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Patent code US8829010

Compile Data Set for Download or QSAR
Found 57 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM131002
PNG
(US8829010, 53)
Show SMILES CN(C)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3C)C(F)(F)F)c12 |(-5.29,3.68,;-3.96,2.91,;-3.19,4.25,;-3.96,1.37,;-5.29,.6,;-5.29,-.94,;-3.96,-1.71,;-2.63,-.94,;-1.06,-1.33,;-.5,-2.77,;-.22,-.04,;-1.19,1.16,;-.79,2.64,;-1.27,4.11,;-.02,5.01,;1.23,4.11,;2.69,4.58,;.75,2.64,;1.66,1.4,;1.26,-.09,;2.35,-1.18,;3.83,-.78,;4.23,.71,;3.14,1.8,;3.54,3.28,;4.92,-1.87,;6.41,-1.47,;4.52,-3.36,;6.01,-2.96,;-2.63,.6,)|
Show InChI InChI=1S/C20H20F3N7/c1-11-8-12(20(21,22)23)6-7-13(11)17-14(9-26-29(17)4)16-15-18(28(2)3)24-10-25-19(15)30(5)27-16/h6-10H,1-5H3
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n/an/a 1.06n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130952
PNG
(US8829010, 3)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CC(F)C4)c23)c1-c1ccc(cc1)C1CC1
Show InChI InChI=1S/C22H22FN7/c1-28-20(15-7-5-14(6-8-15)13-3-4-13)17(9-26-28)19-18-21(29(2)27-19)24-12-25-22(18)30-10-16(23)11-30/h5-9,12-13,16H,3-4,10-11H2,1-2H3
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n/an/a<1.31n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130985
PNG
(US8829010, 36)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CC[C@@H](C4)S(C)(=O)=O)c23)c1-c1ccc(cc1)C1CC1 |r|
Show InChI InChI=1S/C24H27N7O2S/c1-29-22(17-8-6-16(7-9-17)15-4-5-15)19(12-27-29)21-20-23(30(2)28-21)25-14-26-24(20)31-11-10-18(13-31)34(3,32)33/h6-9,12,14-15,18H,4-5,10-11,13H2,1-3H3/t18-/m0/s1
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n/an/a 1.43n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM9049
PNG
(US11419874, Example 15 | US8829010, 35 | US8829010...)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H18F3N7/c1-28-17(12-4-6-13(7-5-12)20(21,22)23)14(10-26-28)16-15-18(29(2)27-16)24-11-25-19(15)30-8-3-9-30/h4-7,10-11H,3,8-9H2,1-2H3
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n/an/a 1.48n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130980
PNG
(US8829010, 31)
Show SMILES CC(=O)N[C@@H]1CCN(C1)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C3CC3)c12 |r|
Show InChI InChI=1S/C25H28N8O/c1-15(34)29-19-10-11-33(13-19)25-21-22(30-32(3)24(21)26-14-27-25)20-12-28-31(2)23(20)18-8-6-17(7-9-18)16-4-5-16/h6-9,12,14,16,19H,4-5,10-11,13H2,1-3H3,(H,29,34)/t19-/m1/s1
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n/an/a 1.52n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130958
PNG
(US8829010, 9)
Show SMILES CCc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CCC3)c12
Show InChI InChI=1S/C21H23N7/c1-4-14-6-8-15(9-7-14)19-16(12-24-26(19)2)18-17-20(27(3)25-18)22-13-23-21(17)28-10-5-11-28/h6-9,12-13H,4-5,10-11H2,1-3H3
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n/an/a 1.64n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM9049
PNG
(US11419874, Example 15 | US8829010, 35 | US8829010...)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H18F3N7/c1-28-17(12-4-6-13(7-5-12)20(21,22)23)14(10-26-28)16-15-18(29(2)27-16)24-11-25-19(15)30-8-3-9-30/h4-7,10-11H,3,8-9H2,1-2H3
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n/an/a 1.67n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130972
PNG
(US8829010, 23)
Show SMILES COC(=O)NC1CN(C1)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C3CC3)c12
Show InChI InChI=1S/C24H26N8O2/c1-30-21(16-8-6-15(7-9-16)14-4-5-14)18(10-27-30)20-19-22(31(2)29-20)25-13-26-23(19)32-11-17(12-32)28-24(33)34-3/h6-10,13-14,17H,4-5,11-12H2,1-3H3,(H,28,33)
