6.54,-1.33,;5.77,-2.67,;5.77,,;6.54,1.33,;5.77,2.67,;4.23,,;3.46,1.33,;1.92,1.33,;1.15,,;-.39,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.46,,;-5,,;-5.77,-1.33,;-7.31,-1.33,;-8.08,,;-9.62,,;-10.39,1.33,;-9.62,2.67,;-10.39,4,;-8.85,4,;-8.08,2.67,;-7.31,1.33,;-5,-2.67,;-3.46,-2.67,;1.92,-1.33,;1.15,-2.67,;1.92,-4,;3.46,-4,;4.23,-2.67,;3.46,-1.33,)| Show InChI InChI=1S/C27H25ClFN5O5S/c1-38-19-13-20(39-2)24(29)22(23(19)28)17-4-5-18(26-25(17)30-7-8-31-26)27(35)33-21-6-3-16(14-32-21)15-34-9-11-40(36,37)12-10-34/h3-8,13-14H,9-12,15H2,1-2H3,(H,32,33,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102511
(US8536175, 25)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(cn2)C(=O)N2CCN(C)CC2)c2nccnc12 |(10.4,-2.67,;8.86,-2.67,;8.09,-1.33,;8.85,,;8.09,1.33,;8.86,2.67,;8.09,4,;6.55,1.33,;5.78,2.67,;5.78,,;6.55,-1.33,;5.78,-2.67,;4.23,,;3.47,1.33,;1.93,1.33,;1.15,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.47,,;-5,,;-5.78,-1.33,;-5,-2.67,;-3.47,-2.67,;-7.31,-1.33,;-8.08,-2.67,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.63,2.67,;-10.39,4,;-10.39,1.33,;-9.63,,;1.93,-1.33,;1.15,-2.67,;1.93,-4,;3.47,-4,;4.23,-2.67,;3.47,-1.33,)| Show InChI InChI=1S/C28H26Cl2N6O4/c1-35-10-12-36(13-11-35)28(38)16-4-7-21(33-15-16)34-27(37)18-6-5-17(25-26(18)32-9-8-31-25)22-23(29)19(39-2)14-20(40-3)24(22)30/h4-9,14-15H,10-13H2,1-3H3,(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102527
(US8536175, 95)Show SMILES CCN1CCN(Cc2ccc(NC(=O)c3ccc(-c4cc(OC)cc(OC)c4F)c4nccnc34)nc2)CC1 Show InChI InChI=1S/C29H31FN6O3/c1-4-35-11-13-36(14-12-35)18-19-5-8-25(33-17-19)34-29(37)22-7-6-21(27-28(22)32-10-9-31-27)23-15-20(38-2)16-24(39-3)26(23)30/h5-10,15-17H,4,11-14,18H2,1-3H3,(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102539
(US8536175, 143)Show SMILES COc1cc(OC)c(F)c(c1)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nccnc12 Show InChI InChI=1S/C28H29FN6O3/c1-34-10-12-35(13-11-34)17-18-4-7-24(32-16-18)33-28(36)21-6-5-20(26-27(21)31-9-8-30-26)22-14-19(37-2)15-23(38-3)25(22)29/h4-9,14-16H,10-13,17H2,1-3H3,(H,32,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102550
(US8536175, 176)Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2ncccc12 |(8.08,3.99,;8.85,2.66,;8.08,1.33,;8.85,-.01,;8.08,-1.34,;8.85,-2.67,;10.39,-2.67,;6.54,-1.34,;5.77,-2.67,;5.77,-.01,;6.54,1.33,;5.77,2.66,;4.23,-.01,;3.46,1.33,;1.92,1.33,;1.15,-.01,;-.39,-.01,;-1.16,1.33,;-1.16,-1.34,;-2.7,-1.34,;-3.47,-.01,;-5.01,-.01,;-5.78,-1.34,;-7.32,-1.34,;-8.09,-.01,;-7.32,1.33,;-8.09,2.66,;-9.63,2.66,;-10.4,3.99,;-10.4,1.33,;-9.63,-.01,;-5.01,-2.67,;-3.47,-2.67,;1.92,-1.34,;1.15,-2.67,;1.92,-4.01,;3.46,-4.01,;4.23,-2.67,;3.46,-1.34,)| Show InChI InChI=1S/C29H29ClFN5O3/c1-35-11-13-36(14-12-35)17-18-6-9-24(33-16-18)34-29(37)21-8-7-19(20-5-4-10-32-28(20)21)25-26(30)22(38-2)15-23(39-3)27(25)31/h4-10,15-16H,11-14,17H2,1-3H3,(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102513
