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Patent code US8815926

Compile Data Set for Download or QSAR

Found 334 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129810
PNG
(US8815926, 89)
Show SMILES COc1ccc(CO)cc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C |r|
Show InChI InChI=1S/C30H29Cl2N3O3/c1-16(2)34-28-26(33-29(34)23-13-19(15-36)7-11-25(23)38-5)30(37)35(24-14-21(32)8-6-17(24)3)27(28)22-10-9-20(31)12-18(22)4/h6-14,16,27,36H,15H2,1-5H3/t27-/m0/s1
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n/an/a 0.0400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129937
PNG
(US8815926, 218)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C(=O)NCCO |r|
Show InChI InChI=1S/C32H32Cl2N4O4/c1-17(2)37-29-27(36-30(37)24-15-20(7-11-26(24)42-5)31(40)35-12-13-39)32(41)38(25-16-22(34)8-6-18(25)3)28(29)23-10-9-21(33)14-19(23)4/h6-11,14-17,28,39H,12-13H2,1-5H3,(H,35,40)/t28-/m0/s1
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM130042
PNG
(US8815926, 325)
Show SMILES COC[C@@H](C)n1c(nc2C(=O)N([C@H](c12)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1)-c1cnc(nc1OC)N(C)C |r|
Show InChI InChI=1S/C28H29Cl2N7O4/c1-15(14-40-5)36-23-21(32-24(36)19-12-31-28(34(2)3)33-25(19)41-6)27(39)37(18-11-20(30)26(38)35(4)13-18)22(23)16-7-9-17(29)10-8-16/h7-13,15,22H,14H2,1-6H3/t15-,22+/m1/s1
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129738
PNG
(US8815926, 17)
Show SMILES COc1ccc(CNC(C)=O)cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C32H32Cl2N4O3/c1-17(2)37-30-28(36-31(37)25-14-21(16-35-20(5)39)8-12-27(25)41-6)32(40)38(26-15-23(34)9-7-18(26)3)29(30)24-11-10-22(33)13-19(24)4/h7-15,17,29H,16H2,1-6H3,(H,35,39)
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129796
PNG
(US8815926, 75)
Show SMILES COc1ncc(-c2nc3C(=O)N([C@H](c3n2C(C)C)c2ccc(Cl)cc2C)c2cc(Cl)ccc2C)c(OC)n1 |r|
Show InChI InChI=1S/C28H27Cl2N5O3/c1-14(2)34-24-22(32-25(34)20-13-31-28(38-6)33-26(20)37-5)27(36)35(21-12-18(30)8-7-15(21)3)23(24)19-10-9-17(29)11-16(19)4/h7-14,23H,1-6H3/t23-/m0/s1
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129730
PNG
(US8815926, 9)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C(=O)N(C)C
Show InChI InChI=1S/C32H32Cl2N4O3/c1-17(2)37-29-27(35-30(37)24-15-20(31(39)36(5)6)9-13-26(24)41-7)32(40)38(25-16-22(34)10-8-18(25)3)28(29)23-12-11-21(33)14-19(23)4/h8-17,28H,1-7H3
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129892
PNG
(US8815926, 173)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1ccc(F)c(Cl)c1)C(N)=O
Show InChI InChI=1S/C28H23Cl2FN4O3/c1-14(2)34-25-23(33-27(34)19-12-16(26(32)36)6-11-22(19)38-3)28(37)35(18-9-10-21(31)20(30)13-18)24(25)15-4-7-17(29)8-5-15/h4-14,24H,1-3H3,(H2,32,36)
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129966
PNG
(US8815926, 247)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(C#N)c(F)c1)c1cccc(Cl)c1F)N(C)C
Show InChI InChI=1S/C28H24ClF2N7O2/c1-14(2)37-24-22(34-25(37)17-13-33-28(36(3)4)35-26(17)40-5)27(39)38(20-8-6-7-18(29)21(20)31)23(24)15-9-10-16(12-32)19(30)11-15/h6-11,13-14,23H,1-5H3
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129945
PNG
(US8815926, 226)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C(=O)NC(C)C |r|
Show InChI InChI=1S/C33H34Cl2N4O3/c1-17(2)36-32(40)21-9-13-27(42-7)25(15-21)31-37-28-30(38(31)18(3)4)29(24-12-11-22(34)14-20(24)6)39(33(28)41)26-16-23(35)10-8-19(26)5/h8-18,29H,1-7H3,(H,36,40)/t29-/m0/s1
