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Patent code US8969341

Compile Data Set for Download or QSAR

Found 345 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143673
PNG
(US8969341, 180)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c[nH]c1=O)N(C)C |r|
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US Patent
n/an/a 0.0680n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143676
PNG
(US8969341, 183)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)c[nH]c1=O)N(C)C |r|
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n/an/a 0.0970n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143548
PNG
(US8969341, 143)
Show SMILES COc1ccccc1-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1OCCN(C)C |r|
Show InChI InChI=1S/C32H34Cl2N4O3/c1-19(2)30-28-29(35-38(30)24-9-7-8-10-26(24)40-6)32(39)37(31(28)23-13-11-21(33)17-20(23)3)25-18-22(34)12-14-27(25)41-16-15-36(4)5/h7-14,17-19,31H,15-16H2,1-6H3/t31-/m0/s1
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n/an/a 0.101n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143574
PNG
(US8969341, 149)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1)N(C)C
Show InChI InChI=1S/C27H27Cl2N7O3/c1-14(2)22-20-21(32-36(22)19-12-30-27(33(3)4)31-24(19)39-6)26(38)35(17-11-18(29)25(37)34(5)13-17)23(20)15-7-9-16(28)10-8-15/h7-14,23H,1-6H3
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n/an/a 0.103n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143571
PNG
(US8969341, 148)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)cn(C)c1=O)N(C)C
Show InChI InChI=1S/C27H27Cl2N7O3/c1-14(2)22-20-21(32-36(22)19-12-30-27(33(3)4)31-24(19)39-6)26(38)35(18-11-17(29)13-34(5)25(18)37)23(20)15-7-9-16(28)10-8-15/h7-14,23H,1-6H3
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n/an/a 0.120n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143671
PNG
(US8969341, 178)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)c(=O)n(C)c1)N(C)C |r|
Show InChI InChI=1S/C28H27ClN8O3/c1-15(2)23-21-22(33-37(23)20-13-31-28(34(3)4)32-25(20)40-6)27(39)36(18-11-19(29)26(38)35(5)14-18)24(21)17-9-7-16(12-30)8-10-17/h7-11,13-15,24H,1-6H3/t24-/m0/s1
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n/an/a 0.120n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143719
PNG
(US8969341, 195)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)c(F)c1)c1cc(Cl)cn(C)c1=O)N(C)C
Show InChI InChI=1S/C27H26Cl2FN7O3/c1-13(2)22-20-21(33-37(22)19-11-31-27(34(3)4)32-24(19)40-6)26(39)36(18-10-15(28)12-35(5)25(18)38)23(20)14-7-8-16(29)17(30)9-14/h7-13,23H,1-6H3
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n/an/a 0.128n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143652
PNG
(US8969341, 171)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)cn(C)c1=O)N(C)C |r|
Show InChI InChI=1S/C28H27ClN8O3/c1-15(2)23-21-22(33-37(23)20-13-31-28(34(3)4)32-25(20)40-6)27(39)36(19-11-18(29)14-35(5)26(19)38)24(21)17-9-7-16(12-30)8-10-17/h7-11,13-15,24H,1-6H3/t24-/m0/s1
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n/an/a 0.129n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143558
PNG
(US8969341, 147)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c[nH]c1=O)N(C)C
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n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143598
PNG
(US8969341, 156)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1c[nH]c(=O)c(Cl)c1)N(C)C
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n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143511
PNG
(US8969341, 126)
Show SMILES COc1ccc(CN)cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C30H30Cl2N4O2/c1-16(2)28-26-27(34-36(28)24-13-19(15-33)7-11-25(24)38-5)30(37)35(23-14-21(32)8-6-17(23)3)29(26)22-10-9-20(31)12-18(22)4/h6-14,16,29H,15,33H2,1-5H3
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n/an/a 0.146n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143727
PNG
(US8969341, 197)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)c(F)c1)c1cc(Cl)c(=O)n(C)c1)N(C)C
Show InChI InChI=1S/C27H26Cl2FN7O3/c1-13(2)22-20-21(33-37(22)19-11-31-27(34(3)4)32-24(19)40-6)26(39)36(15-10-17(29)25(38)35(5)12-15)23(20)14-7-8-16(28)18(30)9-14/h7-13,23H,1-6H3
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n/an/a 0.155n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143669
PNG
(US8969341, 176)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1 |r|
