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Patent code US8987248

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150313
PNG
(US8987248, 106)
Show SMILES FC(F)(F)Oc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCC(CC1)C#N)NC(=O)c1ccccc1
Show InChI InChI=1S/C26H27F3N4O3/c27-26(28,29)36-23-8-6-19(7-9-23)21-14-22(31-24(34)20-4-2-1-3-5-20)17-33(16-21)25(35)32-12-10-18(15-30)11-13-32/h1-9,18,21-22H,10-14,16-17H2,(H,31,34)
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n/an/a 7.05n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150314
PNG
(US8987248, 115)
Show SMILES FC(F)(F)Oc1ccc(cc1)C1CC(CN(C1)C(=O)c1ccncc1)NC(=O)c1ccccc1
Show InChI InChI=1S/C25H22F3N3O3/c26-25(27,28)34-22-8-6-17(7-9-22)20-14-21(30-23(32)18-4-2-1-3-5-18)16-31(15-20)24(33)19-10-12-29-13-11-19/h1-13,20-21H,14-16H2,(H,30,32)
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n/an/a 11.1n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150322
PNG
(US8987248, 156)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCC(CC1)C#N)NC(=O)c1cccc(OC)c1
Show InChI InChI=1S/C28H34N4O3/c1-3-20-7-9-22(10-8-20)24-15-25(30-27(33)23-5-4-6-26(16-23)35-2)19-32(18-24)28(34)31-13-11-21(17-29)12-14-31/h4-10,16,21,24-25H,3,11-15,18-19H2,1-2H3,(H,30,33)
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n/an/a 11.1n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150319
PNG
(US8987248, 133)
Show SMILES C[C@@H]1CC[C@@H](C)N1C(=O)N1CC(CC(C1)c1ccc(cc1)C(F)(F)F)NC(=O)c1ccccc1 |r|
Show InChI InChI=1S/C26H30F3N3O2/c1-17-8-9-18(2)32(17)25(34)31-15-21(19-10-12-22(13-11-19)26(27,28)29)14-23(16-31)30-24(33)20-6-4-3-5-7-20/h3-7,10-13,17-18,21,23H,8-9,14-16H2,1-2H3,(H,30,33)/t17-,18-,21?,23?/m1/s1
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n/an/a 14.6n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150320
PNG
(US8987248, 134)
Show SMILES FC(F)(F)c1ccc(cc1)C1CC(CN(C1)C(=O)N1CCS(=O)(=O)CC1)NC(=O)c1ccccc1
Show InChI InChI=1S/C24H26F3N3O4S/c25-24(26,27)20-8-6-17(7-9-20)19-14-21(28-22(31)18-4-2-1-3-5-18)16-30(15-19)23(32)29-10-12-35(33,34)13-11-29/h1-9,19,21H,10-16H2,(H,28,31)
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n/an/a 15.4n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150315
PNG
(US8987248, 119)
Show SMILES Cc1ccc(cc1C)C1CC(CN(C1)C(=O)C1(N)CCC1)NC(=O)c1ccccc1
Show InChI InChI=1S/C25H31N3O2/c1-17-9-10-20(13-18(17)2)21-14-22(27-23(29)19-7-4-3-5-8-19)16-28(15-21)24(30)25(26)11-6-12-25/h3-5,7-10,13,21-22H,6,11-12,14-16,26H2,1-2H3,(H,27,29)
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n/an/a 15.7n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150317
PNG
(US8987248, 128)
Show SMILES FC(F)(F)c1ccc(cc1)C1CC(CN(C1)C(=O)N1CCOCC1)NC(=O)c1ccccc1
Show InChI InChI=1S/C24H26F3N3O3/c25-24(26,27)20-8-6-17(7-9-20)19-14-21(28-22(31)18-4-2-1-3-5-18)16-30(15-19)23(32)29-10-12-33-13-11-29/h1-9,19,21H,10-16H2,(H,28,31)
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n/an/a 17.0n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150307
PNG
(US8987248, 91)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCCC1)NC(=O)Nc1ccccc1
Show InChI InChI=1S/C25H32N4O2/c1-2-19-10-12-20(13-11-19)21-16-23(27-24(30)26-22-8-4-3-5-9-22)18-29(17-21)25(31)28-14-6-7-15-28/h3-5,8-13,21,23H,2,6-7,14-18H2,1H3,(H2,26,27,30)
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n/an/a 17.4n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150312
PNG
(US8987248, 105)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCOCC1)OC(=O)Nc1ccccc1