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129947
PNG
(US8815926, 228)
Show SMILES COc1ccc(CNC(=O)CO)cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C32H32Cl2N4O4/c1-17(2)37-30-28(36-31(37)24-13-20(7-11-26(24)42-5)15-35-27(40)16-39)32(41)38(25-14-22(34)8-6-18(25)3)29(30)23-10-9-21(33)12-19(23)4/h6-14,17,29,39H,15-16H2,1-5H3,(H,35,40)
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM130000
PNG
(US8815926, 281)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)cn(C)c1=O)N(C)C |r|
Show InChI InChI=1S/C27H27Cl2N7O3/c1-14(2)35-22-20(31-23(35)18-12-30-27(33(3)4)32-24(18)39-6)26(38)36(19-11-17(29)13-34(5)25(19)37)21(22)15-7-9-16(28)10-8-15/h7-14,21H,1-6H3/t21-/m0/s1
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM130035
PNG
(US8815926, 317)
Show SMILES COC[C@@H](C)n1c(nc2C(=O)N([C@H](c12)c1ccc(Cl)cc1)c1ccc(F)c(Cl)c1)-c1cnc(OC)nc1OC |r|
Show InChI InChI=1S/C27H24Cl2FN5O4/c1-14(13-37-2)34-23-21(32-24(34)18-12-31-27(39-4)33-25(18)38-3)26(36)35(17-9-10-20(30)19(29)11-17)22(23)15-5-7-16(28)8-6-15/h5-12,14,22H,13H2,1-4H3/t14-,22+/m1/s1
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129942
PNG
(US8815926, 223)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C(=O)N(C)C |r|
Show InChI InChI=1S/C32H32Cl2N4O3/c1-17(2)37-29-27(35-30(37)24-15-20(31(39)36(5)6)9-13-26(24)41-7)32(40)38(25-16-22(34)10-8-18(25)3)28(29)23-12-11-21(33)14-19(23)4/h8-17,28H,1-7H3/t28-/m0/s1
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129838
PNG
(US8815926, 117)
Show SMILES COc1ncc(-c2nc3C(=O)N(C(c3n2[C@H](C)CO)c2ccc(Cl)cc2)c2cc(Cl)ccc2C)c(OC)n1 |r|
Show InChI InChI=1S/C27H25Cl2N5O4/c1-14-5-8-18(29)11-20(14)34-22(16-6-9-17(28)10-7-16)23-21(26(34)36)31-24(33(23)15(2)13-35)19-12-30-27(38-4)32-25(19)37-3/h5-12,15,22,35H,13H2,1-4H3/t15-,22?/m1/s1
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129737
PNG
(US8815926, 16)
Show SMILES COc1ccc(CN)cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C30H30Cl2N4O2/c1-16(2)35-28-26(34-29(35)23-13-19(15-33)7-11-25(23)38-5)30(37)36(24-14-21(32)8-6-17(24)3)27(28)22-10-9-20(31)12-18(22)4/h6-14,16,27H,15,33H2,1-5H3
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129928
PNG
(US8815926, 209)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(=O)NC(C)C
Show InChI InChI=1S/C32H32Cl2N4O3/c1-17(2)35-31(39)21-10-14-26(41-6)24(15-21)30-36-27-29(37(30)18(3)4)28(20-8-12-22(33)13-9-20)38(32(27)40)25-16-23(34)11-7-19(25)5/h7-18,28H,1-6H3,(H,35,39)
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129884
PNG
(US8815926, 164)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)cnc1O)N(C)C |r|
Show InChI InChI=1S/C26H25Cl2N7O3/c1-13(2)34-21-19(31-22(34)17-12-30-26(33(3)4)32-24(17)38-5)25(37)35(18-10-16(28)11-29-23(18)36)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3,(H,29,36)/t20-/m0/s1
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Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129894
PNG
(US8815926, 175)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(N)=O
Show InChI InChI=1S/C29H26Cl2N4O3/c1-15(2)34-26-24(33-28(34)21-13-18(27(32)36)8-12-23(21)38-4)29(37)35(22-14-20(31)9-5-16(22)3)25(26)17-6-10-19(30)11-7-17/h5-15,25H,1-4H3,(H2,32,36)
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n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM130001
