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Patent code US8987319

Compile Data Set for Download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Androgen receptor


(Homo sapiens (Human))
BDBM50331713
PNG
(5,7-dichloro-3-(trifluoromethyl)-1,2,3,4-tetrahydr...)
Show SMILES OC1(CCc2c1[nH]c1c(Cl)cc(Cl)cc21)C(F)(F)F
Show InChI InChI=1S/C12H8Cl2F3NO/c13-5-3-7-6-1-2-11(19,12(15,16)17)10(6)18-9(7)8(14)4-5/h3-4,18-19H,1-2H2
PDB
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US Patent
n/an/a 13n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151588
PNG
(US8987319, 9b)
Show SMILES O[C@@]1(CCCc2c1[nH]c1cc(Cl)c(Cl)cc21)C(F)(F)F
Show InChI InChI=1S/C13H10Cl2F3NO/c14-8-4-7-6-2-1-3-12(20,13(16,17)18)11(6)19-10(7)5-9(8)15/h4-5,19-20H,1-3H2/t12-/m1/s1
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n/an/a 13n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331698
PNG
(5,6-dichloro-9H-carbazol-1-ol | CHEMBL1288959)
Show SMILES Oc1cccc2c1[nH]c1ccc(Cl)c(Cl)c21
Show InChI InChI=1S/C12H7Cl2NO/c13-7-4-5-8-10(11(7)14)6-2-1-3-9(16)12(6)15-8/h1-5,15-16H
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n/an/a 15n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151593
PNG
(US8987319, 16)
Show SMILES OC1(CCCc2c1[nH]c1cc(Cl)c(F)cc21)C(F)(F)F
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n/an/a 20n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151589
PNG
(US8987319, 10)
Show SMILES O[C@@]1(CCCc2c1[nH]c1c(Cl)cc(Cl)cc21)C(F)(F)F
Show InChI InChI=1S/C13H10Cl2F3NO/c14-6-4-8-7-2-1-3-12(20,13(16,17)18)11(7)19-10(8)9(15)5-6/h4-5,19-20H,1-3H2/t12-/m1/s1
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n/an/a 20n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331697
PNG
(2-bromo-6,7-dichloro-9H-carbazol-1-ol | CHEMBL1288...)
Show SMILES Oc1c(Br)ccc2c1[nH]c1cc(Cl)c(Cl)cc21
Show InChI InChI=1S/C12H6BrCl2NO/c13-7-2-1-5-6-3-8(14)9(15)4-10(6)16-11(5)12(7)17/h1-4,16-17H
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n/an/a 34n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331710
PNG
(6,7-dichloro-1-(perfluoroethyl)-2,3,4,9-tetrahydro...)
Show SMILES OC1(CCCc2c1[nH]c1cc(Cl)c(Cl)cc21)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C14H10Cl2F5NO/c15-8-4-7-6-2-1-3-12(23,13(17,18)14(19,20)21)11(6)22-10(7)5-9(8)16/h4-5,22-23H,1-3H2
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n/an/a 34n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331701
PNG
(6,8-dichloro-1-(trifluoromethyl)-2,3,4,9-tetrahydr...)
Show SMILES OC1(CCCc2c1[nH]c1c(Cl)cc(Cl)cc21)C(F)(F)F
Show InChI InChI=1S/C13H10Cl2F3NO/c14-6-4-8-7-2-1-3-12(20,13(16,17)18)11(7)19-10(8)9(15)5-6/h4-5,19-20H,1-3H2
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n/an/a 34n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151602
PNG
(US8987319, 28)
Show SMILES OC1(CCCc2c1[nH]c1c(F)cc(Cl)cc21)C(F)(F)F
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n/an/a 54n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151592
PNG
(US8987319, 15)
Show SMILES OC1C(F)CC(c2c1[nH]c1ccc(Cl)c(Cl)c21)C(F)(F)F
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n/an/a 70n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331702
PNG
(5,8-dichloro-1-(trifluoromethyl)-2,3,4,9-tetrahydr...)
Show SMILES OC1(CCCc2c1[nH]c1c(Cl)ccc(Cl)c21)C(F)(F)F
Show InChI InChI=1S/C13H10Cl2F3NO/c14-7-3-4-8(15)10-9(7)6-2-1-5-12(20,11(6)19-10)13(16,17)18/h3-4,19-20H,1-2,5H2
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n/an/a 85n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331704
PNG
(8-chloro-6-fluoro-1-(trifluoromethyl)-2,3,4,9-tetr...)
Show SMILES OC1(CCCc2c1[nH]c1c(Cl)cc(F)cc21)C(F)(F)F
