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Patent code US8933024

Compile Data Set for Download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Endothelial lipase


(Homo sapiens (Human))		BDBM142068
PNG
(US8933024, 46)
Show SMILES CC(C)C(NC(=O)n1sc2ncccc2c1=O)c1ccc2OCCCOc2c1
Show InChI InChI=1S/C20H21N3O4S/c1-12(2)17(13-6-7-15-16(11-13)27-10-4-9-26-15)22-20(25)23-19(24)14-5-3-8-21-18(14)28-23/h3,5-8,11-12,17H,4,9-10H2,1-2H3,(H,22,25)
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n/an/a 28n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142060
PNG
(US8933024, 4)
Show SMILES COc1cc(cc(CO)c1OC)C(C)NC(=O)n1sc2ncccc2c1=O
Show InChI InChI=1S/C18H19N3O5S/c1-10(11-7-12(9-22)15(26-3)14(8-11)25-2)20-18(24)21-17(23)13-5-4-6-19-16(13)27-21/h4-8,10,22H,9H2,1-3H3,(H,20,24)
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n/an/a 40n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142062
PNG
(US8933024, 18)
Show SMILES O=C(NCc1ccccc1)n1sc2ncccc2c1=O
Show InChI InChI=1S/C14H11N3O2S/c18-13-11-7-4-8-15-12(11)20-17(13)14(19)16-9-10-5-2-1-3-6-10/h1-8H,9H2,(H,16,19)
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Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142080
PNG
(US8933024, 161)
Show SMILES COCCOc1ccc(cc1OC)[C@@H](C)NC(=O)n1sc2ncccc2c1=O |r|
Show InChI InChI=1S/C19H21N3O5S/c1-12(13-6-7-15(16(11-13)26-3)27-10-9-25-2)21-19(24)22-18(23)14-5-4-8-20-17(14)28-22/h4-8,11-12H,9-10H2,1-3H3,(H,21,24)/t12-/m1/s1
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n/an/a 80n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142076
PNG
(US8933024, 130)
Show SMILES CN(C)Cc1ccc(CNC(=O)n2sc3ncccc3c2=O)cc1
Show InChI InChI=1S/C17H18N4O2S/c1-20(2)11-13-7-5-12(6-8-13)10-19-17(23)21-16(22)14-4-3-9-18-15(14)24-21/h3-9H,10-11H2,1-2H3,(H,19,23)
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Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142063
PNG
(US8933024, 28)
Show SMILES COc1ccc(OC)c(CNC(=O)n2sc3ncccc3c2=O)c1
Show InChI InChI=1S/C16H15N3O4S/c1-22-11-5-6-13(23-2)10(8-11)9-18-16(21)19-15(20)12-4-3-7-17-14(12)24-19/h3-8H,9H2,1-2H3,(H,18,21)
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Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142070
PNG
(US8933024, 55)
Show SMILES CSc1ccc(CNC(=O)n2sc3ncccc3c2=O)cc1
Show InChI InChI=1S/C15H13N3O2S2/c1-21-11-6-4-10(5-7-11)9-17-15(20)18-14(19)12-3-2-8-16-13(12)22-18/h2-8H,9H2,1H3,(H,17,20)
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n/an/a 116n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142067
PNG
(US8933024, 39)
Show SMILES Cc1cccc(C)c1CNC(=O)n1sc2ncccc2c1=O
Show InChI InChI=1S/C16H15N3O2S/c1-10-5-3-6-11(2)13(10)9-18-16(21)19-15(20)12-7-4-8-17-14(12)22-19/h3-8H,9H2,1-2H3,(H,18,21)
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Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142069
PNG
(US8933024, 50)
Show SMILES FC(F)Oc1ccccc1CNC(=O)n1sc2ncccc2c1=O
Show InChI InChI=1S/C15H11F2N3O3S/c16-14(17)23-11-6-2-1-4-9(11)8-19-15(22)20-13(21)10-5-3-7-18-12(10)24-20/h1-7,14H,8H2,(H,19,22)
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n/an/a 138n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142065
PNG
(US8933024, 37)
Show SMILES COc1ccc(cc1OC)C(C)NC(=O)n1sc2ncccc2c1=O
Show InChI InChI=1S/C17H17N3O4S/c1-10(11-6-7-13(23-2)14(9-11)24-3)19-17(22)20-16(21)12-5-4-8-18-15(12)25-20/h4-10H,1-3H3,(H,19,22)
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n/an/a 148n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142066
PNG
(US8933024, 38)
Show SMILES COc1cccc(CNC(=O)n2sc3ncccc3c2=O)c1
Show InChI InChI=1S/C15H13N3O3S/c1-21-11-5-2-4-10(8-11)9-17-15(20)18-14(19)12-6-3-7-16-13(12)22-18/h2-8H,9H2,1H3,(H,17,20)
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n/an/a 182n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142061
PNG
(US8933024, 5)
