BindingDB logo
myBDB logout

Patent code US8846673

Compile Data Set for Download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134239
PNG
(US8846673, 217)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(cc1)C(=O)Nc1nnn[nH]1
Show InChI InChI=1S/C26H19N9O2/c27-24-22-21(30-31-24)14-20(15-6-8-17(9-7-15)25(36)29-26-32-34-35-33-26)28-23(22)16-10-12-19(13-11-16)37-18-4-2-1-3-5-18/h1-14H,(H3,27,30,31)(H2,29,32,33,34,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.700n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134247
PNG
(US8846673, 245)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(C(O)=O)c(F)c1
Show InChI InChI=1S/C25H17FN4O3/c26-19-12-15(8-11-18(19)25(31)32)20-13-21-22(24(27)30-29-21)23(28-20)14-6-9-17(10-7-14)33-16-4-2-1-3-5-16/h1-13H,(H,31,32)(H3,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134240
PNG
(US8846673, 219)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(cc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C27H21N5O4/c28-26-24-22(31-32-26)14-21(16-6-8-18(9-7-16)27(35)29-15-23(33)34)30-25(24)17-10-12-20(13-11-17)36-19-4-2-1-3-5-19/h1-14H,15H2,(H,29,35)(H,33,34)(H3,28,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134237
PNG
(US8846673, 193)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H18N4O3/c26-24-22-21(28-29-24)14-20(15-6-8-17(9-7-15)25(30)31)27-23(22)16-10-12-19(13-11-16)32-18-4-2-1-3-5-18/h1-14H,(H,30,31)(H3,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134242
PNG
(US8846673, 225)
Show SMILES Nc1n[nH]c2c(cnc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccccn1
Show InChI InChI=1S/C23H17N5O/c24-23-20-21(15-9-11-17(12-10-15)29-16-6-2-1-3-7-16)26-14-18(22(20)27-28-23)19-8-4-5-13-25-19/h1-14H,(H3,24,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134251
PNG
(US8846673, 262)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4cccc(F)c4)cc3)c12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H17FN4O3/c26-17-2-1-3-19(12-17)33-18-10-8-15(9-11-18)23-22-21(29-30-24(22)27)13-20(28-23)14-4-6-16(7-5-14)25(31)32/h1-13H,(H,31,32)(H3,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134241
PNG
(US8846673, 223)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C25H18N8O/c26-24-22-21(28-29-24)14-20(15-6-8-17(9-7-15)25-30-32-33-31-25)27-23(22)16-10-12-19(13-11-16)34-18-4-2-1-3-5-18/h1-14H,(H3,26,28,29)(H,30,31,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134246
PNG
(US8846673, 242)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCN(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C30H28N6O2/c31-29-27-26(34-35-29)19-25(20-15-17-36(18-16-20)30(37)32-22-7-3-1-4-8-22)33-28(27)21-11-13-24(14-12-21)38-23-9-5-2-6-10-23/h1-14,19-20H,15-18H2,(H,32,37)(H3,31,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134245
PNG
(US8846673, 238)
Show SMILES COC(=O)C(=O)N1CCCC(C1)c1cc2[nH]nc(N)c2c(n1)-c1ccc(Oc2ccccc2)cc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134238
PNG
(US8846673, 216)
Show SMILES CNC(=O)c1ccc(cc1)-c1cc2[nH]nc(N)c2c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H21N5O2/c1-28-26(32)18-9-7-16(8-10-18)21-15-22-23(25(27)31-30-22)24(29-21)17-11-13-20(14-12-17)33-19-5-3-2-4-6-19/h2-15H,1H3,(H,28,32)(H3,27,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134248
PNG
(US8846673, 249)
Show SMILES CN(C)C(=O)Cn1ccc(Nc2cc3[nH]nc(N)c3c(n2)-c2ccc(Oc3ccccc3)cc2)n1
Show InChI InChI=1S/C25H24N8O2/c1-32(2)22(34)15-33-13-12-20(31-33)27-21-14-19-23(25(26)30-29-19)24(28-21)16-8-10-18(11-9-16)35-17-6-4-3-5-7-17/h3-14H,15H2,1-2H3,(H3,26,29,30)(H,27,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134243
PNG
(US8846673, 236)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)Nc1ccccc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134244
PNG
(US8846673, 237)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134233
PNG
(US8846673, 130)
Show SMILES COc1cccc(c1)-c1cnc(Nc2ccccc2Cl)c(Cl)c1C#N
Show InChI InChI=1S/C19H13Cl2N3O/c1-25-13-6-4-5-12(9-13)15-11-23-19(18(21)14(15)10-22)24-17-8-3-2-7-16(17)20/h2-9,11H,1H3,(H,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 230n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134235
