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Patent code US8916576

Compile Data Set for Download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141001
PNG
(US10570123, Example 205 | US8916576, 205)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCC(O)C3)ccc2n1
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n/an/a 8n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141005
PNG
(US10570123, Example 210 | US8916576, 210)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CC[C@@H](C3)N(C)C)c(OC)cc2n1 |r|
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n/an/a 10n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140996
PNG
(US10570123, Example 199 | US8916576, 199)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3)ccc2n1
Show InChI InChI=1S/C31H33N7O2/c1-2-6-29(39)33-23-8-5-7-21(17-23)30-35-28-12-10-25(40-16-15-38-13-3-4-14-38)19-26(28)31(36-30)34-24-9-11-27-22(18-24)20-32-37-27/h5,7-12,17-20H,2-4,6,13-16H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141001
PNG
(US10570123, Example 205 | US8916576, 205)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCC(O)C3)ccc2n1
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n/an/a 11n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140998
PNG
(US10570123, Example 201 | US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140999
PNG
(US10570123, Example 203 | US8916576, 203)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCN(C)CC3)ccc2n1
Show InChI InChI=1S/C32H36N8O2/c1-3-5-30(41)34-24-7-4-6-22(18-24)31-36-29-11-9-26(42-17-16-40-14-12-39(2)13-15-40)20-27(29)32(37-31)35-25-8-10-28-23(19-25)21-33-38-28/h4,6-11,18-21H,3,5,12-17H2,1-2H3,(H,33,38)(H,34,41)(H,35,36,37)
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n/an/a 12n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140999
PNG
(US10570123, Example 203 | US8916576, 203)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCN(C)CC3)ccc2n1
Show InChI InChI=1S/C32H36N8O2/c1-3-5-30(41)34-24-7-4-6-22(18-24)31-36-29-11-9-26(42-17-16-40-14-12-39(2)13-15-40)20-27(29)32(37-31)35-25-8-10-28-23(19-25)21-33-38-28/h4,6-11,18-21H,3,5,12-17H2,1-2H3,(H,33,38)(H,34,41)(H,35,36,37)
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n/an/a 12n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140997
PNG
(US10570123, Example 200 | US8916576, 200)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCCC3)ccc2n1
Show InChI InChI=1S/C32H35N7O2/c1-2-7-30(40)34-24-9-6-8-22(18-24)31-36-29-13-11-26(41-17-16-39-14-4-3-5-15-39)20-27(29)32(37-31)35-25-10-12-28-23(19-25)21-33-38-28/h6,8-13,18-21H,2-5,7,14-17H2,1H3,(H,33,38)(H,34,40)(H,35,36,37)
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n/an/a 12n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140996
PNG
(US10570123, Example 199 | US8916576, 199)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3)ccc2n1
Show InChI InChI=1S/C31H33N7O2/c1-2-6-29(39)33-23-8-5-7-21(17-23)30-35-28-12-10-25(40-16-15-38-13-3-4-14-38)19-26(28)31(36-30)34-24-9-11-27-22(18-24)20-32-37-27/h5,7-12,17-20H,2-4,6,13-16H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140999
PNG
(US10570123, Example 203 | US8916576, 203)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCN(C)CC3)ccc2n1
Show InChI InChI=1S/C32H36N8O2/c1-3-5-30(41)34-24-7-4-6-22(18-24)31-36-29-11-9-26(42-17-16-40-14-12-39(2)13-15-40)20-27(29)32(37-31)35-25-8-10-28-23(19-25)21-33-38-28/h4,6-11,18-21H,3,5,12-17H2,1-2H3,(H,33,38)(H,34,41)(H,35,36,37)
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n/an/a 12n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141001
PNG
(US10570123, Example 205 | US8916576, 205)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCC(O)C3)ccc2n1
PDB
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n/an/a 12n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141001
PNG
(US10570123, Example 205 | US8916576, 205)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCC(O)C3)ccc2n1
PDB
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n/an/a 13n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140997
PNG
(US10570123, Example 200 | US8916576, 200)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCCC3)ccc2n1
Show InChI InChI=1S/C32H35N7O2/c1-2-7-30(40)34-24-9-6-8-22(18-24)31-36-29-13-11-26(41-17-16-39-14-4-3-5-15-39)20-27(29)32(37-31)35-25-10-12-28-23(19-25)21-33-38-28/h6,8-13,18-21H,2-5,7,14-17H2,1H3,(H,33,38)(H,34,40)(H,35,36,37)