PNG
(US8815926, 282)
Show SMILES COc1ncc(-c2nc3C(=O)N([C@H](c3n2C(C)C)c2ccc(Cl)cc2)c2cc(Cl)cnc2O)c(OC)n1 |r|
Show InChI InChI=1S/C25H22Cl2N6O4/c1-12(2)32-20-18(30-21(32)16-11-29-25(37-4)31-23(16)36-3)24(35)33(17-9-15(27)10-28-22(17)34)19(20)13-5-7-14(26)8-6-13/h5-12,19H,1-4H3,(H,28,34)/t19-/m0/s1
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n/an/a 0.102n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM130034
PNG
(US8815926, 316)
Show SMILES COc1ncc(-c2nc3C(=O)N([C@H](c3n2[C@H](C)CO)c2ccc(Cl)cc2)c2cccc(Cl)c2F)c(OC)n1 |r|
Show InChI InChI=1S/C26H22Cl2FN5O4/c1-13(12-35)33-22-20(31-23(33)16-11-30-26(38-3)32-24(16)37-2)25(36)34(18-6-4-5-17(28)19(18)29)21(22)14-7-9-15(27)10-8-14/h4-11,13,21,35H,12H2,1-3H3/t13-,21+/m1/s1
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n/an/a 0.107n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129890
PNG
(US8815926, 171 | US8815926, 174)
Show SMILES COc1cnc(nc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F)N(C)C
Show InChI InChI=1S/C27H25Cl2FN6O2/c1-14(2)35-24-22(32-25(35)21-19(38-5)13-31-27(33-21)34(3)4)26(37)36(18-8-6-7-17(29)20(18)30)23(24)15-9-11-16(28)12-10-15/h6-14,23H,1-5H3
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n/an/a 0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129888
PNG
(US8815926, 169)
Show SMILES COc1ncc(-c2nc3C(=O)N([C@H](c3n2C(C)C)c2ccc(Cl)cc2)c2cc(Cl)ccc2C)c(OC)n1 |r|
Show InChI InChI=1S/C27H25Cl2N5O3/c1-14(2)33-23-21(31-24(33)19-13-30-27(37-5)32-25(19)36-4)26(35)34(20-12-18(29)9-6-15(20)3)22(23)16-7-10-17(28)11-8-16/h6-14,22H,1-5H3/t22-/m0/s1
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n/an/a 0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129916
PNG
(US8815926, 197)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1ccc(F)c(Cl)c1)C(=O)N(C)C
Show InChI InChI=1S/C30H27Cl2FN4O3/c1-16(2)36-27-25(34-28(36)21-14-18(29(38)35(3)4)8-13-24(21)40-5)30(39)37(20-11-12-23(33)22(32)15-20)26(27)17-6-9-19(31)10-7-17/h6-16,26H,1-5H3
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n/an/a 0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129763
PNG
(US8815926, 42)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(cc1)[N+]#[C-])c1cc(Cl)ccc1C)N(C)C
Show InChI InChI=1S/C29H28ClN7O2/c1-16(2)36-25-23(33-26(36)21-15-32-29(35(5)6)34-27(21)39-7)28(38)37(22-14-19(30)11-8-17(22)3)24(25)18-9-12-20(31-4)13-10-18/h8-16,24H,1-3,5-7H3
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n/an/a 0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129893
PNG
(US8815926, 174)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F)C(N)=O
Show InChI InChI=1S/C28H23Cl2FN4O3/c1-14(2)34-25-23(33-27(34)18-13-16(26(32)36)9-12-21(18)38-3)28(37)35(20-6-4-5-19(30)22(20)31)24(25)15-7-10-17(29)11-8-15/h4-14,24H,1-3H3,(H2,32,36)
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n/an/a 0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129834
PNG
(US8815926, 113)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1[C@H](C)CO)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)N(C)C |r|
Show InChI InChI=1S/C28H28Cl2N6O3/c1-15-6-9-19(30)12-21(15)36-23(17-7-10-18(29)11-8-17)24-22(27(36)38)32-25(35(24)16(2)14-37)20-13-31-28(34(3)4)33-26(20)39-5/h6-13,16,23,37H,14H2,1-5H3/t16-,23?/m1/s1
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n/an/a 0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129924
