BindingDB logo
myBDB logout

Patent code US8822448

Compile Data Set for Download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130711
PNG
(US8822448, 23)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)NCC1(CCCCC1)N1CCOCC1
Show InChI InChI=1S/C28H37N5O4/c1-19-15-24-22(25-23(27(35)31-24)17-30-33(25)20-5-11-36-12-6-20)16-21(19)26(34)29-18-28(7-3-2-4-8-28)32-9-13-37-14-10-32/h15-17,20H,2-14,18H2,1H3,(H,29,34)(H,31,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.400n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130738
PNG
(US8822448, 129)
Show SMILES CCc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CCCCOC)[C@H](C)C1 |r|
Show InChI InChI=1S/C28H39N5O4/c1-4-20-15-25-23(26-24(27(34)30-25)17-29-33(26)21-7-13-37-14-8-21)16-22(20)28(35)32-11-10-31(19(2)18-32)9-5-6-12-36-3/h15-17,19,21H,4-14,18H2,1-3H3,(H,30,34)/t19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.10n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130781
PNG
(US8822448, 211)
Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C |r|
Show InChI InChI=1S/C25H30F3N5O2/c1-15-10-21-19(22-20(23(34)30-21)12-29-33(22)14-17-4-3-5-17)11-18(15)24(35)32-9-8-31(16(2)13-32)7-6-25(26,27)28/h10-12,16-17H,3-9,13-14H2,1-2H3,(H,30,34)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.20n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130780
PNG
(US8822448, 210)
Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(CC4CC4)ncc3c(=O)[nH]c2cc1C |r|
Show InChI InChI=1S/C24H28F3N5O2/c1-14-9-20-18(21-19(22(33)29-20)11-28-32(21)13-16-3-4-16)10-17(14)23(34)31-8-7-30(15(2)12-31)6-5-24(25,26)27/h9-11,15-16H,3-8,12-13H2,1-2H3,(H,29,33)/t15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.30n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130729
PNG
(US8822448, 94)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(CC1)OCC(F)F
Show InChI InChI=1S/C24H28F2N4O4/c1-14-10-20-18(11-17(14)24(32)29-6-2-16(3-7-29)34-13-21(25)26)22-19(23(31)28-20)12-27-30(22)15-4-8-33-9-5-15/h10-12,15-16,21H,2-9,13H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.70n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130779
PNG
(US8822448, 208)
Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCC(F)(F)CC1 |r|
Show InChI InChI=1S/C26H30F5N5O2/c1-15-11-21-19(12-18(15)24(38)35-10-9-34(16(2)14-35)8-7-26(29,30)31)22-20(23(37)33-21)13-32-36(22)17-3-5-25(27,28)6-4-17/h11-13,16-17H,3-10,14H2,1-2H3,(H,33,37)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.70n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130778
PNG
(US8822448, 207)
Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r|
Show InChI InChI=1S/C25H30F3N5O3/c1-15-11-21-19(22-20(23(34)30-21)13-29-33(22)17-3-9-36-10-4-17)12-18(15)24(35)32-8-7-31(16(2)14-32)6-5-25(26,27)28/h11-13,16-17H,3-10,14H2,1-2H3,(H,30,34)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.70n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130794
PNG
(US8822448, 648)
Show SMILES COCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C |r|
Show InChI InChI=1S/C26H35N5O3/c1-17-12-23-21(24-22(25(32)28-23)14-27-31(24)16-19-6-4-7-19)13-20(17)26(33)30-10-9-29(18(2)15-30)8-5-11-34-3/h12-14,18-19H,4-11,15-16H2,1-3H3,(H,28,32)/t18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130709
PNG
(US8822448, 17)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C26H28N6O3/c1-17-14-22-20(24-21(25(33)29-22)16-28-32(24)18-5-12-35-13-6-18)15-19(17)26(34)31-10-8-30(9-11-31)23-4-2-3-7-27-23/h2-4,7,14-16,18H,5-6,8-13H2,1H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.10n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130710
PNG
(US8822448, 22)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(CC1)Oc1ccccn1
Show InChI InChI=1S/C27H29N5O4/c1-17-14-23-21(25-22(26(33)30-23)16-29-32(25)18-7-12-35-13-8-18)15-20(17)27(34)31-10-5-19(6-11-31)36-24-4-2-3-9-28-24/h2-4,9,14-16,18-19H,5-8,10-13H2,1H3,(H,30,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.20n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130782
PNG
(US8822448, 212)
Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCCC1 |r|
Show InChI InChI=1S/C25H30F3N5O2/c1-15-11-21-19(22-20(23(34)30-21)13-29-33(22)17-5-3-4-6-17)12-18(15)24(35)32-10-9-31(16(2)14-32)8-7-25(26,27)28/h11-13,16-17H,3-10,14H2,1-2H3,(H,30,34)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.40n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130751
PNG
(US8822448, 169)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(CC1)OC1CCC1
Show InChI InChI=1S/C26H32N4O4/c1-16-13-23-21(24-22(25(31)28-23)15-27-30(24)17-7-11-33-12-8-17)14-20(16)26(32)29-9-5-19(6-10-29)34-18-3-2-4-18/h13-15,17-19H,2-12H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.5n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130776
PNG
(US8822448, 203)
Show SMILES Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCC(CC1)OCC(F)(F)F |r|
Show InChI InChI=1S/C23H25F3N4O4/c1-13-8-19-17(20-18(21(31)28-19)10-27-30(20)14-4-7-33-11-14)9-16(13)22(32)29-5-2-15(3-6-29)34-12-23(24,25)26/h8-10,14-15H,2-7,11-12H2,1H3,(H,28,31)/t14-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.80n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130740
