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Patent code US8999982

Compile Data Set for Download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153641
PNG
(US8999982, Ref4)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4ccsc4)cc3)c2cc1OC
Show InChI InChI=1S/C22H18N2O4S/c1-26-20-11-17-18(12-21(20)27-2)23-9-7-19(17)28-16-5-3-15(4-6-16)24-22(25)14-8-10-29-13-14/h3-13H,1-2H3,(H,24,25)
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n/an/a 7.04E+3n/an/an/an/a8.0n/a



Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153643
PNG
(US8999982, Ref6)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cccs4)cc3)c2cc1OC
Show InChI InChI=1S/C22H18N2O4S/c1-26-19-12-16-17(13-20(19)27-2)23-10-9-18(16)28-15-7-5-14(6-8-15)24-22(25)21-4-3-11-29-21/h3-13H,1-2H3,(H,24,25)
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n/an/a 8.29E+3n/an/an/an/a8.0n/a



Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153652
PNG
(US8999982, 3-fluoro-4-((6-methoxy-7-(3- morpholino...)
Show SMILES COc1cc2c(Oc3ccc(N)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C23H26FN3O4/c1-28-22-14-17-19(15-23(22)30-10-2-7-27-8-11-29-12-9-27)26-6-5-20(17)31-21-4-3-16(25)13-18(21)24/h3-6,13-15H,2,7-12,25H2,1H3
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n/an/a 8.50E+3n/an/an/an/a8.0n/a



Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153644
PNG
(US8999982, Ref7)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4ccccn4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19N3O4/c1-28-21-13-17-19(14-22(21)29-2)25-12-10-20(17)30-16-8-6-15(7-9-16)26-23(27)18-5-3-4-11-24-18/h3-14H,1-2H3,(H,26,27)
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n/an/a 9.30E+3n/an/an/an/a8.0n/a



Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153649
PNG
(US8999982, 5-((6,7-dimethoxyquinolin-4- yl)oxy)pyr...)
Show SMILES COc1cc2nccc(Oc3ccc(N)nc3)c2cc1OC
Show InChI InChI=1S/C16H15N3O3/c1-20-14-7-11-12(8-15(14)21-2)18-6-5-13(11)22-10-3-4-16(17)19-9-10/h3-9H,1-2H3,(H2,17,19)
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n/an/a>1.00E+4n/an/an/an/a8.0n/a



Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153653
PNG
(US8999982, tert-butyl 4-(((4-(4-amino-2- fluorophe...)
Show SMILES COc1cc2c(Oc3ccc(N)cc3F)ccnc2cc1OCC1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H32FN3O5/c1-27(2,3)36-26(32)31-11-8-17(9-12-31)16-34-25-15-21-19(14-24(25)33-4)22(7-10-30-21)35-23-6-5-18(29)13-20(23)28/h5-7,10,13-15,17H,8-9,11-12,16,29H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/a8.0n/a



Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50317324
PNG
(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2cc1OC
Show InChI InChI=1S/C28H20F4N4O4/c1-38-24-13-18-21(14-25(24)39-2)33-11-10-22(18)40-23-9-8-16(12-20(23)29)35-27(37)19-15-34-36(26(19)28(30,31)32)17-6-4-3-5-7-17/h3-15H,1-2H3,(H,35,37)
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Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153640
PNG
(US8999982, Ref3)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4ccco4)cc3)c2cc1OC
Show InChI InChI=1S/C22H18N2O5/c1-26-20-12-16-17(13-21(20)27-2)23-10-9-18(16)29-15-7-5-14(6-8-15)24-22(25)19-4-3-11-28-19/h3-13H,1-2H3,(H,24,25)
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Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153642
PNG
(US8999982, Ref5)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4ccncc4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19N3O4/c1-28-21-13-18-19(14-22(21)29-2)25-12-9-20(18)30-17-5-3-16(4-6-17)26-23(27)15-7-10-24-11-8-15/h3-14H,1-2H3,(H,26,27)
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Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153648
PNG
(US8999982, 3-chloro-4-((6,7- dimethoxyquinolin-4- ...)
Show SMILES COc1cc2nccc(Oc3ccc(N)cc3Cl)c2cc1OC
Show InChI InChI=1S/C17H15ClN2O3/c1-21-16-8-11-13(9-17(16)22-2)20-6-5-14(11)23-15-4-3-10(19)7-12(15)18/h3-9H,19H2,1-2H3
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Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153650
PNG
(US8999982, 4-((6,7-dimethoxyquinolin-4- yl)oxy)-2-...)
Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1N
Show InChI InChI=1S/C18H18N2O4/c1-21-16-8-11(4-5-13(16)19)24-15-6-7-20-14-10-18(23-3)17(22-2)9-12(14)15/h4-10H,19H2,1-3H3
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Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153639
PNG
(US8999982, Ref2)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cc(on4)-c4ccccc4)cc3F)c2cc1OC
Show InChI InChI=1S/C27H20FN3O5/c1-33-25-13-18-20(14-26(25)34-2)29-11-10-22(18)35-23-9-8-17(12-19(23)28)30-27(32)21-15-24(36-31-21)16-6-4-3-5-7-16/h3-15H,1-2H3,(H,30,32)
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Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153651
PNG
(US8999982, 4-((6,7-dimethoxyquinolin-4- yl)oxy)-2-...)
Show SMILES COc1cc2nccc(Oc3ccc(N)c(C)c3)c2cc1OC
Show InChI InChI=1S/C18H18N2O3/c1-11-8-12(4-5-14(11)19)23-16-6-7-20-15-10-18(22-3)17(21-2)9-13(15)16/h4-10H,19H2,1-3H3
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Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153646
PNG
(US8999982, 4-((6,7-dimethoxyquinolin-4- yl)oxy)ani...)
Show SMILES COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC
Show InChI InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3
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Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153645
PNG
(US8999982, 4-((6,7-dimethoxyquinolin-4- yl)oxy)-3-...)
Show SMILES COc1cc2nccc(Oc3ccc(N)cc3F)c2cc1OC
Show InChI InChI=1S/C17H15FN2O3/c1-21-16-8-11-13(9-17(16)22-2)20-6-5-14(11)23-15-4-3-10(19)7-12(15)18/h3-9H,19H2,1-2H3
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Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM153647
PNG
(US8999982, 4-((6,7-dimethoxyquinolin-4- yl)oxy)-3-...)
Show SMILES COc1cc2nccc(Oc3ccc(N)cc3C)c2cc1OC
Show InChI InChI=1S/C18H18N2O3/c1-11-8-12(19)4-5-15(11)23-16-6-7-20-14-10-18(22-3)17(21-2)9-13(14)16/h4-10H,19H2,1-3H3
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Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...

US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%