PNG
(US8815926, 205)
Show SMILES COc1nc(N)ncc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C |r|
Show InChI InChI=1S/C26H24Cl2N6O2/c1-13(2)33-22-20(31-23(33)18-12-30-26(29)32-24(18)36-4)25(35)34(19-11-17(28)8-5-14(19)3)21(22)15-6-9-16(27)10-7-15/h5-13,21H,1-4H3,(H2,29,30,32)/t21-/m0/s1
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n/an/a 0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM130006
PNG
(US8815926, 287)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)c(F)c1)c1cc(Cl)c(=O)n(C)c1)N(C)C
Show InChI InChI=1S/C27H26Cl2FN7O3/c1-13(2)36-22-20(32-23(36)16-11-31-27(34(3)4)33-24(16)40-6)26(39)37(15-10-18(29)25(38)35(5)12-15)21(22)14-7-8-17(28)19(30)9-14/h7-13,21H,1-6H3
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n/an/a 0.117n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129742
PNG
(US8815926, 21)
Show SMILES COc1cc(CO)ccc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C
Show InChI InChI=1S/C29H27Cl2N3O3/c1-16(2)33-27-25(32-28(33)22-12-6-18(15-35)13-24(22)37-4)29(36)34(23-14-21(31)9-5-17(23)3)26(27)19-7-10-20(30)11-8-19/h5-14,16,26,35H,15H2,1-4H3
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n/an/a 0.120n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129964
PNG
(US8815926, 245 | US8815926, 275)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cn1)c1cc(Cl)ccc1C)N(C)C
Show InChI InChI=1S/C27H27Cl2N7O2/c1-14(2)35-23-21(32-24(35)18-13-31-27(34(4)5)33-25(18)38-6)26(37)36(20-11-16(28)8-7-15(20)3)22(23)19-10-9-17(29)12-30-19/h7-14,22H,1-6H3
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n/an/a 0.120n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129964
PNG
(US8815926, 245 | US8815926, 275)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cn1)c1cc(Cl)ccc1C)N(C)C
Show InChI InChI=1S/C27H27Cl2N7O2/c1-14(2)35-23-21(32-24(35)18-13-31-27(34(4)5)33-25(18)38-6)26(37)36(20-11-16(28)8-7-15(20)3)22(23)19-10-9-17(29)12-30-19/h7-14,22H,1-6H3
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n/an/a 0.122n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM130025
PNG
(US8815926, 307)
Show SMILES COc1ncc(-c2nc3C(=O)N([C@H](c3n2C(C)C)c2ccc(Cl)cc2)c2cc(Cl)c(=O)n(C)c2)c(OC)n1 |r|
Show InChI InChI=1S/C26H24Cl2N6O4/c1-13(2)33-21-19(30-22(33)17-11-29-26(38-5)31-23(17)37-4)25(36)34(16-10-18(28)24(35)32(3)12-16)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3/t20-/m0/s1
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n/an/a 0.124n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129744
PNG
(US8815926, 23)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(=O)N(C)C
Show InChI InChI=1S/C31H30Cl2N4O3/c1-17(2)36-28-26(34-29(36)23-15-20(30(38)35(4)5)10-14-25(23)40-6)31(39)37(24-16-22(33)11-7-18(24)3)27(28)19-8-12-21(32)13-9-19/h7-17,27H,1-6H3
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n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129757
PNG
(US8815926, 36)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)N(C)C
Show InChI InChI=1S/C28H28Cl2N6O2/c1-15(2)35-24-22(32-25(35)20-14-31-28(34(4)5)33-26(20)38-6)27(37)36(21-13-19(30)10-7-16(21)3)23(24)17-8-11-18(29)12-9-17/h7-15,23H,1-6H3
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n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129909
PNG
(US8815926, 190)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)C(=O)N(C)C |r|
