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Patent code US8999981

Compile Data Set for Download or QSAR

Found 252 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153901
PNG
(US8999981, A146)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
PDB
MMDB

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US Patent
1.70 -50.9n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153898
PNG
(US8999981, A143)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
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US Patent
1.90 -50.6n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153757
PNG
(US8999981, A2)
Show SMILES C[C@H]1CN(C)C2(CCCC2)CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
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US Patent
3.05 -49.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM154004
PNG
(US8999981, F60)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(cn3)C(F)(F)F)n[nH]c2C1(C)C |r|
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US Patent
4.17 -48.6n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153933
PNG
(US8999981, E3)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc4ccccc4cn3)n[nH]c2C1(C)C |r|
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US Patent
5.51 -47.9n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153934
PNG
(US8999981, E4)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc4cnccc4n3)n[nH]c2C1(C)C |r|
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US Patent
6.17 -47.6n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153936
PNG
(US8999981, E6)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc(n[nH]3)C3CC3)n[nH]c2C1(C)C |r|
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US Patent
6.81 -47.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153888
PNG
(US8999981, A133)
Show SMILES C[C@H]1CN(C)C2(CCC2)CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
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US Patent
8.58 -46.8n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153850
PNG
(US8999981, A95)
Show SMILES CCN1C[C@H](C)N(C[C@H]1C)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
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US Patent
9.11 -46.7n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153838
PNG
(US8999981, A83)
Show SMILES CCCN1C[C@H](C)N(C[C@H]1CCO)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
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US Patent
9.53 -46.5n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM154005
PNG
(US8999981, G1 | US8999981, G3)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(cn3)C#N)n[nH]c2C1(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM154000
PNG
(US8999981, F56)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(Cl)cn3)n[nH]c2C1(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153999
PNG
(US8999981, F55)
Show SMILES COc1ccc(nc1)C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H](C)N(C[C@@H]1C)C1CCOCC1)C2(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153995
PNG
(US8999981, F51)
Show SMILES CCc1ccc(nc1)C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H](C)N(C[C@@H]1C)C1CCOCC1)C2(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153996
PNG
(US8999981, F52)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(cn3)N3CCOCC3)n[nH]c2C1(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153988
PNG
(US8999981, F44)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cccc(C)c3)n[nH]c2C1(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153902
PNG
(US8999981, A147)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CC1CCOC1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153991
PNG
(US8999981, F47)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cccc(F)c3)n[nH]c2C1(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM154005
PNG
(US8999981, G1 | US8999981, G3)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(cn3)C#N)n[nH]c2C1(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153978
PNG
(US8999981, F34)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cc(C)nn3C)n[nH]c2C1(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153973
PNG
(US8999981, F29)
Show SMILES C.COc1ccc(nc1)C(=O)Nc1n[nH]c2c1CN(C(=O)N1CCN(CC3CCOCC3)C[C@@H]1C)C2(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153904
PNG
(US8999981, A149)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(F)cn3)n[nH]c2C1(C)C |r|
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US Patent
<10<-46.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153829
PNG
(US8999981, A74)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3nc(Cl)c(Cl)s3)n[nH]c2C1(C)C |r|
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US Patent
10.4 -46.3n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153940
PNG
(US8999981, E10)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc(nn3C)C(C)(C)C)n[nH]c2C1(C)C |r|
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US Patent
10.6 -46.3n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153990
PNG
(US8999981, F46)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cc3)n[nH]c2C1(C)C |r|
PDB
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Similars

