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Patent code US8921412

Compile Data Set for Download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351408
PNG
(CHEMBL1819199)
Show SMILES CSc1ccc(Cc2cc3[C@@H]4O[C@H](COCCCCCOc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C25H31ClO6S/c1-33-17-7-5-15(6-8-17)11-16-12-18-20(13-19(16)26)31-10-4-2-3-9-30-14-21-22(27)23(28)24(29)25(18)32-21/h5-8,12-13,21-25,27-29H,2-4,9-11,14H2,1H3/t21-,22-,23+,24-,25+/m1/s1
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n/an/a 0.778n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351415
PNG
(CHEMBL1819096)
Show SMILES CCOc1ccc(Cc2cc3[C@@H]4O[C@H](COCCCCCOc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C26H33ClO7/c1-2-32-18-8-6-16(7-9-18)12-17-13-19-21(14-20(17)27)33-11-5-3-4-10-31-15-22-23(28)24(29)25(30)26(19)34-22/h6-9,13-14,22-26,28-30H,2-5,10-12,15H2,1H3/t22-,23-,24+,25-,26+/m1/s1
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n/an/a 0.899n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351413
PNG
(CHEMBL1819095)
Show SMILES CCOc1ccc(Cc2cc3[C@@H]4O[C@H](COC\C=C/COc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r,c:17|
Show InChI InChI=1S/C25H29ClO7/c1-2-31-17-7-5-15(6-8-17)11-16-12-18-20(13-19(16)26)32-10-4-3-9-30-14-21-22(27)23(28)24(29)25(18)33-21/h3-8,12-13,21-25,27-29H,2,9-11,14H2,1H3/b4-3-/t21-,22-,23+,24-,25+/m1/s1
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n/an/a 0.974n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351411
PNG
(CHEMBL1819093)
Show SMILES CCOc1ccc(Cc2cc3[C@@H]4O[C@H](COCCOc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C23H27ClO7/c1-2-29-15-5-3-13(4-6-15)9-14-10-16-18(11-17(14)24)30-8-7-28-12-19-20(25)21(26)22(27)23(16)31-19/h3-6,10-11,19-23,25-27H,2,7-9,12H2,1H3/t19-,20-,21+,22-,23+/m1/s1
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n/an/a 1.34n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351407
PNG
(CHEMBL1819198)
Show SMILES CSc1ccc(Cc2cc3[C@@H]4O[C@H](COCCCCOc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C24H29ClO6S/c1-32-16-6-4-14(5-7-16)10-15-11-17-19(12-18(15)25)30-9-3-2-8-29-13-20-21(26)22(27)23(28)24(17)31-20/h4-7,11-12,20-24,26-28H,2-3,8-10,13H2,1H3/t20-,21-,22+,23-,24+/m1/s1
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n/an/a 1.35n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351405
PNG
(CHEMBL1819196)
Show SMILES CCc1ccc(Cc2cc3[C@@H]4O[C@H](COCCCCCOc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C26H33ClO6/c1-2-16-6-8-17(9-7-16)12-18-13-19-21(14-20(18)27)32-11-5-3-4-10-31-15-22-23(28)24(29)25(30)26(19)33-22/h6-9,13-14,22-26,28-30H,2-5,10-12,15H2,1H3/t22-,23-,24+,25-,26+/m1/s1
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n/an/a 1.38n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351410
PNG
(CHEMBL1819201)
Show SMILES O[C@H]1[C@H](O)[C@H]2COCCCCCOc3cc(Cl)c(Cc4ccc5OCCOc5c4)cc3[C@H](O2)[C@@H]1O |r|
Show InChI InChI=1S/C26H31ClO8/c27-18-13-20-17(12-16(18)10-15-4-5-19-21(11-15)34-9-8-33-19)26-25(30)24(29)23(28)22(35-26)14-31-6-2-1-3-7-32-20/h4-5,11-13,22-26,28-30H,1-3,6-10,14H2/t22-,23-,24+,25-,26+/m1/s1
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n/an/a 1.38n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351406
PNG
(CHEMBL1819197)
Show SMILES CCc1ccc(Cc2cc3[C@@H]4O[C@H](COCCCCCCOc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C27H35ClO6/c1-2-17-7-9-18(10-8-17)13-19-14-20-22(15-21(19)28)33-12-6-4-3-5-11-32-16-23-24(29)25(30)26(31)27(20)34-23/h7-10,14-15,23-27,29-31H,2-6,11-13,16H2,1H3/t23-,24-,25+,26-,27+/m1/s1
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n/an/a 1.40n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351404