Show InChI InChI=1S/C31H30Cl2N4O3/c1-17(2)36-28-26(34-29(36)23-15-20(30(38)35(4)5)10-14-25(23)40-6)31(39)37(24-16-22(33)11-7-18(24)3)27(28)19-8-12-21(32)13-9-19/h7-17,27H,1-6H3/t27-/m0/s1
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n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129743
PNG
(US8815926, 22)
Show SMILES COc1cc(CO)ccc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C30H29Cl2N3O3/c1-16(2)34-28-26(33-29(34)23-10-7-19(15-36)13-25(23)38-5)30(37)35(24-14-21(32)8-6-17(24)3)27(28)22-11-9-20(31)12-18(22)4/h6-14,16,27,36H,15H2,1-5H3
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n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129969
PNG
(US8815926, 250)
Show SMILES COc1cnc(CC#N)cc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F |r|
Show InChI InChI=1S/C28H22Cl2FN5O2/c1-15(2)35-26-24(34-27(35)19-13-18(11-12-32)33-14-22(19)38-3)28(37)36(21-6-4-5-20(30)23(21)31)25(26)16-7-9-17(29)10-8-16/h4-10,13-15,25H,11H2,1-3H3/t25-/m0/s1
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n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129782
PNG
(US8815926, 61)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C)N1CC(O)C1
Show InChI InChI=1S/C29H28Cl2N6O3/c1-15(2)36-25-23(33-26(36)21-12-32-29(34-27(21)40-4)35-13-20(38)14-35)28(39)37(22-11-19(31)8-5-16(22)3)24(25)17-6-9-18(30)10-7-17/h5-12,15,20,24,38H,13-14H2,1-4H3
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n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM130040
PNG
(US8815926, 323)
Show SMILES COC[C@@H](C)n1c(nc2C(=O)N([C@H](c12)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1)-c1cnc(OC)nc1OC |r|
Show InChI InChI=1S/C27H26Cl2N6O5/c1-14(13-38-3)34-22-20(31-23(34)18-11-30-27(40-5)32-24(18)39-4)26(37)35(17-10-19(29)25(36)33(2)12-17)21(22)15-6-8-16(28)9-7-15/h6-12,14,21H,13H2,1-5H3/t14-,21+/m1/s1
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n/an/a 0.135n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129748
PNG
(US8815926, 27)
Show SMILES COc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2)c2cc(Cl)ccc2C)c(OC)n1
Show InChI InChI=1S/C27H25Cl2N5O3/c1-14(2)33-23-21(31-24(33)19-13-30-27(37-5)32-25(19)36-4)26(35)34(20-12-18(29)9-6-15(20)3)22(23)16-7-10-17(28)11-8-16/h6-14,22H,1-5H3
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n/an/a 0.137n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129878
PNG
(US8815926, 158)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)cnc1O)N(C)C
Show InChI InChI=1S/C26H25Cl2N7O3/c1-13(2)34-21-19(31-22(34)17-12-30-26(33(3)4)32-24(17)38-5)25(37)35(18-10-16(28)11-29-23(18)36)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3,(H,29,36)
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n/an/a 0.140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129848
PNG
(US8815926, 127)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cnc(O)c(Cl)c1)N(C)C
Show InChI InChI=1S/C26H25Cl2N7O3/c1-13(2)34-21-19(31-22(34)17-12-30-26(33(3)4)32-24(17)38-5)25(37)35(16-10-18(28)23(36)29-11-16)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3,(H,29,36)
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n/an/a 0.140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129791
PNG
(US8815926, 70)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F)C(=O)N(C)C