(US8536175, 34)Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccc(-c3c(Cl)c(OC)cc(OC)c3Cl)c3nccnc23)cn1 |(-11.55,,;-10.78,-1.33,;-9.24,-1.33,;-8.47,,;-6.93,,;-6.16,-1.33,;-6.93,-2.67,;-8.47,-2.67,;-4.62,-1.33,;-3.85,,;-2.31,,;-1.54,-1.33,;,-1.33,;.77,,;,1.33,;2.31,,;3.08,1.33,;4.62,1.33,;5.39,,;6.93,,;7.7,-1.33,;6.93,-2.67,;9.24,-1.33,;10.01,-2.67,;11.55,-2.67,;10.01,,;9.24,1.33,;10.01,2.67,;9.24,4,;7.7,1.33,;6.93,2.67,;4.62,-1.33,;5.39,-2.67,;4.62,-4,;3.08,-4,;2.31,-2.67,;3.08,-1.33,;-2.31,-2.67,;-3.85,-2.67,)| Show InChI InChI=1S/C28H28Cl2N6O3/c1-4-35-11-13-36(14-12-35)22-8-5-17(16-33-22)34-28(37)19-7-6-18(26-27(19)32-10-9-31-26)23-24(29)20(38-2)15-21(39-3)25(23)30/h5-10,15-16H,4,11-14H2,1-3H3,(H,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102505
(US8536175, 10)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(cc2)N2CCN(CC2)C(C)C)c2nccnc12 |(11.55,-2.67,;10.01,-2.67,;9.24,-1.33,;10.01,,;9.24,1.33,;10.01,2.67,;9.24,4,;7.7,1.33,;6.93,2.67,;6.93,,;7.7,-1.33,;6.93,-2.67,;5.39,,;4.62,1.33,;3.08,1.33,;2.31,,;.77,,;,1.33,;,-1.33,;-1.54,-1.33,;-2.31,,;-3.85,,;-4.62,-1.33,;-3.85,-2.67,;-2.31,-2.67,;-6.16,-1.33,;-6.93,,;-8.47,,;-9.24,-1.33,;-8.47,-2.67,;-6.93,-2.67,;-10.78,-1.33,;-11.55,-2.67,;-11.55,,;3.08,-1.33,;2.31,-2.67,;3.08,-4,;4.62,-4,;5.39,-2.67,;4.62,-1.33,)| Show InChI InChI=1S/C30H31Cl2N5O3/c1-18(2)36-13-15-37(16-14-36)20-7-5-19(6-8-20)35-30(38)22-10-9-21(28-29(22)34-12-11-33-28)25-26(31)23(39-3)17-24(40-4)27(25)32/h5-12,17-18H,13-16H2,1-4H3,(H,35,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130082
(US8815901, 172)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2ncccc12 |(7.42,4,;8.19,2.67,;7.42,1.33,;8.19,,;7.42,-1.33,;8.19,-2.67,;9.73,-2.67,;5.88,-1.33,;5.11,-2.67,;5.11,,;5.88,1.33,;5.11,2.67,;3.57,,;2.8,1.33,;1.26,1.33,;.49,,;-1.05,,;-1.82,1.33,;-1.82,-1.33,;-3.36,-1.33,;-4.26,-.09,;-5.73,-.56,;-5.73,-2.1,;-7.06,-2.87,;-8.4,-2.1,;-9.73,-2.87,;-8.4,-.56,;-4.26,-2.58,;1.26,-1.33,;.49,-2.67,;1.26,-4,;2.8,-4,;3.57,-2.67,;2.8,-1.33,)| Show InChI InChI=1S/C24H23Cl2N5O3/c1-31(2)12-13-11-28-24(29-13)30-23(32)16-8-7-14(15-6-5-9-27-22(15)16)19-20(25)17(33-3)10-18(34-4)21(19)26/h5-11H,12H2,1-4H3,(H2,28,29,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM9224
(US8536175, 6 | US8815901, 6)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(cn2)C(N)=O)c2nccnc12 |(9.24,-2.67,;7.7,-2.67,;6.93,-1.33,;7.7,,;6.93,1.33,;7.7,2.67,;6.93,4,;5.39,1.33,;4.62,2.67,;4.62,,;5.39,-1.33,;4.62,-2.67,;3.08,,;2.31,1.33,;.77,1.33,;;-1.54,,;-2.31,1.33,;-2.31,-1.33,;-3.85,-1.33,;-4.62,,;-6.16,,;-6.93,-1.33,;-6.16,-2.67,;-4.62,-2.67,;-8.47,-1.33,;-9.24,-2.67,;-9.24,,;.77,-1.33,;,-2.67,;.77,-4,;2.31,-4,;3.08,-2.67,;2.31,-1.33,)| Show InChI InChI=1S/C23H17Cl2N5O4/c1-33-14-9-15(34-2)19(25)17(18(14)24)12-4-5-13(21-20(12)27-7-8-28-21)23(32)30-16-6-3-11(10-29-16)22(26)31/h3-10H,1-2H3,(H2,26,31)(H,29,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM9224
