BindingDB logo
myBDB logout

Patent code US8877967

Compile Data Set for Download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Procathepsin L


(Homo sapiens (Human))
BDBM138145
PNG
(US8877967, 11)
Show SMILES NC(=S)NN=C(c1cc(Br)cc(c1)C(=O)c1ccccc1F)c1ccccc1F |w:4.3|
Show InChI InChI=1S/C21H14BrF2N3OS/c22-14-10-12(9-13(11-14)20(28)16-6-2-4-8-18(16)24)19(26-27-21(25)29)15-5-1-3-7-17(15)23/h1-11H,(H3,25,27,29)/b26-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.12n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138142
PNG
(US8877967, 3)
Show SMILES CN(N=C(c1ccccc1)c1cccc(c1)C(=O)c1ccccc1)C(N)=S |w:2.1|
Show InChI InChI=1S/C22H19N3OS/c1-25(22(23)27)24-20(16-9-4-2-5-10-16)18-13-8-14-19(15-18)21(26)17-11-6-3-7-12-17/h2-15H,1H3,(H2,23,27)/b24-20+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 10.5n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138142
PNG
(US8877967, 3)
Show SMILES CN(N=C(c1ccccc1)c1cccc(c1)C(=O)c1ccccc1)C(N)=S |w:2.1|
Show InChI InChI=1S/C22H19N3OS/c1-25(22(23)27)24-20(16-9-4-2-5-10-16)18-13-8-14-19(15-18)21(26)17-11-6-3-7-12-17/h2-15H,1H3,(H2,23,27)/b24-20+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 17.4n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138143
PNG
(US8877967, 6)
Show SMILES NC(=S)NN=C(c1ccccc1)c1cccc(c1)C(O)c1ccccc1 |w:18.20,4.3|
Show InChI InChI=1S/C21H19N3OS/c22-21(26)24-23-19(15-8-3-1-4-9-15)17-12-7-13-18(14-17)20(25)16-10-5-2-6-11-16/h1-14,20,25H,(H3,22,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23.8n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138146
PNG
(US8877967, 13)
Show SMILES NC(=S)NN=C(c1ccc(F)cc1)c1cccc(c1)C(=O)c1ccc(F)cc1 |w:4.3|
Show InChI InChI=1S/C21H15F2N3OS/c22-17-8-4-13(5-9-17)19(25-26-21(24)28)15-2-1-3-16(12-15)20(27)14-6-10-18(23)11-7-14/h1-12H,(H3,24,26,28)/b25-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 24.3n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138154
PNG
(US8877967, 25)
Show SMILES NC(=S)NN=C(c1ccccc1)c1cc(cc(c1)C(=O)c1ccccc1)C(=O)c1ccccc1 |w:4.3|
Show InChI InChI=1S/C28H21N3O2S/c29-28(34)31-30-25(19-10-4-1-5-11-19)22-16-23(26(32)20-12-6-2-7-13-20)18-24(17-22)27(33)21-14-8-3-9-15-21/h1-18H,(H3,29,31,34)/b30-25-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 25n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138150
PNG
(US8877967, 33)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(OC)cc1 |w:21.23,9.10|
Show InChI InChI=1S/C24H24N6O2S2/c1-31-19-10-6-15(7-11-19)21(27-29-23(25)33)17-4-3-5-18(14-17)22(28-30-24(26)34)16-8-12-20(32-2)13-9-16/h3-14H,1-2H3,(H3,25,29,33)(H3,26,30,34)/b27-21-,28-22+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 587n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138144
PNG
(US8877967, 9)
Show SMILES Cc1cccc(c1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1cccc(C)c1 |w:16.18|
Show InChI InChI=1S/C23H21N3OS/c1-15-6-3-8-17(12-15)21(25-26-23(24)28)18-9-5-11-20(14-18)22(27)19-10-4-7-16(2)13-19/h3-14H,1-2H3,(H3,24,26,28)/b25-21+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.03E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138150
PNG
(US8877967, 33)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(OC)cc1 |w:21.23,9.10|
Show InChI InChI=1S/C24H24N6O2S2/c1-31-19-10-6-15(7-11-19)21(27-29-23(25)33)17-4-3-5-18(14-17)22(28-30-24(26)34)16-8-12-20(32-2)13-9-16/h3-14H,1-2H3,(H3,25,29,33)(H3,26,30,34)/b27-21-,28-22+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.11E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138154
PNG
(US8877967, 25)
Show SMILES NC(=S)NN=C(c1ccccc1)c1cc(cc(c1)C(=O)c1ccccc1)C(=O)c1ccccc1 |w:4.3|
