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Patent code US8962637

Compile Data Set for Download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148383
PNG
(US8962637, 108)
Show SMILES Cc1ccc(NC(=O)CC2CCCC2)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1
Show InChI InChI=1S/C33H42N6O2/c1-24-8-9-28(35-32(40)20-25-6-2-3-7-25)21-31(24)39-17-14-30-26(23-39)22-34-33(37-30)36-27-10-12-29(13-11-27)41-19-18-38-15-4-5-16-38/h8-13,21-22,25H,2-7,14-20,23H2,1H3,(H,35,40)(H,34,36,37)
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n/an/a 1n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148382
PNG
(US8962637, 107)
Show SMILES Cc1ccc(NC(=O)N2CCCCC2)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1
Show InChI InChI=1S/C32H41N7O2/c1-24-7-8-27(35-32(40)38-16-3-2-4-17-38)21-30(24)39-18-13-29-25(23-39)22-33-31(36-29)34-26-9-11-28(12-10-26)41-20-19-37-14-5-6-15-37/h7-12,21-22H,2-6,13-20,23H2,1H3,(H,35,40)(H,33,34,36)
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n/an/a 1n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148373
PNG
(US8962637, 98)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)C(=O)NCCO)ncc2C1
Show InChI InChI=1S/C31H29F3N6O3/c1-19-5-8-25(37-29(43)21-3-2-4-23(15-21)31(32,33)34)16-27(19)40-13-11-26-22(18-40)17-36-30(39-26)38-24-9-6-20(7-10-24)28(42)35-12-14-41/h2-10,15-17,41H,11-14,18H2,1H3,(H,35,42)(H,37,43)(H,36,38,39)
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n/an/a 1n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148381
PNG
(US8962637, 106)
Show SMILES Cc1ccc(NC(=O)c2ccc(s2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1
Show InChI InChI=1S/C32H33F3N6O2S/c1-21-4-5-24(37-30(42)28-10-11-29(44-28)32(33,34)35)18-27(21)41-15-12-26-22(20-41)19-36-31(39-26)38-23-6-8-25(9-7-23)43-17-16-40-13-2-3-14-40/h4-11,18-19H,2-3,12-17,20H2,1H3,(H,37,42)(H,36,38,39)
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n/an/a 2n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148369
PNG
(US8962637, 186 | US8962637, 94)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3cncnc3)ncc2C1
Show InChI InChI=1S/C26H22F3N7O/c1-16-5-6-20(33-24(37)17-3-2-4-19(9-17)26(27,28)29)10-23(16)36-8-7-22-18(14-36)11-32-25(35-22)34-21-12-30-15-31-13-21/h2-6,9-13,15H,7-8,14H2,1H3,(H,33,37)(H,32,34,35)
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n/an/a 2n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148367
PNG
(US8962637, 92)
Show SMILES CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C35H36F3N7O2/c1-22-6-9-29(41-33(47)24-4-3-5-26(18-24)35(36,37)38)19-31(22)45-17-14-30-25(21-45)20-39-34(43-30)42-27-10-7-23(8-11-27)32(46)40-28-12-15-44(2)16-13-28/h3-11,18-20,28H,12-17,21H2,1-2H3,(H,40,46)(H,41,47)(H,39,42,43)
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n/an/a 2n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148297
PNG
(US8962637, 17)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C34H34F3N7O2/c1-22-6-9-28(39-31(45)24-4-3-5-26(18-24)34(35,36)37)19-30(22)44-13-12-29-25(21-44)20-38-33(41-29)40-27-10-7-23(8-11-27)32(46)43-16-14-42(2)15-17-43/h3-11,18-20H,12-17,21H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 2n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148424
PNG
(US8962637, 155)
Show SMILES CC(CC(=O)Nc1ccc(C)c(c1)N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1)C(F)(F)F
Show InChI InChI=1S/C31H37F3N6O2/c1-21-5-6-25(36-29(41)17-22(2)31(32,33)34)18-28(21)40-14-11-27-23(20-40)19-35-30(38-27)37-24-7-9-26(10-8-24)42-16-15-39-12-3-4-13-39/h5-10,18-19,22H,3-4,11-17,20H2,1-2H3,(H,36,41)(H,35,37,38)
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Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148419
PNG
(US8962637, 148)
Show SMILES CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1
Show InChI InChI=1S/C34H35F3N8O2/c1-21-6-7-26(41-31(46)22-4-3-5-24(16-22)34(35,36)37)17-30(21)45-15-12-28-23(20-45)18-39-33(43-28)42-27-8-9-29(38-19-27)32(47)40-25-10-13-44(2)14-11-25/h3-9,16-19,25H,10-15,20H2,1-2H3,(H,40,47)(H,41,46)(H,39,42,43)
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n/an/a 2.40n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148406
PNG
(US8962637, 132)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1