Show InChI InChI=1S/C25H31N3O4/c1-2-19-8-10-20(11-9-19)21-16-23(32-24(29)26-22-6-4-3-5-7-22)18-28(17-21)25(30)27-12-14-31-15-13-27/h3-11,21,23H,2,12-18H2,1H3,(H,26,29)
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n/an/a 18.4n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150305
PNG
(US8987248, 83)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1CCCC1)NC(=O)c1ccc(cn1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C32H34F3N3O2/c1-2-21-10-12-22(13-11-21)26-17-28(20-38(19-26)31(40)23-6-3-4-7-23)37-30(39)29-15-14-25(18-36-29)24-8-5-9-27(16-24)32(33,34)35/h5,8-16,18,23,26,28H,2-4,6-7,17,19-20H2,1H3,(H,37,39)
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n/an/a 19.7n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150324
PNG
(BDBM150325 | US8987248, 170)
Show SMILES OC1CCN(CC1)C(=O)N1CC(CC(C1)c1ccc(cc1)C(F)(F)F)NC(=O)C1CCCC1
Show InChI InChI=1S/C24H32F3N3O3/c25-24(26,27)19-7-5-16(6-8-19)18-13-20(28-22(32)17-3-1-2-4-17)15-30(14-18)23(33)29-11-9-21(31)10-12-29/h5-8,17-18,20-21,31H,1-4,9-15H2,(H,28,32)
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n/an/a 21.3n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150323
PNG
(US8987248, 162)
Show SMILES Cc1cccc(n1)C(=O)NC1CC(CN(C1)C(=O)N1CCOCC1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H27F3N4O3/c1-16-3-2-4-21(28-16)22(32)29-20-13-18(17-5-7-19(8-6-17)24(25,26)27)14-31(15-20)23(33)30-9-11-34-12-10-30/h2-8,18,20H,9-15H2,1H3,(H,29,32)
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n/an/a 25n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150301
PNG
(US8987248, 7)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C(C)(C)CF)C(=O)Nc1ccccc1
Show InChI InChI=1S/C25H31FN2O2/c1-4-18-10-12-19(13-11-18)20-14-21(23(29)27-22-8-6-5-7-9-22)16-28(15-20)24(30)25(2,3)17-26/h5-13,20-21H,4,14-17H2,1-3H3,(H,27,29)
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n/an/a 29n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150318
PNG
(US8987248, 129)
Show SMILES OC1CCN(CC1)C(=O)N1CC(CC(C1)c1ccc(cc1)C(F)(F)F)NC(=O)c1ccccc1
Show InChI InChI=1S/C25H28F3N3O3/c26-25(27,28)20-8-6-17(7-9-20)19-14-21(29-23(33)18-4-2-1-3-5-18)16-31(15-19)24(34)30-12-10-22(32)11-13-30/h1-9,19,21-22,32H,10-16H2,(H,29,33)
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n/an/a 33.6n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150321
PNG
(US8987248, 141)
Show SMILES FC(F)(F)c1ccc(cc1)C1CC(CN(C1)C(=O)N1CCNC(=O)C1)NC(=O)c1ccccc1
Show InChI InChI=1S/C24H25F3N4O3/c25-24(26,27)19-8-6-16(7-9-19)18-12-20(29-22(33)17-4-2-1-3-5-17)14-31(13-18)23(34)30-11-10-28-21(32)15-30/h1-9,18,20H,10-15H2,(H,28,32)(H,29,33)
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n/an/a 53.7n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150326
PNG
(US8987248, 178)
Show SMILES FC(F)(F)c1ccc(cc1)C1CC(CN(C1)C(=O)N1CCC(CC1)C#N)NC(=O)C1CCCC1
Show InChI InChI=1S/C25H31F3N4O2/c26-25(27,28)21-7-5-18(6-8-21)20-13-22(30-23(33)19-3-1-2-4-19)16-32(15-20)24(34)31-11-9-17(14-29)10-12-31/h5-8,17,19-20,22H,1-4,9-13,15-16H2,(H,30,33)
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n/an/a 63n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150316
PNG
(US8987248, 121)
Show SMILES CC(C)c1cccc(c1)C1CC(CN(C1)C(=O)N1CCOCC1)NC(=O)c1ccccc1
Show InChI InChI=1S/C26H33N3O3/c1-19(2)21-9-6-10-22(15-21)23-16-24(27-25(30)20-7-4-3-5-8-20)18-29(17-23)26(31)28-11-13-32-14-12-28/h3-10,15,19,23-24H,11-14,16-18H2,1-2H3,(H,27,30)
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n/an/a 79.9n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150324
PNG
(BDBM150325 | US8987248, 170)
