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Patent code US9034897

Compile Data Set for Download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159297
PNG
(US9034897, 14a)
Show SMILES CCC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C25H22F2N4O2/c1-2-23(33)30-7-6-21-19(13-30)24(15-5-3-4-14(8-15)12-28)29-31(21)25-18-9-16(26)10-20(27)17(18)11-22(25)32/h3-5,8-10,22,25,32H,2,6-7,11,13H2,1H3/t22-,25-/m1/s1
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n/an/a 70n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159298
PNG
(US9034897, 14b)
Show SMILES O[C@@H]1Cc2c(cc(F)cc2F)[C@H]1n1nc(c2CN(CCc12)C(=O)C1CC1)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C26H22F2N4O2/c27-17-9-19-18(21(28)10-17)11-23(33)25(19)32-22-6-7-31(26(34)15-4-5-15)13-20(22)24(30-32)16-3-1-2-14(8-16)12-29/h1-3,8-10,15,23,25,33H,4-7,11,13H2/t23-,25-/m1/s1
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n/an/a 83.1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159259
PNG
(US9034897, 11a)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1cccc(OC(F)(F)F)c1 |r|
Show InChI InChI=1S/C24H20F5N3O3/c1-12(33)31-6-5-20-18(11-31)22(13-3-2-4-15(7-13)35-24(27,28)29)30-32(20)23-17-8-14(25)9-19(26)16(17)10-21(23)34/h2-4,7-9,21,23,34H,5-6,10-11H2,1H3/t21-,23-/m1/s1
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n/an/a 171n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159321
PNG
(US9034897, 22a)
Show SMILES CCNC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(Cl)cc2Cl)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C25H23Cl2N5O2/c1-2-29-25(34)31-7-6-21-19(13-31)23(15-5-3-4-14(8-15)12-28)30-32(21)24-18-9-16(26)10-20(27)17(18)11-22(24)33/h3-5,8-10,22,24,33H,2,6-7,11,13H2,1H3,(H,29,34)/t22-,24-/m1/s1
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n/an/a 180n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159260
PNG
(US9034897, 11b)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@@H]1[C@@H](O)Cc2c1cc(F)cc2F)-c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C23H20ClF2N3O2/c1-12(30)28-6-5-20-18(11-28)22(13-3-2-4-14(24)7-13)27-29(20)23-17-8-15(25)9-19(26)16(17)10-21(23)31/h2-4,7-9,21,23,31H,5-6,10-11H2,1H3/t21-,23-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159261
PNG
(US9034897, 11c)
Show SMILES COc1ccc(F)c(c1)-c1nn([C@H]2[C@H](O)Cc3c2cc(F)cc3F)c2CCN(Cc12)C(C)=O |r|
Show InChI InChI=1S/C24H22F3N3O3/c1-12(31)29-6-5-21-18(11-29)23(17-9-14(33-2)3-4-19(17)26)28-30(21)24-16-7-13(25)8-20(27)15(16)10-22(24)32/h3-4,7-9,22,24,32H,5-6,10-11H2,1-2H3/t22-,24-/m1/s1
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n/an/a 204n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159262
PNG
(US9034897, 11d)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2Br)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C24H20BrFN4O2/c1-13(31)29-6-5-21-19(12-29)23(15-4-2-3-14(7-15)11-27)28-30(21)24-18-8-16(26)9-20(25)17(18)10-22(24)32/h2-4,7-9,22,24,32H,5-6,10,12H2,1H3/t22-,24-/m1/s1
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n/an/a 226n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159315
PNG
(US9034897, 19a)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2C)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C25H23FN4O2/c1-14-8-18(26)10-20-19(14)11-23(32)25(20)30-22-6-7-29(15(2)31)13-21(22)24(28-30)17-5-3-4-16(9-17)12-27/h3-5,8-10,23,25,32H,6-7,11,13H2,1-2H3/t23-,25-/m1/s1
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n/an/a 231n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159263
PNG
(US9034897, 11e)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1cccc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C23H19F5N4O2/c1-11(33)31-6-5-18-15(10-31)21(17-3-2-4-20(29-17)23(26,27)28)30-32(18)22-14-7-12(24)8-16(25)13(14)9-19(22)34/h2-4,7-8,19,22,34H,5-6,9-10H2,1H3/t19-,22-/m1/s1
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n/an/a 239n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159299