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n/an/a<2.11n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130996
PNG
(US8829010, 47)
Show SMILES CC(C)c1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CCC3)c12
Show InChI InChI=1S/C22H25N7/c1-14(2)15-6-8-16(9-7-15)20-17(12-25-27(20)3)19-18-21(28(4)26-19)23-13-24-22(18)29-10-5-11-29/h6-9,12-14H,5,10-11H2,1-4H3
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n/an/a 2.16n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130978
PNG
(US8829010, 29)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC(C4)S(=O)(=O)CC4CC4)c23)c1-c1ccc(cc1)C1CC1
Show InChI InChI=1S/C27H31N7O2S/c1-32-25(20-9-7-19(8-10-20)18-5-6-18)22(13-30-32)24-23-26(33(2)31-24)28-16-29-27(23)34-12-11-21(14-34)37(35,36)15-17-3-4-17/h7-10,13,16-18,21H,3-6,11-12,14-15H2,1-2H3
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n/an/a 2.47n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130981
PNG
(US8829010, 32)
Show SMILES Cn1ccc(n1)C1CN(C1)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C3CC3)c12
Show InChI InChI=1S/C26H27N9/c1-32-11-10-21(30-32)19-13-35(14-19)26-22-23(31-34(3)25(22)27-15-28-26)20-12-29-33(2)24(20)18-8-6-17(7-9-18)16-4-5-16/h6-12,15-16,19H,4-5,13-14H2,1-3H3
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n/an/a 2.58n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130974
PNG
(US8829010, 25)
Show SMILES CN(C)S(=O)(=O)C1CCN(C1)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C3CC3)c12
Show InChI InChI=1S/C25H30N8O2S/c1-30(2)36(34,35)19-11-12-33(14-19)25-21-22(29-32(4)24(21)26-15-27-25)20-13-28-31(3)23(20)18-9-7-17(8-10-18)16-5-6-16/h7-10,13,15-16,19H,5-6,11-12,14H2,1-4H3
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n/an/a 2.70n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130968
PNG
(US8829010, 19)
Show SMILES Cn1ccc(n1)C1CN(C1)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(Cl)c(F)c3)c12
Show InChI InChI=1S/C23H21ClFN9/c1-31-7-6-18(29-31)14-10-34(11-14)23-19-20(30-33(3)22(19)26-12-27-23)15-9-28-32(2)21(15)13-4-5-16(24)17(25)8-13/h4-9,12,14H,10-11H2,1-3H3
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n/an/a<2.87n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130976
PNG
(US8829010, 27)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC(C4)S(C)(=O)=O)c23)c1-c1ccc(cc1)C1CC1
Show InChI InChI=1S/C24H27N7O2S/c1-29-22(17-8-6-16(7-9-17)15-4-5-15)19(12-27-29)21-20-23(30(2)28-21)25-14-26-24(20)31-11-10-18(13-31)34(3,32)33/h6-9,12,14-15,18H,4-5,10-11,13H2,1-3H3
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n/an/a 2.98n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130962
PNG
(US8829010, 13)
Show SMILES CCc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CCC(C3)S(=O)(=O)N(C)C)c12
Show InChI InChI=1S/C24H30N8O2S/c1-6-16-7-9-17(10-8-16)22-19(13-27-30(22)4)21-20-23(31(5)28-21)25-15-26-24(20)32-12-11-18(14-32)35(33,34)29(2)3/h7-10,13,15,18H,6,11-12,14H2,1-5H3
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Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130957
PNG
(US8829010, 8)
Show SMILES CCc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC(F)C3)c12
Show InChI InChI=1S/C21H22FN7/c1-4-13-5-7-14(8-6-13)19-16(9-25-27(19)2)18-17-20(28(3)26-18)23-12-24-21(17)29-10-15(22)11-29/h5-9,12,15H,4,10-11H2,1-3H3
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Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130982
PNG
(US8829010, 33)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(cc1)C1CC1
