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Patent code US8835465

Compile Data Set for Download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM131727
PNG
(US8835465, 47)
Show SMILES C[C@H](Nc1ccc(c(Nc2cc([nH]n2)C2CC2)n1)[N+]([O-])=O)c1ccc(F)cc1
Show InChI InChI=1S/C19H19FN6O2/c1-11(12-4-6-14(20)7-5-12)21-17-9-8-16(26(27)28)19(22-17)23-18-10-15(24-25-18)13-2-3-13/h4-11,13H,2-3H2,1H3,(H3,21,22,23,24,25)/t11-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 63n/an/an/an/an/a25



AstraZeneca AB

US Patent


Assay Description
Trk A kinase activity was measured for its ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substrate using an Ampli...

US Patent US8835465 (2014)


BindingDB Entry DOI: 10.7270/Q2X9290K
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM131726
PNG
(US8835465, 24)
Show SMILES C[C@H](Nc1nc(Nc2cc([nH]n2)C2CC2)c(F)cc1CNC(=O)C1CCC(=O)N1)c1ccc(F)cc1
Show InChI InChI=1S/C25H27F2N7O2/c1-13(14-4-6-17(26)7-5-14)29-23-16(12-28-25(36)19-8-9-22(35)30-19)10-18(27)24(32-23)31-21-11-20(33-34-21)15-2-3-15/h4-7,10-11,13,15,19H,2-3,8-9,12H2,1H3,(H,28,36)(H,30,35)(H3,29,31,32,33,34)/t13-,19?/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 109n/an/an/an/an/a25



AstraZeneca AB

US Patent


Assay Description
Trk A kinase activity was measured for its ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substrate using an Ampli...

US Patent US8835465 (2014)


BindingDB Entry DOI: 10.7270/Q2X9290K
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM131725
PNG
(US8835465, 21)
Show SMILES C[C@H](Nc1nc(Nc2cc([nH]n2)C2CC2)c(Cl)cc1Cl)c1ccc(F)cc1
Show InChI InChI=1S/C19H18Cl2FN5/c1-10(11-4-6-13(22)7-5-11)23-18-14(20)8-15(21)19(25-18)24-17-9-16(26-27-17)12-2-3-12/h4-10,12H,2-3H2,1H3,(H3,23,24,25,26,27)/t10-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 611n/an/an/an/an/a25



AstraZeneca AB

US Patent


Assay Description
Trk A kinase activity was measured for its ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substrate using an Ampli...

US Patent US8835465 (2014)


BindingDB Entry DOI: 10.7270/Q2X9290K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%