PNG
(CHEMBL1819099)
Show SMILES CCc1ccc(Cc2cc3[C@@H]4O[C@H](COCCCCOc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C25H31ClO6/c1-2-15-5-7-16(8-6-15)11-17-12-18-20(13-19(17)26)31-10-4-3-9-30-14-21-22(27)23(28)24(29)25(18)32-21/h5-8,12-13,21-25,27-29H,2-4,9-11,14H2,1H3/t21-,22-,23+,24-,25+/m1/s1
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n/an/a 1.40n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351403
PNG
(CHEMBL1819098)
Show SMILES CCc1ccc(Cc2cc3[C@@H]4O[C@H](COCCCOc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C24H29ClO6/c1-2-14-4-6-15(7-5-14)10-16-11-17-19(12-18(16)25)30-9-3-8-29-13-20-21(26)22(27)23(28)24(17)31-20/h4-7,11-12,20-24,26-28H,2-3,8-10,13H2,1H3/t20-,21-,22+,23-,24+/m1/s1
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n/an/a 1.59n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351414
PNG
(CHEMBL1817684)
Show SMILES CCOc1ccc(Cc2cc3[C@@H]4O[C@H](COCCCCOc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C25H31ClO7/c1-2-31-17-7-5-15(6-8-17)11-16-12-18-20(13-19(16)26)32-10-4-3-9-30-14-21-22(27)23(28)24(29)25(18)33-21/h5-8,12-13,21-25,27-29H,2-4,9-11,14H2,1H3/t21-,22-,23+,24-,25+/m1/s1
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n/an/a 2.27n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM141897
PNG
(US8921412, 15)
Show SMILES CCOc1ccc(Cc2cc3[C@@H]4O[C@H](COC[C@@H]5C[C@@H]5COc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C26H31ClO7/c1-2-32-18-5-3-14(4-6-18)7-15-9-19-21(10-20(15)27)33-12-17-8-16(17)11-31-13-22-23(28)24(29)25(30)26(19)34-22/h3-6,9-10,16-17,22-26,28-30H,2,7-8,11-13H2,1H3/t16-,17+,22+,23+,24-,25+,26-/m0/s1
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n/an/a 2.30n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351412
PNG
(CHEMBL1819094)
Show SMILES CCOc1ccc(Cc2cc3[C@@H]4O[C@H](COCCCOc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C24H29ClO7/c1-2-30-16-6-4-14(5-7-16)10-15-11-17-19(12-18(15)25)31-9-3-8-29-13-20-21(26)22(27)23(28)24(17)32-20/h4-7,11-12,20-24,26-28H,2-3,8-10,13H2,1H3/t20-,21-,22+,23-,24+/m1/s1
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n/an/a 2.95n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351416
PNG
(CHEMBL1819097)
Show SMILES CCOc1ccc(Cc2cc3[C@@H]4O[C@H](COCCCCCCOc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C27H35ClO7/c1-2-33-19-9-7-17(8-10-19)13-18-14-20-22(15-21(18)28)34-12-6-4-3-5-11-32-16-23-24(29)25(30)26(31)27(20)35-23/h7-10,14-15,23-27,29-31H,2-6,11-13,16H2,1H3/t23-,24-,25+,26-,27+/m1/s1
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n/an/a 3.63n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50351409
PNG
(CHEMBL1819200)
Show SMILES O[C@H]1[C@H](O)[C@H]2COCCCCOc3cc(Cl)c(Cc4ccc5OCCOc5c4)cc3[C@H](O2)[C@@H]1O |r|
Show InChI InChI=1S/C25H29ClO8/c26-17-12-19-16(11-15(17)9-14-3-4-18-20(10-14)33-8-7-32-18)25-24(29)23(28)22(27)21(34-25)13-30-5-1-2-6-31-19/h3-4,10-12,21-25,27-29H,1-2,5-9,13H2/t21-,22-,23+,24-,25+/m1/s1
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n/an/a 3.65n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM141898
PNG
(US8921412, 16)
Show SMILES CCOc1ccc(Cc2cc3[C@@H]4O[C@H](COC[C@H]5C[C@H]5COc3cc2Cl)[C@@H](O)[C@H](O)[C@H]4O)cc1 |r|
Show InChI InChI=1S/C26H31ClO7/c1-2-32-18-5-3-14(4-6-18)7-15-9-19-21(10-20(15)27)33-12-17-8-16(17)11-31-13-22-23(28)24(29)25(30)26(19)34-22/h3-6,9-10,16-17,22-26,28-30H,2,7-8,11-13H2,1H3/t16-,17+,22-,23-,24+,25-,26+/m1/s1
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n/an/a 14n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...

US Patent US8921412 (2014)


BindingDB Entry DOI: 10.7270/Q2M907C4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%