PNG
(US8822448, 139)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CCCC(F)(F)F)CC1
Show InChI InChI=1S/C25H30F3N5O3/c1-16-13-21-19(22-20(23(34)30-21)15-29-33(22)17-3-11-36-12-4-17)14-18(16)24(35)32-9-7-31(8-10-32)6-2-5-25(26,27)28/h13-15,17H,2-12H2,1H3,(H,30,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130771
PNG
(US8822448, 198)
Show SMILES Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCC(CC1)OCC1CC1 |r|
Show InChI InChI=1S/C25H30N4O4/c1-15-10-22-20(23-21(24(30)27-22)12-26-29(23)17-6-9-32-14-17)11-19(15)25(31)28-7-4-18(5-8-28)33-13-16-2-3-16/h10-12,16-18H,2-9,13-14H2,1H3,(H,27,30)/t17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.20n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130793
PNG
(US8822448, 640)
Show SMILES COCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(CC4CC4)ncc3c(=O)[nH]c2cc1C |r|
Show InChI InChI=1S/C25H33N5O3/c1-16-11-22-20(23-21(24(31)27-22)13-26-30(23)15-18-5-6-18)12-19(16)25(32)29-9-8-28(17(2)14-29)7-4-10-33-3/h11-13,17-18H,4-10,14-15H2,1-3H3,(H,27,31)/t17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.30n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130726
PNG
(US8822448, 86)
Show SMILES CCOCC1CN(C1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C23H28N4O4/c1-3-30-13-15-11-26(12-15)23(29)17-9-18-20(8-14(17)2)25-22(28)19-10-24-27(21(18)19)16-4-6-31-7-5-16/h8-10,15-16H,3-7,11-13H2,1-2H3,(H,25,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.30n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130759
PNG
(US8822448, 183)
Show SMILES COCCCCN1C[C@H](C)N(C[C@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r|
Show InChI InChI=1S/C28H39N5O4/c1-18-13-25-23(26-24(27(34)30-25)15-29-33(26)21-7-11-37-12-8-21)14-22(18)28(35)32-17-19(2)31(16-20(32)3)9-5-6-10-36-4/h13-15,19-21H,5-12,16-17H2,1-4H3,(H,30,34)/t19-,20+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.5n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130775
PNG
(US8822448, 202)
Show SMILES Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCC(CC1)OC1CCC1 |r|
Show InChI InChI=1S/C25H30N4O4/c1-15-11-22-20(23-21(24(30)27-22)13-26-29(23)16-7-10-32-14-16)12-19(15)25(31)28-8-5-18(6-9-28)33-17-3-2-4-17/h11-13,16-18H,2-10,14H2,1H3,(H,27,30)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.70n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130762
PNG
(US8822448, 186)
Show SMILES COCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCCC1 |r|
Show InChI InChI=1S/C27H37N5O3/c1-18-14-24-22(25-23(26(33)29-24)16-28-32(25)20-8-4-5-9-20)15-21(18)27(34)31-12-11-30(19(2)17-31)10-6-7-13-35-3/h14-16,19-20H,4-13,17H2,1-3H3,(H,29,33)/t19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.80n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130717
PNG
(US8822448, 53)
Show SMILES CCCOC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C25H32N4O4/c1-3-10-33-18-4-8-28(9-5-18)25(31)19-14-20-22(13-16(19)2)27-24(30)21-15-26-29(23(20)21)17-6-11-32-12-7-17/h13-15,17-18H,3-12H2,1-2H3,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.90n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130715
PNG
(US8822448, 49)
Show SMILES CN1CCN(CC1c1cccnc1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C27H30N6O3/c1-17-12-23-21(25-22(26(34)30-23)15-29-33(25)19-5-10-36-11-6-19)13-20(17)27(35)32-9-8-31(2)24(16-32)18-4-3-7-28-14-18/h3-4,7,12-15,19,24H,5-6,8-11,16H2,1-2H3,(H,30,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.90n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130721
PNG
(US8822448, 66)
Show SMILES COCCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C25H32N4O4/c1-16-13-22-20(14-19(16)25(31)28-8-3-17(4-9-28)5-10-32-2)23-21(24(30)27-22)15-26-29(23)18-6-11-33-12-7-18/h13-15,17-18H,3-12H2,1-2H3,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.30n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130750
PNG
(US8822448, 168)
Show SMILES CCOCCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C26H34N4O4/c1-3-33-11-6-18-4-9-29(10-5-18)26(32)20-15-21-23(14-17(20)2)28-25(31)22-16-27-30(24(21)22)19-7-12-34-13-8-19/h14-16,18-19H,3-13H2,1-2H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.30n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130785
PNG
(US8822448, 217)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(COC2CC2)CC1
Show InChI InChI=1S/C26H32N4O4/c1-16-12-23-21(24-22(25(31)28-23)14-27-30(24)18-6-10-33-11-7-18)13-20(16)26(32)29-8-4-17(5-9-29)15-34-19-2-3-19/h12-14,17-19H,2-11,15H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.40n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130755
PNG
(US8822448, 178)
Show SMILES C[C@H](F)COC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r|
Show InChI InChI=1S/C24H29FN4O4/c1-14-9-21-19(22-20(23(30)27-21)11-26-29(22)16-5-8-32-13-16)10-18(14)24(31)28-6-3-17(4-7-28)33-12-15(2)25/h9-11,15-17H,3-8,12-13H2,1-2H3,(H,27,30)/t15-,16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.40n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130757
