Affinity Data by Patent

Patent code US8877791

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Pyruvate kinase PKM (Homo sapiens (Human))	BDBM82190 (Salicylic acid derivative, compound 2) Show SMILES Cc1ccc(C)n1-c1ccc(O)c(c1)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Beth Israel Deaconess Medical Center, Inc. US Patent					Assay Description Primary screening was performed using PKM2 in the presence of FBP. Compounds were chosen as potential "hits" if the compound demonstrated inhibition ...				US Patent US8877791 (2014) BindingDB Entry DOI: 10.7270/Q2D21WBN
Beth Israel Deaconess Medical Center, Inc. US Patent					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Homo sapiens (Human))	BDBM50261993 (5-(methylthio)thiophene-2-carboxylic acid \| CHEMBL...) Show SMILES CSc1ccc(s1)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	US Patent	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Beth Israel Deaconess Medical Center, Inc. US Patent					Assay Description Primary screening was performed using PKM2 in the presence of FBP. Compounds were chosen as potential "hits" if the compound demonstrated inhibition ...				US Patent US8877791 (2014) BindingDB Entry DOI: 10.7270/Q2D21WBN
Beth Israel Deaconess Medical Center, Inc. US Patent					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Homo sapiens (Human))	BDBM138386 (US8877791, B1) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Beth Israel Deaconess Medical Center, Inc. US Patent					Assay Description Primary screening was performed using PKM2 in the presence of FBP. Compounds were chosen as potential "hits" if the compound demonstrated inhibition ...				US Patent US8877791 (2014) BindingDB Entry DOI: 10.7270/Q2D21WBN
Beth Israel Deaconess Medical Center, Inc. US Patent					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Homo sapiens (Human))	BDBM138387 (US8877791, D1) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Beth Israel Deaconess Medical Center, Inc. US Patent					Assay Description Primary screening was performed using PKM2 in the presence of FBP. Compounds were chosen as potential "hits" if the compound demonstrated inhibition ...				US Patent US8877791 (2014) BindingDB Entry DOI: 10.7270/Q2D21WBN
Beth Israel Deaconess Medical Center, Inc. US Patent					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Homo sapiens (Human))	BDBM138388 (US8877791, G1) Show SMILES CC(C)NC(=C)c1cc2c(s1)c1cc(C)ccc1oc2=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Beth Israel Deaconess Medical Center, Inc. US Patent					Assay Description Primary screening was performed using PKM2 in the presence of FBP. Compounds were chosen as potential "hits" if the compound demonstrated inhibition ...				US Patent US8877791 (2014) BindingDB Entry DOI: 10.7270/Q2D21WBN
Beth Israel Deaconess Medical Center, Inc. US Patent					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Homo sapiens (Human))	BDBM138389 (US8877791, H1) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Beth Israel Deaconess Medical Center, Inc. US Patent					Assay Description Primary screening was performed using PKM2 in the presence of FBP. Compounds were chosen as potential "hits" if the compound demonstrated inhibition ...				US Patent US8877791 (2014) BindingDB Entry DOI: 10.7270/Q2D21WBN
Beth Israel Deaconess Medical Center, Inc. US Patent					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Homo sapiens (Human))	BDBM138385 (US8877791, A1) Show SMILES CC(=O)CSc1ccc(cc1)-n1c(C)ccc1C Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Beth Israel Deaconess Medical Center, Inc. US Patent					Assay Description Primary screening was performed using PKM2 in the presence of FBP. Compounds were chosen as potential "hits" if the compound demonstrated inhibition ...				US Patent US8877791 (2014) BindingDB Entry DOI: 10.7270/Q2D21WBN
Beth Israel Deaconess Medical Center, Inc. US Patent					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Homo sapiens (Human))	BDBM11995 (2-chloro-5-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic ac...) Show SMILES Cc1ccc(C)n1-c1ccc(Cl)c(c1)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Beth Israel Deaconess Medical Center, Inc. US Patent					Assay Description Primary screening was performed using PKM2 in the presence of FBP. Compounds were chosen as potential "hits" if the compound demonstrated inhibition ...				US Patent US8877791 (2014) BindingDB Entry DOI: 10.7270/Q2D21WBN
Beth Israel Deaconess Medical Center, Inc. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%