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Patent code US9029360

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158161
PNG
(US9029360, 4)
Show SMILES CCc1nc2CCN(CCc2s1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C16H16BrN5OS/c1-2-15-19-11-3-5-21(6-4-13(11)24-15)16(23)12-7-14-18-8-10(17)9-22(14)20-12/h7-9H,2-6H2,1H3
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n/an/a 33n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158163
PNG
(US9029360, 6)
Show SMILES Cc1nc2CCN(CCc2s1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C15H15BrN5OS/c1-9-18-11-2-4-20(5-3-13(11)23-9)15(22)12-6-14-17-7-10(16)8-21(14)19-12/h6-8,18H,2-5H2,1H3
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n/an/a 43n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158167
PNG
(US9029360, 10)
Show SMILES Clc1cnc2cc(nn2c1)C(=O)N1CCc2ncsc2CC1
Show InChI InChI=1S/C14H12ClN5OS/c15-9-6-16-13-5-11(18-20(13)7-9)14(21)19-3-1-10-12(2-4-19)22-8-17-10/h5-8H,1-4H2
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n/an/a 59n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158170
PNG
(US9029360, 13)
Show SMILES Cc1nc2CCN(CCc2s1)C(=O)c1cc2ncc(Cl)cn2n1
Show InChI InChI=1S/C15H14ClN5OS/c1-9-18-11-2-4-20(5-3-13(11)23-9)15(22)12-6-14-17-7-10(16)8-21(14)19-12/h6-8H,2-5H2,1H3
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n/an/a 63n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158168
PNG
(US9029360, 11)
Show SMILES Brc1cnc2cc(nn2c1)C(=O)N1CCc2[nH]c(=O)sc2CC1
Show InChI InChI=1S/C14H12BrN5O2S/c15-8-6-16-12-5-10(18-20(12)7-8)13(21)19-3-1-9-11(2-4-19)23-14(22)17-9/h5-7H,1-4H2,(H,17,22)
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n/an/a 66n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158162
PNG
(US9029360, 5)
Show SMILES Brc1cnc2cc(nn2c1)C(=O)N1CCc2ncsc2CC1
Show InChI InChI=1S/C14H12BrN5OS/c15-9-6-16-13-5-11(18-20(13)7-9)14(21)19-3-1-10-12(2-4-19)22-8-17-10/h5-8H,1-4H2
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n/an/a 110n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158176
PNG
(US9029360, 19)
Show SMILES Clc1cnc2cc(nn2c1)C(=O)N1CCc2[nH]c(=O)sc2CC1
Show InChI InChI=1S/C14H12ClN5O2S/c15-8-6-16-12-5-10(18-20(12)7-8)13(21)19-3-1-9-11(2-4-19)23-14(22)17-9/h5-7H,1-4H2,(H,17,22)
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n/an/a 128n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158158
PNG
(US9029360, 1)
Show SMILES Clc1ccc2CCN(CCc2n1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C16H13BrClN5O/c17-11-8-19-15-7-13(21-23(15)9-11)16(24)22-5-3-10-1-2-14(18)20-12(10)4-6-22/h1-2,7-9H,3-6H2
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n/an/a 146n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158169
PNG
(US9029360, 12)
Show SMILES CC(C)c1nc2CCN(CCc2s1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C17H18BrN5OS/c1-10(2)16-20-12-3-5-22(6-4-14(12)25-16)17(24)13-7-15-19-8-11(18)9-23(15)21-13/h7-10H,3-6H2,1-2H3
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n/an/a 148n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158159
PNG
(US9029360, 2)
Show SMILES COc1ccc2CCN(CCc2n1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C17H16BrN5O2/c1-25-16-3-2-11-4-6-22(7-5-13(11)20-16)17(24)14-8-15-19-9-12(18)10-23(15)21-14/h2-3,8-10H,4-7H2,1H3
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n/an/a 230n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158175
PNG
(US9029360, 18)
Show SMILES CC(C)c1nc2CCN(CCc2s1)C(=O)c1cc2ncc(Cl)cn2n1
Show InChI InChI=1S/C17H18ClN5OS/c1-10(2)16-20-12-3-5-22(6-4-14(12)25-16)17(24)13-7-15-19-8-11(18)9-23(15)21-13/h7-10H,3-6H2,1-2H3
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n/an/a 235n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158164
PNG
(US9029360, 7)