PNG
(US8822448, 181)
Show SMILES C[C@H]1CN(CCN1c1ccc(F)c(C)n1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCN(C)C1 |r|
Show InChI InChI=1S/C28H32FN7O2/c1-16-11-24-21(26-22(27(37)32-24)13-30-36(26)19-7-8-33(4)15-19)12-20(16)28(38)34-9-10-35(17(2)14-34)25-6-5-23(29)18(3)31-25/h5-6,11-13,17,19H,7-10,14-15H2,1-4H3,(H,32,37)/t17-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.40n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130770
PNG
(US8822448, 195)
Show SMILES COCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(CC4CC4)ncc3c(=O)[nH]c2cc1C |r|
Show InChI InChI=1S/C26H35N5O3/c1-17-12-23-21(24-22(25(32)28-23)14-27-31(24)16-19-6-7-19)13-20(17)26(33)30-10-9-29(18(2)15-30)8-4-5-11-34-3/h12-14,18-19H,4-11,15-16H2,1-3H3,(H,28,32)/t18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.40n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130719
PNG
(US8822448, 56)
Show SMILES CCOCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C25H32N4O4/c1-3-32-15-17-4-8-28(9-5-17)25(31)19-13-20-22(12-16(19)2)27-24(30)21-14-26-29(23(20)21)18-6-10-33-11-7-18/h12-14,17-18H,3-11,15H2,1-2H3,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.40n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130772
PNG
(US8822448, 199)
Show SMILES CCCOC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r|
Show InChI InChI=1S/C24H30N4O4/c1-3-9-32-17-4-7-27(8-5-17)24(30)18-12-19-21(11-15(18)2)26-23(29)20-13-25-28(22(19)20)16-6-10-31-14-16/h11-13,16-17H,3-10,14H2,1-2H3,(H,26,29)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.70n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130760
PNG
(US8822448, 184)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CCC(F)(F)F)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r|
Show InChI InChI=1S/C26H32F3N5O3/c1-15-10-22-20(23-21(24(35)31-22)12-30-34(23)18-4-8-37-9-5-18)11-19(15)25(36)33-14-16(2)32(13-17(33)3)7-6-26(27,28)29/h10-12,16-18H,4-9,13-14H2,1-3H3,(H,31,35)/t16-,17+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.70n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130795
PNG
(US8822448, 655)
Show SMILES COCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCCC1 |r|
Show InChI InChI=1S/C26H35N5O3/c1-17-13-23-21(24-22(25(32)28-23)15-27-31(24)19-7-4-5-8-19)14-20(17)26(33)30-11-10-29(18(2)16-30)9-6-12-34-3/h13-15,18-19H,4-12,16H2,1-3H3,(H,28,32)/t18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.70n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130736
PNG
(US8822448, 127)
Show SMILES COCCCCN(C)[C@H]1CCN(C1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r|
Show InChI InChI=1S/C27H37N5O4/c1-18-14-24-22(25-23(26(33)29-24)16-28-32(25)19-7-12-36-13-8-19)15-21(18)27(34)31-10-6-20(17-31)30(2)9-4-5-11-35-3/h14-16,19-20H,4-13,17H2,1-3H3,(H,29,33)/t20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130743
PNG
(US8822448, 148)
Show SMILES CCOCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r|
Show InChI InChI=1S/C24H30N4O4/c1-3-31-13-16-4-7-27(8-5-16)24(30)18-11-19-21(10-15(18)2)26-23(29)20-12-25-28(22(19)20)17-6-9-32-14-17/h10-12,16-17H,3-9,13-14H2,1-2H3,(H,26,29)/t17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.10n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130737
PNG
(US8822448, 128)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CCC(F)(F)F)CC1
Show InChI InChI=1S/C24H28F3N5O3/c1-15-12-20-18(21-19(22(33)29-20)14-28-32(21)16-2-10-35-11-3-16)13-17(15)23(34)31-8-6-30(7-9-31)5-4-24(25,26)27/h12-14,16H,2-11H2,1H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.20n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130742
PNG
(US8822448, 146)
Show SMILES COCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCC1 |r|
Show InChI InChI=1S/C26H35N5O3/c1-17-13-23-21(24-22(25(32)28-23)15-27-31(24)19-7-6-8-19)14-20(17)26(33)30-11-10-29(18(2)16-30)9-4-5-12-34-3/h13-15,18-19H,4-12,16H2,1-3H3,(H,28,32)/t18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.20n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130758
PNG
(US8822448, 182)
Show SMILES C[C@@H]1CN(CCN1c1ccc(F)c(C)n1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCN(C)C1 |r|
Show InChI InChI=1S/C28H32FN7O2/c1-16-11-24-21(26-22(27(37)32-24)13-30-36(26)19-7-8-33(4)15-19)12-20(16)28(38)34-9-10-35(17(2)14-34)25-6-5-23(29)18(3)31-25/h5-6,11-13,17,19H,7-10,14-15H2,1-4H3,(H,32,37)/t17-,19+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.5n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130714
PNG
(US8822448, 41)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(CC1)OCC1CC1
Show InChI InChI=1S/C26H32N4O4/c1-16-12-23-21(24-22(25(31)28-23)14-27-30(24)18-6-10-33-11-7-18)13-20(16)26(32)29-8-4-19(5-9-29)34-15-17-2-3-17/h12-14,17-19H,2-11,15H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.70n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130769
PNG
(US8822448, 193)
Show SMILES COCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCC(F)(F)CC1 |r|