PNG
(US9034897, 14c)
Show SMILES CC(C)C(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C26H24F2N4O2/c1-14(2)26(34)31-7-6-22-20(13-31)24(16-5-3-4-15(8-16)12-29)30-32(22)25-19-9-17(27)10-21(28)18(19)11-23(25)33/h3-5,8-10,14,23,25,33H,6-7,11,13H2,1-2H3/t23-,25-/m1/s1
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n/an/a 250n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159306
PNG
(US9034897, 17a)
Show SMILES COC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C24H20F2N4O3/c1-33-24(32)29-6-5-20-18(12-29)22(14-4-2-3-13(7-14)11-27)28-30(20)23-17-8-15(25)9-19(26)16(17)10-21(23)31/h2-4,7-9,21,23,31H,5-6,10,12H2,1H3/t21-,23-/m1/s1
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n/an/a 260n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159264
PNG
(US9034897, 11f)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1ccc(F)c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C24H19F6N3O2/c1-11(34)32-5-4-20-16(10-32)22(12-2-3-18(26)17(6-12)24(28,29)30)31-33(20)23-15-7-13(25)8-19(27)14(15)9-21(23)35/h2-3,6-8,21,23,35H,4-5,9-10H2,1H3/t21-,23-/m1/s1
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n/an/a 270n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159265
PNG
(US9034897, 11g)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(Cl)cc2Cl)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C24H20Cl2N4O2/c1-13(31)29-6-5-21-19(12-29)23(15-4-2-3-14(7-15)11-27)28-30(21)24-18-8-16(25)9-20(26)17(18)10-22(24)32/h2-4,7-9,22,24,32H,5-6,10,12H2,1H3/t22-,24-/m1/s1
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n/an/a 350n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159266
PNG
(US9034897, 11h)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@@H]1[C@@H](O)Cc2c1cc(F)cc2F)-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C24H20F5N3O2/c1-12(33)31-6-5-20-18(11-31)22(13-3-2-4-14(7-13)24(27,28)29)30-32(20)23-17-8-15(25)9-19(26)16(17)10-21(23)34/h2-4,7-9,21,23,34H,5-6,10-11H2,1H3/t21-,23-/m0/s1
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n/an/a 370n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159267
PNG
(US9034897, 11i)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1c2cc(F)cc(F)c2C[C@]1(C)O)-c1ccc(F)c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F6N3O2/c1-12(35)33-6-5-21-17(11-33)22(13-3-4-19(27)18(7-13)25(29,30)31)32-34(21)23-15-8-14(26)9-20(28)16(15)10-24(23,2)36/h3-4,7-9,23,36H,5-6,10-11H2,1-2H3/t23-,24-/m0/s1
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n/an/a 375n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159318
PNG
(US9034897, 21a)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2Cl)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C24H20ClFN4O2/c1-13(31)29-6-5-21-19(12-29)23(15-4-2-3-14(7-15)11-27)28-30(21)24-18-8-16(26)9-20(25)17(18)10-22(24)32/h2-4,7-9,22,24,32H,5-6,10,12H2,1H3/t22-,24-/m1/s1
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n/an/a 393n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159268
PNG
(US9034897, 11j)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(Cl)cc2F)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C24H20ClFN4O2/c1-13(31)29-6-5-21-19(12-29)23(15-4-2-3-14(7-15)11-27)28-30(21)24-18-8-16(25)9-20(26)17(18)10-22(24)32/h2-4,7-9,22,24,32H,5-6,10,12H2,1H3/t22-,24-/m1/s1
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n/an/a 439n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159269
PNG
(US9034897, 11k)
Show SMILES COc1cccc(c1)-c1nn([C@H]2[C@H](O)Cc3c2cc(F)cc3F)c2CCN(Cc12)C(C)=O |r|
Show InChI InChI=1S/C24H23F2N3O3/c1-13(30)28-7-6-21-19(12-28)23(14-4-3-5-16(8-14)32-2)27-29(21)24-18-9-15(25)10-20(26)17(18)11-22(24)31/h3-5,8-10,22,24,31H,6-7,11-12H2,1-2H3/t22-,24-/m1/s1
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n/an/a 442n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159304
PNG
(US9034897, 16a)