Show InChI InChI=1S/C33H33F3N8O2/c1-21-6-7-25(39-30(45)22-4-3-5-24(16-22)33(34,35)36)17-29(21)44-11-10-27-23(20-44)18-38-32(41-27)40-26-8-9-28(37-19-26)31(46)43-14-12-42(2)13-15-43/h3-9,16-19H,10-15,20H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 3n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148297
PNG
(US8962637, 17)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C34H34F3N7O2/c1-22-6-9-28(39-31(45)24-4-3-5-26(18-24)34(35,36)37)19-30(22)44-13-12-29-25(21-44)20-38-33(41-29)40-27-10-7-23(8-11-27)32(46)43-16-14-42(2)15-17-43/h3-11,18-20H,12-17,21H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 3n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148398
PNG
(US8962637, 123)
Show SMILES CC(CC(=O)Nc1ccc(C)c(c1)N1CCc2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2C1)C(F)(F)F
Show InChI InChI=1S/C30H36F3N7O/c1-20-4-5-24(35-28(41)16-21(2)30(31,32)33)17-27(20)40-11-10-26-22(19-40)18-34-29(37-26)36-23-6-8-25(9-7-23)39-14-12-38(3)13-15-39/h4-9,17-18,21H,10-16,19H2,1-3H3,(H,35,41)(H,34,36,37)
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n/an/a 3n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148358
PNG
(US8962637, 83)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1
Show InChI InChI=1S/C29H26F3N7O2/c1-17-6-7-21(36-26(40)18-4-3-5-20(12-18)29(30,31)32)13-25(17)39-11-10-23-19(16-39)14-35-28(38-23)37-22-8-9-24(34-15-22)27(41)33-2/h3-9,12-15H,10-11,16H2,1-2H3,(H,33,41)(H,36,40)(H,35,37,38)
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n/an/a 4n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148422
PNG
(US8962637, 153)
Show SMILES Cc1ccc(NC(=O)NC2CCCC2)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1
Show InChI InChI=1S/C32H41N7O2/c1-23-8-9-27(36-32(40)35-25-6-2-3-7-25)20-30(23)39-17-14-29-24(22-39)21-33-31(37-29)34-26-10-12-28(13-11-26)41-19-18-38-15-4-5-16-38/h8-13,20-21,25H,2-7,14-19,22H2,1H3,(H,33,34,37)(H2,35,36,40)
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n/an/a 4n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148406
PNG
(US8962637, 132)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1
Show InChI InChI=1S/C33H33F3N8O2/c1-21-6-7-25(39-30(45)22-4-3-5-24(16-22)33(34,35)36)17-29(21)44-11-10-27-23(20-44)18-38-32(41-27)40-26-8-9-28(37-19-26)31(46)43-14-12-42(2)13-15-43/h3-9,16-19H,10-15,20H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 5n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148419
PNG
(US8962637, 148)
Show SMILES CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1
Show InChI InChI=1S/C34H35F3N8O2/c1-21-6-7-26(41-31(46)22-4-3-5-24(16-22)34(35,36)37)17-30(21)45-15-12-28-23(20-45)18-39-33(43-28)42-27-8-9-29(38-19-27)32(47)40-25-10-13-44(2)14-11-25/h3-9,16-19,25H,10-15,20H2,1-2H3,(H,40,47)(H,41,46)(H,39,42,43)
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n/an/a 5n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148417
PNG
(US8962637, 146)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cc(ccn3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C32H33F3N8O/c1-21-3-4-25(38-30(44)28-17-23(9-11-36-28)32(33,34)35)18-29(21)43-12-10-27-22(20-43)19-37-31(40-27)39-24-5-7-26(8-6-24)42-15-13-41(2)14-16-42/h3-9,11,17-19H,10,12-16,20H2,1-2H3,(H,38,44)(H,37,39,40)
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n/an/a 5n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148436
PNG
(US8962637, 167)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cc(ccn3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C33H33F3N8O2/c1-21-3-6-26(39-30(45)28-17-24(9-11-37-28)33(34,35)36)18-29(21)44-12-10-27-23(20-44)19-38-32(41-27)40-25-7-4-22(5-8-25)31(46)43-15-13-42(2)14-16-43/h3-9,11,17-19H,10,12-16,20H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 5.30n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148374
PNG
(US8962637, 99)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)C(=O)N3CCCC3)ncc2C1
Show InChI InChI=1S/C33H31F3N6O2/c1-21-7-10-27(38-30(43)23-5-4-6-25(17-23)33(34,35)36)18-29(21)42-16-13-28-24(20-42)19-37-32(40-28)39-26-11-8-22(9-12-26)31(44)41-14-2-3-15-41/h4-12,17-19H,2-3,13-16,20H2,1H3,(H,38,43)(H,37,39,40)
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n/an/a 6n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148431