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n/an/a 14n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141004
PNG
(US10570123, Example 209 | US8916576, 209)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCN(C)CC3)c(OC)cc2n1
Show InChI InChI=1S/C33H38N8O3/c1-4-6-31(42)35-24-8-5-7-22(17-24)32-37-28-20-29(43-3)30(44-16-15-41-13-11-40(2)12-14-41)19-26(28)33(38-32)36-25-9-10-27-23(18-25)21-34-39-27/h5,7-10,17-21H,4,6,11-16H2,1-3H3,(H,34,39)(H,35,42)(H,36,37,38)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141004
PNG
(US10570123, Example 209 | US8916576, 209)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCN(C)CC3)c(OC)cc2n1
Show InChI InChI=1S/C33H38N8O3/c1-4-6-31(42)35-24-8-5-7-22(17-24)32-37-28-20-29(43-3)30(44-16-15-41-13-11-40(2)12-14-41)19-26(28)33(38-32)36-25-9-10-27-23(18-25)21-34-39-27/h5,7-10,17-21H,4,6,11-16H2,1-3H3,(H,34,39)(H,35,42)(H,36,37,38)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140997
PNG
(US10570123, Example 200 | US8916576, 200)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCCC3)ccc2n1
Show InChI InChI=1S/C32H35N7O2/c1-2-7-30(40)34-24-9-6-8-22(18-24)31-36-29-13-11-26(41-17-16-39-14-4-3-5-15-39)20-27(29)32(37-31)35-25-10-12-28-23(19-25)21-33-38-28/h6,8-13,18-21H,2-5,7,14-17H2,1H3,(H,33,38)(H,34,40)(H,35,36,37)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141005
PNG
(US10570123, Example 210 | US8916576, 210)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CC[C@@H](C3)N(C)C)c(OC)cc2n1 |r|
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n/an/a 18n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141036
PNG
(US10570123, Example 262 | US8916576, 262)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OC)c(OCCOC)cc2n1
Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-26(39-12-11-37-2)25(38-3)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)
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Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140996
PNG
(US10570123, Example 199 | US8916576, 199)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3)ccc2n1
Show InChI InChI=1S/C31H33N7O2/c1-2-6-29(39)33-23-8-5-7-21(17-23)30-35-28-12-10-25(40-16-15-38-13-3-4-14-38)19-26(28)31(36-30)34-24-9-11-27-22(18-24)20-32-37-27/h5,7-12,17-20H,2-4,6,13-16H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
PDB
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n/an/a 26n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141034
PNG
(US8916576, 259)
Show SMILES CCCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O/c1-2-3-11-24(33)28-19-8-6-7-17(14-19)25-30-23-10-5-4-9-21(23)26(31-25)29-20-12-13-22-18(15-20)16-27-32-22/h4-10,12-16H,2-3,11H2,1H3,(H,27,32)(H,28,33)(H,29,30,31)
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n/an/a 29n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141003
PNG
(US10570123, Example 207 | US8916576, 207)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1
Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a 29n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140997
PNG
(US10570123, Example 200 | US8916576, 200)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCCC3)ccc2n1
Show InChI InChI=1S/C32H35N7O2/c1-2-7-30(40)34-24-9-6-8-22(18-24)31-36-29-13-11-26(41-17-16-39-14-4-3-5-15-39)20-27(29)32(37-31)35-25-10-12-28-23(19-25)21-33-38-28/h6,8-13,18-21H,2-5,7,14-17H2,1H3,(H,33,38)(H,34,40)(H,35,36,37)
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n/an/a 32n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140998
PNG
(US10570123, Example 201 | US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 32n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140998
PNG
(US10570123, Example 201 | US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 35n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140993
PNG
(US10570123, Example 141 | US8916576, 141)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN(C)C)ccc2n1
Show InChI InChI=1S/C29H31N7O2/c1-4-6-27(37)31-21-8-5-7-19(15-21)28-33-26-12-10-23(38-14-13-36(2)3)17-24(26)29(34-28)32-22-9-11-25-20(16-22)18-30-35-25/h5,7-12,15-18H,4,6,13-14H2,1-3H3,(H,30,35)(H,31,37)(H,32,33,34)
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n/an/a 40n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141003
PNG
(US10570123, Example 207 | US8916576, 207)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1
Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a 44n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141002