Show InChI InChI=1S/C22H23N7/c1-27-20(16-8-6-15(7-9-16)14-4-5-14)17(12-25-27)19-18-21(28(2)26-19)23-13-24-22(18)29-10-3-11-29/h6-9,12-14H,3-5,10-11H2,1-2H3
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n/an/a 3.41n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130989
PNG
(US8829010, 40)
Show SMILES CCc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC(C3)OC)c12
Show InChI InChI=1S/C22H25N7O/c1-5-14-6-8-15(9-7-14)20-17(10-25-27(20)2)19-18-21(28(3)26-19)23-13-24-22(18)29-11-16(12-29)30-4/h6-10,13,16H,5,11-12H2,1-4H3
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n/an/a 3.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130969
PNG
(US8829010, 20)
Show SMILES CN(C)S(=O)(=O)C1CCN(C1)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(Cl)c(F)c3)c12
Show InChI InChI=1S/C22H24ClFN8O2S/c1-29(2)35(33,34)14-7-8-32(11-14)22-18-19(28-31(4)21(18)25-12-26-22)15-10-27-30(3)20(15)13-5-6-16(23)17(24)9-13/h5-6,9-10,12,14H,7-8,11H2,1-4H3
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n/an/a 3.59n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130990
PNG
(US8829010, 41)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(CBr)cc1
Show InChI InChI=1S/C20H20BrN7/c1-26-18(14-6-4-13(10-21)5-7-14)15(11-24-26)17-16-19(27(2)25-17)22-12-23-20(16)28-8-3-9-28/h4-7,11-12H,3,8-10H2,1-2H3
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n/an/a 4.20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130977
PNG
(US8829010, 28)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CC(C4)c4ccno4)c23)c1-c1ccc(cc1)C1CC1
Show InChI InChI=1S/C25H24N8O/c1-31-23(17-7-5-16(6-8-17)15-3-4-15)19(11-28-31)22-21-24(32(2)30-22)26-14-27-25(21)33-12-18(13-33)20-9-10-29-34-20/h5-11,14-15,18H,3-4,12-13H2,1-2H3
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n/an/a 4.25n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130960
PNG
(US8829010, 11)
Show SMILES Cc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CCC(C3)S(=O)(=O)C3CC3)c12
Show InChI InChI=1S/C24H27N7O2S/c1-15-4-6-16(7-5-15)22-19(12-27-29(22)2)21-20-23(30(3)28-21)25-14-26-24(20)31-11-10-18(13-31)34(32,33)17-8-9-17/h4-7,12,14,17-18H,8-11,13H2,1-3H3
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n/an/a 4.29n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM131001
PNG
(US8829010, 52)
Show SMILES CN(C)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3C)C3CC3)c12 |(-5.29,3.68,;-3.96,2.91,;-3.19,4.25,;-3.96,1.37,;-5.29,.6,;-5.29,-.94,;-3.96,-1.71,;-2.63,-.94,;-1.06,-1.33,;-.5,-2.77,;-.22,-.04,;-1.19,1.16,;-.79,2.64,;-1.27,4.11,;-.02,5.01,;1.23,4.11,;2.69,4.58,;.75,2.64,;1.66,1.4,;1.26,-.09,;2.35,-1.18,;3.83,-.78,;4.23,.71,;3.14,1.8,;3.54,3.28,;4.92,-1.87,;5.32,-3.36,;6.41,-2.27,;-2.63,.6,)|
Show InChI InChI=1S/C22H25N7/c1-13-10-15(14-6-7-14)8-9-16(13)20-17(11-25-28(20)4)19-18-21(27(2)3)23-12-24-22(18)29(5)26-19/h8-12,14H,6-7H2,1-5H3
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n/an/a 4.36n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130963
PNG
(US8829010, 14)
Show SMILES CCc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC(C3)c3ccn(C)n3)c12
Show InChI InChI=1S/C25H27N9/c1-5-16-6-8-17(9-7-16)23-19(12-28-32(23)3)22-21-24(33(4)30-22)26-15-27-25(21)34-13-18(14-34)20-10-11-31(2)29-20/h6-12,15,18H,5,13-14H2,1-4H3
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n/an/a 4.47n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130975
PNG
(US8829010, 26)
Show SMILES CN(C1CCN(C1)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C3CC3)c12)C(C)=O
Show InChI InChI=1S/C26H30N8O/c1-16(35)31(2)20-11-12-34(14-20)26-22-23(30-33(4)25(22)27-15-28-26)21-13-29-32(3)24(21)19-9-7-18(8-10-19)17-5-6-17/h7-10,13,15,17,20H,5-6,11-12,14H2,1-4H3
