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Patent code US8853215

Compile Data Set for Download or QSAR
Found 17 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135825
PNG
(US8853215, 3)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1c[nH]cn1
Show InChI InChI=1S/C18H24N4O/c1-18(2,3)14-6-4-5-7-16(14)21-8-10-22(11-9-21)17(23)15-12-19-13-20-15/h4-7,12-13H,8-11H2,1-3H3,(H,19,20)
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n/an/a 3.80n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135836
PNG
(US8853215, 59)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1nc[nH]n1
Show InChI InChI=1S/C17H23N5O/c1-17(2,3)13-6-4-5-7-14(13)21-8-10-22(11-9-21)16(23)15-18-12-19-20-15/h4-7,12H,8-11H2,1-3H3,(H,18,19,20)
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n/an/a 15n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135837
PNG
(US8853215, 69)
Show SMILES CC(C)(C)c1cc(Br)ccc1N1CCN(CC1)C(=O)CC(O)=O
Show InChI InChI=1S/C17H23BrN2O3/c1-17(2,3)13-10-12(18)4-5-14(13)19-6-8-20(9-7-19)15(21)11-16(22)23/h4-5,10H,6-9,11H2,1-3H3,(H,22,23)
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n/an/a 30n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135839
PNG
(US8853215, 90)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C(=O)C1NC(=O)NC1=O
Show InChI InChI=1S/C19H24N4O4/c1-19(2,3)12-6-4-5-7-13(12)22-8-10-23(11-9-22)17(26)15(24)14-16(25)21-18(27)20-14/h4-7,14H,8-11H2,1-3H3,(H2,20,21,25,27)
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n/an/a 34n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135832
PNG
(US8853215, 44)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C(O)=O
Show InChI InChI=1S/C16H22N2O3/c1-16(2,3)12-6-4-5-7-13(12)17-8-10-18(11-9-17)14(19)15(20)21/h4-7H,8-11H2,1-3H3,(H,20,21)
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n/an/a 38n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135828
PNG
(US8853215, 19)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1ccc(cc1)-c1noc(=O)[nH]1
Show InChI InChI=1S/C23H26N4O3/c1-23(2,3)18-6-4-5-7-19(18)26-12-14-27(15-13-26)21(28)17-10-8-16(9-11-17)20-24-22(29)30-25-20/h4-11H,12-15H2,1-3H3,(H,24,25,29)
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n/an/a 49n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135827
PNG
(US8853215, 9)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)CC(O)=O
Show InChI InChI=1S/C17H24N2O3/c1-17(2,3)13-6-4-5-7-14(13)18-8-10-19(11-9-18)15(20)12-16(21)22/h4-7H,8-12H2,1-3H3,(H,21,22)
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n/an/a 54n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135834
PNG
(US8853215, 56)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C21H27N3O/c1-21(2,3)18-11-7-8-12-19(18)23-13-15-24(16-14-23)20(25)22-17-9-5-4-6-10-17/h4-12H,13-16H2,1-3H3,(H,22,25)
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n/an/a 58n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135833
PNG
(US8853215, 55)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)CCC(=O)NS(C)(=O)=O
Show InChI InChI=1S/C19H29N3O4S/c1-19(2,3)15-7-5-6-8-16(15)21-11-13-22(14-12-21)18(24)10-9-17(23)20-27(4,25)26/h5-8H,9-14H2,1-4H3,(H,20,23)
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n/an/a 64n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135841
PNG
(US8853215, 1)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C12CC3CC(CC(C3)(C1)C(O)=O)C2 |TLB:25:24:30:20.19.21,25:20:30:26.24.23,27:24:19:30.22.21,THB:23:24:19:30.22.21,23:22:26.24.25:19|
Show InChI InChI=1S/C26H36N2O3/c1-24(2,3)20-6-4-5-7-21(20)27-8-10-28(11-9-27)22(29)25-13-18-12-19(14-25)16-26(15-18,17-25)23(30)31/h4-7,18-19H,8-17H2,1-3H3,(H,30,31)
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n/an/a 95n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135838
PNG
(US8853215, 71)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C1(CC1)C(O)=O
Show InChI InChI=1S/C19H26N2O3/c1-18(2,3)14-6-4-5-7-15(14)20-10-12-21(13-11-20)16(22)19(8-9-19)17(23)24/h4-7H,8-13H2,1-3H3,(H,23,24)
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n/an/a 150n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135831
PNG
(US8853215, 41)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1ccc(OCC2CCNCC2)cc1
Show InChI InChI=1S/C27H37N3O2/c1-27(2,3)24-6-4-5-7-25(24)29-16-18-30(19-17-29)26(31)22-8-10-23(11-9-22)32-20-21-12-14-28-15-13-21/h4-11,21,28H,12-20H2,1-3H3
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n/an/a 250n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135835
PNG
(US8853215, 58)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)Cc1nnn[nH]1
Show InChI InChI=1S/C17H24N6O/c1-17(2,3)13-6-4-5-7-14(13)22-8-10-23(11-9-22)16(24)12-15-18-20-21-19-15/h4-7H,8-12H2,1-3H3,(H,18,19,20,21)
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n/an/a 300n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135840
PNG
(US8853215, 110)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C(O)CO
Show InChI InChI=1S/C17H26N2O3/c1-17(2,3)13-6-4-5-7-14(13)18-8-10-19(11-9-18)16(22)15(21)12-20/h4-7,15,20-21H,8-12H2,1-3H3
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n/an/a 330n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135830
PNG
(US8853215, 39)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)C(=O)NS(=O)(=O)NCC1CC1
Show InChI InChI=1S/C20H30N4O4S/c1-20(2,3)16-6-4-5-7-17(16)23-10-12-24(13-11-23)19(26)18(25)22-29(27,28)21-14-15-8-9-15/h4-7,15,21H,8-14H2,1-3H3,(H,22,25)
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n/an/a 430n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135829
PNG
(US8853215, 34)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H26N2O3/c1-22(2,3)18-6-4-5-7-19(18)23-12-14-24(15-13-23)20(25)16-8-10-17(11-9-16)21(26)27/h4-11H,12-15H2,1-3H3,(H,26,27)
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n/an/a 480n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM135826
PNG
(US8853215, 6)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)NCC(O)=O
Show InChI InChI=1S/C17H25N3O3/c1-17(2,3)13-6-4-5-7-14(13)19-8-10-20(11-9-19)16(23)18-12-15(21)22/h4-7H,8-12H2,1-3H3,(H,18,23)(H,21,22)
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n/an/a 540n/an/an/an/a7.54



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...

US Patent US8853215 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SP7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%