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Patent code US8829199

Compile Data Set for Download or QSAR

Found 333 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130859
PNG
(US8829199, 114)
Show SMILES CC1CCC(C)N1Cc1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1
Show InChI InChI=1S/C27H29N7O/c1-15-4-5-16(2)33(15)14-18-6-8-22-19(10-18)11-25(32-22)26(35)21-13-29-34(27(21)28)20-7-9-23-24(12-20)31-17(3)30-23/h6-13,15-16,32H,4-5,14,28H2,1-3H3,(H,30,31)
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n/an/a 0.320n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130860
PNG
(US8829199, 115)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3cc(CN4CCCC(F)C4)ccc3[nH]2)c1N
Show InChI InChI=1S/C26H26FN7O/c1-15-30-22-7-5-19(11-23(22)31-15)34-26(28)20(12-29-34)25(35)24-10-17-9-16(4-6-21(17)32-24)13-33-8-2-3-18(27)14-33/h4-7,9-12,18,32H,2-3,8,13-14,28H2,1H3,(H,30,31)
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n/an/a 0.670n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130811
PNG
(US8829199, 40)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(OCC4(C)COC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H24N6O3/c1-14-28-19-6-4-16(8-21(19)29-14)31-24(26)18(10-27-31)23(32)22-7-15-3-5-17(9-20(15)30-22)34-13-25(2)11-33-12-25/h3-10,30H,11-13,26H2,1-2H3,(H,28,29)
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n/an/a 0.810n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM130879
PNG
(US8829199, 155)
Show SMILES CC(=O)N1CCN(Cc2ccc3cc([nH]c3c2)C(=O)c2cnn(c2N)-c2ccc3nc(C)nc3c2)CC1
Show InChI InChI=1S/C27H28N8O2/c1-16-30-22-6-5-20(13-24(22)31-16)35-27(28)21(14-29-35)26(37)25-12-19-4-3-18(11-23(19)32-25)15-33-7-9-34(10-8-33)17(2)36/h3-6,11-14,32H,7-10,15,28H2,1-2H3,(H,30,31)
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n/an/a 1.20n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130866
PNG
(US8829199, 132)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 1.40n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130881
PNG
(US8829199, 158)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3cc(CN4CCCC4)ccc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O/c1-15-28-21-7-5-18(12-22(21)29-15)32-25(26)19(13-27-32)24(33)23-11-17-10-16(4-6-20(17)30-23)14-31-8-2-3-9-31/h4-7,10-13,30H,2-3,8-9,14,26H2,1H3,(H,28,29)
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n/an/a 1.40n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130880
PNG
(US8829199, 157)
Show SMILES CN1CCN(Cc2ccc3[nH]c(cc3c2)C(=O)c2cnn(c2N)-c2ccc3nc(C)nc3c2)CC1
Show InChI InChI=1S/C26H28N8O/c1-16-29-22-6-4-19(13-23(22)30-16)34-26(27)20(14-28-34)25(35)24-12-18-11-17(3-5-21(18)31-24)15-33-9-7-32(2)8-10-33/h3-6,11-14,31H,7-10,15,27H2,1-2H3,(H,29,30)
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n/an/a 1.60n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM130872
PNG
(US8829199, 141)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)N2CCOCC2)c1N
Show InChI InChI=1S/C24H23N7O2/c1-14-27-19-5-4-17(12-21(19)28-14)31-24(25)18(13-26-31)23(32)22-10-15-2-3-16(11-20(15)29-22)30-6-8-33-9-7-30/h2-5,10-13,29H,6-9,25H2,1H3,(H,27,28)
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n/an/a 1.60n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130879
PNG
(US8829199, 155)
Show SMILES CC(=O)N1CCN(Cc2ccc3cc([nH]c3c2)C(=O)c2cnn(c2N)-c2ccc3nc(C)nc3c2)CC1
Show InChI InChI=1S/C27H28N8O2/c1-16-30-22-6-5-20(13-24(22)31-16)35-27(28)21(14-29-35)26(37)25-12-19-4-3-18(11-23(19)32-25)15-33-7-9-34(10-8-33)17(2)36/h3-6,11-14,32H,7-10,15,28H2,1-2H3,(H,30,31)
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n/an/a 1.80n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130868
PNG
(US8829199, 134)
Show SMILES CN1CCN(CC1)C(=O)c1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1
Show InChI InChI=1S/C26H26N8O2/c1-15-29-21-6-4-18(13-22(21)30-15)34-25(27)19(14-28-34)24(35)23-12-17-11-16(3-5-20(17)31-23)26(36)33-9-7-32(2)8-10-33/h3-6,11-14,31H,7-10,27H2,1-2H3,(H,29,30)