Show SMILES CO[C@@H]1Cc2c(cc(F)cc2F)[C@H]1n1nc(c2CN(CCc12)C(C)=O)-c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C24H22ClF2N3O2/c1-13(31)29-7-6-21-19(12-29)23(14-4-3-5-15(25)8-14)28-30(21)24-18-9-16(26)10-20(27)17(18)11-22(24)32-2/h3-5,8-10,22,24H,6-7,11-12H2,1-2H3/t22-,24-/m1/s1
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n/an/a 446n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159291
PNG
(US9034897, 12b)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1CCc2ccccc12)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H22FN3O/c1-15(28)26-13-12-22-20(14-26)23(17-6-9-18(24)10-7-17)25-27(22)21-11-8-16-4-2-3-5-19(16)21/h2-7,9-10,21H,8,11-14H2,1H3/t21-/m0/s1
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n/an/a 479n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM47354
PNG
(US9034897, 11l)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H20F3N3O2/c1-12(30)28-7-6-20-18(11-28)22(13-2-4-14(24)5-3-13)27-29(20)23-17-8-15(25)9-19(26)16(17)10-21(23)31/h2-5,8-9,21,23,31H,6-7,10-11H2,1H3/t21-,23-/m1/s1
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n/an/a 495n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159317
PNG
(US9034897, 20a)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2C1CC1)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C27H25FN4O2/c1-15(33)31-8-7-24-23(14-31)26(18-4-2-3-16(9-18)13-29)30-32(24)27-22-11-19(28)10-20(17-5-6-17)21(22)12-25(27)34/h2-4,9-11,17,25,27,34H,5-8,12,14H2,1H3/t25-,27-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159307
PNG
(US9034897, 18a)
Show SMILES O[C@@H]1Cc2c(cc(F)cc2F)[C@H]1n1nc(c2CN(CC3CC3)CCc12)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C25H24F3N3O/c26-16-5-3-15(4-6-16)24-20-13-30(12-14-1-2-14)8-7-22(20)31(29-24)25-19-9-17(27)10-21(28)18(19)11-23(25)32/h3-6,9-10,14,23,25,32H,1-2,7-8,11-13H2/t23-,25-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM47355
PNG
(US9034897, 11m)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(Cl)cc2Cl)-c1cccc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C23H19Cl2F3N4O2/c1-11(33)31-6-5-18-15(10-31)21(17-3-2-4-20(29-17)23(26,27)28)30-32(18)22-14-7-12(24)8-16(25)13(14)9-19(22)34/h2-4,7-8,19,22,34H,5-6,9-10H2,1H3/t19-,22-/m1/s1
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n/an/a 518n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM47356
PNG
(US9034897, 11n)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(Cl)cc2F)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H20ClF2N3O2/c1-12(30)28-7-6-20-18(11-28)22(13-2-4-15(25)5-3-13)27-29(20)23-17-8-14(24)9-19(26)16(17)10-21(23)31/h2-5,8-9,21,23,31H,6-7,10-11H2,1H3/t21-,23-/m1/s1
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n/an/a 568n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM47357
PNG
(US9034897, 11o)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@@H]1[C@@H](O)Cc2c1cc(F)cc2F)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C24H20F2N4O2/c1-13(31)29-6-5-21-19(12-29)23(15-4-2-3-14(7-15)11-27)28-30(21)24-18-8-16(25)9-20(26)17(18)10-22(24)32/h2-4,7-9,22,24,32H,5-6,10,12H2,1H3/t22-,24-/m0/s1
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n/an/a 675n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159274
PNG
(US9034897, 11p)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2ccc(Cl)cc12)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C24H21ClN4O2/c1-14(30)28-8-7-21-20(13-28)23(17-4-2-3-15(9-17)12-26)27-29(21)24-19-11-18(25)6-5-16(19)10-22(24)31/h2-6,9,11,22,24,31H,7-8,10,13H2,1H3/t22-,24-/m1/s1
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n/an/a 685n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159290
PNG
(US9034897, 12a)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@@H]1CCc2ccccc12)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H22FN3O/c1-15(28)26-13-12-22-20(14-26)23(17-6-9-18(24)10-7-17)25-27(22)21-11-8-16-4-2-3-5-19(16)21/h2-7,9-10,21H,8,11-14H2,1H3/t21-/m1/s1
PDB

