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Patent code US9067922

Compile Data Set for Download or QSAR

Found 243 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165905
PNG
(US9067922, 247)
Show SMILES OCc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C19H13ClFN3O4S/c20-17-8-15(3-1-12(17)11-25)28-18-5-4-16(7-13(18)9-22)29(26,27)24-19-6-2-14(21)10-23-19/h1-8,10,25H,11H2,(H,23,24)
KEGG

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n/an/a 1n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165898
PNG
(US9067922, 239)
Show SMILES OCc1ncc(Oc2ccc(c(F)c2)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C17H12ClF2N3O4S/c18-13-5-12(8-21-15(13)9-24)27-11-2-3-16(14(20)6-11)28(25,26)23-17-4-1-10(19)7-22-17/h1-8,24H,9H2,(H,22,23)
KEGG

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n/an/a 2n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165900
PNG
(US9067922, 241)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(Cl)c(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H9Cl2FN4O3S/c20-16-6-13(7-17(21)15(16)9-24)29-18-3-2-14(5-11(18)8-23)30(27,28)26-19-4-1-12(22)10-25-19/h1-7,10H,(H,25,26)
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n/an/a 3n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165745
PNG
(US9067922, 235 | US9067922, 79)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N
Show InChI InChI=1S/C21H15FN4O3S/c1-13-7-17(8-14(2)19(13)11-24)29-20-5-4-18(9-15(20)10-23)30(27,28)26-21-6-3-16(22)12-25-21/h3-9,12H,1-2H3,(H,25,26)
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n/an/a 7n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165896
PNG
(US9067922, 237)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(F)c(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H9ClF2N4O3S/c20-16-6-13(7-17(22)15(16)9-24)29-18-3-2-14(5-11(18)8-23)30(27,28)26-19-4-1-12(21)10-25-19/h1-7,10H,(H,25,26)
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n/an/a 8n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165893
PNG
(US9067922, 232)
Show SMILES Clc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10Cl2N4O3S/c20-14-2-6-19(24-11-14)25-29(26,27)16-4-5-18(13(7-16)10-23)28-15-3-1-12(9-22)17(21)8-15/h1-8,11H,(H,24,25)
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n/an/a 12n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165745
PNG
(US9067922, 235 | US9067922, 79)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N
Show InChI InChI=1S/C21H15FN4O3S/c1-13-7-17(8-14(2)19(13)11-24)29-20-5-4-18(9-15(20)10-23)30(27,28)26-21-6-3-16(22)12-25-21/h3-9,12H,1-2H3,(H,25,26)
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n/an/a 13n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165667
PNG
(US9067922, 1)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10ClFN4O3S/c20-17-8-15(3-1-12(17)9-22)28-18-5-4-16(7-13(18)10-23)29(26,27)25-19-6-2-14(21)11-24-19/h1-8,11H,(H,24,25)
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n/an/a 13n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165769
PNG
(US9067922, 104)
Show SMILES Fc1ccnc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)c1
Show InChI InChI=1S/C19H10ClFN4O3S/c20-17-9-15(2-1-12(17)10-22)28-18-4-3-16(7-13(18)11-23)29(26,27)25-19-8-14(21)5-6-24-19/h1-9H,(H,24,25)
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n/an/a 15n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165744
PNG
(US9067922, 78)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10ClF2N3O3S/c19-15-8-13(2-4-16(15)21)27-17-5-3-14(7-11(17)9-22)28(25,26)24-18-6-1-12(20)10-23-18/h1-8,10H,(H,23,24)
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n/an/a 19n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM60431
PNG
(US9067922, 249)
Show SMILES Cc1cc(Oc2ccc(c(F)c2)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N
Show InChI InChI=1S/C20H15F2N3O3S/c1-12-7-16(8-13(2)17(12)10-23)28-15-4-5-19(18(22)9-15)29(26,27)25-20-6-3-14(21)11-24-20/h3-9,11H,1-2H3,(H,24,25)
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n/an/a 21n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165780
PNG
(US9067922, 115)
Show SMILES COc1cccc(C)c1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C20H16FN3O4S/c1-13-4-3-5-18(27-2)20(13)28-17-8-7-16(10-14(17)11-22)29(25,26)24-19-9-6-15(21)12-23-19/h3-10,12H,1-2H3,(H,23,24)
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n/an/a 24n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165736
PNG
(US9067922, 70)