PNG
(US10570123, Example 206 | US8916576, 206)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3=O)c(OC)cc2n1
Show InChI InChI=1S/C32H33N7O4/c1-3-6-29(40)34-22-8-4-7-20(15-22)31-36-26-18-27(42-2)28(43-14-13-39-12-5-9-30(39)41)17-24(26)32(37-31)35-23-10-11-25-21(16-23)19-33-38-25/h4,7-8,10-11,15-19H,3,5-6,9,12-14H2,1-2H3,(H,33,38)(H,34,40)(H,35,36,37)
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n/an/a 48n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140994
PNG
(US10570123, Example 160 | US8916576, 160)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCCN3CCOCC3)c(OC)cc2n1
Show InChI InChI=1S/C33H37N7O4/c1-3-6-31(41)35-24-8-4-7-22(17-24)32-37-28-20-29(42-2)30(44-14-5-11-40-12-15-43-16-13-40)19-26(28)33(38-32)36-25-9-10-27-23(18-25)21-34-39-27/h4,7-10,17-21H,3,5-6,11-16H2,1-2H3,(H,34,39)(H,35,41)(H,36,37,38)
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n/an/a 50n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140998
PNG
(US10570123, Example 201 | US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 51n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140995
PNG
(US10570123, Example 167 | US8916576, 167)
Show SMILES COc1cc2nc(nc(Nc3ccc4[nH]ncc4c3)c2cc1OCCN1CCCC1)-c1cccc(NC(=O)CN2CCOCC2)c1
Show InChI InChI=1S/C34H38N8O4/c1-44-30-20-29-27(19-31(30)46-16-13-41-9-2-3-10-41)34(37-26-7-8-28-24(18-26)21-35-40-28)39-33(38-29)23-5-4-6-25(17-23)36-32(43)22-42-11-14-45-15-12-42/h4-8,17-21H,2-3,9-16,22H2,1H3,(H,35,40)(H,36,43)(H,37,38,39)
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n/an/a 60n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141003
PNG
(US10570123, Example 207 | US8916576, 207)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1
Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a 61n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141002
PNG
(US10570123, Example 206 | US8916576, 206)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3=O)c(OC)cc2n1
Show InChI InChI=1S/C32H33N7O4/c1-3-6-29(40)34-22-8-4-7-20(15-22)31-36-26-18-27(42-2)28(43-14-13-39-12-5-9-30(39)41)17-24(26)32(37-31)35-23-10-11-25-21(16-23)19-33-38-25/h4,7-8,10-11,15-19H,3,5-6,9,12-14H2,1-2H3,(H,33,38)(H,34,40)(H,35,36,37)
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n/an/a 64n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140998
PNG
(US10570123, Example 201 | US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 64n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141000
PNG
(US10570123, Example 204 | US8916576, 204)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3=O)ccc2n1
Show InChI InChI=1S/C31H31N7O3/c1-2-5-28(39)33-22-7-3-6-20(16-22)30-35-27-12-10-24(41-15-14-38-13-4-8-29(38)40)18-25(27)31(36-30)34-23-9-11-26-21(17-23)19-32-37-26/h3,6-7,9-12,16-19H,2,4-5,8,13-15H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
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n/an/a 67n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140998
PNG
(US10570123, Example 201 | US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 68n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141037
PNG
(US10570123, Example 263 | US8916576, 263)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccc(OCCOC)cc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-16-22(37-13-12-36-2)9-10-23(25)28(33-27)31-21-8-11-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 90n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140991
PNG
(US10570123, Example 55 | US8916576, 55)
Show SMILES O=C(COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)Nc1cccnc1
Show InChI InChI=1S/C28H21N7O2/c36-26(31-21-6-4-12-29-16-21)17-37-22-7-3-5-18(14-22)27-33-25-9-2-1-8-23(25)28(34-27)32-20-10-11-24-19(13-20)15-30-35-24/h1-16H,17H2,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a 90n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140998
PNG
(US10570123, Example 201 | US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 95n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141000
PNG
(US10570123, Example 204 | US8916576, 204)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3=O)ccc2n1
Show InChI InChI=1S/C31H31N7O3/c1-2-5-28(39)33-22-7-3-6-20(16-22)30-35-27-12-10-24(41-15-14-38-13-4-8-29(38)40)18-25(27)31(36-30)34-23-9-11-26-21(17-23)19-32-37-26/h3,6-7,9-12,16-19H,2,4-5,8,13-15H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