(US8536175, 6 | US8815901, 6)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(cn2)C(N)=O)c2nccnc12 |(9.24,-2.67,;7.7,-2.67,;6.93,-1.33,;7.7,,;6.93,1.33,;7.7,2.67,;6.93,4,;5.39,1.33,;4.62,2.67,;4.62,,;5.39,-1.33,;4.62,-2.67,;3.08,,;2.31,1.33,;.77,1.33,;;-1.54,,;-2.31,1.33,;-2.31,-1.33,;-3.85,-1.33,;-4.62,,;-6.16,,;-6.93,-1.33,;-6.16,-2.67,;-4.62,-2.67,;-8.47,-1.33,;-9.24,-2.67,;-9.24,,;.77,-1.33,;,-2.67,;.77,-4,;2.31,-4,;3.08,-2.67,;2.31,-1.33,)| Show InChI InChI=1S/C23H17Cl2N5O4/c1-33-14-9-15(34-2)19(25)17(18(14)24)12-4-5-13(21-20(12)27-7-8-28-21)23(32)30-16-6-3-11(10-29-16)22(26)31/h3-10H,1-2H3,(H2,26,31)(H,29,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102515
(US8536175, 43)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCOCC3)nc2)c2nccnc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.33,;8.85,,;8.08,1.33,;8.85,2.67,;8.08,4,;6.54,1.33,;5.77,2.67,;5.77,,;6.54,-1.33,;5.77,-2.67,;4.23,,;3.46,1.33,;1.92,1.33,;1.15,,;-.39,,;-1.16,1.33,;-1.16,-1.33,;-2.69,-1.33,;-3.46,,;-5,,;-5.77,-1.33,;-7.31,-1.33,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.62,2.67,;-10.39,1.33,;-9.62,,;-5,-2.67,;-3.46,-2.67,;1.92,-1.33,;1.15,-2.67,;1.92,-4,;3.46,-4,;4.23,-2.67,;3.46,-1.33,)| Show InChI InChI=1S/C27H25Cl2N5O4/c1-36-20-13-21(37-2)24(29)22(23(20)28)18-5-6-19(26-25(18)30-7-8-31-26)27(35)33-16-3-4-17(32-14-16)15-34-9-11-38-12-10-34/h3-8,13-14H,9-12,15H2,1-2H3,(H,33,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102545
(US8536175, 167)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCNCC3)cn2)c2ncccc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.34,;8.85,-0,;8.08,1.33,;8.85,2.66,;8.08,4,;6.54,1.33,;5.77,2.66,;5.77,-0,;6.54,-1.34,;5.77,-2.67,;4.23,-0,;3.46,1.33,;1.92,1.33,;1.15,-0,;-.39,-0,;-1.16,1.33,;-1.16,-1.34,;-2.7,-1.34,;-3.47,-0,;-5.01,-0,;-5.78,-1.34,;-7.32,-1.34,;-8.09,-0,;-7.32,1.33,;-8.09,2.66,;-9.63,2.66,;-10.4,1.33,;-9.63,-0,;-5.01,-2.67,;-3.47,-2.67,;1.92,-1.34,;1.15,-2.67,;1.92,-4.01,;3.46,-4.01,;4.23,-2.67,;3.46,-1.34,)| Show InChI InChI=1S/C28H27Cl2N5O3/c1-37-21-14-22(38-2)26(30)24(25(21)29)18-6-7-20(27-19(18)4-3-9-32-27)28(36)34-23-8-5-17(15-33-23)16-35-12-10-31-11-13-35/h3-9,14-15,31H,10-13,16H2,1-2H3,(H,33,34,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102532