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n/an/a 712n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159275
PNG
(US9034897, 11q)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C24H20F5N3O2/c1-12(33)31-6-5-20-18(11-31)22(13-3-2-4-14(7-13)24(27,28)29)30-32(20)23-17-8-15(25)9-19(26)16(17)10-21(23)34/h2-4,7-9,21,23,34H,5-6,10-11H2,1H3/t21-,23-/m1/s1
PDB

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n/an/a 773n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159276
PNG
(US9034897, 11r)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@@H]1[C@@H](O)Cc2c1cc(F)cc2F)-c1cccc(OC(F)(F)F)c1 |r|
Show InChI InChI=1S/C24H20F5N3O3/c1-12(33)31-6-5-20-18(11-31)22(13-3-2-4-15(7-13)35-24(27,28)29)30-32(20)23-17-8-14(25)9-19(26)16(17)10-21(23)34/h2-4,7-9,21,23,34H,5-6,10-11H2,1H3/t21-,23-/m0/s1
PDB

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n/an/a 789n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159277
PNG
(US9034897, 11s)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2ccc(Cl)cc12)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H21ClFN3O2/c1-13(29)27-9-8-20-19(12-27)22(14-3-6-17(25)7-4-14)26-28(20)23-18-11-16(24)5-2-15(18)10-21(23)30/h2-7,11,21,23,30H,8-10,12H2,1H3/t21-,23-/m1/s1
PDB

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n/an/a 804n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159278
PNG
(US9034897, 11t)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C24H20F2N4O2/c1-13(31)29-6-5-21-19(12-29)23(15-4-2-3-14(7-15)11-27)28-30(21)24-18-8-16(25)9-20(26)17(18)10-22(24)32/h2-4,7-9,22,24,32H,5-6,10,12H2,1H3/t22-,24-/m1/s1
PDB

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n/an/a 881n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159279
PNG
(US9034897, 11u)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2cc(Cl)c(Cl)cc12)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H20Cl2FN3O2/c1-12(30)28-7-6-20-17(11-28)22(13-2-4-15(26)5-3-13)27-29(20)23-16-10-19(25)18(24)8-14(16)9-21(23)31/h2-5,8,10,21,23,31H,6-7,9,11H2,1H3/t21-,23-/m1/s1
PDB

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n/an/a 1.01E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159305
PNG
(US9034897, 16b)
Show SMILES CO[C@@H]1Cc2c(cc(F)cc2F)[C@H]1n1nc(c2CN(CCc12)C(C)=O)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C24H22F3N3O2/c1-13(31)29-8-7-21-19(12-29)23(14-3-5-15(25)6-4-14)28-30(21)24-18-9-16(26)10-20(27)17(18)11-22(24)32-2/h3-6,9-10,22,24H,7-8,11-12H2,1-2H3/t22-,24-/m1/s1
PDB

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n/an/a 1.16E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159280
PNG
(US9034897, 11v)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C23H20ClF2N3O2/c1-12(30)28-6-5-20-18(11-28)22(13-3-2-4-14(24)7-13)27-29(20)23-17-8-15(25)9-19(26)16(17)10-21(23)31/h2-4,7-9,21,23,31H,5-6,10-11H2,1H3/t21-,23-/m1/s1
PDB

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n/an/a 1.19E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159281
PNG
(US9034897, 11w)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@@H]1c2cc(F)cc(F)c2C[C@@]1(C)O)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C25H22F2N4O2/c1-14(32)30-7-6-22-20(13-30)23(16-5-3-4-15(8-16)12-28)29-31(22)24-18-9-17(26)10-21(27)19(18)11-25(24,2)33/h3-5,8-10,24,33H,6-7,11,13H2,1-2H3/t24-,25-/m1/s1
PDB