PNG
(US8846673, 137)
Show SMILES CC(C)Oc1cccc(c1)-c1cnc(Nc2ccccc2C)c2[nH]nc(N)c12
Show InChI InChI=1S/C22H23N5O/c1-13(2)28-16-9-6-8-15(11-16)17-12-24-22(20-19(17)21(23)27-26-20)25-18-10-5-4-7-14(18)3/h4-13H,1-3H3,(H,24,25)(H3,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 240n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134231
PNG
(US8846673, 120)
Show SMILES Nc1n[nH]c2nc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1cccs1
Show InChI InChI=1S/C21H15N5OS/c22-19-17-18(23-20(16-7-4-12-28-16)24-21(17)26-25-19)13-8-10-15(11-9-13)27-14-5-2-1-3-6-14/h1-12H,(H3,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 240n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134225
PNG
(US8846673, 95)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C26H19N5O/c27-26-23-21(16-6-9-20(10-7-16)32-19-4-2-1-3-5-19)15-29-24(25(23)30-31-26)18-8-11-22-17(14-18)12-13-28-22/h1-15,28H,(H3,27,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 250n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134236
PNG
(US8846673, 155)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc2ccccc2c1
Show InChI InChI=1S/C28H20N4O/c29-28-26-25(31-32-28)17-24(21-11-10-18-6-4-5-7-20(18)16-21)30-27(26)19-12-14-23(15-13-19)33-22-8-2-1-3-9-22/h1-17H,(H3,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 260n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134234
PNG
(US8846673, 132)
Show SMILES COc1ccc(cc1)-c1cnc(Nc2ccccc2C)c2[nH]nc(N)c12
Show InChI InChI=1S/C20H19N5O/c1-12-5-3-4-6-16(12)23-20-18-17(19(21)25-24-18)15(11-22-20)13-7-9-14(26-2)10-8-13/h3-11H,1-2H3,(H,22,23)(H3,21,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 260n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134222
PNG
(US8846673, 62)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ncc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C25H21N5O3S/c1-34(31,32)30-18-7-5-6-17(14-18)23-24-22(25(26)29-28-24)21(15-27-23)16-10-12-20(13-11-16)33-19-8-3-2-4-9-19/h2-15,30H,1H3,(H3,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 270n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134226
PNG
(US8846673, 96)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ncc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C25H21N5O3S/c1-34(31,32)30-18-11-7-17(8-12-18)23-24-22(25(26)29-28-24)21(15-27-23)16-9-13-20(14-10-16)33-19-5-3-2-4-6-19/h2-15,30H,1H3,(H3,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 280n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134224
PNG
(US8846673, 92)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(O)cc1
Show InChI InChI=1S/C24H18N4O2/c25-24-21-20(15-8-12-19(13-9-15)30-18-4-2-1-3-5-18)14-26-22(23(21)27-28-24)16-6-10-17(29)11-7-16/h1-14,29H,(H3,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 280n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134249
PNG
(US8846673, 250)
Show SMILES COc1ccc2cc(ccc2c1)-c1nc(cc2[nH]nc(N)c12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18N4O3/c1-31-18-9-8-15-10-17(7-6-16(15)11-18)22-21-20(27-28-23(21)25)12-19(26-22)13-2-4-14(5-3-13)24(29)30/h2-12H,1H3,(H,29,30)(H3,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 280n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134250
PNG
(US8846673, 255)
Show SMILES CC(C)Oc1ccc(cc1)-c1nc(cc2[nH]nc(N)c12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H20N4O3/c1-12(2)29-16-9-7-14(8-10-16)20-19-18(25-26-21(19)23)11-17(24-20)13-3-5-15(6-4-13)22(27)28/h3-12H,1-2H3,(H,27,28)(H3,23,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 290n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134232
PNG
(US8846673, 128)
Show SMILES COc1cccc(c1)-c1cnc(Nc2ccccc2)c2[nH]nc(N)c12
Show InChI InChI=1S/C19H17N5O/c1-25-14-9-5-6-12(10-14)15-11-21-19(17-16(15)18(20)24-23-17)22-13-7-3-2-4-8-13/h2-11H,1H3,(H,21,22)(H3,20,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 290n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134214
PNG
(US8846673, 5)
Show SMILES Cc1cccc(Oc2ccc(cc2)-c2cc(nc(N)c2C(N)=N)C2CCCC2)c1