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n/an/a 110n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140998
PNG
(US10570123, Example 201 | US8916576, 201)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-11-9-22(37-13-12-36-2)16-23(25)28(33-27)31-21-8-10-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a 120n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141006
PNG
(US8916576, 211)
Show SMILES CCCC(=O)Oc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C25H21N5O2/c1-2-6-23(31)32-19-8-5-7-16(14-19)24-28-22-10-4-3-9-20(22)25(29-24)27-18-11-12-21-17(13-18)15-26-30-21/h3-5,7-15H,2,6H2,1H3,(H,26,30)(H,27,28,29)
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n/an/a 130n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141000
PNG
(US10570123, Example 204 | US8916576, 204)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3=O)ccc2n1
Show InChI InChI=1S/C31H31N7O3/c1-2-5-28(39)33-22-7-3-6-20(16-22)30-35-27-12-10-24(41-15-14-38-13-4-8-29(38)40)18-25(27)31(36-30)34-23-9-11-26-21(17-23)19-32-37-26/h3,6-7,9-12,16-19H,2,4-5,8,13-15H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
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n/an/a 150n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140990
PNG
(US10570123, Example 54 | US8916576, 54)
Show SMILES COCCNC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O3/c1-34-12-11-27-24(33)16-35-20-6-4-5-17(14-20)25-30-23-8-3-2-7-21(23)26(31-25)29-19-9-10-22-18(13-19)15-28-32-22/h2-10,13-15H,11-12,16H2,1H3,(H,27,33)(H,28,32)(H,29,30,31)
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n/an/a 150n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141033
PNG
(US10570123, Example 258 | US8916576, 258)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCC3CC3)ccc2n1
Show InChI InChI=1S/C29H28N6O2/c1-2-4-27(36)31-21-6-3-5-19(13-21)28-33-26-12-10-23(37-17-18-7-8-18)15-24(26)29(34-28)32-22-9-11-25-20(14-22)16-30-35-25/h3,5-6,9-16,18H,2,4,7-8,17H2,1H3,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a 180n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141033
PNG
(US10570123, Example 258 | US8916576, 258)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCC3CC3)ccc2n1
Show InChI InChI=1S/C29H28N6O2/c1-2-4-27(36)31-21-6-3-5-19(13-21)28-33-26-12-10-23(37-17-18-7-8-18)15-24(26)29(34-28)32-22-9-11-25-20(14-22)16-30-35-25/h3,5-6,9-16,18H,2,4,7-8,17H2,1H3,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a 260n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141032
PNG
(US10570123, Example 243 | US8916576, 243)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3n(C)ncc3c2)c2cc(OCCN(C)C)ccc2n1
Show InChI InChI=1S/C30H33N7O2/c1-5-7-28(38)32-22-9-6-8-20(16-22)29-34-26-12-11-24(39-15-14-36(2)3)18-25(26)30(35-29)33-23-10-13-27-21(17-23)19-31-37(27)4/h6,8-13,16-19H,5,7,14-15H2,1-4H3,(H,32,38)(H,33,34,35)
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n/an/a>300n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141035
PNG
(US10570123, Example 261 | US8916576, 261)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3n(ncc3c2)C(=O)OC(C)(C)C)c2cc(OCCOC)c(OC)cc2n1
Show InChI InChI=1S/C34H38N6O6/c1-7-9-30(41)36-23-11-8-10-21(16-23)31-38-26-19-28(44-6)29(45-15-14-43-5)18-25(26)32(39-31)37-24-12-13-27-22(17-24)20-35-40(27)33(42)46-34(2,3)4/h8,10-13,16-20H,7,9,14-15H2,1-6H3,(H,36,41)(H,37,38,39)
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n/an/a>300n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140992
PNG
(US10570123, Example 84 | US8916576, 84)
Show SMILES NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C23H18N6O2/c24-21(30)13-31-17-5-3-4-14(11-17)22-27-20-7-2-1-6-18(20)23(28-22)26-16-8-9-19-15(10-16)12-25-29-19/h1-12H,13H2,(H2,24,30)(H,25,29)(H,26,27,28)
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n/an/a 520n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141040
PNG
(US8916576, 272)
Show SMILES CC(=O)Oc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C23H17N5O2/c1-14(29)30-18-6-4-5-15(12-18)22-26-21-8-3-2-7-19(21)23(27-22)25-17-9-10-20-16(11-17)13-24-28-20/h2-13H,1H3,(H,24,28)(H,25,26,27)
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n/an/a 570n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))		BDBM140993
PNG
(US10570123, Example 141 | US8916576, 141)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN(C)C)ccc2n1