PNG
(US8962637, 162)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1
Show InChI InChI=1S/C32H29ClF3N7O2/c1-41-13-15-42(16-14-41)24-8-5-22(6-9-24)39-31-37-19-25-27(40-31)11-12-43(30(25)45)28-18-23(7-10-26(28)33)38-29(44)20-3-2-4-21(17-20)32(34,35)36/h2-10,17-19H,11-16H2,1H3,(H,38,44)(H,37,39,40)
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n/an/a 6n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148417
PNG
(US8962637, 146)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cc(ccn3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C32H33F3N8O/c1-21-3-4-25(38-30(44)28-17-23(9-11-36-28)32(33,34)35)18-29(21)43-12-10-27-22(20-43)19-37-31(40-27)39-24-5-7-26(8-6-24)42-15-13-41(2)14-16-42/h3-9,11,17-19H,10,12-16,20H2,1-2H3,(H,38,44)(H,37,39,40)
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n/an/a 6n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148448
PNG
(US8962637, 179)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cc(ccn3)C(F)(F)F)ccc2Cl)cc1
Show InChI InChI=1S/C28H23ClF3N7O2/c1-33-25(40)16-2-4-19(5-3-16)37-27-35-14-17-15-39(11-9-22(17)38-27)24-13-20(6-7-21(24)29)36-26(41)23-12-18(8-10-34-23)28(30,31)32/h2-8,10,12-14H,9,11,15H2,1H3,(H,33,40)(H,36,41)(H,35,37,38)
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n/an/a 6.40n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148373
PNG
(US8962637, 98)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)C(=O)NCCO)ncc2C1
Show InChI InChI=1S/C31H29F3N6O3/c1-19-5-8-25(37-29(43)21-3-2-4-23(15-21)31(32,33)34)16-27(19)40-13-11-26-22(18-40)17-36-30(39-26)38-24-9-6-20(7-10-24)28(42)35-12-14-41/h2-10,15-17,41H,11-14,18H2,1H3,(H,35,42)(H,37,43)(H,36,38,39)
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n/an/a 7n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148325
PNG
(US8962637, 137 | US8962637, 51)
Show SMILES CN1CCN(Cc2cccc(Nc3ncc4CN(CCc4n3)c3cc(NC(=O)c4cccc(c4)C(F)(F)F)ccc3C)c2)CC1
Show InChI InChI=1S/C34H36F3N7O/c1-23-9-10-29(39-32(45)25-6-4-7-27(18-25)34(35,36)37)19-31(23)44-12-11-30-26(22-44)20-38-33(41-30)40-28-8-3-5-24(17-28)21-43-15-13-42(2)14-16-43/h3-10,17-20H,11-16,21-22H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 7n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148367
PNG
(US8962637, 92)
Show SMILES CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C35H36F3N7O2/c1-22-6-9-29(41-33(47)24-4-3-5-26(18-24)35(36,37)38)19-31(22)45-17-14-30-25(21-45)20-39-34(43-30)42-27-10-7-23(8-11-27)32(46)40-28-12-15-44(2)16-13-28/h3-11,18-20,28H,12-17,21H2,1-2H3,(H,40,46)(H,41,47)(H,39,42,43)
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n/an/a 7n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148447
PNG
(US8962637, 178)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)N3CCNCC3)ncc2C1=O
Show InChI InChI=1S/C32H30F3N7O2/c1-20-5-6-24(38-29(43)21-3-2-4-22(17-21)32(33,34)35)18-28(20)42-14-11-27-26(30(42)44)19-37-31(40-27)39-23-7-9-25(10-8-23)41-15-12-36-13-16-41/h2-10,17-19,36H,11-16H2,1H3,(H,38,43)(H,37,39,40)
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n/an/a 7n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148394
PNG
(US8962637, 119)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(nc3)C(N)=O)ncc2C1
Show InChI InChI=1S/C28H24F3N7O2/c1-16-5-6-20(35-26(40)17-3-2-4-19(11-17)28(29,30)31)12-24(16)38-10-9-22-18(15-38)13-34-27(37-22)36-21-7-8-23(25(32)39)33-14-21/h2-8,11-14H,9-10,15H2,1H3,(H2,32,39)(H,35,40)(H,34,36,37)
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n/an/a 8n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148443
PNG
(US8962637, 174)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1
Show InChI InChI=1S/C32H31ClF3N7O/c1-41-13-15-42(16-14-41)26-8-5-24(6-9-26)39-31-37-19-22-20-43(12-11-28(22)40-31)29-18-25(7-10-27(29)33)38-30(44)21-3-2-4-23(17-21)32(34,35)36/h2-10,17-19H,11-16,20H2,1H3,(H,38,44)(H,37,39,40)
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n/an/a 8.80n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148398
PNG
(US8962637, 123)
Show SMILES CC(CC(=O)Nc1ccc(C)c(c1)N1CCc2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2C1)C(F)(F)F