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n/an/a 2n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130872
PNG
(US8829199, 141)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)N2CCOCC2)c1N
Show InChI InChI=1S/C24H23N7O2/c1-14-27-19-5-4-17(12-21(19)28-14)31-24(25)18(13-26-31)23(32)22-10-15-2-3-16(11-20(15)29-22)30-6-8-33-9-7-30/h2-5,10-13,29H,6-9,25H2,1H3,(H,27,28)
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n/an/a 2.5n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130814
PNG
(US8829199, 47)
Show SMILES C[C@H]1COCCN1Cc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1 |r|
Show InChI InChI=1S/C26H27N7O2/c1-15-14-35-8-7-32(15)13-17-3-4-18-10-24(31-22(18)9-17)25(34)20-12-28-33(26(20)27)19-5-6-21-23(11-19)30-16(2)29-21/h3-6,9-12,15,31H,7-8,13-14,27H2,1-2H3,(H,29,30)/t15-/m0/s1
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n/an/a 2.70n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130801
PNG
(US8829199, 6)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(OCCN4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H27N7O3/c1-16-29-21-5-3-18(13-23(21)30-16)33-26(27)20(15-28-33)25(34)24-12-17-2-4-19(14-22(17)31-24)36-11-8-32-6-9-35-10-7-32/h2-5,12-15,31H,6-11,27H2,1H3,(H,29,30)
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n/an/a 2.70n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130903
PNG
(US10689705, Compound 7 | US8829199, 196)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(F)(F)CC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H25F2N7O/c1-15-31-20-5-4-18(12-22(20)32-15)35-25(29)19(13-30-35)24(36)23-11-17-3-2-16(10-21(17)33-23)14-34-8-6-26(27,28)7-9-34/h2-5,10-13,33H,6-9,14,29H2,1H3,(H,31,32)
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n/an/a 2.90n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130875
PNG
(US8829199, 150)
Show SMILES CCc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H18N6O/c1-2-19-25-16-8-7-13(10-17(16)26-19)27-21(22)14(11-23-27)20(28)18-9-12-5-3-4-6-15(12)24-18/h3-11,24H,2,22H2,1H3,(H,25,26)
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n/an/a 2.90n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130802
PNG
(US8829199, 7)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(OC4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H24N6O3/c1-14-28-20-5-3-16(11-22(20)29-14)31-25(26)19(13-27-31)24(32)23-10-15-2-4-18(12-21(15)30-23)34-17-6-8-33-9-7-17/h2-5,10-13,17,30H,6-9,26H2,1H3,(H,28,29)
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n/an/a 3n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130884
PNG
(US8829199, 164)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C(O)=O)c1N
Show InChI InChI=1S/C21H16N6O3/c1-10-24-16-5-3-13(8-17(16)25-10)27-20(22)14(9-23-27)19(28)18-7-12-6-11(21(29)30)2-4-15(12)26-18/h2-9,26H,22H2,1H3,(H,24,25)(H,29,30)
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n/an/a 3n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM130806
PNG
(US8829199, 27)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C(=O)N2CCCC(F)(F)C2)c1N
Show InChI InChI=1S/C26H23F2N7O2/c1-14-31-20-6-4-17(11-21(20)32-14)35-24(29)18(12-30-35)23(36)22-10-16-9-15(3-5-19(16)33-22)25(37)34-8-2-7-26(27,28)13-34/h3-6,9-12,33H,2,7-8,13,29H2,1H3,(H,31,32)
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n/an/a 3.10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130801
PNG
(US8829199, 6)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(OCCN4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H27N7O3/c1-16-29-21-5-3-18(13-23(21)30-16)33-26(27)20(15-28-33)25(34)24-12-17-2-4-19(14-22(17)31-24)36-11-8-32-6-9-35-10-7-32/h2-5,12-15,31H,6-11,27H2,1H3,(H,29,30)
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n/an/a 3.20n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130866
PNG
(US8829199, 132)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 3.40n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM130866
PNG
(US8829199, 132)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 3.5n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130883