Show InChI InChI=1S/C28H37F2N5O3/c1-18-14-24-22(15-21(18)27(37)34-12-11-33(19(2)17-34)10-4-5-13-38-3)25-23(26(36)32-24)16-31-35(25)20-6-8-28(29,30)9-7-20/h14-16,19-20H,4-13,17H2,1-3H3,(H,32,36)/t19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.70n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130733
PNG
(US8822448, 109)
Show SMILES CCOCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r|
Show InChI InChI=1S/C28H39N5O4/c1-4-36-12-6-5-9-31-10-11-32(18-20(31)3)28(35)22-16-23-25(15-19(22)2)30-27(34)24-17-29-33(26(23)24)21-7-13-37-14-8-21/h15-17,20-21H,4-14,18H2,1-3H3,(H,30,34)/t20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.80n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130790
PNG
(US8822448, 283)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC2(COc3ccccc23)CC1
Show InChI InChI=1S/C29H30N4O4/c1-18-14-24-21(26-22(27(34)31-24)16-30-33(26)19-6-12-36-13-7-19)15-20(18)28(35)32-10-8-29(9-11-32)17-37-25-5-3-2-4-23(25)29/h2-5,14-16,19H,6-13,17H2,1H3,(H,31,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.90n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130728
PNG
(US8822448, 92)
Show SMILES CCOCC1CCN(C1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C24H30N4O4/c1-3-31-14-16-4-7-27(13-16)24(30)18-11-19-21(10-15(18)2)26-23(29)20-12-25-28(22(19)20)17-5-8-32-9-6-17/h10-12,16-17H,3-9,13-14H2,1-2H3,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.10n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130777
PNG
(US8822448, 204)
Show SMILES COCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(CC4CC(F)(F)C4)ncc3c(=O)[nH]c2cc1C |r|
Show InChI InChI=1S/C27H35F2N5O3/c1-17-10-23-21(24-22(25(35)31-23)14-30-34(24)16-19-12-27(28,29)13-19)11-20(17)26(36)33-8-7-32(18(2)15-33)6-4-5-9-37-3/h10-11,14,18-19H,4-9,12-13,15-16H2,1-3H3,(H,31,35)/t18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.20n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130752
PNG
(US8822448, 173)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CCCOC(F)(F)F)CC1
Show InChI InChI=1S/C25H30F3N5O4/c1-16-13-21-19(22-20(23(34)30-21)15-29-33(22)17-3-11-36-12-4-17)14-18(16)24(35)32-8-6-31(7-9-32)5-2-10-37-25(26,27)28/h13-15,17H,2-12H2,1H3,(H,30,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.30n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130774
PNG
(US8822448, 201)
Show SMILES CCOCCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r|
Show InChI InChI=1S/C25H32N4O4/c1-3-32-10-6-17-4-8-28(9-5-17)25(31)19-13-20-22(12-16(19)2)27-24(30)21-14-26-29(23(20)21)18-7-11-33-15-18/h12-14,17-18H,3-11,15H2,1-2H3,(H,27,30)/t18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.60n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130756
PNG
(US8822448, 179)
Show SMILES COCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCC1 |r|
Show InChI InChI=1S/C25H33N5O3/c1-16-12-22-20(23-21(24(31)27-22)14-26-30(23)18-6-4-7-18)13-19(16)25(32)29-10-9-28(17(2)15-29)8-5-11-33-3/h12-14,17-18H,4-11,15H2,1-3H3,(H,27,31)/t17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.80n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130765
PNG
(US8822448, 189)
Show SMILES COCCCCN1C[C@H](C)N(C[C@H]1C)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C |r|
Show InChI InChI=1S/C28H39N5O3/c1-18-12-25-23(26-24(27(34)30-25)14-29-33(26)17-21-8-7-9-21)13-22(18)28(35)32-16-19(2)31(15-20(32)3)10-5-6-11-36-4/h12-14,19-21H,5-11,15-17H2,1-4H3,(H,30,34)/t19-,20+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.90n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130748
PNG
(US8822448, 162)
Show SMILES CCc1cc2[nH]c(=O)c3cnn(C4CCC4)c3c2cc1C(=O)N1CCN(CCC(F)(F)F)CC1
Show InChI InChI=1S/C24H28F3N5O2/c1-2-15-12-20-18(21-19(22(33)29-20)14-28-32(21)16-4-3-5-16)13-17(15)23(34)31-10-8-30(9-11-31)7-6-24(25,26)27/h12-14,16H,2-11H2,1H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130716
PNG
(US8822448, 50)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CC1)c1cnccn1
Show InChI InChI=1S/C25H27N7O3/c1-16-12-21-19(23-20(24(33)29-21)14-28-32(23)17-2-10-35-11-3-17)13-18(16)25(34)31-8-6-30(7-9-31)22-15-26-4-5-27-22/h4-5,12-15,17H,2-3,6-11H2,1H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.5n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130766
PNG
(US8822448, 190)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CCC(F)(F)F)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C |r|
Show InChI InChI=1S/C26H32F3N5O2/c1-15-9-22-20(23-21(24(35)31-22)11-30-34(23)14-18-5-4-6-18)10-19(15)25(36)33-13-16(2)32(12-17(33)3)8-7-26(27,28)29/h9-11,16-18H,4-8,12-14H2,1-3H3,(H,31,35)/t16-,17+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.5n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130704
PNG
(US8822448, 6)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCCCC1
Show InChI InChI=1S/C22H26N4O3/c1-14-11-19-17(12-16(14)22(28)25-7-3-2-4-8-25)20-18(21(27)24-19)13-23-26(20)15-5-9-29-10-6-15/h11-13,15H,2-10H2,1H3,(H,24,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.60n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130744
PNG
(US8822448, 150)
