Affinity Data by Patent

Patent code US8921404

Found 9 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hormone-sensitive lipase (Rattus norvegicus (Rat))	BDBM141540 (US8921404, 5) Show SMILES CC1CCN(CC1)C(=O)Oc1nsc2ccccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	7.0	37
Sanofi US Patent					Assay Description To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...				US Patent US8921404 (2014) BindingDB Entry DOI: 10.7270/Q24748KQ
Sanofi US Patent					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Rattus norvegicus (Rat))	BDBM141538 (US8921404, 3) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	7.0	37
Sanofi US Patent					Assay Description To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...				US Patent US8921404 (2014) BindingDB Entry DOI: 10.7270/Q24748KQ
Sanofi US Patent					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Rattus norvegicus (Rat))	BDBM141539 (US8921404, 4) Show SMILES CC1CCN(CC1)C(=O)Oc1nsc2ncccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	7.0	37
Sanofi US Patent					Assay Description To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...				US Patent US8921404 (2014) BindingDB Entry DOI: 10.7270/Q24748KQ
Sanofi US Patent					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Rattus norvegicus (Rat))	BDBM141536 (US8921404, 1) Show SMILES CC1CCN(CC1)C(=O)Oc1noc2cc(Cl)ccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	7.0	37
Sanofi US Patent					Assay Description To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...				US Patent US8921404 (2014) BindingDB Entry DOI: 10.7270/Q24748KQ
Sanofi US Patent					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Rattus norvegicus (Rat))	BDBM141537 (US8921404, 2) Show SMILES CC1CCN(CC1)C(=O)Oc1noc2ncccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	7.0	37
Sanofi US Patent					Assay Description To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...				US Patent US8921404 (2014) BindingDB Entry DOI: 10.7270/Q24748KQ
Sanofi US Patent					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Rattus norvegicus (Rat))	BDBM141544 (US8921404, 11) Show SMILES CC1CCN(CC1)C(=O)Oc1noc2nc(C)ccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	260	n/a	n/a	n/a	n/a	7.0	37
Sanofi US Patent					Assay Description To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...				US Patent US8921404 (2014) BindingDB Entry DOI: 10.7270/Q24748KQ
Sanofi US Patent					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Rattus norvegicus (Rat))	BDBM141543 (US8921404, 10) Show SMILES CC1CCN(CC1)C(=O)Oc1noc2nc(Cl)ccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	670	n/a	n/a	n/a	n/a	7.0	37
Sanofi US Patent					Assay Description To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...				US Patent US8921404 (2014) BindingDB Entry DOI: 10.7270/Q24748KQ
Sanofi US Patent					More data for this Ligand-Target Pair
Endothelial lipase (Rattus norvegicus (Rat))	BDBM141541 (US8921404, 7) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi US Patent					Assay Description The phospholipase-specific substrate 1,2-bis(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine, (manu...				US Patent US8921404 (2014) BindingDB Entry DOI: 10.7270/Q24748KQ
Sanofi US Patent					More data for this Ligand-Target Pair
Endothelial lipase (Rattus norvegicus (Rat))	BDBM141542 (US8921404, 8) Show SMILES CCCCCCNC(=O)Nc1noc2ccccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi US Patent					Assay Description The phospholipase-specific substrate 1,2-bis(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine, (manu...				US Patent US8921404 (2014) BindingDB Entry DOI: 10.7270/Q24748KQ
Sanofi US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%