Affinity Data by Patent

Patent code US8841450

Found 2 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM50437436 (CHEMBL2409216 \| US8841450, I-1) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...				US Patent US8841450 (2014) BindingDB Entry DOI: 10.7270/Q2NS0SKK
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM50437437 (CHEMBL2409217 \| US8841450, I-2) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	90	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...				US Patent US8841450 (2014) BindingDB Entry DOI: 10.7270/Q2NS0SKK
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair

* indicates data uncertainty>20%