Show SMILES CN(CCC(F)(F)F)C1CN(C1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C24H28F3N5O3/c1-14-9-20-18(21-19(22(33)29-20)11-28-32(21)15-3-7-35-8-4-15)10-17(14)23(34)31-12-16(13-31)30(2)6-5-24(25,26)27/h9-11,15-16H,3-8,12-13H2,1-2H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130739
PNG
(US8822448, 133)
Show SMILES COCC(F)(F)CN1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C25H31F2N5O4/c1-16-11-21-19(22-20(23(33)29-21)13-28-32(22)17-3-9-36-10-4-17)12-18(16)24(34)31-7-5-30(6-8-31)14-25(26,27)15-35-2/h11-13,17H,3-10,14-15H2,1-2H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.30n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130741
PNG
(US8822448, 145)
Show SMILES COCCCCN1C[C@@H]2C[C@H]1CN2C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r|
Show InChI InChI=1S/C27H35N5O4/c1-17-11-24-22(25-23(26(33)29-24)14-28-32(25)18-5-9-36-10-6-18)13-21(17)27(34)31-16-19-12-20(31)15-30(19)7-3-4-8-35-2/h11,13-14,18-20H,3-10,12,15-16H2,1-2H3,(H,29,33)/t19-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.30n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130720
PNG
(US8822448, 63)
Show SMILES CCOCCCN1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C26H35N5O4/c1-3-34-12-4-7-29-8-10-30(11-9-29)26(33)20-16-21-23(15-18(20)2)28-25(32)22-17-27-31(24(21)22)19-5-13-35-14-6-19/h15-17,19H,3-14H2,1-2H3,(H,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.40n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130763
PNG
(US8822448, 187)
Show SMILES COCCCCN1C[C@H](C)N(C[C@H]1C)C(=O)c1cc2c3n(CC4CC4)ncc3c(=O)[nH]c2cc1C |r|
Show InChI InChI=1S/C27H37N5O3/c1-17-11-24-22(25-23(26(33)29-24)13-28-32(25)16-20-7-8-20)12-21(17)27(34)31-15-18(2)30(14-19(31)3)9-5-6-10-35-4/h11-13,18-20H,5-10,14-16H2,1-4H3,(H,29,33)/t18-,19+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.40n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130753
PNG
(US8822448, 176)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(CC1)OCC(C)(F)F
Show InChI InChI=1S/C25H30F2N4O4/c1-15-11-21-19(22-20(23(32)29-21)13-28-31(22)16-5-9-34-10-6-16)12-18(15)24(33)30-7-3-17(4-8-30)35-14-25(2,26)27/h11-13,16-17H,3-10,14H2,1-2H3,(H,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.40n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130705
PNG
(US8822448, 12)
Show SMILES Clc1ccc2N(CCc2c1)C(=O)c1ccc2c3n(ncc3c(=O)[nH]c2c1)C1CCOCC1
Show InChI InChI=1S/C24H21ClN4O3/c25-16-2-4-21-14(11-16)5-8-28(21)24(31)15-1-3-18-20(12-15)27-23(30)19-13-26-29(22(18)19)17-6-9-32-10-7-17/h1-4,11-13,17H,5-10H2,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.60n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130734
PNG
(US8822448, 119)
Show SMILES COc1cc2[nH]c(=O)c3cnn(C4CCCC4)c3c2cc1C(=O)NCC(C)(C)N1CCOCC1
Show InChI InChI=1S/C25H33N5O4/c1-25(2,29-8-10-34-11-9-29)15-26-23(31)18-12-17-20(13-21(18)33-3)28-24(32)19-14-27-30(22(17)19)16-6-4-5-7-16/h12-14,16H,4-11,15H2,1-3H3,(H,26,31)(H,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.90n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130713
PNG
(US8822448, 40)
Show SMILES CCOC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C24H30N4O4/c1-3-32-17-4-8-27(9-5-17)24(30)18-13-19-21(12-15(18)2)26-23(29)20-14-25-28(22(19)20)16-6-10-31-11-7-16/h12-14,16-17H,3-11H2,1-2H3,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.90n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130773
PNG
(US8822448, 200)
Show SMILES Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCN(CCCC(F)(F)F)CC1 |r|
Show InChI InChI=1S/C24H28F3N5O3/c1-15-11-20-18(21-19(22(33)29-20)13-28-32(21)16-3-10-35-14-16)12-17(15)23(34)31-8-6-30(7-9-31)5-2-4-24(25,26)27/h11-13,16H,2-10,14H2,1H3,(H,29,33)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130708
PNG
(US8822448, 16)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC2(CCN(Cc3ccccc3)CC2)CC1
Show InChI InChI=1S/C33H39N5O3/c1-23-19-29-27(30-28(31(39)35-29)21-34-38(30)25-7-17-41-18-8-25)20-26(23)32(40)37-15-11-33(12-16-37)9-13-36(14-10-33)22-24-5-3-2-4-6-24/h2-6,19-21,25H,7-18,22H2,1H3,(H,35,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.10n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130712
PNG
(US8822448, 28)
Show SMILES COCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C24H30N4O4/c1-15-11-21-19(12-18(15)24(30)27-7-3-16(4-8-27)14-31-2)22-20(23(29)26-21)13-25-28(22)17-5-9-32-10-6-17/h11-13,16-17H,3-10,14H2,1-2H3,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.10n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130725
PNG
(US8822448, 84)
Show SMILES COCCCCN1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C26H35N5O4/c1-18-15-23-21(24-22(25(32)28-23)17-27-31(24)19-5-13-35-14-6-19)16-20(18)26(33)30-10-8-29(9-11-30)7-3-4-12-34-2/h15-17,19H,3-14H2,1-2H3,(H,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.30n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130767
PNG
(US8822448, 191)
Show SMILES Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCC(CC1)OCC(C)(F)F |r|
Show InChI InChI=1S/C24H28F2N4O4/c1-14-9-20-18(21-19(22(31)28-20)11-27-30(21)15-5-8-33-12-15)10-17(14)23(32)29-6-3-16(4-7-29)34-13-24(2,25)26/h9-11,15-16H,3-8,12-13H2,1-2H3,(H,28,31)/t15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.5n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130754