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n/an/a 5.14n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130955
PNG
(US8829010, 6)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(cc1)C(F)F
Show InChI InChI=1S/C20H19F2N7/c1-27-17(12-4-6-13(7-5-12)18(21)22)14(10-25-27)16-15-19(28(2)26-16)23-11-24-20(15)29-8-3-9-29/h4-7,10-11,18H,3,8-9H2,1-2H3
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n/an/a 5.25n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130973
PNG
(US8829010, 24)
Show SMILES CN(C)[C@@H]1CCN(C1)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C3CC3)c12 |r|
Show InChI InChI=1S/C25H30N8/c1-30(2)19-11-12-33(14-19)25-21-22(29-32(4)24(21)26-15-27-25)20-13-28-31(3)23(20)18-9-7-17(8-10-18)16-5-6-16/h7-10,13,15-16,19H,5-6,11-12,14H2,1-4H3/t19-/m1/s1
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n/an/a 5.37n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130997
PNG
(US8829010, 48)
Show SMILES COc1ccc(-c2c(cnn2C)-c2nn(C)c3ncnc(N4CCC4)c23)c(Cl)c1 |(6.41,-1.47,;4.92,-1.87,;3.83,-.78,;2.35,-1.18,;1.26,-.09,;1.66,1.4,;.75,2.64,;-.79,2.64,;-1.27,4.11,;-.02,5.01,;1.23,4.11,;2.69,4.58,;-1.19,1.16,;-.22,-.04,;-1.06,-1.33,;-.5,-2.77,;-2.63,-.94,;-3.96,-1.71,;-5.29,-.94,;-5.29,.6,;-3.96,1.37,;-3.96,2.91,;-5.29,3.68,;-4.52,5.02,;-3.19,4.25,;-2.63,.6,;3.14,1.8,;3.54,3.28,;4.23,.71,)|
Show InChI InChI=1S/C20H20ClN7O/c1-26-18(13-6-5-12(29-3)9-15(13)21)14(10-24-26)17-16-19(27(2)25-17)22-11-23-20(16)28-7-4-8-28/h5-6,9-11H,4,7-8H2,1-3H3
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n/an/a 5.39n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130966
PNG
(US8829010, 17)
Show SMILES CCc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC(C3)NC(=O)OC)c12
Show InChI InChI=1S/C23H26N8O2/c1-5-14-6-8-15(9-7-14)20-17(10-26-29(20)2)19-18-21(30(3)28-19)24-13-25-22(18)31-11-16(12-31)27-23(32)33-4/h6-10,13,16H,5,11-12H2,1-4H3,(H,27,32)
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n/an/a 5.48n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130987
PNG
(US8829010, 38)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CC(F)(F)C4)c23)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H16F5N7/c1-30-16(11-3-5-12(6-4-11)20(23,24)25)13(7-28-30)15-14-17(31(2)29-15)26-10-27-18(14)32-8-19(21,22)9-32/h3-7,10H,8-9H2,1-2H3
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n/an/a 5.55n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130979
PNG
(US8829010, 30)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCCC4)c23)c1-c1ccc(cc1)C1CC1
Show InChI InChI=1S/C23H25N7/c1-28-21(17-9-7-16(8-10-17)15-5-6-15)18(13-26-28)20-19-22(29(2)27-20)24-14-25-23(19)30-11-3-4-12-30/h7-10,13-15H,3-6,11-12H2,1-2H3
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n/an/a 5.63n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130956
PNG
(US8829010, 7)
Show SMILES CCc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC[C@H](C3)N(C)C)c12 |r|
Show InChI InChI=1S/C24H30N8/c1-6-16-7-9-17(10-8-16)22-19(13-27-30(22)4)21-20-23(31(5)28-21)25-15-26-24(20)32-12-11-18(14-32)29(2)3/h7-10,13,15,18H,6,11-12,14H2,1-5H3/t18-/m1/s1
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n/an/a<5.84n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130994
PNG
(US8829010, 45)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CC(F)(F)C4)c23)c1-c1ccc(cc1)C1CC1
Show InChI InChI=1S/C22H21F2N7/c1-29-19(15-7-5-14(6-8-15)13-3-4-13)16(9-27-29)18-17-20(30(2)28-18)25-12-26-21(17)31-10-22(23,24)11-31/h5-9,12-13H,3-4,10-11H2,1-2H3