Show InChI InChI=1S/C13H10ClF4NO/c14-9-5-6(15)4-8-7-2-1-3-12(20,13(16,17)18)11(7)19-10(8)9/h4-5,19-20H,1-3H2
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n/an/a 90n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331712
PNG
(6,8-dichloro-2,2-difluoro-1-(trifluoromethyl)-2,3,...)
Show SMILES OC1(c2[nH]c3c(Cl)cc(Cl)cc3c2CCC1(F)F)C(F)(F)F
Show InChI InChI=1S/C13H8Cl2F5NO/c14-5-3-7-6-1-2-11(16,17)12(22,13(18,19)20)10(6)21-9(7)8(15)4-5/h3-4,21-22H,1-2H2
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n/an/a 100n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151601
PNG
(US8987319, 27)
Show SMILES OC1(CCc2c1[nH]c1cc(Cl)c(Cl)cc21)C(F)(F)F
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n/an/a 120n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151599
PNG
(US8987319, 25)
Show SMILES OC1(CCCc2c1[nH]c1c(Cl)c(Cl)ccc21)C(F)(F)F
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n/an/a 130n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151590
PNG
(US8987319, 12)
Show SMILES OC1(C(F)CCc2c1[nH]c1cc(Cl)c(Cl)cc21)C(F)(F)F
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n/an/a 140n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151603
PNG
(US8987319, 29)
Show SMILES OC1(CCc2c1[nH]c1ccc(Cl)c(Cl)c21)C(F)(F)F
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n/an/a 175n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151595
PNG
(US8987319, 19)
Show SMILES OC1(c2[nH]c3cc(Cl)c(Cl)cc3c2CCC1(F)F)C(F)(F)F
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n/an/a 220n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151604
PNG
(US8987319, 30)
Show SMILES OC1(CCCc2c1[nH]c1c(cc(cc21)C#N)C(F)(F)F)C(F)(F)F
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n/an/a 390n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151597
PNG
(US8987319, 23)
Show SMILES CC1CCc2c([nH]c3ccc(Cl)c(Cl)c23)C1(O)C(F)(F)F
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n/an/a 400n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151598
PNG
(US8987319, 24)
Show SMILES OC1(CCCc2c1[nH]c1cc(Cl)c(Cl)c(Cl)c21)C(F)(F)F
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n/an/a 410n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331707
PNG
(1-hydroxy-1-(trifluoromethyl)-2,3,4,9-tetrahydro-1...)
Show SMILES OC1(CCCc2c1[nH]c1ccc(cc21)C#N)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O/c15-14(16,17)13(20)5-1-2-9-10-6-8(7-18)3-4-11(10)19-12(9)13/h3-4,6,19-20H,1-2,5H2
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n/an/a 480n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151591
PNG
(US8987319, 14)
Show SMILES OC1(CCCc2c1[nH]c1ccc(F)c(Cl)c21)C(F)(F)F
PDB
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n/an/a 520n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331703
PNG
(2,4-dichloro-6-(trifluoromethyl)-5,6,7,8,9,10-hexa...)
Show SMILES OC1(CCCCc2c1[nH]c1c(Cl)cc(Cl)cc21)C(F)(F)F
Show InChI InChI=1S/C14H12Cl2F3NO/c15-7-5-9-8-3-1-2-4-13(21,14(17,18)19)12(8)20-11(9)10(16)6-7/h5-6,20-21H,1-4H2
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US Patent
n/an/a 600n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331699
PNG
(2-benzyl-6,7-dichloro-9H-carbazol-1-ol | CHEMBL129...)
Show SMILES Oc1c(Cc2ccccc2)ccc2c1[nH]c1cc(Cl)c(Cl)cc21
Show InChI InChI=1S/C19H13Cl2NO/c20-15-9-14-13-7-6-12(8-11-4-2-1-3-5-11)19(23)18(13)22-17(14)10-16(15)21/h1-7,9-10,22-23H,8H2
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n/an/a>1.00E+3n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151600
PNG
(US8987319, 26)
Show SMILES CC1CC(c2c([nH]c3cc(Cl)c(Cl)cc23)C1O)C(F)(F)F