Show SMILES COc1ncc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C18H12ClFN4O4S/c1-27-18-15(19)7-13(10-23-18)28-16-4-3-14(6-11(16)8-21)29(25,26)24-17-5-2-12(20)9-22-17/h2-7,9-10H,1H3,(H,22,24)
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n/an/a 25n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165737
PNG
(US9067922, 71)
Show SMILES COc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)ccc1Cl
Show InChI InChI=1S/C19H13ClFN3O4S/c1-27-18-9-14(3-5-16(18)20)28-17-6-4-15(8-12(17)10-22)29(25,26)24-19-7-2-13(21)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 27n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165728
PNG
(US9067922, 62)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(Cl)cc(c3)C#N)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10ClFN4O3S/c20-14-5-12(9-22)6-16(8-14)28-18-3-2-17(7-13(18)10-23)29(26,27)25-19-4-1-15(21)11-24-19/h1-8,11H,(H,24,25)
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n/an/a 27n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165764
PNG
(US9067922, 99)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(F)c3)cc2F)nc1
Show InChI InChI=1S/C18H10F3N3O3S/c19-12-2-6-18(23-10-12)24-28(25,26)17-5-4-14(8-16(17)21)27-13-3-1-11(9-22)15(20)7-13/h1-8,10H,(H,23,24)
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n/an/a 29n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165863
PNG
(US9067922, 202)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cncc(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C17H10ClFN4O3S/c18-12-6-14(10-21-8-12)26-16-3-2-15(5-11(16)7-20)27(24,25)23-17-4-1-13(19)9-22-17/h1-6,8-10H,(H,22,23)
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n/an/a 37n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165864
PNG
(US9067922, 203)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(c3)C3CC3)c(c2)C#N)nc1
Show InChI InChI=1S/C22H15FN4O3S/c23-17-4-8-22(26-13-17)27-31(28,29)19-6-7-21(16(9-19)12-25)30-18-5-3-15(11-24)20(10-18)14-1-2-14/h3-10,13-14H,1-2H2,(H,26,27)
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n/an/a 37n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165797
PNG
(US9067922, 132)
Show SMILES COc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1F
Show InChI InChI=1S/C19H13F2N3O4S/c1-27-18-5-3-14(9-16(18)21)28-17-6-4-15(8-12(17)10-22)29(25,26)24-19-7-2-13(20)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 38n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165727
PNG
(US9067922, 61)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)ccc1C#N
Show InChI InChI=1S/C20H13FN4O3S/c1-13-8-17(4-2-14(13)10-22)28-19-6-5-18(9-15(19)11-23)29(26,27)25-20-7-3-16(21)12-24-20/h2-9,12H,1H3,(H,24,25)
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n/an/a 39n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165809
PNG
(US9067922, 144)
Show SMILES COc1cc(F)c(F)cc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C19H12F3N3O4S/c1-28-17-7-14(21)15(22)8-18(17)29-16-4-3-13(6-11(16)9-23)30(26,27)25-19-5-2-12(20)10-24-19/h2-8,10H,1H3,(H,24,25)
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n/an/a 40n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165806
PNG
(US9067922, 141)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C19H13F2N3O3S/c1-12-8-15(3-5-17(12)21)27-18-6-4-16(9-13(18)10-22)28(25,26)24-19-7-2-14(20)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 43n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165743
PNG
(US9067922, 77)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(F)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10F3N3O3S/c19-12-1-6-18(23-10-12)24-28(25,26)14-3-5-17(11(7-14)9-22)27-13-2-4-15(20)16(21)8-13/h1-8,10H,(H,23,24)
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n/an/a 43n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165677
PNG
(US9067922, 12)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(cc3F)C#N)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10F2N4O3S/c20-14-2-6-19(24-11-14)25-29(26,27)15-3-5-17(13(8-15)10-23)28-18-4-1-12(9-22)7-16(18)21/h1-8,11H,(H,24,25)
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n/an/a 47n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165713
PNG
(US9067922, 47)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3F)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10ClF2N3O3S/c19-12-1-4-17(15(21)8-12)27-16-5-3-14(7-11(16)9-22)28(25,26)24-18-6-2-13(20)10-23-18/h1-8,10H,(H,23,24)
