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Patent code US8927577

Compile Data Set for Download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Pro-glucagon


(Homo sapiens (Human))		BDBM142039
PNG
(US8927577, 118 | US8927577, 20 | US8927577, 35)
Show SMILES Cc1cc2cc(F)ccc2nc1NC(C1CC(C)(C)C1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C27H30FN3O3/c1-16-12-19-13-21(28)8-9-22(19)30-25(16)31-24(20-14-27(2,3)15-20)17-4-6-18(7-5-17)26(34)29-11-10-23(32)33/h4-9,12-13,20,24H,10-11,14-15H2,1-3H3,(H,29,34)(H,30,31)(H,32,33)
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 14n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142041
PNG
(US8927577, 22)
Show SMILES CC1(C)CC(C1)C(Nc1cnc2cc(F)ccc2c1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C26H28FN3O3/c1-26(2)13-19(14-26)24(30-21-11-18-7-8-20(27)12-22(18)29-15-21)16-3-5-17(6-4-16)25(33)28-10-9-23(31)32/h3-8,11-12,15,19,24,30H,9-10,13-14H2,1-2H3,(H,28,33)(H,31,32)
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 25n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142039
PNG
(US8927577, 118 | US8927577, 20 | US8927577, 35)
Show SMILES Cc1cc2cc(F)ccc2nc1NC(C1CC(C)(C)C1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C27H30FN3O3/c1-16-12-19-13-21(28)8-9-22(19)30-25(16)31-24(20-14-27(2,3)15-20)17-4-6-18(7-5-17)26(34)29-11-10-23(32)33/h4-9,12-13,20,24H,10-11,14-15H2,1-3H3,(H,29,34)(H,30,31)(H,32,33)
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 39n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142042
PNG
(US8927577, 23)
Show SMILES CC1(C)CC(C1)C(Nc1cnc2ccc(F)cc2c1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C26H28FN3O3/c1-26(2)13-19(14-26)24(30-21-12-18-11-20(27)7-8-22(18)29-15-21)16-3-5-17(6-4-16)25(33)28-10-9-23(31)32/h3-8,11-12,15,19,24,30H,9-10,13-14H2,1-2H3,(H,28,33)(H,31,32)
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 50n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142038
PNG
(US8927577, 117 | US8927577, 19 | US8927577, 32)
Show SMILES Cc1cc2ccccc2nc1NC(C1CC(C)(C)C1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C27H31N3O3/c1-17-14-20-6-4-5-7-22(20)29-25(17)30-24(21-15-27(2,3)16-21)18-8-10-19(11-9-18)26(33)28-13-12-23(31)32/h4-11,14,21,24H,12-13,15-16H2,1-3H3,(H,28,33)(H,29,30)(H,31,32)
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 53n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142038
PNG
(US8927577, 117 | US8927577, 19 | US8927577, 32)
Show SMILES Cc1cc2ccccc2nc1NC(C1CC(C)(C)C1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C27H31N3O3/c1-17-14-20-6-4-5-7-22(20)29-25(17)30-24(21-15-27(2,3)16-21)18-8-10-19(11-9-18)26(33)28-13-12-23(31)32/h4-11,14,21,24H,12-13,15-16H2,1-3H3,(H,28,33)(H,29,30)(H,31,32)
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 74n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142030
PNG
(US8927577, 11 | US8927577, 30 | US8927577, 31)
Show SMILES CC(C)CC(Nc1nc2ccccc2cc1C)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H29N3O3/c1-16(2)14-22(28-24-17(3)15-20-6-4-5-7-21(20)27-24)18-8-10-19(11-9-18)25(31)26-13-12-23(29)30/h4-11,15-16,22H,12-14H2,1-3H3,(H,26,31)(H,27,28)(H,29,30)
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 76n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142035
PNG
(US8927577, 16)
Show SMILES CC(C)CC(Nc1ccc2cc(ccc2n1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H26F3N3O3/c1-15(2)13-21(16-3-5-17(6-4-16)24(34)29-12-11-23(32)33)31-22-10-7-18-14-19(25(26,27)28)8-9-20(18)30-22/h3-10,14-15,21H,11-13H2,1-2H3,(H,29,34)(H,30,31)(H,32,33)
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 91n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142030
PNG
(US8927577, 11 | US8927577, 30 | US8927577, 31)
Show SMILES CC(C)CC(Nc1nc2ccccc2cc1C)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H29N3O3/c1-16(2)14-22(28-24-17(3)15-20-6-4-5-7-21(20)27-24)18-8-10-19(11-9-18)25(31)26-13-12-23(29)30/h4-11,15-16,22H,12-14H2,1-3H3,(H,26,31)(H,27,28)(H,29,30)
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 101n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142037
PNG
(US8927577, 18)
Show SMILES CC(C)CC(Nc1cnc2ccccc2c1C)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H29N3O3/c1-16(2)14-22(28-23-15-27-21-7-5-4-6-20(21)17(23)3)18-8-10-19(11-9-18)25(31)26-13-12-24(29)30/h4-11,15-16,22,28H,12-14H2,1-3H3,(H,26,31)(H,29,30)
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 109n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142040
PNG
(US8927577, 21)
Show SMILES Cc1cc2ccc(F)cc2nc1NC(C1CC(C)(C)C1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C27H30FN3O3/c1-16-12-19-8-9-21(28)13-22(19)30-25(16)31-24(20-14-27(2,3)15-20)17-4-6-18(7-5-17)26(34)29-11-10-23(32)33/h4-9,12-13,20,24H,10-11,14-15H2,1-3H3,(H,29,34)(H,30,31)(H,32,33)
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 133n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142046
PNG
(US8927577, 27)
