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Patent code US9073911

Compile Data Set for Download or QSAR
Found 108 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167453
PNG
(US9073911, 2)
Show SMILES Clc1cccc(c1)-c1cc(n[nH]1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 0.300n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167463
PNG
(US9073911, 12)
Show SMILES Clc1ccc(cc1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
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 0.400n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167466
PNG
(US9073911, 15)
Show SMILES Clc1cccc(c1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
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 0.400n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167453
PNG
(US9073911, 2)
Show SMILES Clc1cccc(c1)-c1cc(n[nH]1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 0.400n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167463
PNG
(US9073911, 12)
Show SMILES Clc1ccc(cc1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
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 0.5n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167461
PNG
(US9073911, 10)
Show SMILES Clc1ccccc1-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 0.5n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167491
PNG
(US9073911, 40)
Show SMILES FC(F)Oc1cccc(c1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 0.5n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167466
PNG
(US9073911, 15)
Show SMILES Clc1cccc(c1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
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 0.600n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167497
PNG
(US9073911, 46)
Show SMILES FC(F)Oc1ccc(cc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
Show InChI InChI=1S/C21H20F2N4O3/c22-21(23)30-17-7-5-16(6-8-17)27-11-9-18(26-27)20(28)25-15-3-1-14(2-4-15)19-13-24-10-12-29-19/h1-9,11,19,21,24H,10,12-13H2,(H,25,28)/t19-/m0/s1
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 0.600n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167486
PNG
(US9073911, 35)
Show SMILES FC(F)(F)c1ccc(nc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)14-3-6-18(25-11-14)28-9-7-16(27-28)19(29)26-15-4-1-13(2-5-15)17-12-24-8-10-30-17/h1-7,9,11,17,24H,8,10,12H2,(H,26,29)/t17-/m0/s1
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 0.600n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167483
PNG
(US9073911, 32)
Show SMILES Clc1ccc(nc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C19H18ClN5O2/c20-14-3-6-18(22-11-14)25-9-7-16(24-25)19(26)23-15-4-1-13(2-5-15)17-12-21-8-10-27-17/h1-7,9,11,17,21H,8,10,12H2,(H,23,26)/t17-/m1/s1
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 0.700n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167452
PNG
(US9073911, 1)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cc([nH]n1)-c1ccccc1 |r|
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 0.700n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167454
PNG
(US9073911, 3)
Show SMILES Fc1ccc(cc1)-c1cc(n[nH]1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 0.800n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167464
PNG
(US9073911, 13)
Show SMILES Clc1ccccc1-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
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 0.800n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167459
PNG
(US9073911, 8)
Show SMILES Fc1ccccc1-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 0.900n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167493
PNG
(US9073911, 42)
Show SMILES CCn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1cccc(OC(F)F)c1 |r|
Show InChI InChI=1S/C23H24F2N4O3/c1-2-29-20(13-19(28-29)16-4-3-5-18(12-16)32-23(24)25)22(30)27-17-8-6-15(7-9-17)21-14-26-10-11-31-21/h3-9,12-13,21,23,26H,2,10-11,14H2,1H3,(H,27,30)/t21-/m1/s1
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 1n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167464