Show SMILES Clc1cc2CCN(CCc2nn1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C15H12BrClN6O/c16-10-7-18-14-6-12(21-23(14)8-10)15(24)22-3-1-9-5-13(17)20-19-11(9)2-4-22/h5-8H,1-4H2
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n/an/a 340n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158174
PNG
(US9029360, 17)
Show SMILES Cn1c2CCN(CCc2c2ccccc12)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C20H18BrN5O/c1-24-17-5-3-2-4-14(17)15-6-8-25(9-7-18(15)24)20(27)16-10-19-22-11-13(21)12-26(19)23-16/h2-5,10-12H,6-9H2,1H3
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n/an/a 550n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158171
PNG
(US9029360, 14)
Show SMILES Brc1cnc2cc(nn2c1)C(=O)N1CCc2cccnc2CC1
Show InChI InChI=1S/C16H14BrN5O/c17-12-9-19-15-8-14(20-22(15)10-12)16(23)21-6-3-11-2-1-5-18-13(11)4-7-21/h1-2,5,8-10H,3-4,6-7H2
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n/an/a 603n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158172
PNG
(US9029360, 15)
Show SMILES Cn1cnc2CCN(CCc12)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C15H15BrN6O/c1-20-9-18-11-2-4-21(5-3-13(11)20)15(23)12-6-14-17-7-10(16)8-22(14)19-12/h6-9H,2-5H2,1H3
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n/an/a 692n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158173
PNG
(US9029360, 16)
Show SMILES Cn1c2CCN(CCc2sc1=O)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C15H14BrN5O2S/c1-19-11-2-4-20(5-3-12(11)24-15(19)23)14(22)10-6-13-17-7-9(16)8-21(13)18-10/h6-8H,2-5H2,1H3
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n/an/a 1.29E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158160
PNG
(US9029360, 3)
Show SMILES Brc1cnc2cc(nn2c1)C(=O)N1CCc2ccsc2CC1
Show InChI InChI=1S/C15H13BrN4OS/c16-11-8-17-14-7-12(18-20(14)9-11)15(21)19-4-1-10-3-6-22-13(10)2-5-19/h3,6-9H,1-2,4-5H2
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n/an/a 1.39E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158166
PNG
(US9029360, 9)
Show SMILES Cc1cnc2cc(nn2c1)C(=O)N1CCc2ncsc2CC1
Show InChI InChI=1S/C15H15N5OS/c1-10-7-16-14-6-12(18-20(14)8-10)15(21)19-4-2-11-13(3-5-19)22-9-17-11/h6-9H,2-5H2,1H3
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n/an/a 1.42E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM158165
PNG
(US9029360, 8)
Show SMILES COCc1nc2CCN(CCc2s1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C16H16BrN5O2S/c1-24-9-15-19-11-2-4-21(5-3-13(11)25-15)16(23)12-6-14-18-7-10(17)8-22(14)20-12/h6-8H,2-5,9H2,1H3
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n/an/a 1.55E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Activation of the mGluR5 receptor expressed in cell lines results in an increase in intracellular calcium concentration. Using calcium sensitive fluo...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158174
PNG
(US9029360, 17)
Show SMILES Cn1c2CCN(CCc2c2ccccc12)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C20H18BrN5O/c1-24-17-5-3-2-4-14(17)15-6-8-25(9-7-18(15)24)20(27)16-10-19-22-11-13(21)12-26(19)23-16/h2-5,10-12H,6-9H2,1H3
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158162
PNG
(US9029360, 5)
Show SMILES Brc1cnc2cc(nn2c1)C(=O)N1CCc2ncsc2CC1
Show InChI InChI=1S/C14H12BrN5OS/c15-9-6-16-13-5-11(18-20(13)7-9)14(21)19-3-1-10-12(2-4-19)22-8-17-10/h5-8H,1-4H2
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158165
PNG
(US9029360, 8)
Show SMILES COCc1nc2CCN(CCc2s1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C16H16BrN5O2S/c1-24-9-15-19-11-2-4-21(5-3-13(11)25-15)16(23)12-6-14-18-7-10(17)8-22(14)20-12/h6-8H,2-5,9H2,1H3
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158168
PNG
(US9029360, 11)
Show SMILES Brc1cnc2cc(nn2c1)C(=O)N1CCc2[nH]c(=O)sc2CC1
Show InChI InChI=1S/C14H12BrN5O2S/c15-8-6-16-12-5-10(18-20(12)7-8)13(21)19-3-1-9-11(2-4-19)23-14(22)17-9/h5-7H,1-4H2,(H,17,22)