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n/an/a 50n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165832
PNG
(US9067922, 167)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(F)c3Cl)c(c2)C#N)nc1
Show InChI InChI=1S/C18H9ClF3N3O3S/c19-17-15(5-3-13(21)18(17)22)28-14-4-2-12(7-10(14)8-23)29(26,27)25-16-6-1-11(20)9-24-16/h1-7,9H,(H,24,25)
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n/an/a 50n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165817
PNG
(US9067922, 152)
Show SMILES Cc1cccc(C)c1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C20H16FN3O3S/c1-13-4-3-5-14(2)20(13)27-18-8-7-17(10-15(18)11-22)28(25,26)24-19-9-6-16(21)12-23-19/h3-10,12H,1-2H3,(H,23,24)
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n/an/a 50n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165822
PNG
(US9067922, 157)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(F)c3F)c(c2)C#N)nc1
Show InChI InChI=1S/C18H9F4N3O3S/c19-11-1-6-16(24-9-11)25-29(26,27)12-2-4-14(10(7-12)8-23)28-15-5-3-13(20)17(21)18(15)22/h1-7,9H,(H,24,25)
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n/an/a 51n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165892
PNG
(US9067922, 231)
Show SMILES FC(F)Oc1ncc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C18H10ClF3N4O4S/c19-14-6-12(9-25-17(14)30-18(21)22)29-15-3-2-13(5-10(15)7-23)31(27,28)26-16-4-1-11(20)8-24-16/h1-6,8-9,18H,(H,24,26)
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n/an/a 53n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165709
PNG
(US9067922, 43)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(F)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10F2N4O3S/c20-14-2-6-19(24-11-14)25-29(26,27)16-4-5-18(13(7-16)10-23)28-15-3-1-12(9-22)17(21)8-15/h1-8,11H,(H,24,25)
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n/an/a 53n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165861
PNG
(US9067922, 200)
Show SMILES COc1ccc(C)c(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)c1
Show InChI InChI=1S/C20H16FN3O4S/c1-13-3-5-16(27-2)10-19(13)28-18-7-6-17(9-14(18)11-22)29(25,26)24-20-8-4-15(21)12-23-20/h3-10,12H,1-2H3,(H,23,24)
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n/an/a 53n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165813
PNG
(US9067922, 148)
Show SMILES COc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C19H13ClFN3O4S/c1-27-18-5-3-14(9-16(18)20)28-17-6-4-15(8-12(17)10-22)29(25,26)24-19-7-2-13(21)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 53n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165704
PNG
(US9067922, 38)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(Cl)c3Cl)c(c2)C#N)nc1
Show InChI InChI=1S/C18H9Cl2F2N3O3S/c19-17-13(22)3-5-15(18(17)20)28-14-4-2-12(7-10(14)8-23)29(26,27)25-16-6-1-11(21)9-24-16/h1-7,9H,(H,24,25)
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n/an/a 55n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165692
PNG
(US9067922, 26)
Show SMILES Cc1cc(Cl)c(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1C#N
Show InChI InChI=1S/C20H12ClFN4O3S/c1-12-6-17(21)19(8-13(12)9-23)29-18-4-3-16(7-14(18)10-24)30(27,28)26-20-5-2-15(22)11-25-20/h2-8,11H,1H3,(H,25,26)
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n/an/a 57n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165742
PNG
(US9067922, 76)
Show SMILES COc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)ccc1C#N
Show InChI InChI=1S/C20H13FN4O4S/c1-28-19-9-16(4-2-13(19)10-22)29-18-6-5-17(8-14(18)11-23)30(26,27)25-20-7-3-15(21)12-24-20/h2-9,12H,1H3,(H,24,25)
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n/an/a 57n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165685
PNG
(US9067922, 19)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(c3)C#N)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10F2N4O3S/c20-14-1-6-19(24-11-14)25-29(26,27)16-3-5-18(13(8-16)10-23)28-15-2-4-17(21)12(7-15)9-22/h1-8,11H,(H,24,25)
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n/an/a 57n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165772
PNG
(US9067922, 107)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(Cl)c(F)cc3Cl)c(c2)C#N)nc1
Show InChI InChI=1S/C18H9Cl2F2N3O3S/c19-13-7-17(14(20)6-15(13)22)28-16-3-2-12(5-10(16)8-23)29(26,27)25-18-4-1-11(21)9-24-18/h1-7,9H,(H,24,25)
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n/an/a 58n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165891
PNG
(US9067922, 230)
Show SMILES Fc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(cn2)C#N)cc1Cl