PNG
(US9073911, 13)
Show SMILES Clc1ccccc1-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
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 1n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167455
PNG
(US9073911, 4)
Show SMILES COc1cccc(c1)-c1cc(n[nH]1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 1n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167480
PNG
(US9073911, 29)
Show SMILES Fc1ccc(cc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C20H19FN4O2/c21-15-3-7-17(8-4-15)25-11-9-18(24-25)20(26)23-16-5-1-14(2-6-16)19-13-22-10-12-27-19/h1-9,11,19,22H,10,12-13H2,(H,23,26)/t19-/m1/s1
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 1.10n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167483
PNG
(US9073911, 32)
Show SMILES Clc1ccc(nc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C19H18ClN5O2/c20-14-3-6-18(22-11-14)25-9-7-16(24-25)19(26)23-15-4-1-13(2-5-15)17-12-21-8-10-27-17/h1-7,9,11,17,21H,8,10,12H2,(H,23,26)/t17-/m1/s1
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 1.10n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167458
PNG
(US9073911, 7)
Show SMILES COc1ccc(cc1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 1.20n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167467
PNG
(US9073911, 16)
Show SMILES COc1cccc(c1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
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 1.30n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167482
PNG
(US9073911, 31)
Show SMILES Fc1ccc(cc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
Show InChI InChI=1S/C20H19FN4O2/c21-15-3-7-17(8-4-15)25-11-9-18(24-25)20(26)23-16-5-1-14(2-6-16)19-13-22-10-12-27-19/h1-9,11,19,22H,10,12-13H2,(H,23,26)/t19-/m0/s1
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 1.30n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167491
PNG
(US9073911, 40)
Show SMILES FC(F)Oc1cccc(c1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 1.30n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167460
PNG
(US9073911, 9)
Show SMILES COc1ccccc1-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 1.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167496
PNG
(US9073911, 45)
Show SMILES FC(F)Oc1ccc(cc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C21H20F2N4O3/c22-21(23)30-17-7-5-16(6-8-17)27-11-9-18(26-27)20(28)25-15-3-1-14(2-4-15)19-13-24-10-12-29-19/h1-9,11,19,21,24H,10,12-13H2,(H,25,28)/t19-/m1/s1
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 1.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167490
PNG
(US9073911, 39)
Show SMILES Fc1ccc(cc1C#N)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 1.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167487
PNG
(US9073911, 36)
Show SMILES O=C(Nc1ccc(cc1)[C@@H]1CCCNC1)c1cc(n[nH]1)-c1cccc(c1)C#N |r|
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 1.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167467
PNG
(US9073911, 16)
Show SMILES COc1cccc(c1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
PDB

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 1.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167494
PNG
(US9073911, 43)
Show SMILES Fc1c(cccc1-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)C#N |r|
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 1.60n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167468
PNG
(US9073911, 17)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C21H21ClN4O2/c1-26-19(12-18(25-26)15-3-2-4-16(22)11-15)21(27)24-17-7-5-14(6-8-17)20-13-23-9-10-28-20/h2-8,11-12,20,23H,9-10,13H2,1H3,(H,24,27)/t20-/m1/s1
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 1.60n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167492
PNG
(US9073911, 41)
Show SMILES CCn1nc(cc1-c1cccc(OC(F)F)c1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C23H24F2N4O3/c1-2-29-20(16-4-3-5-18(12-16)32-23(24)25)13-19(28-29)22(30)27-17-8-6-15(7-9-17)21-14-26-10-11-31-21/h3-9,12-13,21,23,26H,2,10-11,14H2,1H3,(H,27,30)/t21-/m1/s1