Show InChI InChI=1S/C28H21N3O2S/c29-28(34)31-30-25(19-10-4-1-5-11-19)22-16-23(26(32)20-12-6-2-7-13-20)18-24(17-22)27(33)21-14-8-3-9-15-21/h1-18H,(H3,29,31,34)/b30-25-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.80E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138148
PNG
(US8877967, 18)
Show SMILES COc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:17.19|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-15(8-12-19)21(27)17-4-2-3-16(13-17)20(24-25-22(23)29)14-5-9-18(26)10-6-14/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.20E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138149
PNG
(US8877967, 17)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=O)c1ccc(O)cc1 |w:9.10|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-14(8-12-19)20(24-25-22(23)29)16-3-2-4-17(13-16)21(27)15-5-9-18(26)10-6-15/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.20E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138147
PNG
(US8877967, 19)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:21.23,9.10|
Show InChI InChI=1S/C23H22N6O2S2/c1-31-19-11-7-15(8-12-19)21(27-29-23(25)33)17-4-2-3-16(13-17)20(26-28-22(24)32)14-5-9-18(30)10-6-14/h2-13,30H,1H3,(H3,24,28,32)(H3,25,29,33)/b26-20+,27-21-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.20E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138149
PNG
(US8877967, 17)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=O)c1ccc(O)cc1 |w:9.10|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-14(8-12-19)20(24-25-22(23)29)16-3-2-4-17(13-16)21(27)15-5-9-18(26)10-6-15/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.16E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138148
PNG
(US8877967, 18)
Show SMILES COc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:17.19|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-15(8-12-19)21(27)17-4-2-3-16(13-17)20(24-25-22(23)29)14-5-9-18(26)10-6-14/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.16E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138147
PNG
(US8877967, 19)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:21.23,9.10|
Show InChI InChI=1S/C23H22N6O2S2/c1-31-19-11-7-15(8-12-19)21(27-29-23(25)33)17-4-2-3-16(13-17)20(26-28-22(24)32)14-5-9-18(30)10-6-14/h2-13,30H,1H3,(H3,24,28,32)(H3,25,29,33)/b26-20+,27-21-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.16E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138144
PNG
(US8877967, 9)
Show SMILES Cc1cccc(c1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1cccc(C)c1 |w:16.18|
Show InChI InChI=1S/C23H21N3OS/c1-15-6-3-8-17(12-15)21(25-26-23(24)28)18-9-5-11-20(14-18)22(27)19-10-4-7-16(2)13-19/h3-14H,1-2H3,(H3,24,26,28)/b25-21+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.82E+3n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138146
PNG
(US8877967, 13)
Show SMILES NC(=S)NN=C(c1ccc(F)cc1)c1cccc(c1)C(=O)c1ccc(F)cc1 |w:4.3|
Show InChI InChI=1S/C21H15F2N3OS/c22-17-8-4-13(5-9-17)19(25-26-21(24)28)15-2-1-3-16(12-15)20(27)14-6-10-18(23)11-7-14/h1-12H,(H3,24,26,28)/b25-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.50E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138148
PNG
(US8877967, 18)
Show SMILES COc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:17.19|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-15(8-12-19)21(27)17-4-2-3-16(13-17)20(24-25-22(23)29)14-5-9-18(26)10-6-14/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138148
PNG
(US8877967, 18)
Show SMILES COc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:17.19|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-15(8-12-19)21(27)17-4-2-3-16(13-17)20(24-25-22(23)29)14-5-9-18(26)10-6-14/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138142
PNG
(US8877967, 3)