Show InChI InChI=1S/C30H36F3N7O/c1-20-4-5-24(35-28(41)16-21(2)30(31,32)33)17-27(20)40-11-10-26-22(19-40)18-34-29(37-26)36-23-6-8-25(9-7-23)39-14-12-38(3)13-15-39/h4-9,17-18,21H,10-16,19H2,1-3H3,(H,35,41)(H,34,36,37)
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n/an/a 9n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148441
PNG
(US8962637, 172)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cc(F)cc(c3)C(F)(F)F)ccc2Cl)cc1
Show InChI InChI=1S/C32H28ClF4N7O2/c1-42-10-12-43(13-11-42)24-5-2-22(3-6-24)40-31-38-18-25-27(41-31)8-9-44(30(25)46)28-17-23(4-7-26(28)33)39-29(45)19-14-20(32(35,36)37)16-21(34)15-19/h2-7,14-18H,8-13H2,1H3,(H,39,45)(H,38,40,41)
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n/an/a 9n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148446
PNG
(US8962637, 177)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cc(F)cc(c3)C(F)(F)F)ccc2Cl)cc1
Show InChI InChI=1S/C29H23ClF4N6O2/c1-35-26(41)16-2-4-21(5-3-16)38-28-36-14-18-15-40(9-8-24(18)39-28)25-13-22(6-7-23(25)30)37-27(42)17-10-19(29(32,33)34)12-20(31)11-17/h2-7,10-14H,8-9,15H2,1H3,(H,35,41)(H,37,42)(H,36,38,39)
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n/an/a 10n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148321
PNG
(US8962637, 45)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C33H32F3N7O2/c1-21-6-7-25(38-30(44)22-4-3-5-23(18-22)33(34,35)36)19-29(21)43-13-12-28-27(31(43)45)20-37-32(40-28)39-24-8-10-26(11-9-24)42-16-14-41(2)15-17-42/h3-11,18-20H,12-17H2,1-2H3,(H,38,44)(H,37,39,40)
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n/an/a 10n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM148448
PNG
(US8962637, 179)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cc(ccn3)C(F)(F)F)ccc2Cl)cc1
Show InChI InChI=1S/C28H23ClF3N7O2/c1-33-25(40)16-2-4-19(5-3-16)37-27-35-14-17-15-39(11-9-22(17)38-27)24-13-20(6-7-21(24)29)36-26(41)23-12-18(8-10-34-23)28(30,31)32/h2-8,10,12-14H,9,11,15H2,1H3,(H,33,40)(H,36,41)(H,35,37,38)
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n/an/a 12n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148383
PNG
(US8962637, 108)
Show SMILES Cc1ccc(NC(=O)CC2CCCC2)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1
Show InChI InChI=1S/C33H42N6O2/c1-24-8-9-28(35-32(40)20-25-6-2-3-7-25)21-31(24)39-17-14-30-26(23-39)22-34-33(37-30)36-27-10-12-29(13-11-27)41-19-18-38-15-4-5-16-38/h8-13,21-22,25H,2-7,14-20,23H2,1H3,(H,35,40)(H,34,36,37)
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n/an/a 12n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148445
PNG
(US8962637, 176)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1
Show InChI InChI=1S/C29H24ClF3N6O2/c1-34-26(40)17-5-7-21(8-6-17)37-28-35-15-19-16-39(12-11-24(19)38-28)25-14-22(9-10-23(25)30)36-27(41)18-3-2-4-20(13-18)29(31,32)33/h2-10,13-15H,11-12,16H2,1H3,(H,34,40)(H,36,41)(H,35,37,38)
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n/an/a 13n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148374
PNG
(US8962637, 99)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)C(=O)N3CCCC3)ncc2C1
Show InChI InChI=1S/C33H31F3N6O2/c1-21-7-10-27(38-30(43)23-5-4-6-25(17-23)33(34,35)36)18-29(21)42-16-13-28-24(20-42)19-37-32(40-28)39-26-11-8-22(9-12-26)31(44)41-14-2-3-15-41/h4-12,17-19H,2-3,13-16,20H2,1H3,(H,38,43)(H,37,39,40)
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n/an/a 14n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148448
PNG
(US8962637, 179)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cc(ccn3)C(F)(F)F)ccc2Cl)cc1
Show InChI InChI=1S/C28H23ClF3N7O2/c1-33-25(40)16-2-4-19(5-3-16)37-27-35-14-17-15-39(11-9-22(17)38-27)24-13-20(6-7-21(24)29)36-26(41)23-12-18(8-10-34-23)28(30,31)32/h2-8,10,12-14H,9,11,15H2,1H3,(H,33,40)(H,36,41)(H,35,37,38)
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n/an/a 15n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148429
PNG
(US8962637, 160)
Show SMILES CC(CC(=O)Nc1ccc(C)c(c1)N1CCc2nc(Nc3ccc(OCCN4CCN(C)CC4)cc3)ncc2C1)C(F)(F)F
Show InChI InChI=1S/C32H40F3N7O2/c1-22-4-5-26(37-30(43)18-23(2)32(33,34)35)19-29(22)42-11-10-28-24(21-42)20-36-31(39-28)38-25-6-8-27(9-7-25)44-17-16-41-14-12-40(3)13-15-41/h4-9,19-20,23H,10-18,21H2,1-3H3,(H,37,43)(H,36,38,39)
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n/an/a 15n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148445