Show InChI InChI=1S/C29H31N7O2/c1-4-6-27(37)31-21-8-5-7-19(15-21)28-33-26-12-10-23(38-14-13-36(2)3)17-24(26)29(34-28)32-22-9-11-25-20(16-22)18-30-35-25/h5,7-12,15-18H,4,6,13-14H2,1-3H3,(H,30,35)(H,31,37)(H,32,33,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141020
PNG
(US8916576, 225)
Show SMILES COCC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C24H20N6O2/c1-32-14-22(31)27-20-8-4-2-6-17(20)24-28-21-9-5-3-7-18(21)23(29-24)26-16-10-11-19-15(12-16)13-25-30-19/h2-13H,14H2,1H3,(H,25,30)(H,27,31)(H,26,28,29)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141024
PNG
(US8916576, 233)
Show SMILES Oc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C21H15N5O/c27-19-8-4-2-6-16(19)21-24-18-7-3-1-5-15(18)20(25-21)23-14-9-10-17-13(11-14)12-22-26-17/h1-12,27H,(H,22,26)(H,23,24,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141024
PNG
(US8916576, 233)
Show SMILES Oc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C21H15N5O/c27-19-8-4-2-6-16(19)21-24-18-7-3-1-5-15(18)20(25-21)23-14-9-10-17-13(11-14)12-22-26-17/h1-12,27H,(H,22,26)(H,23,24,25)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))		BDBM140992
PNG
(US10570123, Example 84 | US8916576, 84)
Show SMILES NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C23H18N6O2/c24-21(30)13-31-17-5-3-4-14(11-17)22-27-20-7-2-1-6-18(20)23(28-22)26-16-8-9-19-15(10-16)12-25-29-19/h1-12H,13H2,(H2,24,30)(H,25,29)(H,26,27,28)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141014
PNG
(US8916576, 219)
Show SMILES COC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C23H18N6O2/c1-31-23(30)27-20-9-5-3-7-17(20)22-26-19-8-4-2-6-16(19)21(28-22)25-15-10-11-18-14(12-15)13-24-29-18/h2-13H,1H3,(H,24,29)(H,27,30)(H,25,26,28)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141022
PNG
(US10570123, Example 231 | US8916576, 231)
Show SMILES O=C(CN1CCOCC1)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C27H25N7O2/c35-25(17-34-11-13-36-14-12-34)30-23-7-3-1-5-20(23)27-31-24-8-4-2-6-21(24)26(32-27)29-19-9-10-22-18(15-19)16-28-33-22/h1-10,15-16H,11-14,17H2,(H,28,33)(H,30,35)(H,29,31,32)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))		BDBM141037
PNG
(US10570123, Example 263 | US8916576, 263)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccc(OCCOC)cc2n1
Show InChI InChI=1S/C28H28N6O3/c1-3-5-26(35)30-20-7-4-6-18(14-20)27-32-25-16-22(37-13-12-36-2)9-10-23(25)28(33-27)31-21-8-11-24-19(15-21)17-29-34-24/h4,6-11,14-17H,3,5,12-13H2,1-2H3,(H,29,34)(H,30,35)(H,31,32,33)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))		BDBM140994
PNG
(US10570123, Example 160 | US8916576, 160)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCCN3CCOCC3)c(OC)cc2n1
Show InChI InChI=1S/C33H37N7O4/c1-3-6-31(41)35-24-8-4-7-22(17-24)32-37-28-20-29(42-2)30(44-14-5-11-40-12-15-43-16-13-40)19-26(28)33(38-32)36-25-9-10-27-23(18-25)21-34-39-27/h4,7-10,17-21H,3,5-6,11-16H2,1-2H3,(H,34,39)(H,35,41)(H,36,37,38)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))		BDBM140995
PNG
(US10570123, Example 167 | US8916576, 167)
Show SMILES COc1cc2nc(nc(Nc3ccc4[nH]ncc4c3)c2cc1OCCN1CCCC1)-c1cccc(NC(=O)CN2CCOCC2)c1
Show InChI InChI=1S/C34H38N8O4/c1-44-30-20-29-27(19-31(30)46-16-13-41-9-2-3-10-41)34(37-26-7-8-28-24(18-26)21-35-40-28)39-33(38-29)23-5-4-6-25(17-23)36-32(43)22-42-11-14-45-15-12-42/h4-8,17-21H,2-3,9-16,22H2,1H3,(H,35,40)(H,36,43)(H,37,38,39)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141025
PNG
(US8916576, 234)
Show SMILES COCCNC(=O)COc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O3/c1-34-13-12-27-24(33)16-35-23-9-5-3-7-20(23)26-30-22-8-4-2-6-19(22)25(31-26)29-18-10-11-21-17(14-18)15-28-32-21/h2-11,14-15H,12-13,16H2,1H3,(H,27,33)(H,28,32)(H,29,30,31)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141021
PNG
(US8916576, 230)
Show SMILES CC(C)NC(=O)CNc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H25N7O/c1-16(2)29-24(34)15-27-19-7-5-6-17(12-19)25-31-23-9-4-3-8-21(23)26(32-25)30-20-10-11-22-18(13-20)14-28-33-22/h3-14,16,27H,15H2,1-2H3,(H,28,33)(H,29,34)(H,30,31,32)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141023
PNG
(US8916576, 232)
Show SMILES CC(C)NC(=O)COc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-23-10-6-4-8-20(23)26-30-22-9-5-3-7-19(22)25(31-26)29-18-11-12-21-17(13-18)14-27-32-21/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141039
PNG
(US8916576, 267)
Show SMILES Oc1ccc2nc(nc(Nc3ccc4[nH]ncc4c3)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H15N5O/c27-16-7-9-19-17(11-16)21(25-20(24-19)13-4-2-1-3-5-13)23-15-6-8-18-14(10-15)12-22-26-18/h1-12,27H,(H,22,26)(H,23,24,25)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141032