PNG
(US8822448, 177)
Show SMILES C[C@@H](F)COC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r|
Show InChI InChI=1S/C25H31FN4O4/c1-15-11-22-20(12-19(15)25(32)29-7-3-18(4-8-29)34-14-16(2)26)23-21(24(31)28-22)13-27-30(23)17-5-9-33-10-6-17/h11-13,16-18H,3-10,14H2,1-2H3,(H,28,31)/t16-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.70n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130797
PNG
(US8822448, 668)
Show SMILES COCCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r|
Show InChI InChI=1S/C24H30N4O4/c1-15-11-21-19(12-18(15)24(30)27-7-3-16(4-8-27)5-9-31-2)22-20(23(29)26-21)13-25-28(22)17-6-10-32-14-17/h11-13,16-17H,3-10,14H2,1-2H3,(H,26,29)/t17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.80n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130792
PNG
(US8822448, 624)
Show SMILES COCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCC(F)(F)CC1 |r|
Show InChI InChI=1S/C27H35F2N5O3/c1-17-13-23-21(14-20(17)26(36)33-11-10-32(18(2)16-33)9-4-12-37-3)24-22(25(35)31-23)15-30-34(24)19-5-7-27(28,29)8-6-19/h13-15,18-19H,4-12,16H2,1-3H3,(H,31,35)/t18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 10n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130749
PNG
(US8822448, 166)
Show SMILES COCC(F)(F)CN1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r|
Show InChI InChI=1S/C24H29F2N5O4/c1-15-9-20-18(21-19(22(32)28-20)11-27-31(21)16-3-8-35-12-16)10-17(15)23(33)30-6-4-29(5-7-30)13-24(25,26)14-34-2/h9-11,16H,3-8,12-14H2,1-2H3,(H,28,32)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 10n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130783
PNG
(US8822448, 213)
Show SMILES CN1CCC(CC1)n1ncc2c1c1cc(C(=O)N3CCC(CC3)Oc3ccc(C)cn3)c(C)cc1[nH]c2=O
Show InChI InChI=1S/C29H34N6O3/c1-18-4-5-26(30-16-18)38-21-8-12-34(13-9-21)29(37)22-15-23-25(14-19(22)2)32-28(36)24-17-31-35(27(23)24)20-6-10-33(3)11-7-20/h4-5,14-17,20-21H,6-13H2,1-3H3,(H,32,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 11n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130768
PNG
(US8822448, 192)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C23H25F3N4O3/c1-13-10-19-17(11-16(13)22(32)29-6-2-14(3-7-29)23(24,25)26)20-18(21(31)28-19)12-27-30(20)15-4-8-33-9-5-15/h10-12,14-15H,2-9H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 11n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130723
PNG
(US8822448, 74)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CC2CN(Cc3ccccc3)CC2C1
Show InChI InChI=1S/C30H33N5O3/c1-19-11-27-25(28-26(29(36)32-27)13-31-35(28)23-7-9-38-10-8-23)12-24(19)30(37)34-17-21-15-33(16-22(21)18-34)14-20-5-3-2-4-6-20/h2-6,11-13,21-23H,7-10,14-18H2,1H3,(H,32,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 12n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130727
PNG
(US8822448, 87)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC2(CCCO2)CC1
Show InChI InChI=1S/C25H30N4O4/c1-16-13-21-19(14-18(16)24(31)28-8-6-25(7-9-28)5-2-10-33-25)22-20(23(30)27-21)15-26-29(22)17-3-11-32-12-4-17/h13-15,17H,2-12H2,1H3,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 12n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130703
PNG
(US8822448, 2)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C27H30N6O3/c1-18-13-24-22(25-23(26(34)30-24)16-29-33(25)20-4-11-36-12-5-20)14-21(18)27(35)32-9-7-31(8-10-32)17-19-3-2-6-28-15-19/h2-3,6,13-16,20H,4-5,7-12,17H2,1H3,(H,30,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 12n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130731
PNG
(US8822448, 103)
Show SMILES COCCCCN1CCN(CC1)C(=O)c1cc2c3n(CC4CC4)ncc3c(=O)[nH]c2cc1C
Show InChI InChI=1S/C25H33N5O3/c1-17-13-22-20(23-21(24(31)27-22)15-26-30(23)16-18-5-6-18)14-19(17)25(32)29-10-8-28(9-11-29)7-3-4-12-33-2/h13-15,18H,3-12,16H2,1-2H3,(H,27,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 13n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130730
PNG
(US8822448, 95)
Show SMILES C[C@H](F)COC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r|
Show InChI InChI=1S/C25H31FN4O4/c1-15-11-22-20(12-19(15)25(32)29-7-3-18(4-8-29)34-14-16(2)26)23-21(24(31)28-22)13-27-30(23)17-5-9-33-10-6-17/h11-13,16-18H,3-10,14H2,1-2H3,(H,28,31)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130764
PNG
(US8822448, 188)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CCC(F)(F)F)C(=O)c1cc2c3n(CC4CC4)ncc3c(=O)[nH]c2cc1C |r|
Show InChI InChI=1S/C25H30F3N5O2/c1-14-8-21-19(22-20(23(34)30-21)10-29-33(22)13-17-4-5-17)9-18(14)24(35)32-12-15(2)31(11-16(32)3)7-6-25(26,27)28/h8-10,15-17H,4-7,11-13H2,1-3H3,(H,30,34)/t15-,16+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130787
PNG
(US8822448, 219)
Show SMILES Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCN(CCCOC(F)(F)F)CC1 |r|
Show InChI InChI=1S/C24H28F3N5O4/c1-15-11-20-18(21-19(22(33)29-20)13-28-32(21)16-3-10-35-14-16)12-17(15)23(34)31-7-5-30(6-8-31)4-2-9-36-24(25,26)27/h11-13,16H,2-10,14H2,1H3,(H,29,33)/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130732