PNG
(US8829199, 163)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3=CC(F)C(CN4CCOCC4)C=c3[nH]2)c1N |c:33,t:20|
Show InChI InChI=1S/C25H26FN7O2/c1-14-29-20-3-2-17(11-22(20)30-14)33-25(27)18(12-28-33)24(34)23-9-15-8-19(26)16(10-21(15)31-23)13-32-4-6-35-7-5-32/h2-3,8-12,16,19,31H,4-7,13,27H2,1H3,(H,29,30)
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n/an/a 3.60n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM130811
PNG
(US8829199, 40)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(OCC4(C)COC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H24N6O3/c1-14-28-19-6-4-16(8-21(19)29-14)31-24(26)18(10-27-31)23(32)22-7-15-3-5-17(9-20(15)30-22)34-13-25(2)11-33-12-25/h3-10,30H,11-13,26H2,1-2H3,(H,28,29)
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n/an/a 3.70n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130873
PNG
(US8829199, 145)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C(=O)N2CCOCC2)c1N
Show InChI InChI=1S/C25H23N7O3/c1-14-28-20-5-3-17(12-21(20)29-14)32-24(26)18(13-27-32)23(33)22-11-16-10-15(2-4-19(16)30-22)25(34)31-6-8-35-9-7-31/h2-5,10-13,30H,6-9,26H2,1H3,(H,28,29)
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n/an/a 3.80n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130872
PNG
(US8829199, 141)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)N2CCOCC2)c1N
Show InChI InChI=1S/C24H23N7O2/c1-14-27-19-5-4-17(12-21(19)28-14)31-24(25)18(13-26-31)23(32)22-10-15-2-3-16(11-20(15)29-22)30-6-8-33-9-7-30/h2-5,10-13,29H,6-9,25H2,1H3,(H,27,28)
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n/an/a 4n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130892
PNG
(US8829199, 185)
Show SMILES COc1cc2[nH]c(cc2cc1Cl)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1
Show InChI InChI=1S/C21H17ClN6O2/c1-10-25-15-4-3-12(7-17(15)26-10)28-21(23)13(9-24-28)20(29)18-6-11-5-14(22)19(30-2)8-16(11)27-18/h3-9,27H,23H2,1-2H3,(H,25,26)
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n/an/a 4n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130870
PNG
(US8829199, 138)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3c(NC(CO)CO)cccc3[nH]2)c1N
Show InChI InChI=1S/C23H23N7O3/c1-12-26-19-6-5-14(7-20(19)27-12)30-23(24)16(9-25-30)22(33)21-8-15-17(28-13(10-31)11-32)3-2-4-18(15)29-21/h2-9,13,28-29,31-32H,10-11,24H2,1H3,(H,26,27)
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n/an/a 4.20n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130802
PNG
(US8829199, 7)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(OC4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H24N6O3/c1-14-28-20-5-3-16(11-22(20)29-14)31-25(26)19(13-27-31)24(32)23-10-15-2-4-18(12-21(15)30-23)34-17-6-8-33-9-7-17/h2-5,10-13,17,30H,6-9,26H2,1H3,(H,28,29)
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n/an/a 4.30n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130814
PNG
(US8829199, 47)
Show SMILES C[C@H]1COCCN1Cc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1 |r|
Show InChI InChI=1S/C26H27N7O2/c1-15-14-35-8-7-32(15)13-17-3-4-18-10-24(31-22(18)9-17)25(34)20-12-28-33(26(20)27)19-5-6-21-23(11-19)30-16(2)29-21/h3-6,9-12,15,31H,7-8,13-14,27H2,1-2H3,(H,29,30)/t15-/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130881
PNG
(US8829199, 158)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3cc(CN4CCCC4)ccc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O/c1-15-28-21-7-5-18(12-22(21)29-15)32-25(26)19(13-27-32)24(33)23-11-17-10-16(4-6-20(17)30-23)14-31-8-2-3-9-31/h4-7,10-13,30H,2-3,8-9,14,26H2,1H3,(H,28,29)
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n/an/a 4.60n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130880
PNG
(US8829199, 157)
Show SMILES CN1CCN(Cc2ccc3[nH]c(cc3c2)C(=O)c2cnn(c2N)-c2ccc3nc(C)nc3c2)CC1
Show InChI InChI=1S/C26H28N8O/c1-16-29-22-6-4-19(13-23(22)30-16)34-26(27)20(14-28-34)25(35)24-12-18-11-17(3-5-21(18)31-24)15-33-9-7-32(2)8-10-33/h3-6,11-14,31H,7-10,15,27H2,1-2H3,(H,29,30)