Show InChI InChI=1S/C26H24Cl2N6O4/c1-13(2)21-19-20(31-34(21)18-11-29-26(38-5)30-23(18)37-4)25(36)33(16-10-17(28)24(35)32(3)12-16)22(19)14-6-8-15(27)9-7-14/h6-13,22H,1-5H3/t22-/m0/s1
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n/an/a 0.157n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143645
PNG
(US8969341, 168)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c[nH]c1=O |r|
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n/an/a 0.161n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143546
PNG
(US8969341, 141)
Show SMILES COc1ccccc1-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C |r|
Show InChI InChI=1S/C29H27Cl2N3O2/c1-16(2)27-25-26(32-34(27)22-8-6-7-9-24(22)36-5)29(35)33(23-15-20(31)11-10-17(23)3)28(25)21-13-12-19(30)14-18(21)4/h6-16,28H,1-5H3/t28-/m0/s1
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n/an/a 0.161n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143730
PNG
(US8969341, 198)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)c(F)c1)c1c[nH]c(=O)c(Cl)c1)N(C)C
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n/an/a 0.164n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143723
PNG
(US8969341, 196)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)c(F)c1)c1cc(Cl)c[nH]c1=O)N(C)C
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n/an/a 0.165n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143602
PNG
(US8969341, 157)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)c[nH]c1=O)N(C)C
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n/an/a 0.166n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143513
PNG
(US8969341, 128)
Show SMILES COc1ccc(CNC=O)cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C31H30Cl2N4O3/c1-17(2)29-27-28(35-37(29)25-13-20(15-34-16-38)7-11-26(25)40-5)31(39)36(24-14-22(33)8-6-18(24)3)30(27)23-10-9-21(32)12-19(23)4/h6-14,16-17,30H,15H2,1-5H3,(H,34,38)
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n/an/a 0.169n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143541
PNG
(US8969341, 138)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1C)[N+]#[C-])c1cc(Cl)ccc1C)C#N
Show InChI InChI=1S/C31H26ClN5O2/c1-17(2)29-27-28(35-37(29)25-14-20(16-33)8-12-26(25)39-6)31(38)36(24-15-21(32)9-7-18(24)3)30(27)23-11-10-22(34-5)13-19(23)4/h7-15,17,30H,1-4,6H3
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n/an/a 0.176n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143592
PNG
(US8969341, 155)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1c[nH]c(=O)c(Cl)c1
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n/an/a 0.176n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143499
PNG
(US8969341, 124)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1OCc1nn[nH]n1
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n/an/a 0.180n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143507
PNG
(US8969341, 125)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C#N
Show InChI InChI=1S/C30H26Cl2N4O2/c1-16(2)28-26-27(34-36(28)24-13-19(15-33)7-11-25(24)38-5)30(37)35(23-14-21(32)8-6-17(23)3)29(26)22-10-9-20(31)12-18(22)4/h6-14,16,29H,1-5H3
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n/an/a 0.187n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143465
PNG
(US8969341, 106)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C(=O)N(C)C
Show InChI InChI=1S/C32H32Cl2N4O3/c1-17(2)29-27-28(35-38(29)25-15-20(31(39)36(5)6)9-13-26(25)41-7)32(40)37(24-16-22(34)10-8-18(24)3)30(27)23-12-11-21(33)14-19(23)4/h8-17,30H,1-7H3
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n/an/a 0.195n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143512
PNG
(US8969341, 127)
Show SMILES COc1ccc(CNC(C)=O)cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C32H32Cl2N4O3/c1-17(2)30-28-29(36-38(30)26-14-21(16-35-20(5)39)8-12-27(26)41-6)32(40)37(25-15-23(34)9-7-18(25)3)31(28)24-11-10-22(33)13-19(24)4/h7-15,17,31H,16H2,1-6H3,(H,35,39)
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n/an/a 0.196n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143715
PNG
(US8969341, 194)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(C#N)c(F)c1)c1c[nH]c(=O)c(Cl)c1)N(C)C
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n/an/a 0.197n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143708
PNG
(US8969341, 192)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(C#N)c(F)c1)c1cc(Cl)c(=O)n(C)c1)N(C)C