PNG
(US8962637, 176)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1
Show InChI InChI=1S/C29H24ClF3N6O2/c1-34-26(40)17-5-7-21(8-6-17)37-28-35-15-19-16-39(12-11-24(19)38-28)25-14-22(9-10-23(25)30)36-27(41)18-3-2-4-20(13-18)29(31,32)33/h2-10,13-15H,11-12,16H2,1H3,(H,34,40)(H,36,41)(H,35,37,38)
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n/an/a 15n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148321
PNG
(US8962637, 45)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C33H32F3N7O2/c1-21-6-7-25(38-30(44)22-4-3-5-23(18-22)33(34,35)36)19-29(21)43-13-12-28-27(31(43)45)20-37-32(40-28)39-24-8-10-26(11-9-24)42-16-14-41(2)15-17-42/h3-11,18-20H,12-17H2,1-2H3,(H,38,44)(H,37,39,40)
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n/an/a 15n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148434
PNG
(US8962637, 165)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)S(=O)(=O)NC3CC3)ncc2C1
Show InChI InChI=1S/C31H29F3N6O3S/c1-19-5-6-25(36-29(41)20-3-2-4-22(15-20)31(32,33)34)16-28(19)40-14-13-27-21(18-40)17-35-30(38-27)37-23-9-11-26(12-10-23)44(42,43)39-24-7-8-24/h2-6,9-12,15-17,24,39H,7-8,13-14,18H2,1H3,(H,36,41)(H,35,37,38)
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n/an/a 16n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148291
PNG
(US8962637, 7)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1=O
Show InChI InChI=1S/C34H33F3N6O3/c1-22-7-8-26(39-31(44)23-5-4-6-24(19-23)34(35,36)37)20-30(22)43-16-13-29-28(32(43)45)21-38-33(41-29)40-25-9-11-27(12-10-25)46-18-17-42-14-2-3-15-42/h4-12,19-21H,2-3,13-18H2,1H3,(H,39,44)(H,38,40,41)
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n/an/a 16n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148447
PNG
(US8962637, 178)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)N3CCNCC3)ncc2C1=O
Show InChI InChI=1S/C32H30F3N7O2/c1-20-5-6-24(38-29(43)21-3-2-4-22(17-21)32(33,34)35)18-28(20)42-14-11-27-26(30(42)44)19-37-31(40-27)39-23-7-9-25(10-8-23)41-15-12-36-13-16-41/h2-10,17-19,36H,11-16H2,1H3,(H,38,43)(H,37,39,40)
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n/an/a 17n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148343
PNG
(US8962637, 69 | US8962637, 77)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)C(=O)NCCCN3CCCC3)ncc2C1=O
Show InChI InChI=1S/C36H36F3N7O3/c1-23-8-11-28(42-33(48)25-6-4-7-26(20-25)36(37,38)39)21-31(23)46-19-14-30-29(34(46)49)22-41-35(44-30)43-27-12-9-24(10-13-27)32(47)40-15-5-18-45-16-2-3-17-45/h4,6-13,20-22H,2-3,5,14-19H2,1H3,(H,40,47)(H,42,48)(H,41,43,44)
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n/an/a 17n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148381
PNG
(US8962637, 106)
Show SMILES Cc1ccc(NC(=O)c2ccc(s2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1
Show InChI InChI=1S/C32H33F3N6O2S/c1-21-4-5-24(37-30(42)28-10-11-29(44-28)32(33,34)35)18-27(21)41-15-12-26-22(20-41)19-36-31(39-26)38-23-6-8-25(9-7-23)43-17-16-40-13-2-3-14-40/h4-11,18-19H,2-3,12-17,20H2,1H3,(H,37,42)(H,36,38,39)
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n/an/a 18n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148424
PNG
(US8962637, 155)
Show SMILES CC(CC(=O)Nc1ccc(C)c(c1)N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1)C(F)(F)F
Show InChI InChI=1S/C31H37F3N6O2/c1-21-5-6-25(36-29(41)17-22(2)31(32,33)34)18-28(21)40-14-11-27-23(20-40)19-35-30(38-27)37-24-7-9-26(10-8-24)42-16-15-39-12-3-4-13-39/h5-10,18-19,22H,3-4,11-17,20H2,1-2H3,(H,36,41)(H,35,37,38)
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n/an/a 18n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148392
PNG
(US8962637, 117)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(nc3)C(=O)NC3CC3)ncc2C1
Show InChI InChI=1S/C31H28F3N7O2/c1-18-5-6-23(38-28(42)19-3-2-4-21(13-19)31(32,33)34)14-27(18)41-12-11-25-20(17-41)15-36-30(40-25)39-24-9-10-26(35-16-24)29(43)37-22-7-8-22/h2-6,9-10,13-16,22H,7-8,11-12,17H2,1H3,(H,37,43)(H,38,42)(H,36,39,40)
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n/an/a 18n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148350
PNG