PNG
(US10570123, Example 243 | US8916576, 243)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3n(C)ncc3c2)c2cc(OCCN(C)C)ccc2n1
Show InChI InChI=1S/C30H33N7O2/c1-5-7-28(38)32-22-9-6-8-20(16-22)29-34-26-12-11-24(39-15-14-36(2)3)18-25(26)30(35-29)33-23-10-13-27-21(17-23)19-31-37(27)4/h6,8-13,16-19H,5,7,14-15H2,1-4H3,(H,32,38)(H,33,34,35)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141019
PNG
(US8916576, 224)
Show SMILES CN(C)CCC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H25N7O/c1-33(2)14-13-24(34)29-22-9-5-3-7-19(22)26-30-23-10-6-4-8-20(23)25(31-26)28-18-11-12-21-17(15-18)16-27-32-21/h3-12,15-16H,13-14H2,1-2H3,(H,27,32)(H,29,34)(H,28,30,31)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141038
PNG
(US8916576, 265)
Show SMILES C(CN1CCOCC1)Oc1ccc2nc(nc(Nc3ccc4[nH]ncc4c3)c2c1)-c1ccccc1
Show InChI InChI=1S/C27H26N6O2/c1-2-4-19(5-3-1)26-30-25-9-7-22(35-15-12-33-10-13-34-14-11-33)17-23(25)27(31-26)29-21-6-8-24-20(16-21)18-28-32-24/h1-9,16-18H,10-15H2,(H,28,32)(H,29,30,31)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141038
PNG
(US8916576, 265)
Show SMILES C(CN1CCOCC1)Oc1ccc2nc(nc(Nc3ccc4[nH]ncc4c3)c2c1)-c1ccccc1
Show InChI InChI=1S/C27H26N6O2/c1-2-4-19(5-3-1)26-30-25-9-7-22(35-15-12-33-10-13-34-14-11-33)17-23(25)27(31-26)29-21-6-8-24-20(16-21)18-28-32-24/h1-9,16-18H,10-15H2,(H,28,32)(H,29,30,31)
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n/an/a 7.30E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141018
PNG
(US10570123, Example 223 | US8916576, 223)
Show SMILES O=C(Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)c1ccccn1
Show InChI InChI=1S/C27H19N7O/c35-27(24-11-5-6-14-28-24)32-23-10-4-2-8-20(23)26-31-22-9-3-1-7-19(22)25(33-26)30-18-12-13-21-17(15-18)16-29-34-21/h1-16H,(H,29,34)(H,32,35)(H,30,31,33)
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n/an/a 8.30E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140996
PNG
(US10570123, Example 199 | US8916576, 199)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCCC3)ccc2n1
Show InChI InChI=1S/C31H33N7O2/c1-2-6-29(39)33-23-8-5-7-21(17-23)30-35-28-12-10-25(40-16-15-38-13-3-4-14-38)19-26(28)31(36-30)34-24-9-11-27-22(18-24)20-32-37-27/h5,7-12,17-20H,2-4,6,13-16H2,1H3,(H,32,37)(H,33,39)(H,34,35,36)
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n/an/a 9.50E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM140999
PNG
(US10570123, Example 203 | US8916576, 203)
Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCN3CCN(C)CC3)ccc2n1
Show InChI InChI=1S/C32H36N8O2/c1-3-5-30(41)34-24-7-4-6-22(18-24)31-36-29-11-9-26(42-17-16-40-14-12-39(2)13-15-40)20-27(29)32(37-31)35-25-8-10-28-23(19-25)21-33-38-28/h4,6-11,18-21H,3,5,12-17H2,1-2H3,(H,33,38)(H,34,41)(H,35,36,37)
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n/an/a 9.50E+3n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))		BDBM140990
PNG
(US10570123, Example 54 | US8916576, 54)
Show SMILES COCCNC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O3/c1-34-12-11-27-24(33)16-35-20-6-4-5-17(14-20)25-30-23-8-3-2-7-21(23)26(31-25)29-19-9-10-22-18(13-19)15-28-32-22/h2-10,13-15H,11-12,16H2,1H3,(H,27,33)(H,28,32)(H,29,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141007
PNG
(US8916576, 212)
Show SMILES CCCC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O/c1-2-7-23(32)28-21-10-5-3-8-18(21)25-29-22-11-6-4-9-19(22)24(30-25)27-17-12-13-20-16(14-17)15-26-31-20/h3-6,8-15H,2,7H2,1H3,(H,26,31)(H,28,32)(H,27,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141008
PNG
(US8916576, 213)
Show SMILES COCCN(C)CC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C27H27N7O2/c1-34(13-14-36-2)17-25(35)30-23-9-5-3-7-20(23)27-31-24-10-6-4-8-21(24)26(32-27)29-19-11-12-22-18(15-19)16-28-33-22/h3-12,15-16H,13-14,17H2,1-2H3,(H,28,33)(H,30,35)(H,29,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))		BDBM141040
PNG
(US8916576, 272)
Show SMILES CC(=O)Oc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C23H17N5O2/c1-14(29)30-18-6-4-5-15(12-18)22-26-21-8-3-2-7-19(21)23(27-22)25-17-9-10-20-16(11-17)13-24-28-20/h2-13H,1H3,(H,24,28)(H,25,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141010
PNG
(US8916576, 215)