Show InChI InChI=1S/C28H26ClFN8O3/c1-14(2)23-21-22(34-38(23)20-12-32-28(35(3)4)33-25(20)41-6)27(40)37(17-10-18(29)26(39)36(5)13-17)24(21)15-7-8-16(11-31)19(30)9-15/h7-10,12-14,24H,1-6H3
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n/an/a 0.213n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143711
PNG
(US8969341, 193)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(C#N)c(F)c1)c1cc(Cl)c[nH]c1=O)N(C)C
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n/an/a 0.215n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143523
PNG
(US8969341, 133)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C28H27Cl2N5O3/c1-14(2)24-22-23(33-35(24)21-13-31-28(38-6)32-26(21)37-5)27(36)34(20-12-18(30)8-7-15(20)3)25(22)19-10-9-17(29)11-16(19)4/h7-14,25H,1-6H3
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n/an/a 0.220n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143606
PNG
(US8969341, 158)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1c[nH]c(=O)c(Cl)c1)N(C)C
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n/an/a 0.222n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143584
PNG
(US8969341, 152)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c[nH]c1=O
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n/an/a 0.232n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143461
PNG
(US8969341, 102)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C36H39Cl2N5O3/c1-21(2)33-31-32(36(45)42(28-20-26(38)10-8-22(28)3)34(31)27-12-11-25(37)18-23(27)4)40-43(33)29-19-24(9-13-30(29)46-5)35(44)39-14-17-41-15-6-7-16-41/h8-13,18-21,34H,6-7,14-17H2,1-5H3,(H,39,44)
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n/an/a 0.238n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143590
PNG
(US8969341, 153)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)c(=O)n(C)c1 |r|
Show InChI InChI=1S/C27H26Cl2N6O4/c1-13(2)22-20-21(32-35(22)19-11-30-27(39-6)31-24(19)38-5)26(37)34(16-10-18(29)25(36)33(4)12-16)23(20)17-8-7-15(28)9-14(17)3/h7-13,23H,1-6H3/t23-/m0/s1
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n/an/a 0.241n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143533
PNG
(US8969341, 136)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)[N+]#[C-])c1cc(Cl)ccc1C)C#N
Show InChI InChI=1S/C30H24ClN5O2/c1-17(2)28-26-27(34-36(28)24-14-19(16-32)7-13-25(24)38-5)30(37)35(23-15-21(31)10-6-18(23)3)29(26)20-8-11-22(33-4)12-9-20/h6-15,17,29H,1-3,5H3
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n/an/a 0.242n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143577
PNG
(US8969341, 150)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)c(=O)n(C)c1)N(C)C
Show InChI InChI=1S/C28H27ClN8O3/c1-15(2)23-21-22(33-37(23)20-13-31-28(34(3)4)32-25(20)40-6)27(39)36(18-11-19(29)26(38)35(5)14-18)24(21)17-9-7-16(12-30)8-10-17/h7-11,13-15,24H,1-6H3
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n/an/a 0.25n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143474
PNG
(US8969341, 114)
Show SMILES CNC(=O)c1ccc(OC)c(c1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C30H29Cl2N5O4/c1-15(2)26-24-25(34-37(26)22-12-17(28(38)33-4)7-10-23(22)41-6)30(40)36(19-13-21(32)29(39)35(5)14-19)27(24)20-9-8-18(31)11-16(20)3/h7-15,27H,1-6H3,(H,33,38)
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n/an/a 0.259n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143472
PNG
(US8969341, 112)
Show SMILES COCCn1cc(cc(Cl)c1=O)N1C(c2c(nn(c2C(C)C)-c2ccccc2OC)C1=O)c1ccc(Cl)cc1C
Show InChI InChI=1S/C30H30Cl2N4O4/c1-17(2)27-25-26(33-36(27)23-8-6-7-9-24(23)40-5)30(38)35(28(25)21-11-10-19(31)14-18(21)3)20-15-22(32)29(37)34(16-20)12-13-39-4/h6-11,14-17,28H,12-13H2,1-5H3
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n/an/a 0.267n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143526
PNG
(US8969341, 134)
Show SMILES COc1cnc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C#N
Show InChI InChI=1S/C29H25Cl2N5O2/c1-15(2)27-25-26(34-36(27)23-12-20(13-32)33-14-24(23)38-5)29(37)35(22-11-19(31)7-6-16(22)3)28(25)21-9-8-18(30)10-17(21)4/h6-12,14-15,28H,1-5H3
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n/an/a 0.267n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143625
PNG
(US8969341, 163)
Show SMILES CNc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)cn(C)c1=O