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 1.60n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167484
PNG
(US9073911, 33)
Show SMILES FC(F)(F)c1ccc(nc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)14-3-6-18(25-11-14)28-9-7-16(27-28)19(29)26-15-4-1-13(2-5-15)17-12-24-8-10-30-17/h1-7,9,11,17,24H,8,10,12H2,(H,26,29)/t17-/m1/s1
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 1.60n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167457
PNG
(US9073911, 6)
Show SMILES Cc1c(n[nH]c1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1ccccc1 |r|
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 1.60n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167469
PNG
(US9073911, 18)
Show SMILES Cn1nc(cc1-c1ccccc1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C21H22N4O2/c1-25-19(15-5-3-2-4-6-15)13-18(24-25)21(26)23-17-9-7-16(8-10-17)20-14-22-11-12-27-20/h2-10,13,20,22H,11-12,14H2,1H3,(H,23,26)/t20-/m1/s1
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 1.70n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167488
PNG
(US9073911, 37)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CCCNC1)c1cc(n[nH]1)-c1cccc(c1)C#N |r|
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 1.70n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167465
PNG
(US9073911, 14)
Show SMILES Clc1ccc(cc1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 1.70n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167496
PNG
(US9073911, 45)
Show SMILES FC(F)Oc1ccc(cc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C21H20F2N4O3/c22-21(23)30-17-7-5-16(6-8-17)27-11-9-18(26-27)20(28)25-15-3-1-14(2-4-15)19-13-24-10-12-29-19/h1-9,11,19,21,24H,10,12-13H2,(H,25,28)/t19-/m1/s1
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 1.80n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167489
PNG
(US9073911, 38)
Show SMILES O=C(Nc1ccc(cc1)C1CCNC1)c1cc(n[nH]1)-c1cccc(c1)C#N
PDB

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 2.10n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167478
PNG
(US9073911, 27)
Show SMILES Cc1c(n[nH]c1-c1cccc(c1)C#N)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 2.10n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167493
PNG
(US9073911, 42)
Show SMILES CCn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1cccc(OC(F)F)c1 |r|
Show InChI InChI=1S/C23H24F2N4O3/c1-2-29-20(13-19(28-29)16-4-3-5-18(12-16)32-23(24)25)22(30)27-17-8-6-15(7-9-17)21-14-26-10-11-31-21/h3-9,12-13,21,23,26H,2,10-11,14H2,1H3,(H,27,30)/t21-/m1/s1
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 2.10n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167471
PNG
(US9073911, 20)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cc([nH]n1)-c1cccc(c1)[N+]#[C-] |r|
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 2.20n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167486
PNG
(US9073911, 35)
Show SMILES FC(F)(F)c1ccc(nc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)14-3-6-18(25-11-14)28-9-7-16(27-28)19(29)26-15-4-1-13(2-5-15)17-12-24-8-10-30-17/h1-7,9,11,17,24H,8,10,12H2,(H,26,29)/t17-/m0/s1
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 2.20n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167473
PNG
(US9073911, 22)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H21FN4O2/c1-26-19(12-18(25-26)14-2-6-16(22)7-3-14)21(27)24-17-8-4-15(5-9-17)20-13-23-10-11-28-20/h2-9,12,20,23H,10-11,13H2,1H3,(H,24,27)/t20-/m0/s1
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 2.20n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167455
PNG
(US9073911, 4)
Show SMILES COc1cccc(c1)-c1cc(n[nH]1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
PDB

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 2.20n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167473
PNG
(US9073911, 22)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C21H21FN4O2/c1-26-19(12-18(25-26)14-2-6-16(22)7-3-14)21(27)24-17-8-4-15(5-9-17)20-13-23-10-11-28-20/h2-9,12,20,23H,10-11,13H2,1H3,(H,24,27)/t20-/m0/s1