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n/an/a 1.26E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159282
PNG
(US9034897, 11x)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1ccc(C)cc1 |r|
Show InChI InChI=1S/C24H23F2N3O2/c1-13-3-5-15(6-4-13)23-19-12-28(14(2)30)8-7-21(19)29(27-23)24-18-9-16(25)10-20(26)17(18)11-22(24)31/h3-6,9-10,22,24,31H,7-8,11-12H2,1-2H3/t22-,24-/m1/s1
PDB

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n/an/a 1.52E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159283
PNG
(US9034897, 11y)
Show SMILES COc1cc(ccc1F)-c1nn([C@H]2[C@H](O)Cc3c2cc(F)cc3F)c2CCN(Cc12)C(C)=O |r|
Show InChI InChI=1S/C24H22F3N3O3/c1-12(31)29-6-5-20-17(11-29)23(13-3-4-18(26)22(7-13)33-2)28-30(20)24-16-8-14(25)9-19(27)15(16)10-21(24)32/h3-4,7-9,21,24,32H,5-6,10-11H2,1-2H3/t21-,24-/m1/s1
PDB

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n/an/a 1.92E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159284
PNG
(US9034897, 11z)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1ccc(F)c(c1)C#N |r|
Show InChI InChI=1S/C24H19F3N4O2/c1-12(32)30-5-4-21-18(11-30)23(13-2-3-19(26)14(6-13)10-28)29-31(21)24-17-7-15(25)8-20(27)16(17)9-22(24)33/h2-3,6-8,22,24,33H,4-5,9,11H2,1H3/t22-,24-/m1/s1
PDB

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UniProtKB/SwissProt

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n/an/a 2.13E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM47359
PNG
(US9034897, 11aa)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1cccc(F)c1 |r|
Show InChI InChI=1S/C23H20F3N3O2/c1-12(30)28-6-5-20-18(11-28)22(13-3-2-4-14(24)7-13)27-29(20)23-17-8-15(25)9-19(26)16(17)10-21(23)31/h2-4,7-9,21,23,31H,5-6,10-11H2,1H3/t21-,23-/m1/s1
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n/an/a 2.22E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM47360
PNG
(US9034897, 11ab)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C23H20ClF2N3O2/c1-12(30)28-7-6-20-18(11-28)22(13-2-4-14(24)5-3-13)27-29(20)23-17-8-15(25)9-19(26)16(17)10-21(23)31/h2-5,8-9,21,23,31H,6-7,10-11H2,1H3/t21-,23-/m1/s1
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n/an/a 2.97E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM47361
PNG
(US9034897, 11ac)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2cc(Cl)cc(Cl)c12)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H20Cl2FN3O2/c1-12(30)28-7-6-19-17(11-28)22(13-2-4-16(26)5-3-13)27-29(19)23-20(31)9-14-8-15(24)10-18(25)21(14)23/h2-5,8,10,20,23,31H,6-7,9,11H2,1H3/t20-,23+/m1/s1
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n/an/a 3.88E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM47362
PNG
(US9034897, 11ad)
Show SMILES COc1ccc(cc1)-c1nn([C@H]2[C@H](O)Cc3c2cc(F)cc3F)c2CCN(Cc12)C(C)=O |r|
Show InChI InChI=1S/C24H23F2N3O3/c1-13(30)28-8-7-21-19(12-28)23(14-3-5-16(32-2)6-4-14)27-29(21)24-18-9-15(25)10-20(26)17(18)11-22(24)31/h3-6,9-10,22,24,31H,7-8,11-12H2,1-2H3/t22-,24-/m1/s1
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n/an/a 6.89E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM159308
PNG
(US9034897, 18b)
Show SMILES CC(C)N1CCc2c(C1)c(nn2[C@H]1[C@H](O)Cc2c1cc(F)cc2F)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C24H24F3N3O/c1-13(2)29-8-7-21-19(12-29)23(14-3-5-15(25)6-4-14)28-30(21)24-18-9-16(26)10-20(27)17(18)11-22(24)31/h3-6,9-10,13,22,24,31H,7-8,11-12H2,1-2H3/t22-,24-/m1/s1
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n/an/a 8.19E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9034897 (2015)


BindingDB Entry DOI: 10.7270/Q23R0RNR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%