(US8962637, 189 | US8962637, 75)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C34H32F3N7O3/c1-21-6-9-26(39-30(45)23-4-3-5-24(18-23)34(35,36)37)19-29(21)44-13-12-28-27(32(44)47)20-38-33(41-28)40-25-10-7-22(8-11-25)31(46)43-16-14-42(2)15-17-43/h3-11,18-20H,12-17H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 19n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148334
PNG
(US8962637, 58)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(Br)c3)ccc2C)cc1
Show InChI InChI=1S/C32H32BrN7O2/c1-21-6-7-25(35-30(41)22-4-3-5-23(33)18-22)19-29(21)40-13-12-28-27(31(40)42)20-34-32(37-28)36-24-8-10-26(11-9-24)39-16-14-38(2)15-17-39/h3-11,18-20H,12-17H2,1-2H3,(H,35,41)(H,34,36,37)
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n/an/a 19n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148440
PNG
(US8962637, 171)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1C
Show InChI InChI=1S/C33H31ClF3N7O2/c1-20-16-23(7-9-28(20)43-14-12-42(2)13-15-43)40-32-38-19-25-27(41-32)10-11-44(31(25)46)29-18-24(6-8-26(29)34)39-30(45)21-4-3-5-22(17-21)33(35,36)37/h3-9,16-19H,10-15H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 19n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148369
PNG
(US8962637, 186 | US8962637, 94)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3cncnc3)ncc2C1
Show InChI InChI=1S/C26H22F3N7O/c1-16-5-6-20(33-24(37)17-3-2-4-19(9-17)26(27,28)29)10-23(16)36-8-7-22-18(14-36)11-32-25(35-22)34-21-12-30-15-31-13-21/h2-6,9-13,15H,7-8,14H2,1H3,(H,33,37)(H,32,34,35)
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n/an/a 19n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148446
PNG
(US8962637, 177)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cc(F)cc(c3)C(F)(F)F)ccc2Cl)cc1
Show InChI InChI=1S/C29H23ClF4N6O2/c1-35-26(41)16-2-4-21(5-3-16)38-28-36-14-18-15-40(9-8-24(18)39-28)25-13-22(6-7-23(25)30)37-27(42)17-10-19(29(32,33)34)12-20(31)11-17/h2-7,10-14H,8-9,15H2,1H3,(H,35,41)(H,37,42)(H,36,38,39)
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n/an/a 20n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148440
PNG
(US8962637, 171)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1C
Show InChI InChI=1S/C33H31ClF3N7O2/c1-20-16-23(7-9-28(20)43-14-12-42(2)13-15-43)40-32-38-19-25-27(41-32)10-11-44(31(25)46)29-18-24(6-8-26(29)34)39-30(45)21-4-3-5-22(17-21)33(35,36)37/h3-9,16-19H,10-15H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 20n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148418
PNG
(US8962637, 147)
Show SMILES Cc1ccc(NC(=O)CCC(F)(F)F)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1
Show InChI InChI=1S/C30H35F3N6O2/c1-21-4-5-24(35-28(40)10-12-30(31,32)33)18-27(21)39-15-11-26-22(20-39)19-34-29(37-26)36-23-6-8-25(9-7-23)41-17-16-38-13-2-3-14-38/h4-9,18-19H,2-3,10-17,20H2,1H3,(H,35,40)(H,34,36,37)
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n/an/a 21n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM148392
PNG
(US8962637, 117)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(nc3)C(=O)NC3CC3)ncc2C1
Show InChI InChI=1S/C31H28F3N7O2/c1-18-5-6-23(38-28(42)19-3-2-4-21(13-19)31(32,33)34)14-27(18)41-12-11-25-20(17-41)15-36-30(40-25)39-24-9-10-26(35-16-24)29(43)37-22-7-8-22/h2-6,9-10,13-16,22H,7-8,11-12,17H2,1H3,(H,37,43)(H,38,42)(H,36,39,40)
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n/an/a 24n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148433
PNG
(US8962637, 164)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)CCC(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C30H34F3N7O2/c1-20-3-6-24(35-27(41)9-11-30(31,32)33)17-26(20)40-12-10-25-22(19-40)18-34-29(37-25)36-23-7-4-21(5-8-23)28(42)39-15-13-38(2)14-16-39/h3-8,17-18H,9-16,19H2,1-2H3,(H,35,41)(H,34,36,37)
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n/an/a 26n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148436
PNG
(US8962637, 167)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cc(ccn3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C33H33F3N8O2/c1-21-3-6-26(39-30(45)28-17-24(9-11-37-28)33(34,35)36)18-29(21)44-12-10-27-23(20-44)19-38-32(41-27)40-25-7-4-22(5-8-25)31(46)43-15-13-42(2)14-16-43/h3-9,11,17-19H,10,12-16,20H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 27n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148435
PNG