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 2.30n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167482
PNG
(US9073911, 31)
Show SMILES Fc1ccc(cc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
Show InChI InChI=1S/C20H19FN4O2/c21-15-3-7-17(8-4-15)25-11-9-18(24-25)20(26)23-16-5-1-14(2-6-16)19-13-22-10-12-27-19/h1-9,11,19,22H,10,12-13H2,(H,23,26)/t19-/m0/s1
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 2.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167468
PNG
(US9073911, 17)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C21H21ClN4O2/c1-26-19(12-18(25-26)15-3-2-4-16(22)11-15)21(27)24-17-7-5-14(6-8-17)20-13-23-9-10-28-20/h2-8,11-12,20,23H,9-10,13H2,1H3,(H,24,27)/t20-/m1/s1
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 2.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167480
PNG
(US9073911, 29)
Show SMILES Fc1ccc(cc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C20H19FN4O2/c21-15-3-7-17(8-4-15)25-11-9-18(24-25)20(26)23-16-5-1-14(2-6-16)19-13-22-10-12-27-19/h1-9,11,19,22H,10,12-13H2,(H,23,26)/t19-/m1/s1
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 2.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167492
PNG
(US9073911, 41)
Show SMILES CCn1nc(cc1-c1cccc(OC(F)F)c1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C23H24F2N4O3/c1-2-29-20(16-4-3-5-18(12-16)32-23(24)25)13-19(28-29)22(30)27-17-8-6-15(7-9-17)21-14-26-10-11-31-21/h3-9,12-13,21,23,26H,2,10-11,14H2,1H3,(H,27,30)/t21-/m1/s1
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 2.5n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167461
PNG
(US9073911, 10)
Show SMILES Clc1ccccc1-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 2.60n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167462
PNG
(US9073911, 11)
Show SMILES COc1ccc(cc1OC)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 2.60n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167454
PNG
(US9073911, 3)
Show SMILES Fc1ccc(cc1)-c1cc(n[nH]1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 2.70n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167488
PNG
(US9073911, 37)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CCCNC1)c1cc(n[nH]1)-c1cccc(c1)C#N |r|
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 2.70n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167501
PNG
(US9073911, 50)
Show SMILES Clc1cnc(cn1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C18H17ClN6O2/c19-16-10-22-17(11-21-16)25-7-5-14(24-25)18(26)23-13-3-1-12(2-4-13)15-9-20-6-8-27-15/h1-5,7,10-11,15,20H,6,8-9H2,(H,23,26)/t15-/m1/s1
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 2.70n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167484
PNG
(US9073911, 33)
Show SMILES FC(F)(F)c1ccc(nc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)14-3-6-18(25-11-14)28-9-7-16(27-28)19(29)26-15-4-1-13(2-5-15)17-12-24-8-10-30-17/h1-7,9,11,17,24H,8,10,12H2,(H,26,29)/t17-/m1/s1
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 2.80n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167465
PNG
(US9073911, 14)
Show SMILES Clc1ccc(cc1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 2.80n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167470
PNG
(US9073911, 19)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1)-c1ccccc1 |r|
Show InChI InChI=1S/C21H22N4O2/c1-25-19(13-18(24-25)15-5-3-2-4-6-15)21(26)23-17-9-7-16(8-10-17)20-14-22-11-12-27-20/h2-10,13,20,22H,11-12,14H2,1H3,(H,23,26)/t20-/m0/s1
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 2.80n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167490
PNG
(US9073911, 39)
Show SMILES Fc1ccc(cc1C#N)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 3n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167485
PNG
(US9073911, 34)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1ccn(n1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C21H19N5O2/c22-13-15-1-7-18(8-2-15)26-11-9-19(25-26)21(27)24-17-5-3-16(4-6-17)20-14-23-10-12-28-20/h1-9,11,20,23H,10,12,14H2,(H,24,27)/t20-/m1/s1