Show SMILES CNCC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C24H21N7O/c1-25-14-22(32)28-20-8-4-2-6-17(20)24-29-21-9-5-3-7-18(21)23(30-24)27-16-10-11-19-15(12-16)13-26-31-19/h2-13,25H,14H2,1H3,(H,26,31)(H,28,32)(H,27,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))		BDBM140991
PNG
(US10570123, Example 55 | US8916576, 55)
Show SMILES O=C(COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)Nc1cccnc1
Show InChI InChI=1S/C28H21N7O2/c36-26(31-21-6-4-12-29-16-21)17-37-22-7-3-5-18(14-22)27-33-25-9-2-1-8-23(25)28(34-27)32-20-10-11-24-19(13-20)15-30-35-24/h1-16H,17H2,(H,30,35)(H,31,36)(H,32,33,34)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141009
PNG
(US8916576, 214)
Show SMILES CC(C)(C)C(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O/c1-26(2,3)25(33)30-22-11-7-5-9-19(22)24-29-21-10-6-4-8-18(21)23(31-24)28-17-12-13-20-16(14-17)15-27-32-20/h4-15H,1-3H3,(H,27,32)(H,30,33)(H,28,29,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141010
PNG
(US8916576, 215)
Show SMILES CNCC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C24H21N7O/c1-25-14-22(32)28-20-8-4-2-6-17(20)24-29-21-9-5-3-7-18(21)23(30-24)27-16-10-11-19-15(12-16)13-26-31-19/h2-13,25H,14H2,1H3,(H,26,31)(H,28,32)(H,27,29,30)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141031
PNG
(US8916576, 240)
Show SMILES CC(=O)Oc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C23H17N5O2/c1-14(29)30-21-9-5-3-7-18(21)23-26-20-8-4-2-6-17(20)22(27-23)25-16-10-11-19-15(12-16)13-24-28-19/h2-13H,1H3,(H,24,28)(H,25,26,27)
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n/an/a 2.30E+4n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141012
PNG
(US10570123, Example 217 | US8916576, 217)
Show SMILES O=C(CN1CCCC1)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C27H25N7O/c35-25(17-34-13-5-6-14-34)30-23-9-3-1-7-20(23)27-31-24-10-4-2-8-21(24)26(32-27)29-19-11-12-22-18(15-19)16-28-33-22/h1-4,7-12,15-16H,5-6,13-14,17H2,(H,28,33)(H,30,35)(H,29,31,32)
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n/an/a 3.60E+4n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141016
PNG
(US10570123, Example 221 | US8916576, 221)
Show SMILES CN(C)C(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C24H21N7O/c1-31(2)24(32)28-21-10-6-4-8-18(21)23-27-20-9-5-3-7-17(20)22(29-23)26-16-11-12-19-15(13-16)14-25-30-19/h3-14H,1-2H3,(H,25,30)(H,28,32)(H,26,27,29)
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n/an/a 4.90E+4n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141030
PNG
(US10570123, Example 239 | US8916576, 239)
Show SMILES COc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C22H17N5O/c1-28-20-9-5-3-7-17(20)22-25-19-8-4-2-6-16(19)21(26-22)24-15-10-11-18-14(12-15)13-23-27-18/h2-13H,1H3,(H,23,27)(H,24,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141017
PNG
(US8916576, 222)
Show SMILES O=C(Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)c1cc[nH]cc1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141028
PNG
(US10570123, Example 237 | US8916576, 237)
Show SMILES O=C(COc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)NCc1ccccc1
Show InChI InChI=1S/C30H24N6O2/c37-28(31-17-20-8-2-1-3-9-20)19-38-27-13-7-5-11-24(27)30-34-26-12-6-4-10-23(26)29(35-30)33-22-14-15-25-21(16-22)18-32-36-25/h1-16,18H,17,19H2,(H,31,37)(H,32,36)(H,33,34,35)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141026
PNG
(US10570123, Example 235 | US8916576, 235)
Show SMILES O=C(COc1ccccc1-c1nc(N(CC(=O)NCC2CC2)c2ccc3[nH]ncc3c2)c2ccccc2n1)NCC1CC1
Show InChI InChI=1S/C33H33N7O3/c41-30(34-16-21-9-10-21)19-40(24-13-14-27-23(15-24)18-36-39-27)33-25-5-1-3-7-28(25)37-32(38-33)26-6-2-4-8-29(26)43-20-31(42)35-17-22-11-12-22/h1-8,13-15,18,21-22H,9-12,16-17,19-20H2,(H,34,41)(H,35,42)(H,36,39)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141028
PNG
(US10570123, Example 237 | US8916576, 237)
Show SMILES O=C(COc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)NCc1ccccc1
Show InChI InChI=1S/C30H24N6O2/c37-28(31-17-20-8-2-1-3-9-20)19-38-27-13-7-5-11-24(27)30-34-26-12-6-4-10-23(26)29(35-30)33-22-14-15-25-21(16-22)18-32-36-25/h1-16,18H,17,19H2,(H,31,37)(H,32,36)(H,33,34,35)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141007
PNG
(US8916576, 212)
Show SMILES CCCC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O/c1-2-7-23(32)28-21-10-5-3-8-18(21)25-29-22-11-6-4-9-19(22)24(30-25)27-17-12-13-20-16(14-17)15-26-31-20/h3-6,8-15H,2,7H2,1H3,(H,26,31)(H,28,32)(H,27,29,30)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141011
PNG
(US8916576, 216)
Show SMILES O=C(Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)c1ccoc1