Show SMILES CN(N=C(c1ccccc1)c1cccc(c1)C(=O)c1ccccc1)C(N)=S |w:2.1|
Show InChI InChI=1S/C22H19N3OS/c1-25(22(23)27)24-20(16-9-4-2-5-10-16)18-13-8-14-19(15-18)21(26)17-11-6-3-7-12-17/h2-15H,1H3,(H2,23,27)/b24-20+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138146
PNG
(US8877967, 13)
Show SMILES NC(=S)NN=C(c1ccc(F)cc1)c1cccc(c1)C(=O)c1ccc(F)cc1 |w:4.3|
Show InChI InChI=1S/C21H15F2N3OS/c22-17-8-4-13(5-9-17)19(25-26-21(24)28)15-2-1-3-16(12-15)20(27)14-6-10-18(23)11-7-14/h1-12H,(H3,24,26,28)/b25-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138147
PNG
(US8877967, 19)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:21.23,9.10|
Show InChI InChI=1S/C23H22N6O2S2/c1-31-19-11-7-15(8-12-19)21(27-29-23(25)33)17-4-2-3-16(13-17)20(26-28-22(24)32)14-5-9-18(30)10-6-14/h2-13,30H,1H3,(H3,24,28,32)(H3,25,29,33)/b26-20+,27-21-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138147
PNG
(US8877967, 19)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:21.23,9.10|
Show InChI InChI=1S/C23H22N6O2S2/c1-31-19-11-7-15(8-12-19)21(27-29-23(25)33)17-4-2-3-16(13-17)20(26-28-22(24)32)14-5-9-18(30)10-6-14/h2-13,30H,1H3,(H3,24,28,32)(H3,25,29,33)/b26-20+,27-21-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138147
PNG
(US8877967, 19)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:21.23,9.10|
Show InChI InChI=1S/C23H22N6O2S2/c1-31-19-11-7-15(8-12-19)21(27-29-23(25)33)17-4-2-3-16(13-17)20(26-28-22(24)32)14-5-9-18(30)10-6-14/h2-13,30H,1H3,(H3,24,28,32)(H3,25,29,33)/b26-20+,27-21-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138153
PNG
(US8877967, 24)
Show SMILES NC(=S)NN=C(c1ccc(Br)cc1)c1cccc(c1)C(=NNC(N)=S)c1ccc(Br)cc1 |w:4.3,20.22|
Show InChI InChI=1S/C22H18Br2N6S2/c23-17-8-4-13(5-9-17)19(27-29-21(25)31)15-2-1-3-16(12-15)20(28-30-22(26)32)14-6-10-18(24)11-7-14/h1-12H,(H3,25,29,31)(H3,26,30,32)/b27-19-,28-20+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138149
PNG
(US8877967, 17)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=O)c1ccc(O)cc1 |w:9.10|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-14(8-12-19)20(24-25-22(23)29)16-3-2-4-17(13-16)21(27)15-5-9-18(26)10-6-15/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138145
PNG
(US8877967, 11)
Show SMILES NC(=S)NN=C(c1cc(Br)cc(c1)C(=O)c1ccccc1F)c1ccccc1F |w:4.3|
Show InChI InChI=1S/C21H14BrF2N3OS/c22-14-10-12(9-13(11-14)20(28)16-6-2-4-8-18(16)24)19(26-27-21(25)29)15-5-1-3-7-17(15)23/h1-11H,(H3,25,27,29)/b26-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM138152
PNG
(US8877967, 23)
Show SMILES CC(C)Oc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(OC(C)C)cc1 |w:23.25,11.12|
Show InChI InChI=1S/C28H32N6O2S2/c1-17(2)35-23-12-8-19(9-13-23)25(31-33-27(29)37)21-6-5-7-22(16-21)26(32-34-28(30)38)20-10-14-24(15-11-20)36-18(3)4/h5-18H,1-4H3,(H3,29,33,37)(H3,30,34,38)/b31-25-,32-26+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138150
PNG
(US8877967, 33)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(OC)cc1 |w:21.23,9.10|
Show InChI InChI=1S/C24H24N6O2S2/c1-31-19-10-6-15(7-11-19)21(27-29-23(25)33)17-4-3-5-18(14-17)22(28-30-24(26)34)16-8-12-20(32-2)13-9-16/h3-14H,1-2H3,(H3,25,29,33)(H3,26,30,34)/b27-21-,28-22+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138153
PNG
(US8877967, 24)
Show SMILES NC(=S)NN=C(c1ccc(Br)cc1)c1cccc(c1)C(=NNC(N)=S)c1ccc(Br)cc1 |w:4.3,20.22|
Show InChI InChI=1S/C22H18Br2N6S2/c23-17-8-4-13(5-9-17)19(27-29-21(25)31)15-2-1-3-16(12-15)20(28-30-22(26)32)14-6-10-18(24)11-7-14/h1-12H,(H3,25,29,31)(H3,26,30,32)/b27-19-,28-20+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138147
PNG
(US8877967, 19)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:21.23,9.10|