(US8536175, 112)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCNC(C)(C)C3)nc2)c2nccnc12 |(8.7,-13.78,;7.36,-14.55,;7.36,-16.09,;8.7,-16.86,;8.7,-18.4,;10.03,-19.17,;11.36,-18.4,;7.36,-19.17,;7.36,-20.71,;6.03,-18.4,;6.03,-16.86,;4.69,-16.09,;4.69,-19.17,;3.36,-18.4,;2.03,-19.17,;2.03,-20.71,;.69,-21.48,;.69,-23.02,;-.64,-20.71,;-1.97,-21.48,;-3.31,-20.71,;-4.64,-21.48,;-4.64,-23.02,;-5.98,-23.79,;-7.31,-23.02,;-7.31,-21.48,;-8.64,-20.71,;-9.98,-21.48,;-9.98,-23.02,;-11.31,-23.79,;-10.38,-24.51,;-8.64,-23.79,;-3.31,-23.79,;-1.97,-23.02,;3.36,-21.48,;3.36,-23.02,;4.69,-23.79,;6.03,-23.02,;6.03,-21.48,;4.69,-20.71,)| Show InChI InChI=1S/C29H30Cl2N6O3/c1-29(2)16-37(12-11-35-29)15-18-6-5-17(14-34-18)36-28(38)20-8-7-19(26-27(20)33-10-9-32-26)23-24(30)21(39-3)13-22(40-4)25(23)31/h5-10,13-14,35H,11-12,15-16H2,1-4H3,(H,36,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130074
(US8815901, 85)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc[nH]2)c2ncc(nc12)N(C)CCN(C)C |(5.42,6,;6.19,4.67,;5.42,3.33,;6.19,2,;5.42,.67,;6.19,-.67,;7.73,-.67,;3.88,.67,;3.11,-.67,;3.11,2,;3.88,3.33,;3.11,4.67,;1.57,2,;.8,3.33,;-.74,3.33,;-1.51,2,;-3.05,2,;-3.82,3.33,;-3.82,.67,;-5.36,.67,;-6.27,1.91,;-7.73,1.44,;-7.73,-.1,;-6.27,-.58,;-.74,.67,;-1.51,-.67,;-.74,-2,;.8,-2,;1.57,-.67,;.8,.67,;1.57,-3.33,;.8,-4.67,;3.11,-3.33,;3.88,-4.67,;5.42,-4.67,;6.19,-6,;6.19,-3.33,)| Show InChI InChI=1S/C25H27Cl2N7O3/c1-33(2)10-11-34(3)18-13-30-22-15(24(35)32-25-28-8-9-29-25)7-6-14(23(22)31-18)19-20(26)16(36-4)12-17(37-5)21(19)27/h6-9,12-13H,10-11H2,1-5H3,(H2,28,29,32,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102547
(US8536175, 173)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN(C)CCN(C)C)cn2)c2ncccc12 |(11.55,2.66,;10.01,2.66,;9.24,1.33,;10.01,-0,;9.24,-1.34,;10.01,-2.67,;11.55,-2.67,;7.7,-1.34,;6.93,-2.67,;6.93,-0,;7.7,1.33,;6.93,2.66,;5.39,-0,;4.62,1.33,;3.08,1.33,;2.31,-0,;.77,-0,;-0,1.33,;-0,-1.34,;-1.54,-1.34,;-2.31,-0,;-3.85,-0,;-4.62,-1.34,;-6.16,-1.34,;-6.93,-0,;-6.16,1.33,;-8.47,-0,;-9.24,-1.34,;-10.78,-1.34,;-11.55,-2.67,;-11.55,-0,;-3.85,-2.67,;-2.31,-2.67,;3.08,-1.34,;2.31,-2.67,;3.08,-4.01,;4.62,-4.01,;5.39,-2.67,;4.62,-1.34,)| Show InChI InChI=1S/C29H31Cl2N5O3/c1-35(2)13-14-36(3)17-18-8-11-24(33-16-18)34-29(37)21-10-9-19(20-7-6-12-32-28(20)21)25-26(30)22(38-4)15-23(39-5)27(25)31/h6-12,15-16H,13-14,17H2,1-5H3,(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 245 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102538
(US8536175, 139)Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccn(CCN(C)C)c2)c2nccnc12 |(9.72,-2.68,;8.18,-2.68,;7.41,-1.34,;8.18,-.01,;7.41,1.32,;8.18,2.66,;7.41,3.99,;5.87,1.32,;5.1,2.66,;5.1,-.01,;5.87,-1.34,;5.1,-2.68,;3.56,-.01,;2.79,1.32,;1.25,1.32,;.48,-.01,;-1.06,-.01,;-1.83,1.32,;-1.83,-1.34,;-3.37,-1.34,;-4.28,-.1,;-5.74,-.57,;-5.74,-2.11,;-7.08,-2.88,;-8.41,-2.11,;-8.41,-.57,;-7.08,.2,;-9.74,.2,;-4.28,-2.59,;1.25,-1.34,;.48,-2.68,;1.25,-4.01,;2.79,-4.01,;3.56,-2.68,;2.79,-1.34,)| Show InChI InChI=1S/C25H25F2N5O3/c1-31(2)11-12-32-10-7-15(14-32)30-25(33)17-6-5-16(23-24(17)29-9-8-28-23)20-21(26)18(34-3)13-19(35-4)22(20)27/h5-10,13-14H,11-12H2,1-4H3,(H,30,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 265 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102514