Show InChI InChI=1S/C26H18N6O2/c33-26(16-11-12-34-15-16)30-23-8-4-2-6-20(23)25-29-22-7-3-1-5-19(22)24(31-25)28-18-9-10-21-17(13-18)14-27-32-21/h1-15H,(H,27,32)(H,30,33)(H,28,29,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141029
PNG
(US8916576, 238)
Show SMILES COCCNC(=O)COc1ccccc1-c1nc(N(CC(=O)NCCOC)c2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C31H33N7O5/c1-41-15-13-32-28(39)19-38(22-11-12-25-21(17-22)18-34-37-25)31-23-7-3-5-9-26(23)35-30(36-31)24-8-4-6-10-27(24)43-20-29(40)33-14-16-42-2/h3-12,17-18H,13-16,19-20H2,1-2H3,(H,32,39)(H,33,40)(H,34,37)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141013
PNG
(US10570123, Example 218 | US8916576, 218)
Show SMILES O=C(Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)C1CCCNC1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141023
PNG
(US8916576, 232)
Show SMILES CC(C)NC(=O)COc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-23-10-6-4-8-20(23)26-30-22-9-5-3-7-19(22)25(31-26)29-18-11-12-21-17(13-18)14-27-32-21/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141008
PNG
(US8916576, 213)
Show SMILES COCCN(C)CC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C27H27N7O2/c1-34(13-14-36-2)17-25(35)30-23-9-5-3-7-20(23)27-31-24-10-6-4-8-21(24)26(32-27)29-19-11-12-22-18(15-19)16-28-33-22/h3-12,15-16H,13-14,17H2,1-2H3,(H,28,33)(H,30,35)(H,29,31,32)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141013
PNG
(US10570123, Example 218 | US8916576, 218)
Show SMILES O=C(Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)C1CCCNC1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141025
PNG
(US8916576, 234)
Show SMILES COCCNC(=O)COc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O3/c1-34-13-12-27-24(33)16-35-23-9-5-3-7-20(23)26-30-22-8-4-2-6-19(22)25(31-26)29-18-10-11-21-17(14-18)15-28-32-21/h2-11,14-15H,12-13,16H2,1H3,(H,27,33)(H,28,32)(H,29,30,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141027
PNG
(US10570123, Example 236 | US8916576, 236)
Show SMILES O=C(COc1ccccc1-c1nc(N(CC(=O)NCc2ccccc2)c2ccc3[nH]ncc3c2)c2ccccc2n1)NCc1ccccc1
Show InChI InChI=1S/C39H33N7O3/c47-36(40-22-27-11-3-1-4-12-27)25-46(30-19-20-33-29(21-30)24-42-45-33)39-31-15-7-9-17-34(31)43-38(44-39)32-16-8-10-18-35(32)49-26-37(48)41-23-28-13-5-2-6-14-28/h1-21,24H,22-23,25-26H2,(H,40,47)(H,41,48)(H,42,45)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141015
PNG
(US10570123, Example 220 | US8916576, 220)
Show SMILES O=C(Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)N1CCOCC1
Show InChI InChI=1S/C26H23N7O2/c34-26(33-11-13-35-14-12-33)30-23-8-4-2-6-20(23)25-29-22-7-3-1-5-19(22)24(31-25)28-18-9-10-21-17(15-18)16-27-32-21/h1-10,15-16H,11-14H2,(H,27,32)(H,30,34)(H,28,29,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141029
PNG
(US8916576, 238)
Show SMILES COCCNC(=O)COc1ccccc1-c1nc(N(CC(=O)NCCOC)c2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C31H33N7O5/c1-41-15-13-32-28(39)19-38(22-11-12-25-21(17-22)18-34-37-25)31-23-7-3-5-9-26(23)35-30(36-31)24-8-4-6-10-27(24)43-20-29(40)33-14-16-42-2/h3-12,17-18H,13-16,19-20H2,1-2H3,(H,32,39)(H,33,40)(H,34,37)
PDB
MMDB

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UniProtKB/SwissProt

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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141017
PNG
(US8916576, 222)
Show SMILES O=C(Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)c1cc[nH]cc1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141018
PNG
(US10570123, Example 223 | US8916576, 223)
Show SMILES O=C(Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)c1ccccn1
Show InChI InChI=1S/C27H19N7O/c35-27(24-11-5-6-14-28-24)32-23-10-4-2-8-20(23)26-31-22-9-3-1-7-19(22)25(33-26)30-18-12-13-21-17(15-18)16-29-34-21/h1-16H,(H,29,34)(H,32,35)(H,30,31,33)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM141009
PNG
(US8916576, 214)
Show SMILES CC(C)(C)C(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O/c1-26(2,3)25(33)30-22-11-7-5-9-19(22)24-29-21-10-6-4-8-18(21)23(31-24)28-17-12-13-20-16(14-17)15-27-32-20/h4-15H,1-3H3,(H,27,32)(H,30,33)(H,28,29,31)
PDB
MMDB

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n/an/a>1.00E+5n/an/an/an/an/an/a



Surface Logix, Inc.

US Patent


Assay Description
ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).

US Patent US8916576 (2014)


BindingDB Entry DOI: 10.7270/Q2P55M6K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%