Show SMILES OC1CCN(CC1)C(=O)N1CC(CC(C1)c1ccc(cc1)C(F)(F)F)NC(=O)C1CCCC1
Show InChI InChI=1S/C24H32F3N3O3/c25-24(26,27)19-7-5-16(6-8-19)18-13-20(28-22(32)17-3-1-2-4-17)15-30(14-18)23(33)29-11-9-21(31)10-12-29/h5-8,17-18,20-21,31H,1-4,9-15H2,(H,28,32)
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n/an/a 81n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150304
PNG
(US8987248, 36)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)c1scnc1C)C(=O)Nc1ccccc1
Show InChI InChI=1S/C25H27N3O2S/c1-3-18-9-11-19(12-10-18)20-13-21(24(29)27-22-7-5-4-6-8-22)15-28(14-20)25(30)23-17(2)26-16-31-23/h4-12,16,20-21H,3,13-15H2,1-2H3,(H,27,29)
PDB

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n/an/a 98.2n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150309
PNG
(US8987248, 97)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1CCCC1)NC(=O)NC(C)(C)C
Show InChI InChI=1S/C24H37N3O2/c1-5-17-10-12-18(13-11-17)20-14-21(25-23(29)26-24(2,3)4)16-27(15-20)22(28)19-8-6-7-9-19/h10-13,19-21H,5-9,14-16H2,1-4H3,(H2,25,26,29)
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UniProtKB/SwissProt

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n/an/a 109n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150302
PNG
(US8987248, 8)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)CCOC)C(=O)Nc1ccccc1
Show InChI InChI=1S/C24H30N2O3/c1-3-18-9-11-19(12-10-18)20-15-21(17-26(16-20)23(27)13-14-29-2)24(28)25-22-7-5-4-6-8-22/h4-12,20-21H,3,13-17H2,1-2H3,(H,25,28)
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n/an/a 109n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150310
PNG
(US8987248, 102)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCOCC1)NC(=O)OC
Show InChI InChI=1S/C20H29N3O4/c1-3-15-4-6-16(7-5-15)17-12-18(21-19(24)26-2)14-23(13-17)20(25)22-8-10-27-11-9-22/h4-7,17-18H,3,8-14H2,1-2H3,(H,21,24)
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n/an/a 165n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150308
PNG
(US8987248, 95)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1CCCC1)NC(=O)N(C)c1ccccc1
Show InChI InChI=1S/C27H35N3O2/c1-3-20-13-15-21(16-14-20)23-17-24(19-30(18-23)26(31)22-9-7-8-10-22)28-27(32)29(2)25-11-5-4-6-12-25/h4-6,11-16,22-24H,3,7-10,17-19H2,1-2H3,(H,28,32)
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n/an/a 237n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150311
PNG
(US8987248, 104)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1CCCC1)NS(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C26H34N2O3S/c1-2-20-12-14-22(15-13-20)24-16-25(18-28(17-24)26(29)23-10-6-7-11-23)27-32(30,31)19-21-8-4-3-5-9-21/h3-5,8-9,12-15,23-25,27H,2,6-7,10-11,16-19H2,1H3
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n/an/a 248n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150306
PNG
(US8987248, 90)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1CCCC1)NC(=O)C(C)(C)C
Show InChI InChI=1S/C24H36N2O2/c1-5-17-10-12-18(13-11-17)20-14-21(25-23(28)24(2,3)4)16-26(15-20)22(27)19-8-6-7-9-19/h10-13,19-21H,5-9,14-16H2,1-4H3,(H,25,28)
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n/an/a 359n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150303
PNG
(US8987248, 18)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1(CC)COC1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C26H32N2O3/c1-3-19-10-12-20(13-11-19)21-14-22(24(29)27-23-8-6-5-7-9-23)16-28(15-21)25(30)26(4-2)17-31-18-26/h5-13,21-22H,3-4,14-18H2,1-2H3,(H,27,29)
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n/an/a 483n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%