US Patent
11.2 -46.1n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153974
PNG
(US8999981, F30)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(Cl)cn3)n[nH]c2C1(C)C |r|
PDB
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US Patent
11.9 -46.0n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153998
PNG
(US8999981, F54)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(C)cn3)n[nH]c2C1(C)C |r|
PDB
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US Patent
12.2 -45.9n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153937
PNG
(US8999981, E7)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cnc4ccccc4n3)n[nH]c2C1(C)C |r|
PDB
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US Patent
12.5 -45.9n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153976
PNG
(US8999981, F32)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3csc(C)n3)n[nH]c2C1(C)C |r|
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US Patent
12.8 -45.8n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153970
PNG
(US8999981, F26)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cn3)n[nH]c2C1(C)C |r|
PDB
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US Patent
12.8 -45.8n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153858
PNG
(US8999981, A103)
Show SMILES C[C@H]1CN2CCC[C@H]2CC1C(=O)N1Cc2c(NC(=O)c3csc(Br)n3)n[nH]c2C1(C)C |r|
PDB
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US Patent
12.9 -45.8n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153878
PNG
(US8999981, A123)
Show SMILES C.CCCCN1CCN([C@@H](C)C1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
PDB
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US Patent
13.3 -45.7n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153853
PNG
(US8999981, A122 | US8999981, A98)
Show SMILES C.C[C@H]1CN(CC2CC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
PDB
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US Patent
13.3 -45.7n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153868
PNG
(US8999981, A113)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
PDB
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US Patent
13.9 -45.6n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153831
PNG
(US8999981, A76)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc4cccn4cn3)n[nH]c2C1(C)C |r|
PDB
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US Patent
13.9 -45.6n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153791
PNG
(US8999981, A36)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc(Cl)c(Cl)c3)n[nH]c2C1(C)C |r|
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US Patent
13.9 -45.6n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153981
PNG
(US8999981, F37)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cn(cn3)C3CCC3)n[nH]c2C1(C)C |r|
PDB
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US Patent
14.1 -45.6n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153855
PNG
(US8999981, A100)
Show SMILES CC(C)[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
PDB
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US Patent
14.1 -45.6n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153874
PNG
(US8999981, A119 | US8999981, A121)
Show SMILES C.CCCN1CCN([C@@H](C)C1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
PDB
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US Patent
14.6 -45.5n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153983
PNG
(US8999981, F39)
Show SMILES C.CCC1NC(=CO1)C(=O)Nc1n[nH]c2c1CN(C(=O)N1CCN(CC3CCOCC3)C[C@@H]1C)C2(C)C |r,c:4|
PDB
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US Patent
14.9 -45.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153975
PNG
(US8999981, F31)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cccc(C)n3)n[nH]c2C1(C)C |r|
PDB
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US Patent
15 -45.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153839
PNG
(US8999981, A84 | US8999981, A85)
Show SMILES [H][C@@]1(CN2C[C@H](O)C[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C)[C@@H](C)CC |r|
PDB
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US Patent
15.2 -45.4n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153984
PNG
(US8999981, F40)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3coc(n3)C3CC3)n[nH]c2C1(C)C |r|
PDB
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US Patent
15.7 -45.3n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153844
PNG
(US8999981, A89)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CC=C)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
PDB
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US Patent
15.7 -45.3n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153819
PNG
(US8999981, A64)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc4OCCc4c3)n[nH]c2C1(C)C |r|
PDB
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US Patent
15.9 -45.3n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153768
PNG
(US8999981, A13 | US8999981, A14)
Show SMILES CC1(C)N(Cc2c(NC(=O)c3ccc4ccccc4n3)n[nH]c12)C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 |r|
PDB
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US Patent
16.1 -45.2n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153772
PNG
(US8999981, A17)
Show SMILES COc1cccc(c1)C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H]3CCCN3C[C@@H]1Cc1ccccc1)C2(C)C |r|
PDB
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US Patent
16.1 -45.2n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153815
PNG
(US8999981, A60)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cccc(c3)C#N)n[nH]c2C1(C)C |r|
PDB
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US Patent
17.1 -45.1n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153900
PNG
(US8999981, A145)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CCC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C |r|
PDB
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US Patent
17.6 -45.0n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM153843
PNG
(US8999981, A88)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc4ccccc4n3)n[nH]c2C1(C)C |r|
PDB
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US Patent
17.8 -45.0n/an/an/an/an/a7.430



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)


BindingDB Entry DOI: 10.7270/Q2RR1X0K
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%