(US8536175, 38)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(nc2)N(C)CCN(C)C)c2nccnc12 |(11.17,2.67,;9.63,2.67,;8.86,1.33,;9.63,,;8.86,-1.33,;9.63,-2.67,;11.17,-2.67,;7.31,-1.33,;6.55,-2.67,;6.55,,;7.31,1.33,;6.55,2.67,;5.01,,;4.24,1.33,;2.7,1.33,;1.92,,;.39,,;-.39,1.33,;-.39,-1.33,;-1.92,-1.33,;-2.7,,;-4.24,,;-5.01,-1.33,;-4.24,-2.67,;-2.7,-2.67,;-6.55,-1.33,;-7.32,-2.67,;-7.32,,;-8.86,,;-9.63,-1.33,;-8.86,-2.67,;-11.17,-1.33,;2.7,-1.33,;1.92,-2.67,;2.7,-4,;4.24,-4,;5.01,-2.67,;4.24,-1.33,)| Show InChI InChI=1S/C27H28Cl2N6O3/c1-34(2)12-13-35(3)21-9-6-16(15-32-21)33-27(36)18-8-7-17(25-26(18)31-11-10-30-25)22-23(28)19(37-4)14-20(38-5)24(22)29/h6-11,14-15H,12-13H2,1-5H3,(H,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102525
(US8536175, 91)Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccccn2)c2nccnc12 |(8.09,-2.67,;6.55,-2.67,;5.78,-1.33,;6.55,,;5.78,1.33,;6.55,2.67,;5.78,4,;4.23,1.33,;3.47,2.67,;3.47,,;4.23,-1.33,;3.47,-2.67,;1.93,,;1.15,1.33,;-.38,1.33,;-1.15,,;-2.69,,;-3.47,1.33,;-3.47,-1.33,;-5,-1.33,;-5.78,,;-7.31,,;-8.08,-1.33,;-7.31,-2.67,;-5.78,-2.67,;-.38,-1.33,;-1.15,-2.67,;-.38,-4,;1.15,-4,;1.93,-2.67,;1.15,-1.33,)| Show InChI InChI=1S/C22H16F2N4O3/c1-30-14-11-15(31-2)19(24)17(18(14)23)12-6-7-13(21-20(12)26-9-10-27-21)22(29)28-16-5-3-4-8-25-16/h3-11H,1-2H3,(H,25,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 485 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102501
(US8536175, 2)Show SMILES CCN1CCN(CC1)c1cccc(NC(=O)c2ccc(-c3c(Cl)c(OC)cc(OC)c3Cl)c3nccnc23)c1 |(-10.01,4.67,;-8.47,4.67,;-7.7,3.33,;-6.16,3.33,;-5.39,2,;-6.16,.67,;-7.7,.67,;-8.47,2,;-5.39,-.67,;-6.16,-2,;-5.39,-3.33,;-3.85,-3.33,;-3.08,-2,;-1.54,-2,;-.77,-.67,;-1.54,.67,;.77,-.67,;1.54,.67,;3.08,.67,;3.85,-.67,;5.39,-.67,;6.16,-2,;5.39,-3.33,;7.7,-2,;8.47,-3.33,;10.01,-3.33,;8.47,-.67,;7.7,.67,;8.47,2,;7.7,3.33,;6.16,.67,;5.39,2,;3.08,-2,;3.85,-3.33,;3.08,-4.67,;1.54,-4.67,;.77,-3.33,;1.54,-2,;-3.85,-.67,)| Show InChI InChI=1S/C29H29Cl2N5O3/c1-4-35-12-14-36(15-13-35)19-7-5-6-18(16-19)34-29(37)21-9-8-20(27-28(21)33-11-10-32-27)24-25(30)22(38-2)17-23(39-3)26(24)31/h5-11,16-17H,4,12-15H2,1-3H3,(H,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102510
(US8536175, 24)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(=O)[nH]c2)c2nccnc12 |(6.55,4,;7.32,2.67,;6.55,1.33,;7.31,,;6.55,-1.33,;7.32,-2.67,;8.86,-2.67,;5.01,-1.33,;4.23,-2.67,;4.23,,;5.01,1.33,;4.23,2.67,;2.69,,;1.93,1.33,;.38,1.33,;-.38,,;-1.92,,;-2.69,1.33,;-2.69,-1.33,;-4.23,-1.33,;-5,,;-6.54,,;-7.31,-1.33,;-8.85,-1.33,;-6.54,-2.67,;-5,-2.67,;.38,-1.33,;-.38,-2.67,;.38,-4,;1.93,-4,;2.69,-2.67,;1.93,-1.33,)| Show InChI InChI=1S/C22H16Cl2N4O4/c1-31-14-9-15(32-2)19(24)17(18(14)23)12-4-5-13(21-20(12)25-7-8-26-21)22(30)28-11-3-6-16(29)27-10-11/h3-10H,1-2H3,(H,27,29)(H,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102521