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 3.70n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167497
PNG
(US9073911, 46)
Show SMILES FC(F)Oc1ccc(cc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1 |r|
Show InChI InChI=1S/C21H20F2N4O3/c22-21(23)30-17-7-5-16(6-8-17)27-11-9-18(26-27)20(28)25-15-3-1-14(2-4-15)19-13-24-10-12-29-19/h1-9,11,19,21,24H,10,12-13H2,(H,25,28)/t19-/m0/s1
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 4n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167489
PNG
(US9073911, 38)
Show SMILES O=C(Nc1ccc(cc1)C1CCNC1)c1cc(n[nH]1)-c1cccc(c1)C#N
PDB

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 4.20n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167479
PNG
(US9073911, 28)
Show SMILES Fc1ccc(cc1-c1cc(n[nH]1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)C#N |r|
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 4.30n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167452
PNG
(US9073911, 1)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cc([nH]n1)-c1ccccc1 |r|
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 4.30n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167456
PNG
(US9073911, 5)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1ccccc1 |r|
Show InChI InChI=1S/C21H22N4O2/c1-25-19(13-18(24-25)15-5-3-2-4-6-15)21(26)23-17-9-7-16(8-10-17)20-14-22-11-12-27-20/h2-10,13,20,22H,11-12,14H2,1H3,(H,23,26)/t20-/m1/s1
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 4.5n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167458
PNG
(US9073911, 7)
Show SMILES COc1ccc(cc1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
PDB

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 4.90n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167476
PNG
(US9073911, 25)
Show SMILES CCn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C23H23N5O2/c1-2-28-21(13-20(27-28)18-5-3-4-16(12-18)14-24)23(29)26-19-8-6-17(7-9-19)22-15-25-10-11-30-22/h3-9,12-13,22,25H,2,10-11,15H2,1H3,(H,26,29)/t22-/m1/s1
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 5.10n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167472
PNG
(US9073911, 21)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1ccc(cc1)[N+]#[C-] |r|
Show InChI InChI=1S/C22H21N5O2/c1-23-17-7-3-15(4-8-17)19-13-20(27(2)26-19)22(28)25-18-9-5-16(6-10-18)21-14-24-11-12-29-21/h3-10,13,21,24H,11-12,14H2,2H3,(H,25,28)/t21-/m1/s1
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 5.30n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167472
PNG
(US9073911, 21)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1ccc(cc1)[N+]#[C-] |r|
Show InChI InChI=1S/C22H21N5O2/c1-23-17-7-3-15(4-8-17)19-13-20(27(2)26-19)22(28)25-18-9-5-16(6-10-18)21-14-24-11-12-29-21/h3-10,13,21,24H,11-12,14H2,2H3,(H,25,28)/t21-/m1/s1
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 5.5n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167474
PNG
(US9073911, 23)
Show SMILES COc1cccc(c1)-c1cc(C(=O)Nc2ccc(cc2)[C@H]2CNCCO2)n(C)n1 |r|
Show InChI InChI=1S/C22H24N4O3/c1-26-20(13-19(25-26)16-4-3-5-18(12-16)28-2)22(27)24-17-8-6-15(7-9-17)21-14-23-10-11-29-21/h3-9,12-13,21,23H,10-11,14H2,1-2H3,(H,24,27)/t21-/m1/s1
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 6.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167505
PNG
(US9073911, 54)
Show SMILES FC(F)(F)c1nccc(n1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)18-24-7-5-16(26-18)28-9-6-14(27-28)17(29)25-13-3-1-12(2-4-13)15-11-23-8-10-30-15/h1-7,9,15,23H,8,10-11H2,(H,25,29)/t15-/m1/s1
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 6.5n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167475
PNG
(US9073911, 24)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C22H21N5O2/c1-27-20(12-19(26-27)17-4-2-3-15(11-17)13-23)22(28)25-18-7-5-16(6-8-18)21-14-24-9-10-29-21/h2-8,11-12,21,24H,9-10,14H2,1H3,(H,25,28)/t21-/m1/s1
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 6.70n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167502
PNG
(US9073911, 51)