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n/an/a 5.89n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130995
PNG
(US8829010, 46)
Show SMILES Cc1ccc(-c2c(cnn2C)-c2nn(C)c3ncnc(N4CCC4)c23)c(Cl)c1 |(4.92,-1.87,;3.83,-.78,;2.35,-1.18,;1.26,-.09,;1.66,1.4,;.75,2.64,;-.79,2.64,;-1.27,4.11,;-.02,5.01,;1.23,4.11,;2.69,4.58,;-1.19,1.16,;-.22,-.04,;-1.06,-1.33,;-.5,-2.77,;-2.63,-.94,;-3.96,-1.71,;-5.29,-.94,;-5.29,.6,;-3.96,1.37,;-3.96,2.91,;-5.29,3.68,;-4.52,5.02,;-3.19,4.25,;-2.63,.6,;3.14,1.8,;3.54,3.28,;4.23,.71,)|
Show InChI InChI=1S/C20H20ClN7/c1-12-5-6-13(15(21)9-12)18-14(10-24-26(18)2)17-16-19(27(3)25-17)22-11-23-20(16)28-7-4-8-28/h5-6,9-11H,4,7-8H2,1-3H3
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n/an/a 6.27n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130959
PNG
(US8829010, 10)
Show SMILES Cc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC(C3)c3ccn(C)n3)c12
Show InChI InChI=1S/C24H25N9/c1-15-5-7-16(8-6-15)22-18(11-27-31(22)3)21-20-23(32(4)29-21)25-14-26-24(20)33-12-17(13-33)19-9-10-30(2)28-19/h5-11,14,17H,12-13H2,1-4H3
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n/an/a 6.33n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130988
PNG
(US8829010, 39)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CC(F)C4)c23)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H17F4N7/c1-29-17(11-3-5-12(6-4-11)20(22,23)24)14(7-27-29)16-15-18(30(2)28-16)25-10-26-19(15)31-8-13(21)9-31/h3-7,10,13H,8-9H2,1-2H3
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n/an/a 6.44n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130951
PNG
(US8829010, 1)
Show SMILES Cc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CCC3)c12
Show InChI InChI=1S/C20H21N7/c1-13-5-7-14(8-6-13)18-15(11-23-25(18)2)17-16-19(26(3)24-17)21-12-22-20(16)27-9-4-10-27/h5-8,11-12H,4,9-10H2,1-3H3
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n/an/a<6.79n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130993
PNG
(US8829010, 44)
Show SMILES CC1CN(C1)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C21H20F3N7/c1-12-9-31(10-12)20-16-17(28-30(3)19(16)25-11-26-20)15-8-27-29(2)18(15)13-4-6-14(7-5-13)21(22,23)24/h4-8,11-12H,9-10H2,1-3H3
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n/an/a 6.83n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130961
PNG
(US8829010, 12)
Show SMILES CCc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CCC(C3)S(C)(=O)=O)c12
Show InChI InChI=1S/C23H27N7O2S/c1-5-15-6-8-16(9-7-15)21-18(12-26-28(21)2)20-19-22(29(3)27-20)24-14-25-23(19)30-11-10-17(13-30)33(4,31)32/h6-9,12,14,17H,5,10-11,13H2,1-4H3
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n/an/a 7.08n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM131000
PNG
(US8829010, 51)
Show SMILES Cc1ccc(-c2c(cnn2C)-c2nn(C)c3ncnc(N4CCC4)c23)c(C)c1 |(4.92,-1.87,;3.83,-.78,;2.35,-1.18,;1.26,-.09,;1.66,1.4,;.75,2.64,;-.79,2.64,;-1.27,4.11,;-.02,5.01,;1.23,4.11,;2.69,4.58,;-1.19,1.16,;-.22,-.04,;-1.06,-1.33,;-.5,-2.77,;-2.63,-.94,;-3.96,-1.71,;-5.29,-.94,;-5.29,.6,;-3.96,1.37,;-3.96,2.91,;-5.29,3.68,;-4.52,5.02,;-3.19,4.25,;-2.63,.6,;3.14,1.8,;3.54,3.28,;4.23,.71,)|
Show InChI InChI=1S/C21H23N7/c1-13-6-7-15(14(2)10-13)19-16(11-24-26(19)3)18-17-20(27(4)25-18)22-12-23-21(17)28-8-5-9-28/h6-7,10-12H,5,8-9H2,1-4H3
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n/an/a 7.23n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130992
PNG
(US8829010, 43)
Show SMILES CCc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC(F)(F)C3)c12