PNG
(US8822448, 107)
Show SMILES CCOCCCCN1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1
Show InChI InChI=1S/C27H37N5O4/c1-3-35-13-5-4-8-30-9-11-31(12-10-30)27(34)21-17-22-24(16-19(21)2)29-26(33)23-18-28-32(25(22)23)20-6-14-36-15-7-20/h16-18,20H,3-15H2,1-2H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130718
PNG
(US8822448, 55)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCC4)c3c2cc1C(=O)N1CCN(CC2CCOCC2)CC1
Show InChI InChI=1S/C26H33N5O3/c1-17-13-23-21(24-22(25(32)28-23)15-27-31(24)19-3-2-4-19)14-20(17)26(33)30-9-7-29(8-10-30)16-18-5-11-34-12-6-18/h13-15,18-19H,2-12,16H2,1H3,(H,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130784
PNG
(US8822448, 214)
Show SMILES CCN1CCN(C[C@@H]1c1ccccc1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCN(C)CC1 |r|
Show InChI InChI=1S/C30H36N6O2/c1-4-34-14-15-35(19-27(34)21-8-6-5-7-9-21)30(38)23-17-24-26(16-20(23)2)32-29(37)25-18-31-36(28(24)25)22-10-12-33(3)13-11-22/h5-9,16-18,22,27H,4,10-15,19H2,1-3H3,(H,32,37)/t27-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 16n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130788
PNG
(US8822448, 220)
Show SMILES C[C@@H](F)COC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r|
Show InChI InChI=1S/C24H29FN4O4/c1-14-9-21-19(22-20(23(30)27-21)11-26-29(22)16-5-8-32-13-16)10-18(14)24(31)28-6-3-17(4-7-28)33-12-15(2)25/h9-11,15-17H,3-8,12-13H2,1-2H3,(H,27,30)/t15-,16+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 16n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130722
PNG
(US8822448, 70)
Show SMILES CCOCCCN1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCC1
Show InChI InChI=1S/C25H33N5O3/c1-3-33-13-5-8-28-9-11-29(12-10-28)25(32)19-15-20-22(14-17(19)2)27-24(31)21-16-26-30(23(20)21)18-6-4-7-18/h14-16,18H,3-13H2,1-2H3,(H,27,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 17n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130786
PNG
(US8822448, 218)
Show SMILES Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCC(CC1)OC1CC1 |r|
Show InChI InChI=1S/C24H28N4O4/c1-14-10-21-19(22-20(23(29)26-21)12-25-28(22)15-6-9-31-13-15)11-18(14)24(30)27-7-4-17(5-8-27)32-16-2-3-16/h10-12,15-17H,2-9,13H2,1H3,(H,26,29)/t15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 17n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130702
PNG
(US8822448, 1)
Show SMILES Clc1ccc2N(CCc2c1)C(=O)c1ccc2c3n(ncc3c(=O)[nH]c2c1)C1CCCC1
Show InChI InChI=1S/C24H21ClN4O2/c25-16-6-8-21-14(11-16)9-10-28(21)24(31)15-5-7-18-20(12-15)27-23(30)19-13-26-29(22(18)19)17-3-1-2-4-17/h5-8,11-13,17H,1-4,9-10H2,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 18n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130735
PNG
(US8822448, 123)
Show SMILES COCCCCN1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1OC)C1CCCC1
Show InChI InChI=1S/C26H35N5O4/c1-34-14-6-5-9-29-10-12-30(13-11-29)26(33)20-15-19-22(16-23(20)35-2)28-25(32)21-17-27-31(24(19)21)18-7-3-4-8-18/h15-18H,3-14H2,1-2H3,(H,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 18n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130761
PNG
(US8822448, 185)
Show SMILES Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCN(CCC(F)(F)F)CC1 |r|
Show InChI InChI=1S/C23H26F3N5O3/c1-14-10-19-17(20-18(21(32)28-19)12-27-31(20)15-2-9-34-13-15)11-16(14)22(33)30-7-5-29(6-8-30)4-3-23(24,25)26/h10-12,15H,2-9,13H2,1H3,(H,28,32)/t15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 19n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130791
PNG
(US8822448, 427)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C23H26F3N5O3/c1-14-10-19-17(11-16(14)22(33)30-6-4-29(5-7-30)13-23(24,25)26)20-18(21(32)28-19)12-27-31(20)15-2-8-34-9-3-15/h10-12,15H,2-9,13H2,1H3,(H,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 20n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130724
PNG
(US8822448, 79)
Show SMILES COCCCCN1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCC1
Show InChI InChI=1S/C25H33N5O3/c1-17-14-22-20(23-21(24(31)27-22)16-26-30(23)18-6-5-7-18)15-19(17)25(32)29-11-9-28(10-12-29)8-3-4-13-33-2/h14-16,18H,3-13H2,1-2H3,(H,27,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 23n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130789
PNG
(US8822448, 221)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(O)(CC1)C(F)(F)F
Show InChI InChI=1S/C23H25F3N4O4/c1-13-10-18-16(11-15(13)21(32)29-6-4-22(33,5-7-29)23(24,25)26)19-17(20(31)28-18)12-27-30(19)14-2-8-34-9-3-14/h10-12,14,33H,2-9H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 24n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130796
PNG
(US8822448, 660)
Show SMILES CCOCCCCN1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r|
Show InChI InChI=1S/C26H35N5O4/c1-3-34-12-5-4-7-29-8-10-30(11-9-29)26(33)20-15-21-23(14-18(20)2)28-25(32)22-16-27-31(24(21)22)19-6-13-35-17-19/h14-16,19H,3-13,17H2,1-2H3,(H,28,32)/t19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 28n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM8366
PNG
(CHEMBL1809169 | US8822448, 147 | US9771375, Exampl...)