Show SMILES CC(C)CC(Nc1cnc2ccc(C)cc2c1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H29N3O3/c1-16(2)12-23(28-21-14-20-13-17(3)4-9-22(20)27-15-21)18-5-7-19(8-6-18)25(31)26-11-10-24(29)30/h4-9,13-16,23,28H,10-12H2,1-3H3,(H,26,31)(H,29,30)
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 160n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142020
PNG
(US8927577, 1)
Show SMILES CCC[C@@H](Nc1nc2ccccc2cc1C)c1ccc(cc1)C(=O)NCCC(O)=O |r|
Show InChI InChI=1S/C24H27N3O3/c1-3-6-20(26-23-16(2)15-19-7-4-5-8-21(19)27-23)17-9-11-18(12-10-17)24(30)25-14-13-22(28)29/h4-5,7-12,15,20H,3,6,13-14H2,1-2H3,(H,25,30)(H,26,27)(H,28,29)/t20-/m1/s1
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 173n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142029
PNG
(US8927577, 10)
Show SMILES CC(C)CC(Nc1cc(C)c2ccccc2n1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H29N3O3/c1-16(2)14-22(28-23-15-17(3)20-6-4-5-7-21(20)27-23)18-8-10-19(11-9-18)25(31)26-13-12-24(29)30/h4-11,15-16,22H,12-14H2,1-3H3,(H,26,31)(H,27,28)(H,29,30)
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 198n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142032
PNG
(US8927577, 13)
Show SMILES CC(C)CC(Nc1ccc2cccc(Cl)c2n1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H26ClN3O3/c1-15(2)14-20(27-21-11-10-17-4-3-5-19(25)23(17)28-21)16-6-8-18(9-7-16)24(31)26-13-12-22(29)30/h3-11,15,20H,12-14H2,1-2H3,(H,26,31)(H,27,28)(H,29,30)
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 199n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142022
PNG
(US8927577, 3)
Show SMILES CC(C)CC(Nc1cnc2ccccc2c1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H27N3O3/c1-16(2)13-22(27-20-14-19-5-3-4-6-21(19)26-15-20)17-7-9-18(10-8-17)24(30)25-12-11-23(28)29/h3-10,14-16,22,27H,11-13H2,1-2H3,(H,25,30)(H,28,29)
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 240n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142031
PNG
(US8927577, 12)
Show SMILES CC(C)CC(Nc1cc(C)c2ccc(F)cc2n1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H28FN3O3/c1-15(2)12-21(17-4-6-18(7-5-17)25(32)27-11-10-24(30)31)28-23-13-16(3)20-9-8-19(26)14-22(20)29-23/h4-9,13-15,21H,10-12H2,1-3H3,(H,27,32)(H,28,29)(H,30,31)
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 242n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142021
PNG
(US8927577, 2)
Show SMILES CCC[C@H](Nc1nc2ccccc2cc1C)c1ccc(cc1)C(=O)NCCC(O)=O |r|
Show InChI InChI=1S/C24H27N3O3/c1-3-6-20(26-23-16(2)15-19-7-4-5-8-21(19)27-23)17-9-11-18(12-10-17)24(30)25-14-13-22(28)29/h4-5,7-12,15,20H,3,6,13-14H2,1-2H3,(H,25,30)(H,26,27)(H,28,29)/t20-/m0/s1
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 280n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142036
PNG
(US8927577, 17)
Show SMILES CC(C)CC(Nc1cc2ccccc2nc1C)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H29N3O3/c1-16(2)14-23(28-22-15-20-6-4-5-7-21(20)27-17(22)3)18-8-10-19(11-9-18)25(31)26-13-12-24(29)30/h4-11,15-16,23,28H,12-14H2,1-3H3,(H,26,31)(H,29,30)
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 360n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142024
PNG
(US8927577, 5)
Show SMILES CC(C)CC(Nc1ccc2ccccc2n1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H27N3O3/c1-16(2)15-21(27-22-12-11-17-5-3-4-6-20(17)26-22)18-7-9-19(10-8-18)24(30)25-14-13-23(28)29/h3-12,16,21H,13-15H2,1-2H3,(H,25,30)(H,26,27)(H,28,29)
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 452n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142034
PNG
(US8927577, 15)
Show SMILES CC(C)CC(Nc1ccc2ccc(cc2n1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H26F3N3O3/c1-15(2)13-20(16-3-5-18(6-4-16)24(34)29-12-11-23(32)33)30-22-10-8-17-7-9-19(25(26,27)28)14-21(17)31-22/h3-10,14-15,20H,11-13H2,1-2H3,(H,29,34)(H,30,31)(H,32,33)
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 479n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142028
PNG
(US8927577, 9)
Show SMILES CC(C)CC(Nc1cc2ccccc2cn1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H27N3O3/c1-16(2)13-21(27-22-14-19-5-3-4-6-20(19)15-26-22)17-7-9-18(10-8-17)24(30)25-12-11-23(28)29/h3-10,14-16,21H,11-13H2,1-2H3,(H,25,30)(H,26,27)(H,28,29)
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 531n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142048
PNG
(US8927577, 29)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(CC(F)(F)F)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C22H20F3N3O3/c23-22(24,25)12-19(28-17-11-16-3-1-2-4-18(16)27-13-17)14-5-7-15(8-6-14)21(31)26-10-9-20(29)30/h1-8,11,13,19,28H,9-10,12H2,(H,26,31)(H,29,30)
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 930n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142027
PNG
(US8927577, 8)
Show SMILES CC(C)CC(Nc1nc2ccccc2nc1C)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H28N4O3/c1-15(2)14-21(28-23-16(3)26-19-6-4-5-7-20(19)27-23)17-8-10-18(11-9-17)24(31)25-13-12-22(29)30/h4-11,15,21H,12-14H2,1-3H3,(H,25,31)(H,27,28)(H,29,30)
PDB