Show InChI InChI=1S/C30H27Cl2FN4O3/c1-16(2)36-27-25(34-28(36)20-15-18(29(38)35(3)4)11-14-23(20)40-5)30(39)37(22-8-6-7-21(32)24(22)33)26(27)17-9-12-19(31)13-10-17/h6-16,26H,1-5H3
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n/an/a 0.140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129739
PNG
(US8815926, 18)
Show SMILES COc1ccc(CO)cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C30H29Cl2N3O3/c1-16(2)34-28-26(33-29(34)23-13-19(15-36)7-11-25(23)38-5)30(37)35(24-14-21(32)8-6-17(24)3)27(28)22-10-9-20(31)12-18(22)4/h6-14,16,27,36H,15H2,1-5H3
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n/an/a 0.140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129725
PNG
(US8815926, 4)
Show SMILES COc1ccc(cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C#N
Show InChI InChI=1S/C30H26Cl2N4O2/c1-16(2)35-28-26(34-29(35)23-13-19(15-33)7-11-25(23)38-5)30(37)36(24-14-21(32)8-6-17(24)3)27(28)22-10-9-20(31)12-18(22)4/h6-14,16,27H,1-5H3
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n/an/a 0.140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM130039
PNG
(US8815926, 321)
Show SMILES COC[C@@H](C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1)-c1cnc(nc1OC)N(C)C |r|
Show InChI InChI=1S/C28H29Cl2N7O4/c1-15(14-40-5)36-23-21(32-24(36)19-12-31-28(34(2)3)33-25(19)41-6)27(39)37(18-11-20(30)26(38)35(4)13-18)22(23)16-7-9-17(29)10-8-16/h7-13,15,22H,14H2,1-6H3/t15-,22?/m1/s1
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n/an/a 0.144n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129965
PNG
(US8815926, 246)
Show SMILES CNc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(C#N)c(F)c2)c2cccc(Cl)c2F)c(OC)n1
Show InChI InChI=1S/C27H22ClF2N7O2/c1-13(2)36-23-21(34-24(36)16-12-33-27(32-3)35-25(16)39-4)26(38)37(19-7-5-6-17(28)20(19)30)22(23)14-8-9-15(11-31)18(29)10-14/h5-10,12-13,22H,1-4H3,(H,32,33,35)
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n/an/a 0.150n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129978
PNG
(US8815926, 259)
Show SMILES COC[C@@H](C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1ccc(F)c(Cl)c1)-c1cnc(OC)nc1OC |r|
Show InChI InChI=1S/C27H24Cl2FN5O4/c1-14(13-37-2)34-23-21(32-24(34)18-12-31-27(39-4)33-25(18)38-3)26(36)35(17-9-10-20(30)19(29)11-17)22(23)15-5-7-16(28)8-6-15/h5-12,14,22H,13H2,1-4H3/t14-,22?/m1/s1
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n/an/a 0.150n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129740
PNG
(US8815926, 19)
Show SMILES COc1ccc(CO)cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1C
Show InChI InChI=1S/C29H27Cl2N3O3/c1-16(2)33-27-25(32-28(33)22-13-18(15-35)6-12-24(22)37-4)29(36)34(23-14-21(31)9-5-17(23)3)26(27)19-7-10-20(30)11-8-19/h5-14,16,26,35H,15H2,1-4H3
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n/an/a 0.150n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129762
PNG
(US8815926, 41)
Show SMILES CNc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(cc2)[N+]#[C-])c2cc(Cl)ccc2C)c(OC)n1
Show InChI InChI=1S/C28H26ClN7O2/c1-15(2)35-24-22(33-25(35)20-14-32-28(31-5)34-26(20)38-6)27(37)36(21-13-18(29)10-7-16(21)3)23(24)17-8-11-19(30-4)12-9-17/h7-15,23H,1-3,5-6H3,(H,31,32,34)
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n/an/a 0.150n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 334 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%