(US8536175, 82)Show SMILES CCN1CCN(Cc2cnc3c(ccc(C(=O)Nc4cccnc4)c3n2)-c2c(Cl)c(OC)cc(OC)c2Cl)CC1 |(-8.08,-5.33,;-7.31,-4,;-5.78,-4,;-5,-2.67,;-3.47,-2.67,;-2.69,-4,;-1.15,-4,;-.38,-2.67,;1.15,-2.67,;1.93,-1.33,;1.15,,;1.93,1.33,;1.15,2.67,;-.38,2.67,;-1.15,1.33,;-2.69,1.33,;-3.47,2.67,;-3.47,,;-5,,;-5.78,1.33,;-7.31,1.33,;-8.08,,;-7.31,-1.33,;-5.78,-1.33,;-.38,,;-1.15,-1.33,;3.47,1.33,;4.23,,;3.47,-1.33,;5.78,,;6.55,-1.33,;8.09,-1.33,;6.55,1.33,;5.78,2.67,;6.55,4,;5.78,5.33,;4.23,2.67,;3.47,4,;-3.47,-5.33,;-5,-5.33,)| Show InChI InChI=1S/C29H30Cl2N6O3/c1-4-36-10-12-37(13-11-36)17-19-16-33-27-20(24-25(30)22(39-2)14-23(40-3)26(24)31)7-8-21(28(27)34-19)29(38)35-18-6-5-9-32-15-18/h5-9,14-16H,4,10-13,17H2,1-3H3,(H,35,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 605 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102517
(US8536175, 58 | US8815901, 58)Show SMILES CN1CCN(Cc2cnc(NC(=O)c3ccc(-c4cncc5ccccc45)c4nccnc34)[nH]2)CC1 Show InChI InChI=1S/C27H26N8O/c1-34-10-12-35(13-11-34)17-19-15-31-27(32-19)33-26(36)22-7-6-21(24-25(22)30-9-8-29-24)23-16-28-14-18-4-2-3-5-20(18)23/h2-9,14-16H,10-13,17H2,1H3,(H2,31,32,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102528
(US8536175, 97)Show SMILES CCN1CCN(Cc2ccc(NC(=O)c3ccc(-c4cc(C)cc(OC)c4C)c4nccnc34)nc2)CC1 Show InChI InChI=1S/C30H34N6O2/c1-5-35-12-14-36(15-13-35)19-22-6-9-27(33-18-22)34-30(37)24-8-7-23(28-29(24)32-11-10-31-28)25-16-20(2)17-26(38-4)21(25)3/h6-11,16-18H,5,12-15,19H2,1-4H3,(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 875 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102522
(US8536175, 83)Show SMILES CCN1CCN(Cc2cnc3c(ccc(-c4c(Cl)c(OC)cc(OC)c4Cl)c3n2)C(=O)Nc2cccnc2)CC1 |(8.47,-5.33,;7.7,-4,;6.16,-4,;5.39,-5.33,;3.85,-5.33,;3.08,-4,;1.54,-4,;.77,-2.67,;-.77,-2.67,;-1.54,-1.33,;-.77,,;-1.54,1.33,;-.77,2.67,;.77,2.67,;1.54,1.33,;3.08,1.33,;3.85,,;3.08,-1.33,;5.39,,;6.16,-1.33,;7.7,-1.33,;6.16,1.33,;5.39,2.67,;6.16,4,;5.39,5.33,;3.85,2.67,;3.08,4,;.77,,;1.54,-1.33,;-3.08,1.33,;-3.85,2.67,;-3.85,,;-5.39,,;-6.16,1.33,;-7.7,1.33,;-8.47,,;-7.7,-1.33,;-6.16,-1.33,;3.85,-2.67,;5.39,-2.67,)| Show InChI InChI=1S/C29H30Cl2N6O3/c1-4-36-10-12-37(13-11-36)17-19-16-33-27-21(29(38)35-18-6-5-9-32-15-18)8-7-20(28(27)34-19)24-25(30)22(39-2)14-23(40-3)26(24)31/h5-9,14-16H,4,10-13,17H2,1-3H3,(H,35,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 945 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102529