Show InChI InChI=1S/C21H21F2N7/c1-4-13-5-7-14(8-6-13)18-15(9-26-28(18)2)17-16-19(29(3)27-17)24-12-25-20(16)30-10-21(22,23)11-30/h5-9,12H,4,10-11H2,1-3H3
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n/an/a 7.43n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM131003
PNG
(US8829010, 54)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CC(F)C4)c23)c1-c1ccc(cc1)C(F)F
Show InChI InChI=1S/C20H18F3N7/c1-28-17(11-3-5-12(6-4-11)18(22)23)14(7-26-28)16-15-19(29(2)27-16)24-10-25-20(15)30-8-13(21)9-30/h3-7,10,13,18H,8-9H2,1-2H3
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n/an/a 7.95n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130983
PNG
(US8829010, 34)
Show SMILES COc1ccc(cc1F)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CCC3)c12
Show InChI InChI=1S/C20H20FN7O/c1-26-18(12-5-6-15(29-3)14(21)9-12)13(10-24-26)17-16-19(27(2)25-17)22-11-23-20(16)28-7-4-8-28/h5-6,9-11H,4,7-8H2,1-3H3
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n/an/a<8.44n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130991
PNG
(US8829010, 42)
Show SMILES COC1CN(C1)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C21H20F3N7O/c1-29-18(12-4-6-13(7-5-12)21(22,23)24)15(8-27-29)17-16-19(30(2)28-17)25-11-26-20(16)31-9-14(10-31)32-3/h4-8,11,14H,9-10H2,1-3H3
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n/an/a 8.60n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130986
PNG
(US8829010, 37)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(cn1)C1CC1
Show InChI InChI=1S/C21H22N8/c1-27-19(16-7-6-14(10-22-16)13-4-5-13)15(11-25-27)18-17-20(28(2)26-18)23-12-24-21(17)29-8-3-9-29/h6-7,10-13H,3-5,8-9H2,1-2H3
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n/an/a 8.93n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130998
PNG
(US8829010, 49)
Show SMILES COc1ccc(-c2c(cnn2C)-c2nn(C)c3ncnc(N4CCC4)c23)c(F)c1F |(6.41,-1.47,;4.92,-1.87,;3.83,-.78,;2.35,-1.18,;1.26,-.09,;1.66,1.4,;.75,2.64,;-.79,2.64,;-1.27,4.11,;-.02,5.01,;1.23,4.11,;2.69,4.58,;-1.19,1.16,;-.22,-.04,;-1.06,-1.33,;-.5,-2.77,;-2.63,-.94,;-3.96,-1.71,;-5.29,-.94,;-5.29,.6,;-3.96,1.37,;-3.96,2.91,;-5.29,3.68,;-4.52,5.02,;-3.19,4.25,;-2.63,.6,;3.14,1.8,;3.54,3.28,;4.23,.71,;5.72,1.11,)|
Show InChI InChI=1S/C20H19F2N7O/c1-27-18(11-5-6-13(30-3)16(22)15(11)21)12(9-25-27)17-14-19(28(2)26-17)23-10-24-20(14)29-7-4-8-29/h5-6,9-10H,4,7-8H2,1-3H3
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n/an/a 9.01n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130967
PNG
(US8829010, 18)
Show SMILES COc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC(C3)NC(=O)OC(C)(C)C)c12
Show InChI InChI=1S/C25H30N8O3/c1-25(2,3)36-24(34)29-16-12-33(13-16)23-19-20(30-32(5)22(19)26-14-27-23)18-11-28-31(4)21(18)15-7-9-17(35-6)10-8-15/h7-11,14,16H,12-13H2,1-6H3,(H,29,34)
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n/an/a 9.34n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130970
PNG
(US8829010, 21)
Show SMILES COc1ccc(cc1F)-c1c(cnn1C)-c1nn(C)c2ncnc(-c3ccn(N)n3)c12
Show InChI InChI=1S/C20H18FN9O/c1-28-19(11-4-5-15(31-3)13(21)8-11)12(9-25-28)17-16-18(14-6-7-30(22)26-14)23-10-24-20(16)29(2)27-17/h4-10H,22H2,1-3H3
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n/an/a 9.47n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130953
PNG
(US8829010, 4)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C19H17F3N8/c1-28-16(13-5-4-11(8-23-13)19(20,21)22)12(9-26-28)15-14-17(29(2)27-15)24-10-25-18(14)30-6-3-7-30/h4-5,8-10H,3,6-7H2,1-2H3
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n/an/a 9.54n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130999
PNG