(US8962637, 166)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cc(ccn3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C32H31F3N8O2/c1-20-3-4-23(38-29(44)27-17-21(9-11-36-27)32(33,34)35)18-28(20)43-12-10-26-25(30(43)45)19-37-31(40-26)39-22-5-7-24(8-6-22)42-15-13-41(2)14-16-42/h3-9,11,17-19H,10,12-16H2,1-2H3,(H,38,44)(H,37,39,40)
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n/an/a 27n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148431
PNG
(US8962637, 162)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1
Show InChI InChI=1S/C32H29ClF3N7O2/c1-41-13-15-42(16-14-41)24-8-5-22(6-9-24)39-31-37-19-25-27(40-31)11-12-43(30(25)45)28-18-23(7-10-26(28)33)38-29(44)20-3-2-4-21(17-20)32(34,35)36/h2-10,17-19H,11-16H2,1H3,(H,38,44)(H,37,39,40)
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n/an/a 27n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148325
PNG
(US8962637, 137 | US8962637, 51)
Show SMILES CN1CCN(Cc2cccc(Nc3ncc4CN(CCc4n3)c3cc(NC(=O)c4cccc(c4)C(F)(F)F)ccc3C)c2)CC1
Show InChI InChI=1S/C34H36F3N7O/c1-23-9-10-29(39-32(45)25-6-4-7-27(18-25)34(35,36)37)19-31(23)44-12-11-30-26(22-44)20-38-33(41-30)40-28-8-3-5-24(17-28)21-43-15-13-42(2)14-16-43/h3-10,17-20H,11-16,21-22H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 28n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148361
PNG
(US8962637, 86)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(C)(C)C)ccc2C)cc1
Show InChI InChI=1S/C36H41N7O2/c1-24-9-10-28(38-33(44)25-7-6-8-26(21-25)36(2,3)4)22-32(24)43-16-15-31-30(34(43)45)23-37-35(40-31)39-27-11-13-29(14-12-27)42-19-17-41(5)18-20-42/h6-14,21-23H,15-20H2,1-5H3,(H,38,44)(H,37,39,40)
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n/an/a 28n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148351
PNG
(US8962637, 76)
Show SMILES CN1CCN(CC1)C(=O)Cc1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C35H34F3N7O3/c1-22-6-9-27(40-32(47)24-4-3-5-25(19-24)35(36,37)38)20-30(22)45-13-12-29-28(33(45)48)21-39-34(42-29)41-26-10-7-23(8-11-26)18-31(46)44-16-14-43(2)15-17-44/h3-11,19-21H,12-18H2,1-2H3,(H,40,47)(H,39,41,42)
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n/an/a 30n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148358
PNG
(US8962637, 83)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1
Show InChI InChI=1S/C29H26F3N7O2/c1-17-6-7-21(36-26(40)18-4-3-5-20(12-18)29(30,31)32)13-25(17)39-11-10-23-19(16-39)14-35-28(38-23)37-22-8-9-24(34-15-22)27(41)33-2/h3-9,12-15H,10-11,16H2,1-2H3,(H,33,41)(H,36,40)(H,35,37,38)
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n/an/a 32n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148395
PNG
(US8962637, 120)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cc(Cl)cc(c3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C33H31ClF3N7O2/c1-20-3-4-25(39-30(45)21-15-22(33(35,36)37)17-23(34)16-21)18-29(20)44-10-9-28-27(31(44)46)19-38-32(41-28)40-24-5-7-26(8-6-24)43-13-11-42(2)12-14-43/h3-8,15-19H,9-14H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 36n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148382
PNG
(US8962637, 107)
Show SMILES Cc1ccc(NC(=O)N2CCCCC2)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1
Show InChI InChI=1S/C32H41N7O2/c1-24-7-8-27(35-32(40)38-16-3-2-4-17-38)21-30(24)39-18-13-29-25(23-39)22-33-31(36-29)34-26-9-11-28(12-10-26)41-20-19-37-14-5-6-15-37/h7-12,21-22H,2-6,13-20,23H2,1H3,(H,35,40)(H,33,34,36)
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n/an/a 40n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148405
PNG
(US8962637, 131)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)CCC(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C29H34F3N7O/c1-20-3-4-23(34-27(40)9-11-29(30,31)32)17-26(20)39-12-10-25-21(19-39)18-33-28(36-25)35-22-5-7-24(8-6-22)38-15-13-37(2)14-16-38/h3-8,17-18H,9-16,19H2,1-2H3,(H,34,40)(H,33,35,36)
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n/an/a 40n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148334
PNG
(US8962637, 58)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(Br)c3)ccc2C)cc1
Show InChI InChI=1S/C32H32BrN7O2/c1-21-6-7-25(35-30(41)22-4-3-5-23(33)18-22)19-29(21)40-13-12-28-27(31(40)42)20-34-32(37-28)36-24-8-10-26(11-9-24)39-16-14-38(2)15-17-39/h3-11,18-20H,12-17H2,1-2H3,(H,35,41)(H,34,36,37)