Show SMILES CSc1nn(-c2cccc(C)c2)c2cc(ccc12)C1=CCNCC1 |t:21|
Show InChI InChI=1S/C20H21N3S/c1-14-4-3-5-17(12-14)23-19-13-16(15-8-10-21-11-9-15)6-7-18(19)20(22-23)24-2/h3-8,12-13,21H,9-11H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 30n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130747
PNG
(US8822448, 161)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCC4)c3c2cc1C(=O)N1CCN(CCC(F)(F)F)CC1
Show InChI InChI=1S/C23H26F3N5O2/c1-14-11-19-17(20-18(21(32)28-19)13-27-31(20)15-3-2-4-15)12-16(14)22(33)30-9-7-29(8-10-30)6-5-23(24,25)26/h11-13,15H,2-10H2,1H3,(H,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 31n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130746
PNG
(US8822448, 154)
Show SMILES COCCCCN1CCN(CC1)C(=O)c1cc2c3n(CC4CCOCC4)ncc3c(=O)[nH]c2cc1C
Show InChI InChI=1S/C27H37N5O4/c1-19-15-24-22(16-21(19)27(34)31-10-8-30(9-11-31)7-3-4-12-35-2)25-23(26(33)29-24)17-28-32(25)18-20-5-13-36-14-6-20/h15-17,20H,3-14,18H2,1-2H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 32n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM8368
PNG
(CHEMBL1809167 | US8822447, 106 | US8822448, 179 | ...)
Show SMILES CSc1nn(-c2cccc(F)c2)c2cc(ccc12)C1=CCNCC1 |t:21|
Show InChI InChI=1S/C19H18FN3S/c1-24-19-17-6-5-14(13-7-9-21-10-8-13)11-18(17)23(22-19)16-4-2-3-15(20)12-16/h2-7,11-12,21H,8-10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 40n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM8526
PNG
(CHEMBL1809170 | US8822447, 107 | US8822448, 184 | ...)
Show SMILES CSc1nn(-c2ccc(C)cc2)c2cc(ccc12)C1=CCNCC1 |t:21|
Show InChI InChI=1S/C20H21N3S/c1-14-3-6-17(7-4-14)23-19-13-16(15-9-11-21-12-10-15)5-8-18(19)20(22-23)24-2/h3-9,13,21H,10-12H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 40n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130745
PNG
(US8822448, 152)
Show SMILES CCOCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C(F)(F)F)C1CCOCC1
Show InChI InChI=1S/C25H29F3N4O4/c1-2-35-14-15-3-7-31(8-4-15)24(34)17-11-18-21(12-20(17)25(26,27)28)30-23(33)19-13-29-32(22(18)19)16-5-9-36-10-6-16/h11-13,15-16H,2-10,14H2,1H3,(H,30,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 53n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130707
PNG
(US8822448, 14)
Show SMILES Fc1ccc(cc1)C1CN(CCO1)C(=O)c1ccc2c3n(ncc3c(=O)[nH]c2c1)C1CCOCC1
Show InChI InChI=1S/C26H25FN4O4/c27-18-4-1-16(2-5-18)23-15-30(9-12-35-23)26(33)17-3-6-20-22(13-17)29-25(32)21-14-28-31(24(20)21)19-7-10-34-11-8-19/h1-6,13-14,19,23H,7-12,15H2,(H,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 81n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130706
PNG
(US8822448, 13)
Show SMILES CN1CCN(CC1c1ccccc1)C(=O)c1ccc2c3n(ncc3c(=O)[nH]c2c1)C1CCOCC1
Show InChI InChI=1S/C27H29N5O3/c1-30-11-12-31(17-24(30)18-5-3-2-4-6-18)27(34)19-7-8-21-23(15-19)29-26(33)22-16-28-32(25(21)22)20-9-13-35-14-10-20/h2-8,15-16,20,24H,9-14,17H2,1H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 85n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM8367
PNG
(US8822448, 174)
Show SMILES CSc1nn(-c2ccccc2)c2cc(ccc12)C(=O)N1ONc2ccccc12
Show InChI InChI=1S/C21H16N4O2S/c1-28-20-16-12-11-14(13-19(16)24(22-20)15-7-3-2-4-8-15)21(26)25-18-10-6-5-9-17(18)23-27-25/h2-13,23H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%