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n/an/a 4.80n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130798
PNG
(US8829199, 1)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)C2=CC3C=CC=CC3N2)c1N |c:21,23,t:18|
Show InChI InChI=1S/C20H18N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,12,15,25H,21H2,1H3,(H,23,24)
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n/an/a 5n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130867
PNG
(US8829199, 133)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3c(NCCN4CCOCC4)cccc3[nH]2)c1N
Show InChI InChI=1S/C26H28N8O2/c1-16-30-22-6-5-17(13-23(22)31-16)34-26(27)19(15-29-34)25(35)24-14-18-20(3-2-4-21(18)32-24)28-7-8-33-9-11-36-12-10-33/h2-6,13-15,28,32H,7-12,27H2,1H3,(H,30,31)
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n/an/a 5.10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130799
PNG
(US8829199, 3)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(O)CC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H27N7O2/c1-15-29-21-5-4-18(12-23(21)30-15)33-26(27)20(13-28-33)25(35)24-11-17-3-2-16(10-22(17)31-24)14-32-8-6-19(34)7-9-32/h2-5,10-13,19,31,34H,6-9,14,27H2,1H3,(H,29,30)
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n/an/a 5.30n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM130814
PNG
(US8829199, 47)
Show SMILES C[C@H]1COCCN1Cc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1 |r|
Show InChI InChI=1S/C26H27N7O2/c1-15-14-35-8-7-32(15)13-17-3-4-18-10-24(31-22(18)9-17)25(34)20-12-28-33(26(20)27)19-5-6-21-23(11-19)30-16(2)29-21/h3-6,9-12,15,31H,7-8,13-14,27H2,1-2H3,(H,29,30)/t15-/m0/s1
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n/an/a 5.40n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130806
PNG
(US8829199, 27)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C(=O)N2CCCC(F)(F)C2)c1N
Show InChI InChI=1S/C26H23F2N7O2/c1-14-31-20-6-4-17(11-21(20)32-14)35-24(29)18(12-30-35)23(36)22-10-16-9-15(3-5-19(16)33-22)25(37)34-8-2-7-26(27,28)13-34/h3-6,9-12,33H,2,7-8,13,29H2,1H3,(H,31,32)
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n/an/a 5.40n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM130801
PNG
(US8829199, 6)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(OCCN4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H27N7O3/c1-16-29-21-5-3-18(13-23(21)30-16)33-26(27)20(15-28-33)25(34)24-12-17-2-4-19(14-22(17)31-24)36-11-8-32-6-9-35-10-7-32/h2-5,12-15,31H,6-11,27H2,1H3,(H,29,30)
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n/an/a 5.40n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130799
PNG
(US8829199, 3)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(O)CC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H27N7O2/c1-15-29-21-5-4-18(12-23(21)30-15)33-26(27)20(13-28-33)25(35)24-11-17-3-2-16(10-22(17)31-24)14-32-8-6-19(34)7-9-32/h2-5,10-13,19,31,34H,6-9,14,27H2,1H3,(H,29,30)
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n/an/a 5.5n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130838
PNG
(US8829199, 85)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)-c2ccc(F)cn2)c1N
Show InChI InChI=1S/C25H18FN7O/c1-13-30-20-7-5-17(10-22(20)31-13)33-25(27)18(12-29-33)24(34)23-9-15-3-2-14(8-21(15)32-23)19-6-4-16(26)11-28-19/h2-12,32H,27H2,1H3,(H,30,31)
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n/an/a 5.5n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130896
PNG
(US8829199, 190)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3c(cc(cc3[nH]2)C(C)(C)C)C(C)(C)C)c1N
Show InChI InChI=1S/C28H32N6O/c1-15-31-21-9-8-17(12-23(21)32-15)34-26(29)19(14-30-34)25(35)24-13-18-20(28(5,6)7)10-16(27(2,3)4)11-22(18)33-24/h8-14,33H,29H2,1-7H3,(H,31,32)
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n/an/a 5.5n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130892
PNG
(US8829199, 185)
Show SMILES COc1cc2[nH]c(cc2cc1Cl)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1
Show InChI InChI=1S/C21H17ClN6O2/c1-10-25-15-4-3-12(7-17(15)26-10)28-21(23)13(9-24-28)20(29)18-6-11-5-14(22)19(30-2)8-16(11)27-18/h3-9,27H,23H2,1-2H3,(H,25,26)