Show SMILES FC(F)(F)c1cc(ncn1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-9-17(25-11-24-16)28-7-5-14(27-28)18(29)26-13-3-1-12(2-4-13)15-10-23-6-8-30-15/h1-5,7,9,11,15,23H,6,8,10H2,(H,26,29)/t15-/m1/s1
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 7.10n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167456
PNG
(US9073911, 5)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1ccccc1 |r|
Show InChI InChI=1S/C21H22N4O2/c1-25-19(13-18(24-25)15-5-3-2-4-6-15)21(26)23-17-9-7-16(8-10-17)20-14-22-11-12-27-20/h2-10,13,20,22H,11-12,14H2,1H3,(H,23,26)/t20-/m1/s1
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 7.20n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167459
PNG
(US9073911, 8)
Show SMILES Fc1ccccc1-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 7.30n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167503
PNG
(US9073911, 52)
Show SMILES FC(F)(F)c1cncc(n1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-10-24-11-17(26-16)28-7-5-14(27-28)18(29)25-13-3-1-12(2-4-13)15-9-23-6-8-30-15/h1-5,7,10-11,15,23H,6,8-9H2,(H,25,29)/t15-/m1/s1
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 7.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167471
PNG
(US9073911, 20)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cc([nH]n1)-c1cccc(c1)[N+]#[C-] |r|
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 7.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167476
PNG
(US9073911, 25)
Show SMILES CCn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C23H23N5O2/c1-2-28-21(13-20(27-28)18-5-3-4-16(12-18)14-24)23(29)26-19-8-6-17(7-9-19)22-15-25-10-11-30-22/h3-9,12-13,22,25H,2,10-11,15H2,1H3,(H,26,29)/t22-/m1/s1
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 7.80n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167470
PNG
(US9073911, 19)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1)-c1ccccc1 |r|
Show InChI InChI=1S/C21H22N4O2/c1-25-19(13-18(24-25)15-5-3-2-4-6-15)21(26)23-17-9-7-16(8-10-17)20-14-22-11-12-27-20/h2-10,13,20,22H,11-12,14H2,1H3,(H,23,26)/t20-/m0/s1
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 7.90n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167457
PNG
(US9073911, 6)
Show SMILES Cc1c(n[nH]c1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1ccccc1 |r|
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 8n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167503
PNG
(US9073911, 52)
Show SMILES FC(F)(F)c1cncc(n1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-10-24-11-17(26-16)28-7-5-14(27-28)18(29)25-13-3-1-12(2-4-13)15-9-23-6-8-30-15/h1-5,7,10-11,15,23H,6,8-9H2,(H,25,29)/t15-/m1/s1
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 8.40n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167499
PNG
(US9073911, 48)
Show SMILES Clc1cncc(n1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C18H17ClN6O2/c19-16-10-21-11-17(23-16)25-7-5-14(24-25)18(26)22-13-3-1-12(2-4-13)15-9-20-6-8-27-15/h1-5,7,10-11,15,20H,6,8-9H2,(H,22,26)/t15-/m1/s1
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 8.60n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167474
PNG
(US9073911, 23)
Show SMILES COc1cccc(c1)-c1cc(C(=O)Nc2ccc(cc2)[C@H]2CNCCO2)n(C)n1 |r|
Show InChI InChI=1S/C22H24N4O3/c1-26-20(13-19(25-26)16-4-3-5-18(12-16)28-2)22(27)24-17-8-6-15(7-9-17)21-14-23-10-11-29-21/h3-9,12-13,21,23H,10-11,14H2,1-2H3,(H,24,27)/t21-/m1/s1
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 8.80n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167505
PNG
(US9073911, 54)
Show SMILES FC(F)(F)c1nccc(n1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)18-24-7-5-16(26-18)28-9-6-14(27-28)17(29)25-13-3-1-12(2-4-13)15-11-23-8-10-30-15/h1-7,9,15,23H,8,10-11H2,(H,25,29)/t15-/m1/s1
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 8.80n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167501
PNG
(US9073911, 50)
Show SMILES Clc1cnc(cn1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C18H17ClN6O2/c19-16-10-22-17(11-21-16)25-7-5-14(24-25)18(26)23-13-3-1-12(2-4-13)15-9-20-6-8-27-15/h1-5,7,10-11,15,20H,6,8-9H2,(H,23,26)/t15-/m1/s1