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 979n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142030
PNG
(US8927577, 11 | US8927577, 30 | US8927577, 31)
Show SMILES CC(C)CC(Nc1nc2ccccc2cc1C)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H29N3O3/c1-16(2)14-22(28-24-17(3)15-20-6-4-5-7-21(20)27-24)18-8-10-19(11-9-18)25(31)26-13-12-23(29)30/h4-11,15-16,22H,12-14H2,1-3H3,(H,26,31)(H,27,28)(H,29,30)
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 1.24E+3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142025
PNG
(US8927577, 6)
Show SMILES COc1cccc2ccc(NC(CC(C)C)c3ccc(cc3)C(=O)NCCC(O)=O)nc12
Show InChI InChI=1S/C25H29N3O4/c1-16(2)15-20(17-7-9-19(10-8-17)25(31)26-14-13-23(29)30)27-22-12-11-18-5-4-6-21(32-3)24(18)28-22/h4-12,16,20H,13-15H2,1-3H3,(H,26,31)(H,27,28)(H,29,30)
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 1.86E+3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
Pro-glucagon


(Homo sapiens (Human))		BDBM142023
PNG
(US8927577, 4)
Show SMILES CC(C)CC(Nc1ncc2ccc(F)cc2n1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C23H25FN4O3/c1-14(2)11-19(27-23-26-13-17-7-8-18(24)12-20(17)28-23)15-3-5-16(6-4-15)22(31)25-10-9-21(29)30/h3-8,12-14,19H,9-11H2,1-2H3,(H,25,31)(H,29,30)(H,26,27,28)
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 7.36E+3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun...

US Patent US8927577 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PRV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%