(US8536175, 98)Show SMILES CCN1CCN(Cc2ccc(NC(=O)c3ccc(-c4c(C)c(OC)cc(C)c4Cl)c4nccnc34)nc2)CC1 |(-8.85,4.67,;-9.62,3.33,;-8.85,2,;-7.31,2,;-6.54,.67,;-7.31,-.67,;-6.54,-2,;-5,-2,;-4.23,-.67,;-2.69,-.67,;-1.92,-2,;-.38,-2,;.39,-.67,;-.38,.67,;1.93,-.67,;2.7,.67,;4.24,.67,;5.01,-.67,;6.55,-.67,;7.32,.67,;6.55,2,;8.86,.67,;9.63,2,;11.17,2,;9.63,-.67,;8.86,-2,;9.63,-3.33,;7.32,-2,;6.55,-3.33,;4.24,-2,;5.01,-3.33,;4.24,-4.67,;2.7,-4.67,;1.93,-3.33,;2.7,-2,;-2.69,-3.33,;-4.23,-3.33,;-8.85,-.67,;-9.62,.67,)| Show InChI InChI=1S/C30H33ClN6O2/c1-5-36-12-14-37(15-13-36)18-21-6-9-25(34-17-21)35-30(38)23-8-7-22(28-29(23)33-11-10-32-28)26-20(3)24(39-4)16-19(2)27(26)31/h6-11,16-17H,5,12-15,18H2,1-4H3,(H,34,35,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102516
(US8536175, 56)Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(-c4cncc5ccccc45)c4nccnc34)nc2)CC1 Show InChI InChI=1S/C29H27N7O/c1-35-12-14-36(15-13-35)19-20-6-9-26(33-16-20)34-29(37)24-8-7-23(27-28(24)32-11-10-31-27)25-18-30-17-21-4-2-3-5-22(21)25/h2-11,16-18H,12-15,19H2,1H3,(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102503
(US8536175, 4)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(cc2)N2CCOCC2)c2nccnc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.33,;8.85,,;8.08,1.33,;8.85,2.67,;8.08,4,;6.54,1.33,;5.78,2.67,;5.78,,;6.54,-1.33,;5.78,-2.67,;4.23,,;3.47,1.33,;1.93,1.33,;1.15,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.47,,;-5,,;-5.78,-1.33,;-5,-2.67,;-3.47,-2.67,;-7.31,-1.33,;-8.08,,;-9.63,,;-10.39,-1.33,;-9.63,-2.67,;-8.08,-2.67,;1.93,-1.33,;1.15,-2.67,;1.93,-4,;3.47,-4,;4.23,-2.67,;3.47,-1.33,)| Show InChI InChI=1S/C27H24Cl2N4O4/c1-35-20-15-21(36-2)24(29)22(23(20)28)18-7-8-19(26-25(18)30-9-10-31-26)27(34)32-16-3-5-17(6-4-16)33-11-13-37-14-12-33/h3-10,15H,11-14H2,1-2H3,(H,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102524
(US8536175, 86)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccccn2)c2ncc(nc12)N(C)CCN(C)C |(8.09,-.67,;6.55,-.67,;5.78,.67,;6.55,2,;5.78,3.33,;6.55,4.67,;5.78,6,;4.23,3.33,;3.47,4.67,;3.47,2,;4.23,.67,;3.47,-.67,;1.93,2,;1.15,3.33,;-.38,3.33,;-1.15,2,;-2.69,2,;-3.47,3.33,;-3.47,.67,;-5,.67,;-5.78,2,;-7.31,2,;-8.08,.67,;-7.31,-.67,;-5.78,-.67,;-.38,.67,;-1.15,-.67,;-.38,-2,;1.15,-2,;1.93,-.67,;1.15,.67,;1.92,-3.33,;1.15,-4.67,;3.46,-3.33,;4.23,-4.67,;5.77,-4.67,;6.54,-6,;6.54,-3.33,)| Show InChI InChI=1S/C27H28Cl2N6O3/c1-34(2)12-13-35(3)21-15-31-25-17(27(36)32-20-8-6-7-11-30-20)10-9-16(26(25)33-21)22-23(28)18(37-4)14-19(38-5)24(22)29/h6-11,14-15H,12-13H2,1-5H3,(H,30,32,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.55E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102518
(US8536175, 62 | US8815901, 62)Show SMILES CN1CCN(Cc2cnc(NC(=O)c3ccc(-c4csc5ccccc45)c4nccnc34)[nH]2)CC1 Show InChI InChI=1S/C26H25N7OS/c1-32-10-12-33(13-11-32)15-17-14-29-26(30-17)31-25(34)20-7-6-19(23-24(20)28-9-8-27-23)21-16-35-22-5-3-2-4-18(21)22/h2-9,14,16H,10-13,15H2,1H3,(H2,29,30,31,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102519