Show InChI InChI=1S/C24H26N4O/c1-15-5-4-8-19(13-15)29-18-11-9-16(10-12-18)20-14-21(17-6-2-3-7-17)28-24(27)22(20)23(25)26/h4-5,8-14,17H,2-3,6-7H2,1H3,(H3,25,26)(H2,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 290n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134215
PNG
(US8846673, 17)
Show SMILES CC(C)(C)OC(=O)NC1CCN(C1)c1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c2n1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.64E+3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134223
PNG
(US8846673, 82)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H16Cl2N4O/c25-19-11-8-15(12-20(19)26)22-23-21(24(27)30-29-23)18(13-28-22)14-6-9-17(10-7-14)31-16-4-2-1-3-5-16/h1-13H,(H3,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 9.18E+3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134218
PNG
(US8846673, 43)
Show SMILES CC(C)Oc1ccc(cc1)-c1cncc2[nH]nc(N)c12
Show InChI InChI=1S/C15H16N4O/c1-9(2)20-11-5-3-10(4-6-11)12-7-17-8-13-14(12)15(16)19-18-13/h3-9H,1-2H3,(H3,16,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 9.31E+3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134217
PNG
(US8846673, 31)
Show SMILES Cc1csc(NC(=O)NC2CCN(C2)c2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c3n2)n1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.41E+3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134219
PNG
(US8846673, 44)
Show SMILES Nc1n[nH]c2cncc(-c3ccc(OC4CCCC4)cc3)c12
Show InChI InChI=1S/C17H18N4O/c18-17-16-14(9-19-10-15(16)20-21-17)11-5-7-13(8-6-11)22-12-3-1-2-4-12/h5-10,12H,1-4H2,(H3,18,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 9.49E+3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134228
PNG
(US8846673, 107)
Show SMILES Cc1ccccc1-c1ncc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C25H20N4O/c1-16-7-5-6-10-20(16)23-24-22(25(26)29-28-24)21(15-27-23)17-11-13-19(14-12-17)30-18-8-3-2-4-9-18/h2-15H,1H3,(H3,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.27E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134230
PNG
(US8846673, 113)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H17F3N4O2/c26-25(27,28)34-19-8-4-5-16(13-19)22-23-21(24(29)32-31-23)20(14-30-22)15-9-11-18(12-10-15)33-17-6-2-1-3-7-17/h1-14H,(H3,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.38E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134227
PNG
(US8846673, 102)
Show SMILES CC(C)COc1cccc(c1)-c1ncc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C28H26N4O2/c1-18(2)17-33-23-10-6-7-20(15-23)26-27-25(28(29)32-31-27)24(16-30-26)19-11-13-22(14-12-19)34-21-8-4-3-5-9-21/h3-16,18H,17H2,1-2H3,(H3,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.40E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134221
PNG
(US8846673, 61)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C31H23N5O2/c32-30-27-26(20-13-17-25(18-14-20)38-24-9-5-2-6-10-24)19-33-28(29(27)35-36-30)21-11-15-23(16-12-21)34-31(37)22-7-3-1-4-8-22/h1-19H,(H,34,37)(H3,32,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.49E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134229
PNG
(US8846673, 108)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H17F3N4O/c26-25(27,28)17-6-4-5-16(13-17)22-23-21(24(29)32-31-23)20(14-30-22)15-9-11-19(12-10-15)33-18-7-2-1-3-8-18/h1-14H,(H3,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.61E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134216
PNG
(US8846673, 20)
Show SMILES COc1ccc(Oc2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c3n2)cc1
Show InChI InChI=1S/C25H20N4O3/c1-30-17-11-13-20(14-12-17)32-22-15-21(23-24(26)28-29-25(23)27-22)16-7-9-19(10-8-16)31-18-5-3-2-4-6-18/h2-15H,1H3,(H3,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.79E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM134220
PNG
(US8846673, 47)
Show SMILES Nc1n[nH]c2cncc(-c3ccc(cc3)C(=O)N3CCCC3)c12
Show InChI InChI=1S/C17H17N5O/c18-16-15-13(9-19-10-14(15)20-21-16)11-3-5-12(6-4-11)17(23)22-7-1-2-8-22/h3-6,9-10H,1-2,7-8H2,(H3,18,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.06E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...

US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%