BindingDB logo
myBDB logout

Patent code US8853207

Compile Data Set for Download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM135802
PNG
(US8853207, Example-82)
Show SMILES COc1ccc(cc1)-c1n[nH]c-2c1Cc1sc(cc-21)-c1ccc(NC(=O)CN2CCCC2)nc1
Show InChI InChI=1S/C26H25N5O2S/c1-33-18-7-4-16(5-8-18)25-20-13-22-19(26(20)30-29-25)12-21(34-22)17-6-9-23(27-14-17)28-24(32)15-31-10-2-3-11-31/h4-9,12,14H,2-3,10-11,13,15H2,1H3,(H,29,30)(H,27,28,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 12.2n/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of C-kit kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrate in ...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM135799
PNG
(US8853207, Example-69)
Show SMILES COc1ccc(cc1)-c1cc-2c(Cc3c-2[nH]nc3-c2ccc(OC)cc2)s1
Show InChI InChI=1S/C22H18N2O2S/c1-25-15-7-3-13(4-8-15)19-11-17-20(27-19)12-18-21(23-24-22(17)18)14-5-9-16(26-2)10-6-14/h3-11H,12H2,1-2H3,(H,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 22n/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of C-kit kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrate in ...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM135800
PNG
(US8853207, Example-70)
Show SMILES COc1ccc(cc1)-c1n[nH]c-2c1Cc1sc(cc-21)-c1cccnc1
Show InChI InChI=1S/C20H15N3OS/c1-24-14-6-4-12(5-7-14)19-16-10-18-15(20(16)23-22-19)9-17(25-18)13-3-2-8-21-11-13/h2-9,11H,10H2,1H3,(H,22,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 24.8n/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of C-kit kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrate in ...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM135801
PNG
(US8853207, Example-78)
Show SMILES COc1ccc(cc1)-c1n[nH]c-2c1Cc1sc(cc-21)-c1ccc(N)nc1
Show InChI InChI=1S/C20H16N4OS/c1-25-13-5-2-11(3-6-13)19-15-9-17-14(20(15)24-23-19)8-16(26-17)12-4-7-18(21)22-10-12/h2-8,10H,9H2,1H3,(H2,21,22)(H,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 27.5n/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of C-kit kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrate in ...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM135798
PNG
(US8853207, Example-10)
Show SMILES Oc1cccc(Cc2ccc(cc2)-c2n[nH]c-3c2Cc2sccc-32)c1
Show InChI InChI=1S/C21H16N2OS/c24-16-3-1-2-14(11-16)10-13-4-6-15(7-5-13)20-18-12-19-17(8-9-25-19)21(18)23-22-20/h1-9,11,24H,10,12H2,(H,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 118n/an/an/an/a7.0n/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of PDGFR-beta kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrat...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM135798
PNG
(US8853207, Example-10)
Show SMILES Oc1cccc(Cc2ccc(cc2)-c2n[nH]c-3c2Cc2sccc-32)c1
Show InChI InChI=1S/C21H16N2OS/c24-16-3-1-2-14(11-16)10-13-4-6-15(7-5-13)20-18-12-19-17(8-9-25-19)21(18)23-22-20/h1-9,11,24H,10,12H2,(H,22,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 139n/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of C-kit kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrate in ...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM135802
PNG
(US8853207, Example-82)
Show SMILES COc1ccc(cc1)-c1n[nH]c-2c1Cc1sc(cc-21)-c1ccc(NC(=O)CN2CCCC2)nc1
Show InChI InChI=1S/C26H25N5O2S/c1-33-18-7-4-16(5-8-18)25-20-13-22-19(26(20)30-29-25)12-21(34-22)17-6-9-23(27-14-17)28-24(32)15-31-10-2-3-11-31/h4-9,12,14H,2-3,10-11,13,15H2,1H3,(H,29,30)(H,27,28,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 176n/an/an/an/a7.0n/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of PDGFR-beta kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrat...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM135797
PNG
(US8853207, Example-2)
Show SMILES Nc1ccc(cc1)-c1n[nH]c-2c1Cc1sccc-21
Show InChI InChI=1S/C14H11N3S/c15-9-3-1-8(2-4-9)13-11-7-12-10(5-6-18-12)14(11)17-16-13/h1-6H,7,15H2,(H,16,17)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 201n/an/an/an/an/an/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of C-kit kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrate in ...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM135799
PNG
(US8853207, Example-69)
Show SMILES COc1ccc(cc1)-c1cc-2c(Cc3c-2[nH]nc3-c2ccc(OC)cc2)s1
Show InChI InChI=1S/C22H18N2O2S/c1-25-15-7-3-13(4-8-15)19-11-17-20(27-19)12-18-21(23-24-22(17)18)14-5-9-16(26-2)10-6-14/h3-11H,12H2,1-2H3,(H,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 316n/an/an/an/a7.0n/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of PDGFR-beta kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrat...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM135801
PNG
(US8853207, Example-78)
Show SMILES COc1ccc(cc1)-c1n[nH]c-2c1Cc1sc(cc-21)-c1ccc(N)nc1
Show InChI InChI=1S/C20H16N4OS/c1-25-13-5-2-11(3-6-13)19-15-9-17-14(20(15)24-23-19)8-16(26-17)12-4-7-18(21)22-10-12/h2-8,10H,9H2,1H3,(H2,21,22)(H,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 363n/an/an/an/a7.0n/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of PDGFR-beta kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrat...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM135800
PNG
(US8853207, Example-70)
Show SMILES COc1ccc(cc1)-c1n[nH]c-2c1Cc1sc(cc-21)-c1cccnc1
Show InChI InChI=1S/C20H15N3OS/c1-24-14-6-4-12(5-7-14)19-16-10-18-15(20(16)23-22-19)9-17(25-18)13-3-2-8-21-11-13/h2-9,11H,10H2,1H3,(H,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 479n/an/an/an/a7.0n/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of PDGFR-beta kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrat...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM135797
PNG
(US8853207, Example-2)
Show SMILES Nc1ccc(cc1)-c1n[nH]c-2c1Cc1sccc-21
Show InChI InChI=1S/C14H11N3S/c15-9-3-1-8(2-4-9)13-11-7-12-10(5-6-18-12)14(11)17-16-13/h1-6H,7,15H2,(H,16,17)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 859n/an/an/an/a7.0n/a



Development Center for Biotechnology

US Patent


Assay Description
Inhibition of PDGFR-beta kinase activity by compounds disclosed herein was quantified by measuring the amount of [33P] incorporated into the substrat...

US Patent US8853207 (2014)


BindingDB Entry DOI: 10.7270/Q2HX1BC1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%