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 9.10n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167485
PNG
(US9073911, 34)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1ccn(n1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C21H19N5O2/c22-13-15-1-7-18(8-2-15)26-11-9-19(25-26)21(27)24-17-5-3-16(4-6-17)20-14-23-10-12-28-20/h1-9,11,20,23H,10,12,14H2,(H,24,27)/t20-/m1/s1
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 9.20n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167504
PNG
(US9073911, 53)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1ccn(n1)-c1cnc(cn1)C#N |r|
Show InChI InChI=1S/C19H17N7O2/c20-9-15-10-23-18(12-22-15)26-7-5-16(25-26)19(27)24-14-3-1-13(2-4-14)17-11-21-6-8-28-17/h1-5,7,10,12,17,21H,6,8,11H2,(H,24,27)/t17-/m1/s1
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 11n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167494
PNG
(US9073911, 43)
Show SMILES Fc1c(cccc1-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)C#N |r|
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 11n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167499
PNG
(US9073911, 48)
Show SMILES Clc1cncc(n1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C18H17ClN6O2/c19-16-10-21-11-17(23-16)25-7-5-14(24-25)18(26)22-13-3-1-12(2-4-13)15-9-20-6-8-27-15/h1-5,7,10-11,15,20H,6,8-9H2,(H,22,26)/t15-/m1/s1
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 11.8n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167462
PNG
(US9073911, 11)
Show SMILES COc1ccc(cc1OC)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 12.7n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167479
PNG
(US9073911, 28)
Show SMILES Fc1ccc(cc1-c1cc(n[nH]1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)C#N |r|
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 12.9n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167478
PNG
(US9073911, 27)
Show SMILES Cc1c(n[nH]c1-c1cccc(c1)C#N)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 13.5n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167487
PNG
(US9073911, 36)
Show SMILES O=C(Nc1ccc(cc1)[C@@H]1CCCNC1)c1cc(n[nH]1)-c1cccc(c1)C#N |r|
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 13.8n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167460
PNG
(US9073911, 9)
Show SMILES COc1ccccc1-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
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 14n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167500
PNG
(US9073911, 49)
Show SMILES Clc1nccnc1-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C18H17ClN6O2/c19-16-17(22-7-6-21-16)25-9-5-14(24-25)18(26)23-13-3-1-12(2-4-13)15-11-20-8-10-27-15/h1-7,9,15,20H,8,10-11H2,(H,23,26)/t15-/m1/s1
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 14.2n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167475
PNG
(US9073911, 24)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1cccc(c1)C#N |r|
Show InChI InChI=1S/C22H21N5O2/c1-27-20(12-19(26-27)17-4-2-3-15(11-17)13-23)22(28)25-18-7-5-16(6-8-18)21-14-24-9-10-29-21/h2-8,11-12,21,24H,9-10,14H2,1H3,(H,25,28)/t21-/m1/s1
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 14.2n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167502
PNG
(US9073911, 51)
Show SMILES FC(F)(F)c1cc(ncn1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-9-17(25-11-24-16)28-7-5-14(27-28)18(29)26-13-3-1-12(2-4-13)15-10-23-6-8-30-15/h1-5,7,9,11,15,23H,6,8,10H2,(H,26,29)/t15-/m1/s1
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 14.2n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167498
PNG
(US9073911, 47)
Show SMILES FC(F)(F)c1cnc(nc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)13-9-24-18(25-10-13)28-7-5-15(27-28)17(29)26-14-3-1-12(2-4-14)16-11-23-6-8-30-16/h1-5,7,9-10,16,23H,6,8,11H2,(H,26,29)/t16-/m1/s1
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 19.6n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167498
PNG
(US9073911, 47)