Show InChI InChI=1S/C26H25Cl2N7O3/c1-13(2)21-19-20(32-35(21)18-11-30-26(29-3)31-23(18)38-5)25(37)34(17-10-16(28)12-33(4)24(17)36)22(19)14-6-8-15(27)9-7-14/h6-13,22H,1-5H3,(H,29,30,31)
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n/an/a 0.317n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143554
PNG
(US8969341, 146)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)cn(C)c1=O
Show InChI InChI=1S/C27H26Cl2N6O4/c1-13(2)22-20-21(32-35(22)19-11-30-27(39-6)31-24(19)38-5)26(37)34(18-10-16(29)12-33(4)25(18)36)23(20)17-8-7-15(28)9-14(17)3/h7-13,23H,1-6H3
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n/an/a 0.348n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143640
PNG
(US8969341, 166)
Show SMILES CNc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1c[nH]c(=O)c(Cl)c1
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n/an/a 0.357n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143665
PNG
(US8969341, 175)
Show SMILES CNc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1c[nH]c(=O)c(Cl)c1
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n/an/a 0.367n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143581
PNG
(US8969341, 151)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)cn(C)c1=O)N(C)C
Show InChI InChI=1S/C28H27ClN8O3/c1-15(2)23-21-22(33-37(23)20-13-31-28(34(3)4)32-25(20)40-6)27(39)36(19-11-18(29)14-35(5)26(19)38)24(21)17-9-7-16(12-30)8-10-17/h7-11,13-15,24H,1-6H3
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n/an/a 0.370n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143653
PNG
(US8969341, 172)
Show SMILES CNc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C26H25Cl2N7O3/c1-13(2)21-19-20(32-35(21)18-11-30-26(29-3)31-23(18)38-5)25(37)34(16-10-17(28)24(36)33(4)12-16)22(19)14-6-8-15(27)9-7-14/h6-13,22H,1-5H3,(H,29,30,31)
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n/an/a 0.371n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143703
PNG
(US8969341, 191)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(C#N)c(F)c1)c1cc(Cl)cn(C)c1=O)N(C)C
Show InChI InChI=1S/C28H26ClFN8O3/c1-14(2)23-21-22(34-38(23)20-12-32-28(35(3)4)33-25(20)41-6)27(40)37(19-10-17(29)13-36(5)26(19)39)24(21)15-7-8-16(11-31)18(30)9-15/h7-10,12-14,24H,1-6H3
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n/an/a 0.376n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143468
PNG
(US8969341, 109)
Show SMILES CCn1cc(cc(Cl)c1=O)N1C(c2c(nn(c2C(C)C)-c2ccccc2OC)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H26Cl2N4O3/c1-5-32-15-19(14-20(30)27(32)35)33-26(17-10-12-18(29)13-11-17)23-24(28(33)36)31-34(25(23)16(2)3)21-8-6-7-9-22(21)37-4/h6-16,26H,5H2,1-4H3
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n/an/a 0.377n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143514
PNG
(US8969341, 129)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)c(=O)n(C)c1)C#N
Show InChI InChI=1S/C29H25Cl2N5O3/c1-15(2)26-24-25(33-36(26)22-11-17(13-32)6-9-23(22)39-5)29(38)35(19-12-21(31)28(37)34(4)14-19)27(24)20-8-7-18(30)10-16(20)3/h6-12,14-15,27H,1-5H3
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n/an/a 0.382n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143685
PNG
(US8969341, 186)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)c(F)c1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C26H23Cl2FN6O4/c1-12(2)21-19-20(32-35(21)18-10-30-26(39-5)31-23(18)38-4)25(37)34(14-9-16(28)24(36)33(3)11-14)22(19)13-6-7-15(27)17(29)8-13/h6-12,22H,1-5H3
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n/an/a 0.384n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143469
PNG
(US8969341, 110)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C28H26Cl2N4O3/c1-15(2)25-23-24(31-34(25)21-8-6-7-9-22(21)37-5)28(36)33(18-13-20(30)27(35)32(4)14-18)26(23)19-11-10-17(29)12-16(19)3/h6-15,26H,1-5H3
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n/an/a 0.393n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143518
PNG
(US8969341, 131)
Show SMILES COc1ccc(CNC(C)=O)cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C31H31Cl2N5O4/c1-16(2)28-26-27(35-38(28)24-12-19(14-34-18(4)39)7-10-25(24)42-6)31(41)37(21-13-23(33)30(40)36(5)15-21)29(26)22-9-8-20(32)11-17(22)3/h7-13,15-16,29H,14H2,1-6H3,(H,34,39)
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n/an/a 0.396n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 345 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%