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n/an/a 44n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148361
PNG
(US8962637, 86)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(C)(C)C)ccc2C)cc1
Show InChI InChI=1S/C36H41N7O2/c1-24-9-10-28(38-33(44)25-7-6-8-26(21-25)36(2,3)4)22-32(24)43-16-15-31-30(34(43)45)23-37-35(40-31)39-27-11-13-29(14-12-27)42-19-17-41(5)18-20-42/h6-14,21-23H,15-20H2,1-5H3,(H,38,44)(H,37,39,40)
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n/an/a 45n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148433
PNG
(US8962637, 164)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)CCC(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C30H34F3N7O2/c1-20-3-6-24(35-27(41)9-11-30(31,32)33)17-26(20)40-12-10-25-22(19-40)18-34-29(37-25)36-23-7-4-21(5-8-23)28(42)39-15-13-38(2)14-16-39/h3-8,17-18H,9-16,19H2,1-2H3,(H,35,41)(H,34,36,37)
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n/an/a 46n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148435
PNG
(US8962637, 166)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cc(ccn3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C32H31F3N8O2/c1-20-3-4-23(38-29(44)27-17-21(9-11-36-27)32(33,34)35)18-28(20)43-12-10-26-25(30(43)45)19-37-31(40-26)39-22-5-7-24(8-6-22)42-15-13-41(2)14-16-42/h3-9,11,17-19H,10,12-16H2,1-2H3,(H,38,44)(H,37,39,40)
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n/an/a 48n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148434
PNG
(US8962637, 165)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)S(=O)(=O)NC3CC3)ncc2C1
Show InChI InChI=1S/C31H29F3N6O3S/c1-19-5-6-25(36-29(41)20-3-2-4-22(15-20)31(32,33)34)16-28(19)40-14-13-27-21(18-40)17-35-30(38-27)37-23-9-11-26(12-10-23)44(42,43)39-24-7-8-24/h2-6,9-12,15-17,24,39H,7-8,13-14,18H2,1H3,(H,36,41)(H,35,37,38)
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n/an/a 54n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148351
PNG
(US8962637, 76)
Show SMILES CN1CCN(CC1)C(=O)Cc1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C35H34F3N7O3/c1-22-6-9-27(40-32(47)24-4-3-5-25(19-24)35(36,37)38)20-30(22)45-13-12-29-28(33(45)48)21-39-34(42-29)41-26-10-7-23(8-11-26)18-31(46)44-16-14-43(2)15-17-44/h3-11,19-21H,12-18H2,1-2H3,(H,40,47)(H,39,41,42)
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n/an/a 61n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148429
PNG
(US8962637, 160)
Show SMILES CC(CC(=O)Nc1ccc(C)c(c1)N1CCc2nc(Nc3ccc(OCCN4CCN(C)CC4)cc3)ncc2C1)C(F)(F)F
Show InChI InChI=1S/C32H40F3N7O2/c1-22-4-5-26(37-30(43)18-23(2)32(33,34)35)19-29(22)42-11-10-28-24(21-42)20-36-31(39-28)38-25-6-8-27(9-7-25)44-17-16-41-14-12-40(3)13-15-41/h4-9,19-20,23H,10-18,21H2,1-3H3,(H,37,43)(H,36,38,39)
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n/an/a 66n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148439
PNG
(US8962637, 170)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cc(ccn3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C33H31F3N8O3/c1-20-3-6-24(39-29(45)27-17-22(9-11-37-27)33(34,35)36)18-28(20)44-12-10-26-25(31(44)47)19-38-32(41-26)40-23-7-4-21(5-8-23)30(46)43-15-13-42(2)14-16-43/h3-9,11,17-19H,10,12-16H2,1-2H3,(H,39,45)(H,38,40,41)
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n/an/a 70n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM148291
PNG
(US8962637, 7)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1=O
Show InChI InChI=1S/C34H33F3N6O3/c1-22-7-8-26(39-31(44)23-5-4-6-24(19-23)34(35,36)37)20-30(22)43-16-13-29-28(32(43)45)21-38-33(41-29)40-25-9-11-27(12-10-25)46-18-17-42-14-2-3-15-42/h4-12,19-21H,2-3,13-18H2,1H3,(H,39,44)(H,38,40,41)
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n/an/a 83n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM148321
PNG
(US8962637, 45)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
Show InChI InChI=1S/C33H32F3N7O2/c1-21-6-7-25(38-30(44)22-4-3-5-23(18-22)33(34,35)36)19-29(21)43-13-12-28-27(31(43)45)20-37-32(40-28)39-24-8-10-26(11-9-24)42-16-14-41(2)15-17-42/h3-11,18-20H,12-17H2,1-2H3,(H,38,44)(H,37,39,40)
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n/an/a 116n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%