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n/an/a>1.00E+3n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151587
PNG
(US8987319, 9a)
Show SMILES O[C@]1(CCCc2c1[nH]c1cc(Cl)c(Cl)cc21)C(F)(F)F
Show InChI InChI=1S/C13H10Cl2F3NO/c14-8-4-7-6-2-1-3-12(20,13(16,17)18)11(6)19-10(7)5-9(8)15/h4-5,19-20H,1-3H2/t12-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331700
PNG
(2-benzyl-5,6-dichloro-9H-carbazol-1-ol | CHEMBL129...)
Show SMILES Oc1c(Cc2ccccc2)ccc2c1[nH]c1ccc(Cl)c(Cl)c21
Show InChI InChI=1S/C19H13Cl2NO/c20-14-8-9-15-16(17(14)21)13-7-6-12(19(23)18(13)22-15)10-11-4-2-1-3-5-11/h1-9,22-23H,10H2
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n/an/a>1.00E+3n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331695
PNG
(6-bromo-9H-carbazol-1-ol | CHEMBL1288956)
Show SMILES Oc1cccc2c3cc(Br)ccc3[nH]c12
Show InChI InChI=1S/C12H8BrNO/c13-7-4-5-10-9(6-7)8-2-1-3-11(15)12(8)14-10/h1-6,14-15H
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n/an/a 1.42E+3n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331708
PNG
(6,7-dichloro-1-(trifluoromethyl)-2,3,4,9-tetrahydr...)
Show SMILES OC1(CCCc2c1[nH]c1cc(Cl)c(Cl)cc21)C(F)(F)F
Show InChI InChI=1S/C13H10Cl2F3NO/c14-8-4-7-6-2-1-3-12(20,13(16,17)18)11(6)19-10(7)5-9(8)15/h4-5,19-20H,1-3H2
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n/an/a 1.56E+3n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331696
PNG
(8-hydroxy-9H-carbazole-3-carbonitrile | CHEMBL1288...)
Show SMILES Oc1cccc2c3cc(ccc3[nH]c12)C#N
Show InChI InChI=1S/C13H8N2O/c14-7-8-4-5-11-10(6-8)9-2-1-3-12(16)13(9)15-11/h1-6,15-16H
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n/an/a 4.60E+3n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331706
PNG
(1-hydroxy-1-methyl-2,3,4,9-tetrahydro-1H-carbazole...)
Show SMILES CC1(O)CCCc2c1[nH]c1ccc(cc21)C#N
Show InChI InChI=1S/C14H14N2O/c1-14(17)6-2-3-10-11-7-9(8-15)4-5-12(11)16-13(10)14/h4-5,7,16-17H,2-3,6H2,1H3
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n/an/a 9.20E+3n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151594
PNG
(US8987319, 18)
Show SMILES OC1(C(CCc2c1[nH]c1c(Cl)cc(F)cc21)C(F)(F)F)C(F)(F)F
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n/an/a>1.00E+4n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331711
PNG
(1-hydroxy-1-(perfluoroethyl)-2,3,4,9-tetrahydro-1H...)
Show SMILES OC1(CCCc2c1[nH]c1ccc(cc21)C#N)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C15H11F5N2O/c16-14(17,15(18,19)20)13(23)5-1-2-9-10-6-8(7-21)3-4-11(10)22-12(9)13/h3-4,6,22-23H,1-2,5H2
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n/an/a>1.00E+4n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM151596
PNG
(US8987319, 21)
Show SMILES OC1(CCCc2c1[nH]c1c(Cl)cc(Cl)c(Cl)c21)C(F)(F)F
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n/an/a>1.00E+4n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331705
PNG
(6,7-dichloro-1-methyl-2,3,4,9-tetrahydro-1H-carbaz...)
Show SMILES CC1(O)CCCc2c1[nH]c1cc(Cl)c(Cl)cc21
Show InChI InChI=1S/C13H13Cl2NO/c1-13(17)4-2-3-7-8-5-9(14)10(15)6-11(8)16-12(7)13/h5-6,16-17H,2-4H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))
BDBM50331709
PNG
(5,6-dichloro-1-(trifluoromethyl)-2,3,4,9-tetrahydr...)
Show SMILES OC1(CCCc2c1[nH]c1ccc(Cl)c(Cl)c21)C(F)(F)F
Show InChI InChI=1S/C13H10Cl2F3NO/c14-7-3-4-8-9(10(7)15)6-2-1-5-12(20,11(6)19-8)13(16,17)18/h3-4,19-20H,1-2,5H2
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n/an/a 4.02E+4n/an/an/an/an/a25



Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...


US Patent US8987319 (2015)


BindingDB Entry DOI: 10.7270/Q2MG7N7P
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%