Show SMILES FC(F)(F)c1cnc(nc1)-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)13-9-24-18(25-10-13)28-7-5-15(27-28)17(29)26-14-3-1-12(2-4-14)16-11-23-6-8-30-16/h1-5,7,9-10,16,23H,6,8,11H2,(H,26,29)/t16-/m1/s1
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 19.8n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167469
PNG
(US9073911, 18)
Show SMILES Cn1nc(cc1-c1ccccc1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C21H22N4O2/c1-25-19(15-5-3-2-4-6-15)13-18(24-25)21(26)23-17-9-7-16(8-10-17)20-14-22-11-12-27-20/h2-10,13,20,22H,11-12,14H2,1H3,(H,23,26)/t20-/m1/s1
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 25.4n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167495
PNG
(US9073911, 44)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1cccc(OC(F)F)c1 |r|
Show InChI InChI=1S/C22H22F2N4O3/c1-28-19(12-18(27-28)15-3-2-4-17(11-15)31-22(23)24)21(29)26-16-7-5-14(6-8-16)20-13-25-9-10-30-20/h2-8,11-12,20,22,25H,9-10,13H2,1H3,(H,26,29)/t20-/m1/s1
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 26.2n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167504
PNG
(US9073911, 53)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1ccn(n1)-c1cnc(cn1)C#N |r|
Show InChI InChI=1S/C19H17N7O2/c20-9-15-10-23-18(12-22-15)26-7-5-16(25-26)19(27)24-14-3-1-13(2-4-14)17-11-21-6-8-28-17/h1-5,7,10,12,17,21H,6,8,11H2,(H,24,27)/t17-/m1/s1
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 29.8n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167477
PNG
(US9073911, 26)
Show SMILES CCn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1ccc(cc1)[N+]#[C-] |r|
Show InChI InChI=1S/C23H23N5O2/c1-3-28-21(14-20(27-28)16-4-8-18(24-2)9-5-16)23(29)26-19-10-6-17(7-11-19)22-15-25-12-13-30-22/h4-11,14,22,25H,3,12-13,15H2,1H3,(H,26,29)/t22-/m1/s1
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 31.6n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167495
PNG
(US9073911, 44)
Show SMILES Cn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1cccc(OC(F)F)c1 |r|
Show InChI InChI=1S/C22H22F2N4O3/c1-28-19(12-18(27-28)15-3-2-4-17(11-15)31-22(23)24)21(29)26-16-7-5-14(6-8-16)20-13-25-9-10-30-20/h2-8,11-12,20,22,25H,9-10,13H2,1H3,(H,26,29)/t20-/m1/s1
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 66.3n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167477
PNG
(US9073911, 26)
Show SMILES CCn1nc(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1ccc(cc1)[N+]#[C-] |r|
Show InChI InChI=1S/C23H23N5O2/c1-3-28-21(14-20(27-28)16-4-8-18(24-2)9-5-16)23(29)26-19-10-6-17(7-11-19)22-15-25-12-13-30-22/h4-11,14,22,25H,3,12-13,15H2,1H3,(H,26,29)/t22-/m1/s1
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 73.4n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167500
PNG
(US9073911, 49)
Show SMILES Clc1nccnc1-n1ccc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Show InChI InChI=1S/C18H17ClN6O2/c19-16-17(22-7-6-21-16)25-9-5-14(24-25)18(26)23-13-3-1-12(2-4-13)15-11-20-8-10-27-15/h1-7,9,15,20H,8,10-11H2,(H,23,26)/t15-/m1/s1
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 139n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Mus musculus (Mouse))		BDBM167481
PNG
(US9073911, 30)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1ccnn1-c1ccccc1 |r|
Show InChI InChI=1S/C20H20N4O2/c25-20(18-10-11-22-24(18)17-4-2-1-3-5-17)23-16-8-6-15(7-9-16)19-14-21-12-13-26-19/h1-11,19,21H,12-14H2,(H,23,25)/t19-/m1/s1
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 143n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))		BDBM167481
PNG
(US9073911, 30)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1ccnn1-c1ccccc1 |r|
Show InChI InChI=1S/C20H20N4O2/c25-20(18-10-11-22-24(18)17-4-2-1-3-5-17)23-16-8-6-15(7-9-16)19-14-21-12-13-26-19/h1-11,19,21H,12-14H2,(H,23,25)/t19-/m1/s1
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 1.32E+3n/an/an/an/an/an/a7.4n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...

US Patent US9073911 (2015)


BindingDB Entry DOI: 10.7270/Q2N29VPX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%