Show InChI InChI=1S/C23H22N6O2S2/c1-31-19-11-7-15(8-12-19)21(27-29-23(25)33)17-4-2-3-16(13-17)20(26-28-22(24)32)14-5-9-18(30)10-6-14/h2-13,30H,1H3,(H3,24,28,32)(H3,25,29,33)/b26-20+,27-21-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138153
PNG
(US8877967, 24)
Show SMILES NC(=S)NN=C(c1ccc(Br)cc1)c1cccc(c1)C(=NNC(N)=S)c1ccc(Br)cc1 |w:4.3,20.22|
Show InChI InChI=1S/C22H18Br2N6S2/c23-17-8-4-13(5-9-17)19(27-29-21(25)31)15-2-1-3-16(12-15)20(28-30-22(26)32)14-6-10-18(24)11-7-14/h1-12H,(H3,25,29,31)(H3,26,30,32)/b27-19-,28-20+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138148
PNG
(US8877967, 18)
Show SMILES COc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:17.19|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-15(8-12-19)21(27)17-4-2-3-16(13-17)20(24-25-22(23)29)14-5-9-18(26)10-6-14/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138149
PNG
(US8877967, 17)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=O)c1ccc(O)cc1 |w:9.10|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-14(8-12-19)20(24-25-22(23)29)16-3-2-4-17(13-16)21(27)15-5-9-18(26)10-6-15/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138143
PNG
(US8877967, 6)
Show SMILES NC(=S)NN=C(c1ccccc1)c1cccc(c1)C(O)c1ccccc1 |w:18.20,4.3|
Show InChI InChI=1S/C21H19N3OS/c22-21(26)24-23-19(15-8-3-1-4-9-15)17-12-7-13-18(14-17)20(25)16-10-5-2-6-11-16/h1-14,20,25H,(H3,22,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138151
PNG
(US8877967, 22)
Show SMILES CC(C)Oc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(OC(C)C)cc1 |w:19.21|
Show InChI InChI=1S/C27H29N3O3S/c1-17(2)32-23-12-8-19(9-13-23)25(29-30-27(28)34)21-6-5-7-22(16-21)26(31)20-10-14-24(15-11-20)33-18(3)4/h5-18H,1-4H3,(H3,28,30,34)/b29-25+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138148
PNG
(US8877967, 18)
Show SMILES COc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1 |w:17.19|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-15(8-12-19)21(27)17-4-2-3-16(13-17)20(24-25-22(23)29)14-5-9-18(26)10-6-14/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138149
PNG
(US8877967, 17)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=O)c1ccc(O)cc1 |w:9.10|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-14(8-12-19)20(24-25-22(23)29)16-3-2-4-17(13-16)21(27)15-5-9-18(26)10-6-15/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138149
PNG
(US8877967, 17)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=O)c1ccc(O)cc1 |w:9.10|
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-14(8-12-19)20(24-25-22(23)29)16-3-2-4-17(13-16)21(27)15-5-9-18(26)10-6-15/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin B


(Homo sapiens (Human))
BDBM138151
PNG
(US8877967, 22)
Show SMILES CC(C)Oc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(OC(C)C)cc1 |w:19.21|
Show InChI InChI=1S/C27H29N3O3S/c1-17(2)32-23-12-8-19(9-13-23)25(29-30-27(28)34)21-6-5-7-22(16-21)26(31)20-10-14-24(15-11-20)33-18(3)4/h5-18H,1-4H3,(H3,28,30,34)/b29-25+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a6.0n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin B (Calbiochem) was pre-incubated with test compound at various concentrations for 5 minutes at 37C. The assay was initiated by ...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))
BDBM138152
PNG
(US8877967, 23)
Show SMILES CC(C)Oc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(OC(C)C)cc1 |w:23.25,11.12|
Show InChI InChI=1S/C28H32N6O2S2/c1-17(2)35-23-12-8-19(9-13-23)25(31-33-27(29)37)21-6-5-7-22(16-21)26(32-34-28(30)38)20-10-14-24(15-11-20)36-18(3)4/h5-18H,1-4H3,(H3,29,33,37)(H3,30,34,38)/b31-25-,32-26+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a5.5n/a



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%