(US8829010, 50)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(Cl)cc1Cl |(2.69,4.58,;1.23,4.11,;-.02,5.01,;-1.27,4.11,;-.79,2.64,;-1.19,1.16,;-.22,-.04,;-1.06,-1.33,;-.5,-2.77,;-2.63,-.94,;-3.96,-1.71,;-5.29,-.94,;-5.29,.6,;-3.96,1.37,;-3.96,2.91,;-5.29,3.68,;-4.52,5.02,;-3.19,4.25,;-2.63,.6,;.75,2.64,;1.66,1.4,;1.26,-.09,;2.35,-1.18,;3.83,-.78,;4.92,-1.87,;4.23,.71,;3.14,1.8,;3.54,3.28,)|
Show InChI InChI=1S/C19H17Cl2N7/c1-26-17(12-5-4-11(20)8-14(12)21)13(9-24-26)16-15-18(27(2)25-16)22-10-23-19(15)28-6-3-7-28/h4-5,8-10H,3,6-7H2,1-2H3
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n/an/a 9.72n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130965
PNG
(US8829010, 16)
Show SMILES CCc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC[C@@H](C3)NC(C)=O)c12 |r|
Show InChI InChI=1S/C24H28N8O/c1-5-16-6-8-17(9-7-16)22-19(12-27-30(22)3)21-20-23(31(4)29-21)25-14-26-24(20)32-11-10-18(13-32)28-15(2)33/h6-9,12,14,18H,5,10-11,13H2,1-4H3,(H,28,33)/t18-/m0/s1
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n/an/a 9.87n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130964
PNG
(US8829010, 15)
Show SMILES COC(=O)NC1CN(C1)c1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(C)cc3)c12
Show InChI InChI=1S/C22H24N8O2/c1-13-5-7-14(8-6-13)19-16(9-25-28(19)2)18-17-20(29(3)27-18)23-12-24-21(17)30-10-15(11-30)26-22(31)32-4/h5-9,12,15H,10-11H2,1-4H3,(H,26,31)
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n/an/a 9.89n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130971
PNG
(US8829010, 22)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC(C4)S(=O)(=O)CC4CC4)c23)c1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C24H25ClFN7O2S/c1-31-22(15-5-6-18(25)19(26)9-15)17(10-29-31)21-20-23(32(2)30-21)27-13-28-24(20)33-8-7-16(11-33)36(34,35)12-14-3-4-14/h5-6,9-10,13-14,16H,3-4,7-8,11-12H2,1-2H3
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n/an/a 9.89n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM9153
PNG
(US8829010, 58 | US8829010, 59)
Show SMILES CNc1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C18H16F3N7/c1-22-16-13-14(26-28(3)17(13)24-9-23-16)12-8-25-27(2)15(12)10-4-6-11(7-5-10)18(19,20)21/h4-9H,1-3H3,(H,22,23,24)
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n/an/a 13.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM9153
PNG
(US8829010, 58 | US8829010, 59)
Show SMILES CNc1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C18H16F3N7/c1-22-16-13-14(26-28(3)17(13)24-9-23-16)12-8-25-27(2)15(12)10-4-6-11(7-5-10)18(19,20)21/h4-9H,1-3H3,(H,22,23,24)
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n/an/a 27n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM131005
PNG
(US8829010, 60)
Show SMILES CCNc1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C19H18F3N7/c1-4-23-17-14-15(27-29(3)18(14)25-10-24-17)13-9-26-28(2)16(13)11-5-7-12(8-6-11)19(20,21)22/h5-10H,4H2,1-3H3,(H,23,24,25)
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n/an/a 126n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM130954
PNG
(US8829010, 5)
Show SMILES CCc1ccc(cc1)-n1cncc1-c1nn(C)c2ncnc(N3CC[C@H](C3)N(C)C)c12
Show InChI InChI=1S/C23H28N8/c1-5-16-6-8-17(9-7-16)31-15-24-12-19(31)21-20-22(29(4)27-21)25-14-26-23(20)30-11-10-18(13-30)28(2)3/h6-9,12,14-15,18H,5,10-11,13H2,1-4H3/t18-/m1/s1
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n/an/a 131n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...

US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
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Ligand-Target Pair
* indicates data uncertainty>20%