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158167
PNG
(US9029360, 10)
Show SMILES Clc1cnc2cc(nn2c1)C(=O)N1CCc2ncsc2CC1
Show InChI InChI=1S/C14H12ClN5OS/c15-9-6-16-13-5-11(18-20(13)7-9)14(21)19-3-1-10-12(2-4-19)22-8-17-10/h5-8H,1-4H2
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158164
PNG
(US9029360, 7)
Show SMILES Clc1cc2CCN(CCc2nn1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C15H12BrClN6O/c16-10-7-18-14-6-12(21-23(14)8-10)15(24)22-3-1-9-5-13(17)20-19-11(9)2-4-22/h5-8H,1-4H2
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158171
PNG
(US9029360, 14)
Show SMILES Brc1cnc2cc(nn2c1)C(=O)N1CCc2cccnc2CC1
Show InChI InChI=1S/C16H14BrN5O/c17-12-9-19-15-8-14(20-22(15)10-12)16(23)21-6-3-11-2-1-5-18-13(11)4-7-21/h1-2,5,8-10H,3-4,6-7H2
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158163
PNG
(US9029360, 6)
Show SMILES Cc1nc2CCN(CCc2s1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C15H15BrN5OS/c1-9-18-11-2-4-20(5-3-13(11)23-9)15(22)12-6-14-17-7-10(16)8-21(14)19-12/h6-8,18H,2-5H2,1H3
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158172
PNG
(US9029360, 15)
Show SMILES Cn1cnc2CCN(CCc12)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C15H15BrN6O/c1-20-9-18-11-2-4-21(5-3-13(11)20)15(23)12-6-14-17-7-10(16)8-22(14)19-12/h6-9H,2-5H2,1H3
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158169
PNG
(US9029360, 12)
Show SMILES CC(C)c1nc2CCN(CCc2s1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C17H18BrN5OS/c1-10(2)16-20-12-3-5-22(6-4-14(12)25-16)17(24)13-7-15-19-8-11(18)9-23(15)21-13/h7-10H,3-6H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158160
PNG
(US9029360, 3)
Show SMILES Brc1cnc2cc(nn2c1)C(=O)N1CCc2ccsc2CC1
Show InChI InChI=1S/C15H13BrN4OS/c16-11-8-17-14-7-12(18-20(14)9-11)15(21)19-4-1-10-3-6-22-13(10)2-5-19/h3,6-9H,1-2,4-5H2
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158159
PNG
(US9029360, 2)
Show SMILES COc1ccc2CCN(CCc2n1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C17H16BrN5O2/c1-25-16-3-2-11-4-6-22(7-5-13(11)20-16)17(24)14-8-15-19-9-12(18)10-23(15)21-14/h2-3,8-10H,4-7H2,1H3
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158161
PNG
(US9029360, 4)
Show SMILES CCc1nc2CCN(CCc2s1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C16H16BrN5OS/c1-2-15-19-11-3-5-21(6-4-13(11)24-15)16(23)12-7-14-18-8-10(17)9-22(14)20-12/h7-9H,2-6H2,1H3
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158173
PNG
(US9029360, 16)
Show SMILES Cn1c2CCN(CCc2sc1=O)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C15H14BrN5O2S/c1-19-11-2-4-20(5-3-12(11)24-15(19)23)14(22)10-6-13-17-7-9(16)8-21(13)18-10/h6-8H,2-5H2,1H3
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158166
PNG
(US9029360, 9)
Show SMILES Cc1cnc2cc(nn2c1)C(=O)N1CCc2ncsc2CC1
Show InChI InChI=1S/C15H15N5OS/c1-10-7-16-14-6-12(18-20(14)8-10)15(21)19-4-2-11-13(3-5-19)22-9-17-11/h6-9H,2-5H2,1H3
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158170
PNG
(US9029360, 13)
Show SMILES Cc1nc2CCN(CCc2s1)C(=O)c1cc2ncc(Cl)cn2n1
Show InChI InChI=1S/C15H14ClN5OS/c1-9-18-11-2-4-20(5-3-13(11)23-9)15(22)12-6-14-17-7-10(16)8-21(14)19-12/h6-8H,2-5H2,1H3
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM158158
PNG
(US9029360, 1)
Show SMILES Clc1ccc2CCN(CCc2n1)C(=O)c1cc2ncc(Br)cn2n1
Show InChI InChI=1S/C16H13BrClN5O/c17-11-8-19-15-7-13(21-23(15)9-11)16(24)22-5-3-10-1-2-14(18)20-12(10)4-6-22/h1-2,7-9H,3-6H2
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n/an/a>1.00E+4n/an/an/an/a6.037



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro inhibition of 11beta -HSD1 was determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio international, France) detec...

US Patent US9029360 (2015)


BindingDB Entry DOI: 10.7270/Q25M64GK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%