(US8536175, 69 | US8815901, 69)Show SMILES CN1CCN(Cc2cnc(NC(=O)c3ccc(-c4cscc4C)c4nccnc34)[nH]2)CC1 Show InChI InChI=1S/C23H25N7OS/c1-15-13-32-14-19(15)17-3-4-18(21-20(17)24-5-6-25-21)22(31)28-23-26-11-16(27-23)12-30-9-7-29(2)8-10-30/h3-6,11,13-14H,7-10,12H2,1-2H3,(H2,26,27,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM130067
(US8815901, 17)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncn[nH]2)c2nccnc12 |(5.31,3.91,;6.08,2.57,;5.31,1.24,;6.08,-.1,;5.31,-1.43,;6.08,-2.76,;7.62,-2.76,;3.77,-1.43,;3,-2.76,;3,-.1,;3.77,1.24,;3,2.57,;1.46,-.1,;.69,1.24,;-.85,1.24,;-1.62,-.1,;-3.16,-.1,;-3.93,1.24,;-3.93,-1.43,;-5.47,-1.43,;-6.38,-.18,;-7.84,-.66,;-7.84,-2.2,;-6.38,-2.67,;-.85,-1.43,;-1.62,-2.76,;-.85,-4.1,;.69,-4.1,;1.46,-2.76,;.69,-1.43,)| Show InChI InChI=1S/C19H14Cl2N6O3/c1-29-11-7-12(30-2)15(21)13(14(11)20)9-3-4-10(17-16(9)22-5-6-23-17)18(28)26-19-24-8-25-27-19/h3-8H,1-2H3,(H2,24,25,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102530
(US8536175, 99)Show SMILES CCN1CCN(Cc2ccc(NC(=O)c3ccc(-c4cc(C)c[n+]([O-])c4C)c4nccnc34)nc2)CC1 Show InChI InChI=1S/C28H31N7O2/c1-4-33-11-13-34(14-12-33)18-21-5-8-25(31-16-21)32-28(36)23-7-6-22(26-27(23)30-10-9-29-26)24-15-19(2)17-35(37)20(24)3/h5-10,15-17H,4,11-14,18H2,1-3H3,(H,31,32,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102520
(US8536175, 115 | US8815901, 77)Show SMILES CN1CCN(Cc2cnc(NC(=O)c3ccc(-c4c(C)cccc4C)c4nccnc34)[nH]2)CC1 |(-10.29,.87,;-8.96,.1,;-7.63,.87,;-6.29,.1,;-6.29,-1.44,;-4.96,-2.21,;-3.63,-1.44,;-3.63,.1,;-2.16,.58,;-1.26,-.67,;.28,-.67,;1.05,.67,;.28,2,;2.59,.67,;3.36,2,;4.9,2,;5.67,.67,;7.21,.67,;7.98,2,;7.21,3.33,;9.52,2,;10.29,.67,;9.52,-.67,;7.98,-.67,;7.21,-2,;4.9,-.67,;5.67,-2,;4.9,-3.33,;3.36,-3.33,;2.59,-2,;3.36,-.67,;-2.16,-1.91,;-7.63,-2.21,;-8.96,-1.44,)| Show InChI InChI=1S/C26H29N7O/c1-17-5-4-6-18(2)22(17)20-7-8-21(24-23(20)27-9-10-28-24)25(34)31-26-29-15-19(30-26)16-33-13-11-32(3)12-14-33/h4-10,15H,11-14,16H2,1-3H3,(H2,29,30,31,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102502
(US8536175, 3)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(cc2)C(N)=O)c2nccnc12 |(9.24,-2.67,;7.7,-2.67,;6.93,-1.33,;7.7,,;6.93,1.33,;7.7,2.67,;6.93,4,;5.39,1.33,;4.62,2.67,;4.62,,;5.39,-1.33,;4.62,-2.67,;3.08,,;2.31,1.33,;.77,1.33,;;-1.54,,;-2.31,1.33,;-2.31,-1.33,;-3.85,-1.33,;-4.62,,;-6.16,,;-6.93,-1.33,;-6.16,-2.67,;-4.62,-2.67,;-8.47,-1.33,;-9.24,-2.67,;-9.24,,;.77,-1.33,;,-2.67,;.77,-4,;2.31,-4,;3.08,-2.67,;2.31,-1.33,)| Show InChI InChI=1S/C24H18Cl2N4O4/c1-33-16-11-17(34-2)20(26)18(19(16)25)14-7-8-15(22-21(14)28-9-10-29-22)24(32)30-13-5-3-12(4-6-13)23(27)31/h3-11H,1-2H3,(H2,27,31)(H,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
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