Show InChI InChI=1S/C19H10ClFN4O3S/c20-16-8-14(2-4-17(16)21)28-18-5-3-15(7-13(18)10-23)29(26,27)25-19-6-1-12(9-22)11-24-19/h1-8,11H,(H,24,25)
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n/an/a 62n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165673
PNG
(US9067922, 7)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)cc3F)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10F3N3O3S/c19-12-1-4-17(15(21)8-12)27-16-5-3-14(7-11(16)9-22)28(25,26)24-18-6-2-13(20)10-23-18/h1-8,10H,(H,23,24)
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n/an/a 64n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165779
PNG
(US9067922, 114)
Show SMILES COc1cccc(Cl)c1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C19H13ClFN3O4S/c1-27-17-4-2-3-15(20)19(17)28-16-7-6-14(9-12(16)10-22)29(25,26)24-18-8-5-13(21)11-23-18/h2-9,11H,1H3,(H,23,24)
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n/an/a 69n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165776
PNG
(US9067922, 111)
Show SMILES COc1cccc(F)c1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C19H13F2N3O4S/c1-27-17-4-2-3-15(21)19(17)28-16-7-6-14(9-12(16)10-22)29(25,26)24-18-8-5-13(20)11-23-18/h2-9,11H,1H3,(H,23,24)
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n/an/a 74n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165679
PNG
(US9067922, 10)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(cc3)C#N)c(c2)C#N)nc1
Show InChI InChI=1S/C19H11FN4O3S/c20-15-3-8-19(23-12-15)24-28(25,26)17-6-7-18(14(9-17)11-22)27-16-4-1-13(10-21)2-5-16/h1-9,12H,(H,23,24)
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n/an/a 74n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165862
PNG
(US9067922, 201)
Show SMILES COc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)c(C)c1
Show InChI InChI=1S/C20H16FN3O4S/c1-13-9-16(27-2)4-6-18(13)28-19-7-5-17(10-14(19)11-22)29(25,26)24-20-8-3-15(21)12-23-20/h3-10,12H,1-2H3,(H,23,24)
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n/an/a 74n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165807
PNG
(US9067922, 142)
Show SMILES COc1ccccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C19H14FN3O4S/c1-26-17-4-2-3-5-18(17)27-16-8-7-15(10-13(16)11-21)28(24,25)23-19-9-6-14(20)12-22-19/h2-10,12H,1H3,(H,22,23)
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n/an/a 75n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165738
PNG
(US9067922, 72)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(F)c(cc3F)C#N)c(c2)C#N)nc1
Show InChI InChI=1S/C19H9F3N4O3S/c20-13-1-4-19(25-10-13)26-30(27,28)14-2-3-17(12(5-14)9-24)29-18-7-15(21)11(8-23)6-16(18)22/h1-7,10H,(H,25,26)
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n/an/a 77n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165697
PNG
(US9067922, 31)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)cc3Cl)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10ClF2N3O3S/c19-15-8-12(20)1-4-17(15)27-16-5-3-14(7-11(16)9-22)28(25,26)24-18-6-2-13(21)10-23-18/h1-8,10H,(H,23,24)
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n/an/a 78n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165808
PNG
(US9067922, 143)
Show SMILES COc1cc(Cl)ccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C19H13ClFN3O4S/c1-27-18-9-13(20)2-5-17(18)28-16-6-4-15(8-12(16)10-22)29(25,26)24-19-7-3-14(21)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 79n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165700
PNG
(US9067922, 34)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)ccc1Cl
Show InChI InChI=1S/C19H13ClFN3O3S/c1-12-8-15(3-5-17(12)20)27-18-6-4-16(9-13(18)10-22)28(25,26)24-19-7-2-14(21)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 80n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165705
PNG
(US9067922, 39)
Show SMILES Cc1ccc(Cl)cc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C19H13ClFN3O3S/c1-12-2-3-14(20)9-18(12)27-17-6-5-16(8-13(17)10-22)28(25,26)24-19-7-4-15(21)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 80n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165678
PNG
(US9067922, 13)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3Cl)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10Cl2FN3O3S/c19-12-1-4-17(15(20)8-12)27-16-5-3-14(7-11(16)9-22)28(25,26)24-18-6-2-13(21)10-23-18/h1-8,10H,(H,23,24)
KEGG

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n/an/a 84n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%