Show SMILES CC(NC(=O)n1sc2ncccc2c1=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C17H15N3O4S/c1-10(11-4-5-13-14(9-11)24-8-7-23-13)19-17(22)20-16(21)12-3-2-6-18-15(12)25-20/h2-6,9-10H,7-8H2,1H3,(H,19,22)
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n/an/a 200n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142072
PNG
(US8933024, 114)
Show SMILES COCCOc1ccc(CNC(=O)n2sc3ncccc3c2=O)cn1
Show InChI InChI=1S/C16H16N4O4S/c1-23-7-8-24-13-5-4-11(9-18-13)10-19-16(22)20-15(21)12-3-2-6-17-14(12)25-20/h2-6,9H,7-8,10H2,1H3,(H,19,22)
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Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142075
PNG
(US8933024, 129)
Show SMILES CCOc1ccc(CNC(=O)n2sc3ncccc3c2=O)cc1OC
Show InChI InChI=1S/C17H17N3O4S/c1-3-24-13-7-6-11(9-14(13)23-2)10-19-17(22)20-16(21)12-5-4-8-18-15(12)25-20/h4-9H,3,10H2,1-2H3,(H,19,22)
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n/an/a 230n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142071
PNG
(US8933024, 59)
Show SMILES CSc1cccc(CNC(=O)n2sc3ncccc3c2=O)c1
Show InChI InChI=1S/C15H13N3O2S2/c1-21-11-5-2-4-10(8-11)9-17-15(20)18-14(19)12-6-3-7-16-13(12)22-18/h2-8H,9H2,1H3,(H,17,20)
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n/an/a 264n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142077
PNG
(US8933024, 134)
Show SMILES CC(NC(=O)n1sc2ncccc2c1=O)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C19H20N4O3S/c1-13(14-4-6-15(7-5-14)22-9-11-26-12-10-22)21-19(25)23-18(24)16-3-2-8-20-17(16)27-23/h2-8,13H,9-12H2,1H3,(H,21,25)
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n/an/a 391n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142078
PNG
(US8933024, 142)
Show SMILES COCCN1CCC(CNC(=O)n2sc3ncccc3c2=O)CC1
Show InChI InChI=1S/C16H22N4O3S/c1-23-10-9-19-7-4-12(5-8-19)11-18-16(22)20-15(21)13-3-2-6-17-14(13)24-20/h2-3,6,12H,4-5,7-11H2,1H3,(H,18,22)
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n/an/a 517n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142059
PNG
(US8933024, 3)
Show SMILES COc1cc(CNC(=O)n2sc3ncccc3c2=O)cc(OC)c1OC
Show InChI InChI=1S/C17H17N3O5S/c1-23-12-7-10(8-13(24-2)14(12)25-3)9-19-17(22)20-16(21)11-5-4-6-18-15(11)26-20/h4-8H,9H2,1-3H3,(H,19,22)
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n/an/a 926n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142073
PNG
(US8933024, 115)
Show SMILES COc1cc(CNC(=O)n2sc3ncccc3c2=O)ccc1OCCN(C)C
Show InChI InChI=1S/C19H22N4O4S/c1-22(2)9-10-27-15-7-6-13(11-16(15)26-3)12-21-19(25)23-18(24)14-5-4-8-20-17(14)28-23/h4-8,11H,9-10,12H2,1-3H3,(H,21,25)
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n/an/a 1.38E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142079
PNG
(US8933024, 156)
Show SMILES Cc1ccccc1CNC(=O)n1sc2ncccc2c1=O
Show InChI InChI=1S/C15H13N3O2S/c1-10-5-2-3-6-11(10)9-17-15(20)18-14(19)12-7-4-8-16-13(12)21-18/h2-8H,9H2,1H3,(H,17,20)
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n/an/a 1.58E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142074
PNG
(US8933024, 116)
Show SMILES CC(C)Oc1ncccc1CNC(=O)n1sc2ncccc2c1=O
Show InChI InChI=1S/C16H16N4O3S/c1-10(2)23-13-11(5-3-7-17-13)9-19-16(22)20-15(21)12-6-4-8-18-14(12)24-20/h3-8,10H,9H2,1-2H3,(H,19,22)
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n/an/a 1.59E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM142064
PNG
(US8933024, 29)
Show SMILES Cc1cc(C)c(CNC(=O)n2sc3ncccc3c2=O)c(C)c1
Show InChI InChI=1S/C17H17N3O2S/c1-10-7-11(2)14(12(3)8-10)9-19-17(22)20-16(21)13-5-4-6-18-15(13)23-20/h4-8H,9H2,1-3H3,(H,19,22)
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n/an/a 4.29E+3n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
For characterization of the enzymatic activity of endothelial lipase and the effect of inhibitors, the phospholipase-specific substrate 1,2-bis(4,4-d...

US Patent US8933024 (2015)


BindingDB Entry DOI: 10.7270/Q228069H
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%