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n/an/a 5.5n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM130870
PNG
(US8829199, 138)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3c(NC(CO)CO)cccc3[nH]2)c1N
Show InChI InChI=1S/C23H23N7O3/c1-12-26-19-6-5-14(7-20(19)27-12)30-23(24)16(9-25-30)22(33)21-8-15-17(28-13(10-31)11-32)3-2-4-18(15)29-21/h2-9,13,28-29,31-32H,10-11,24H2,1H3,(H,26,27)
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n/an/a 5.60n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130800
PNG
(US8829199, 5)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(CN4CCNCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H26N8O/c1-15-29-20-5-4-18(12-22(20)30-15)33-25(26)19(13-28-33)24(34)23-11-17-3-2-16(10-21(17)31-23)14-32-8-6-27-7-9-32/h2-5,10-13,27,31H,6-9,14,26H2,1H3,(H,29,30)
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n/an/a 5.60n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130870
PNG
(US8829199, 138)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3c(NC(CO)CO)cccc3[nH]2)c1N
Show InChI InChI=1S/C23H23N7O3/c1-12-26-19-6-5-14(7-20(19)27-12)30-23(24)16(9-25-30)22(33)21-8-15-17(28-13(10-31)11-32)3-2-4-18(15)29-21/h2-9,13,28-29,31-32H,10-11,24H2,1H3,(H,26,27)
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n/an/a 6n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130852
PNG
(US8829199, 92)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)C2=CC3C=CC(=CC3N2)C#N)c1N |c:21,23,t:18|
Show InChI InChI=1S/C21H17N7O/c1-11-25-16-5-4-14(8-18(16)26-11)28-21(23)15(10-24-28)20(29)19-7-13-3-2-12(9-22)6-17(13)27-19/h2-8,10,13,17,27H,23H2,1H3,(H,25,26)
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n/an/a 6.20n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130879
PNG
(US8829199, 155)
Show SMILES CC(=O)N1CCN(Cc2ccc3cc([nH]c3c2)C(=O)c2cnn(c2N)-c2ccc3nc(C)nc3c2)CC1
Show InChI InChI=1S/C27H28N8O2/c1-16-30-22-6-5-20(13-24(22)31-16)35-27(28)21(14-29-35)26(37)25-12-19-4-3-18(11-23(19)32-25)15-33-7-9-34(10-8-33)17(2)36/h3-6,11-14,32H,7-10,15,28H2,1-2H3,(H,30,31)
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n/an/a 6.30n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130869
PNG
(US8829199, 137)
Show SMILES COCCNc1cccc2[nH]c(cc12)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1
Show InChI InChI=1S/C23H23N7O2/c1-13-27-19-7-6-14(10-20(19)28-13)30-23(24)16(12-26-30)22(31)21-11-15-17(25-8-9-32-2)4-3-5-18(15)29-21/h3-7,10-12,25,29H,8-9,24H2,1-2H3,(H,27,28)
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n/an/a 6.40n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM130802
PNG
(US8829199, 7)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(OC4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H24N6O3/c1-14-28-20-5-3-16(11-22(20)29-14)31-25(26)19(13-27-31)24(32)23-10-15-2-4-18(12-21(15)30-23)34-17-6-8-33-9-7-17/h2-5,10-13,17,30H,6-9,26H2,1H3,(H,28,29)
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n/an/a 6.70n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM130858
PNG
(US8829199, 107)
Show SMILES CN1CCC(CC1)c1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1
Show InChI InChI=1S/C26H27N7O/c1-15-29-21-6-5-19(13-23(21)30-15)33-26(27)20(14-28-33)25(34)24-12-18-4-3-17(11-22(18)31-24)16-7-9-32(2)10-8-16/h3-6,11-14,16,31H,7-10,27H2,1-2H3,(H,29,30)
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n/an/a 6.90n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM130895
PNG
(US8829199, 189)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3cc4OCCOc4cc3[nH]2)c1N
Show InChI InChI=1S/C22H18N6O3/c1-11-25-15-3-2-13(8-17(15)26-11)28-22(23)14(10-24-28)21(29)18-6-12-7-19-20(9-16(12)27-18)31-5-4-30-19/h2-3,6-10,27H,4-5,23H2,1H3,(H,25,26)
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n/an/a 7.60n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...

US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 333 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%