Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA gyrase subunit A/B (Staphylococcus aureus) | BDBM50393079 (CHEMBL2152855 | US9040542, 23) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | US Patent | 9 | n/a | n/a | n/a | n/a | n/a | n/a | 7.6 | n/a |
VERTEX PHARMACEUTICALS INCORPORATED US Patent | Assay Description The ATP hydrolysis activity of S. aureus DNA gyrase is measured by coupling the production of ADP through pyruvate kinase/lactate dehydrogenase to th... | US Patent US9040542 (2015) BindingDB Entry DOI: 10.7270/Q2F18XHX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus) | BDBM50393079 (CHEMBL2152855 | US9040542, 23) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | US Patent | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VERTEX PHARMACEUTICALS INCORPORATED US Patent | Assay Description The conversion of ATP to ADP by S. aureus TopoIV enzyme is coupled to the conversion of NADH to NAD+, and the progress of the reaction is measured by... | US Patent US9040542 (2015) BindingDB Entry DOI: 10.7270/Q2F18XHX | |||||||||||
More data for this Ligand-Target Pair |